LOCUS       NM_134366                792 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus Rac family small GTPase 1 (Rac1), mRNA.
ACCESSION   NM_134366 XM_344079
VERSION     NM_134366.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 792)
  AUTHORS   Wan,Y., Zhou,J., Zhang,P., Lin,X. and Li,H.
  TITLE     Inhibition of spinal Rac1 attenuates chronic inflammatory pain by
            regulating the activation of astrocytes
  JOURNAL   Cell Signal 114, 110972 (2024)
   PUBMED   37984604
  REMARK    GeneRIF: Inhibition of spinal Rac1 attenuates chronic inflammatory
            pain by regulating the activation of astrocytes.
REFERENCE   2  (bases 1 to 792)
  AUTHORS   Fu,H., Zhang,P., Zhao,X.D. and Zhong,X.Y.
  TITLE     Interfering with Rac1-activation during neonatal
            monocyte-macrophage differentiation influences the inflammatory
            responses of M1 macrophages
  JOURNAL   Cell Death Dis 14 (9), 619 (2023)
   PUBMED   37735499
  REMARK    GeneRIF: Interfering with Rac1-activation during neonatal
            monocyte-macrophage differentiation influences the inflammatory
            responses of M1 macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 792)
  AUTHORS   Dalto,J.F. and Medina,J.H.
  TITLE     Time-dependent inhibition of Rac1 in the VTA enhances long-term
            aversive memory: implications in active forgetting mechanisms
  JOURNAL   Sci Rep 13 (1), 13507 (2023)
   PUBMED   37598223
  REMARK    GeneRIF: Time-dependent inhibition of Rac1 in the VTA enhances
            long-term aversive memory: implications in active forgetting
            mechanisms.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 792)
  AUTHORS   Li,C., Li,Y., Li,Y., Wang,Y., Teng,Y. and Hao,Y.
  TITLE     MicroRNA-194-5p attenuates hypoxia/reoxygenation-induced apoptosis
            in H9C2 cardiomyocytes by inhibiting the over-activation of RAC1
            protein
  JOURNAL   Mol Med Rep 27 (2) (2023)
   PUBMED   36562344
  REMARK    GeneRIF: MicroRNA1945p attenuates hypoxia/reoxygenationinduced
            apoptosis in H9C2 cardiomyocytes by inhibiting the overactivation
            of RAC1 protein.
REFERENCE   5  (bases 1 to 792)
  AUTHORS   Xu,L., Yang,L., Wu,Y., Wan,X., Tang,X., Xu,Y., Chen,Q., Liu,Y. and
            Liu,S.
  TITLE     Rac1/PAK1 signaling contributes to bone cancer pain by Regulation
            dendritic spine remodeling in rats
  JOURNAL   Mol Pain 19, 17448069231161031 (2023)
   PUBMED   36938611
  REMARK    GeneRIF: Rac1/PAK1 signaling contributes to bone cancer pain by
            Regulation dendritic spine remodeling in rats.
            Erratum:[Mol Pain. 2023 Jan-Dec;19:17448069231182501. doi:
            10.1177/17448069231182501.. PMID: 37608691]
REFERENCE   6  (bases 1 to 792)
  AUTHORS   D'Souza-Schorey,C., Boshans,R.L., McDonough,M., Stahl,P.D. and Van
            Aelst,L.
  TITLE     A role for POR1, a Rac1-interacting protein, in ARF6-mediated
            cytoskeletal rearrangements
  JOURNAL   EMBO J 16 (17), 5445-5454 (1997)
   PUBMED   9312003
REFERENCE   7  (bases 1 to 792)
  AUTHORS   Fanger,G.R., Johnson,N.L. and Johnson,G.L.
  TITLE     MEK kinases are regulated by EGF and selectively interact with
            Rac/Cdc42
  JOURNAL   EMBO J 16 (16), 4961-4972 (1997)
   PUBMED   9305638
REFERENCE   8  (bases 1 to 792)
  AUTHORS   Teramoto,H., Coso,O.A., Miyata,H., Igishi,T., Miki,T. and
            Gutkind,J.S.
  TITLE     Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the
            c-Jun N-terminal kinase/stress-activated protein kinase pathway. A
            role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel
            member of the mixed lineage kinase family
  JOURNAL   J Biol Chem 271 (44), 27225-27228 (1996)
   PUBMED   8910292
REFERENCE   9  (bases 1 to 792)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   10 (bases 1 to 792)
  AUTHORS   Best,A., Ahmed,S., Kozma,R. and Lim,L.
  TITLE     The Ras-related GTPase Rac1 binds tubulin
  JOURNAL   J Biol Chem 271 (7), 3756-3762 (1996)
   PUBMED   8631991
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY491395.1.
            
            On Oct 25, 2004 this sequence version replaced XM_344079.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY491395.1, EV778673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..792
                     /gene="Rac1"
                     /note="Rac family small GTPase 1"
                     /db_xref="GeneID:363875"
                     /db_xref="RGD:619755"
     CDS             1..579
                     /gene="Rac1"
                     /EC_number="3.6.5.2"
                     /note="rho family, small GTP binding protein Rac1;
                     p21-Rac1; ras-related C3 botulinum toxin substrate 1 (rho
                     family small GTP binding protein Rac1)"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 1"
                     /protein_id="NP_599193.1"
                     /db_xref="GeneID:363875"
                     /db_xref="RGD:619755"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR
                     HHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL"
     exon            1..35
                     /gene="Rac1"
                     /inference="alignment:Splign:2.1.0"
     exon            36..107
                     /gene="Rac1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..225
                     /gene="Rac1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..288
                     /gene="Rac1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..448
                     /gene="Rac1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..792
                     /gene="Rac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcaggcca tcaagtgtgt ggtggtggga gacggagccg ttggtaaaac ctgcctgctc
       61 atcagttaca cgaccaatgc gttccctgga gagtacatcc ccaccgtctt tgacaactat
      121 tctgccaatg ttatggtaga tggaaaacca gtgaatctgg gcctctggga cacagctgga
      181 caggaagatt atgacagact gcgtcccctc tcctacccgc aaacagacgt gttcttaatt
      241 tgcttttccc ttgtgagtcc tgcatcattt gaaaatgtcc gtgcaaagtg gtatcctgaa
      301 gtacgacacc actgtcccaa tactcccatc atcctagtgg ggacgaagct tgatcttagg
      361 gatgataagg acacgattga gaagctgaag gagaagaagc tgactcccat tacctacccg
      421 caggggctag ccatggcgaa agagatcggt gctgtcaaat acctggagtg ctcagcactc
      481 acacagcgag gactcaagac agtgtttgat gaagctatcc gagccgttct ctgtccccct
      541 cctgttaaga agaggaagag aaaatgcctg ctgttgtaaa tgtctgagcc cctccctcgg
      601 tcttggtccc tggagccttt gtacgctttg ctcagaaaat ggcggagtct tcgcgtctga
      661 tgccaagttt ttgttacaga ttaatttttc cataaaacca ttttgaacca atgaaccagt
      721 cagtaatttt aaggttctgt tttaaatgta agaattccaa cttacagtct attaaaattc
      781 agccctaaaa tg
//
