LOCUS       NM_001008384            1325 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus Rac family small GTPase 2 (Rac2), mRNA.
ACCESSION   NM_001008384 XM_345854
VERSION     NM_001008384.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1325)
  AUTHORS   Wang,J., Ma,S.H., Tao,R., Xia,L.J., Liu,L. and Jiang,Y.H.
  TITLE     Gene expression profile changes in rat dorsal horn after sciatic
            nerve injury
  JOURNAL   Neurol Res 39 (2), 176-182 (2017)
   PUBMED   28033741
  REMARK    GeneRIF: This study showed that CCL2, NF-kappaB1, RAC2, FCER1G and
            C1Q may contribute to the generation of neuropathic pain after
            sciatic nerve injury via immune and defense pathways.
REFERENCE   2  (bases 1 to 1325)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 1325)
  AUTHORS   Abe,D., Kubota,T., Morozumi,T., Shimizu,T., Nakasone,N., Itagaki,M.
            and Yoshie,H.
  TITLE     Altered gene expression in leukocyte transendothelial migration and
            cell communication pathways in periodontitis-affected gingival
            tissues
  JOURNAL   J Periodontal Res 46 (3), 345-353 (2011)
   PUBMED   21382035
REFERENCE   4  (bases 1 to 1325)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 1325)
  AUTHORS   Lawson,C.D., Donald,S., Anderson,K.E., Patton,D.T. and Welch,H.C.
  TITLE     P-Rex1 and Vav1 cooperate in the regulation of
            formyl-methionyl-leucyl-phenylalanine-dependent neutrophil
            responses
  JOURNAL   J Immunol 186 (3), 1467-1476 (2011)
   PUBMED   21178006
REFERENCE   6  (bases 1 to 1325)
  AUTHORS   Yu,H., Leitenberg,D., Li,B. and Flavell,R.A.
  TITLE     Deficiency of small GTPase Rac2 affects T cell activation
  JOURNAL   J Exp Med 194 (7), 915-926 (2001)
   PUBMED   11581314
REFERENCE   7  (bases 1 to 1325)
  AUTHORS   Ingram,D.A., Hiatt,K., King,A.J., Fisher,L., Shivakumar,R.,
            Derstine,C., Wenning,M.J., Diaz,B., Travers,J.B., Hood,A.,
            Marshall,M., Williams,D.A. and Clapp,D.W.
  TITLE     Hyperactivation of p21(ras) and the hematopoietic-specific Rho
            GTPase, Rac2, cooperate to alter the proliferation of
            neurofibromin-deficient mast cells in vivo and in vitro
  JOURNAL   J Exp Med 194 (1), 57-69 (2001)
   PUBMED   11435472
REFERENCE   8  (bases 1 to 1325)
  AUTHORS   Yang,F.C., Kapur,R., King,A.J., Tao,W., Kim,C., Borneo,J.,
            Breese,R., Marshall,M., Dinauer,M.C. and Williams,D.A.
  TITLE     Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression
            while mediating survival and actin function in primary mast cells
  JOURNAL   Immunity 12 (5), 557-568 (2000)
   PUBMED   10843388
REFERENCE   9  (bases 1 to 1325)
  AUTHORS   Ambruso,D.R., Knall,C., Abell,A.N., Panepinto,J., Kurkchubasche,A.,
            Thurman,G., Gonzalez-Aller,C., Hiester,A., deBoer,M., Harbeck,R.J.,
            Oyer,R., Johnson,G.L. and Roos,D.
  TITLE     Human neutrophil immunodeficiency syndrome is associated with an
            inhibitory Rac2 mutation
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4654-4659 (2000)
   PUBMED   10758162
REFERENCE   10 (bases 1 to 1325)
  AUTHORS   Razzouk,S., Lieberherr,M. and Cournot,G.
  TITLE     Rac-GTPase, osteoclast cytoskeleton and bone resorption
  JOURNAL   Eur J Cell Biol 78 (4), 249-255 (1999)
   PUBMED   10350213
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086399.1.
            
            On Dec 16, 2004 this sequence version replaced XM_345854.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086399.1, FQ225192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680433, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1325
                     /gene="Rac2"
                     /note="Rac family small GTPase 2"
                     /db_xref="GeneID:366957"
                     /db_xref="RGD:1307568"
     exon            1..132
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..676
                     /gene="Rac2"
                     /EC_number="3.6.5.2"
                     /note="RAS-related C3 botulinum substrate 2; ras-related
                     C3 botulinum toxin substrate 2 (rho family, small GTP
                     binding protein Rac2)"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 2"
                     /protein_id="NP_001008385.1"
                     /db_xref="GeneID:366957"
                     /db_xref="RGD:1307568"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVR
                     HHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL"
     exon            133..204
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            205..322
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..385
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            386..545
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..678
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1303
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactgccagg cacctcctag cctctccgta ccactggtgt ccacagcagc gctcctggcc
       61 cccaactgtc atcactgcct gctaggcctc agatgaaatg caggccatca agtgtgtggt
      121 ggtgggtgat ggagccgtgg gcaagacatg ccttctcatc agctacacca ccaatgcctt
      181 ccccggagaa tacatcccca ctgtgtttga caactactca gccaatgtga tggtggacag
      241 taaacctgtg aacctggggc tgtgggacac tgcaggccag gaggactatg accgcctccg
      301 gccactctcc tacccacaga cagacgtgtt cctcatctgc ttctcgctag tcagcccggc
      361 ctcctacgag aacgtccgag ccaagtggtt ccctgaggta cggcaccact gccccagcac
      421 ccccatcatc ctggtgggta ccaagctgga ccttcgagat gacaaggaca ccattgagaa
      481 gctgaaggag aagaagctgg ctcccatcac ctacccgcag ggcctggcac tggccaagga
      541 tattgattca gtgaagtact tggaatgttc tgcactcacc cagcgaggcc tgaagaccgt
      601 cttcgatgag gcaatccgag cagtcctgtg cccacagccc acacggcagc agaaacgccc
      661 ctgcagcctg ctctaggggt gtcttcccag tcttcccact cccacggtcc tgaccctcca
      721 gggctcccca ccaaagccca gcgatatact ggtgggacat gctgtcccct gtgtgtggtg
      781 tttcttcaca gtcatctgca gaacttgcct ctctcctcca tggaggtccc agggtatggg
      841 gtgatgttga taggtcacat cctacccgga agattcctgt gttcccaggg accagagggg
      901 agccccaaga ctcagccatc catcctcatg tcatacagca tcatgcaccc acctgctcca
      961 ggcctttctg acgcctctct cgaagcttcc ggtctctgtg gcctgtcacc acggtgttcg
     1021 ccttgttgga acacctcctt ccctgaacca aagggagaga tgtggaagtc tgctcctctg
     1081 tcttcctttg tcagaaaaac acagaaccaa tctattttgg taaatctctg atctgcccag
     1141 ccaagtgagg gtctgagctc agctgacccc tacagtctct caaggcttcc tatgctactc
     1201 gaagggtggg gctgcaccct cttggcactg cccaccccac ctgccatagc aaatggaaaa
     1261 cacaagtctc ttgcttatgc agaaaataaa tgtgttgatt ctcaaaaaaa aaaaaaaaaa
     1321 aaaaa
//
