LOCUS       NM_001007678            1804 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB interacting factor (Rabif), mRNA.
ACCESSION   NM_001007678 XM_222649
VERSION     NM_001007678.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   van den Berg,L., Koelsch,B.U., Winzen-Reichert,B., Fischer,C.,
            Kutritz,A. and Kindler-Rohrborn,A.
  TITLE     Genetic dissection of the Mss4 locus mediating sex-biased cancer
            resistance in the rat peripheral nervous system
  JOURNAL   Int J Cancer 136 (9), 2099-2108 (2015)
   PUBMED   25303613
  REMARK    GeneRIF: Female-biased transcript levels when controlled by BDIV
            resistance alleles at Mss4.
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Koelsch,B., Winzen-Reichert,B., Fischer,C., Kutritz,A., van den
            Berg,L. and Kindler-Rohrborn,A.
  TITLE     Sex-biased suppression of chemically induced neural carcinogenesis
            in congenic BDIX.BDIV-Mss4a rats
  JOURNAL   Physiol Genomics 43 (10), 631-639 (2011)
   PUBMED   21427360
  REMARK    GeneRIF: Transcription profiling using trigeminal nerve tissue of
            BDIX, BDIV, and BDIX.BDIV-Mss4a congenics of both sexes revealed 61
            genes located in the Mss4a fragment differentially expressed
            between BDIV and BDIX rats.
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Strick,D.J., Francescutti,D.M., Zhao,Y. and Elferink,L.A.
  TITLE     Mammalian suppressor of Sec4 modulates the inhibitory effect of
            Rab15 during early endocytosis
  JOURNAL   J Biol Chem 277 (36), 32722-32729 (2002)
   PUBMED   12105226
  REMARK    GeneRIF: MSS4 modulates Rab15 activity in early endocytosis (also
            called RABIF).
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Yu,H. and Schreiber,S.L.
  TITLE     Cloning, Zn2+ binding, and structural characterization of the
            guanine nucleotide exchange factor human Mss4
  JOURNAL   Biochemistry 34 (28), 9103-9110 (1995)
   PUBMED   7619808
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Burton,J., Roberts,D., Montaldi,M., Novick,P. and De Camilli,P.
  TITLE     A mammalian guanine-nucleotide-releasing protein enhances function
            of yeast secretory protein Sec4
  JOURNAL   Nature 361 (6411), 464-467 (1993)
   PUBMED   8429887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF977877.1, CO393618.1, DY319223.1 and BM388378.1.
            
            On Mar 2, 2007 this sequence version replaced NM_001007678.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161807.1, EV766668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               CF977877.1         25-420
            397-694             CF977877.1         422-719
            695-1065            CO393618.1         335-705
            1066-1680           DY319223.1         58-672
            1681-1804           BM388378.1         1-124               c
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1804
                     /gene="Rabif"
                     /gene_synonym="Mss4; RGD1563962"
                     /note="RAB interacting factor"
                     /db_xref="GeneID:304807"
                     /db_xref="RGD:1359331"
     exon            1..142
                     /gene="Rabif"
                     /gene_synonym="Mss4; RGD1563962"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..388
                     /gene="Rabif"
                     /gene_synonym="Mss4; RGD1563962"
                     /note="guanine-nucleotide-releasing protein mss4;
                     mammalian suppressor of Sec4"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor MSS4"
                     /protein_id="NP_001007679.1"
                     /db_xref="GeneID:304807"
                     /db_xref="RGD:1359331"
                     /translation="MEPCELQNELVSAEGRNRKAVLCQRCGSRVLQPGTALFSRRQLF
                     LPSMRKKPDLVDGSNPDGDVLEEHWLVNDMFIFENVGFTKDVGNVKFLVCADCEIGPI
                     GWHCLDDKNSFYVALERVSHE"
     exon            143..1792
                     /gene="Rabif"
                     /gene_synonym="Mss4; RGD1563962"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtggcagc gcggcaatgg aaccctgcga gctgcagaac gagctagtgt cagccgaagg
       61 ccggaaccgg aaggcggtgc tgtgccagcg ttgtggctct cgggtgctgc agccagggac
      121 tgctcttttc tctcgccggc agcttttcct cccctccatg aggaagaagc cggatctggt
      181 ggacggcagc aatcctgatg gtgatgtcct cgaggaacac tggctggtta atgacatgtt
      241 catctttgag aacgtgggct ttaccaagga cgtgggcaac gtcaagtttc tagtctgtgc
      301 agactgtgag attggaccca ttggctggca ttgcctagat gacaagaaca gcttctatgt
      361 ggccttggag cgagtttccc acgagtaact gaggggtttg ggacttggct ccaccctagc
      421 tataaagctc tgcccacaag aaccgacact gatgtgtcag cagtgctggc agacttcttg
      481 gtactaatat aagcaccggt gtttgccctt gaacttgcag agggccggtc ctgtttcctc
      541 aggcctcaga gcatgtctcc tacttagtcc tctctgtcac atgtgtccta gagccctttc
      601 ccctgacttg gaacatggaa gaacacgcga gtgctctacc agtgtagtct ggttcccggc
      661 actctgcctc cgcacctcga tgccaagctc tcttcttctc agcaagaaca acatttatct
      721 ttagccatca cgacgggaac taagatgcta atatttgaaa ctccaccttt cctcattcta
      781 gaagccaagt gtgatagggt gcacatctgt aatcctaggt cttgagtggg tagaggcagg
      841 aagatcagga gttcaagggc agccttagct acatagactg ggccaagtga gatgttgtct
      901 caaaaaacat aaagcataca agtatttgag agtaatctca ttgtatgtga cctacttatc
      961 tacagtaatt tattcttttt aaaagtaaaa catttacaga tgtcagtatt taaacctcac
     1021 tttagataca tttttagtac tgtgtttgag agcctttttt ccgggtcaat agtggcattt
     1081 tataatgagg atgaacacga ctcctcttcc ctcagatctt gatcaggttt ctctttttag
     1141 tcattccttg cccctgatgt caaccctaag gaaaactcag ccctagctgt gtgccagact
     1201 ctcttgtaaa cctgttccac ggacatttct attgttatgg acaaggtgtt accttttctt
     1261 attattagcc aacttaaatc ttcaatatga tttccagtta ctctgtcatt tctcttctgg
     1321 agtgactcag tagcttaaaa ggactctgtg taaacaggtt caaatactgt gtcatcatcc
     1381 cctcctctga gggcctaaat tgagataagt agagacttca ttattcctca tgccagagct
     1441 taggaagtgg gggcagatca agagttcaag gtcagcctca gttactataa tatcaaattc
     1501 aaggccagcc tgtactatgg agatcttgtt tcaaatgaac aaaacacaaa ataaacaagt
     1561 aggacctgca aaagtgacac gtagttaaaa atgtttgctg ctctttcaga cgacctgagt
     1621 tcaggacctt gcaccctcat gggaggttta ctccagttca aggagatctg cgccttctgg
     1681 tccctgcaga tgccttcatg tgtgtggcac ccatacaaac aagtgagcac actcgcgtac
     1741 acacacacac acgcacgcac gcacgtgaat aaaaatttta caaatgaaaa aaaaaaaaaa
     1801 aaaa
//
