LOCUS       NM_138708               1342 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus Rab geranylgeranyltransferase subunit beta
            (Rabggtb), mRNA.
ACCESSION   NM_138708
VERSION     NM_138708.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1342)
  AUTHORS   Arora,D.K., Syed,I., Machhadieh,B., McKenna,C.E. and Kowluru,A.
  TITLE     Rab-geranylgeranyl transferase regulates glucose-stimulated insulin
            secretion from pancreatic beta cells
  JOURNAL   Islets 4 (5), 354-358 (2012)
   PUBMED   23114750
  REMARK    GeneRIF: siRNA-mediated knockdown of alpha- or beta-subunits of
            RGGT and REP1 markedly attenuates glucose-stimulated insulin
            secretion in insulin 832/13 cells
REFERENCE   2  (bases 1 to 1342)
  AUTHORS   Guo,Z., Wu,Y.W., Das,D., Delon,C., Cramer,J., Yu,S., Thuns,S.,
            Lupilova,N., Waldmann,H., Brunsveld,L., Goody,R.S., Alexandrov,K.
            and Blankenfeldt,W.
  TITLE     Structures of RabGGTase-substrate/product complexes provide
            insights into the evolution of protein prenylation
  JOURNAL   EMBO J 27 (18), 2444-2456 (2008)
   PUBMED   18756270
REFERENCE   3  (bases 1 to 1342)
  AUTHORS   Guo,Z., Wu,Y.W., Tan,K.T., Bon,R.S., Guiu-Rozas,E., Delon,C.,
            Nguyen,T.U., Wetzel,S., Arndt,S., Goody,R.S., Blankenfeldt,W.,
            Alexandrov,K. and Waldmann,H.
  TITLE     Development of selective RabGGTase inhibitors and crystal structure
            of a RabGGTase-inhibitor complex
  JOURNAL   Angew Chem Int Ed Engl 47 (20), 3747-3750 (2008)
   PUBMED   18399557
REFERENCE   4  (bases 1 to 1342)
  AUTHORS   Pylypenko,O., Rak,A., Reents,R., Niculae,A., Sidorovitch,V.,
            Cioaca,M.D., Bessolitsyna,E., Thoma,N.H., Waldmann,H.,
            Schlichting,I., Goody,R.S. and Alexandrov,K.
  TITLE     Structure of Rab escort protein-1 in complex with Rab
            geranylgeranyltransferase
  JOURNAL   Mol Cell 11 (2), 483-494 (2003)
   PUBMED   12620235
REFERENCE   5  (bases 1 to 1342)
  AUTHORS   Zhang,H., Seabra,M.C. and Deisenhofer,J.
  TITLE     Crystal structure of Rab geranylgeranyltransferase at 2.0 A
            resolution
  JOURNAL   Structure 8 (3), 241-251 (2000)
   PUBMED   10745007
REFERENCE   6  (bases 1 to 1342)
  AUTHORS   Armstrong,S.A., Seabra,M.C., Sudhof,T.C., Goldstein,J.L. and
            Brown,M.S.
  TITLE     cDNA cloning and expression of the alpha and beta subunits of rat
            Rab geranylgeranyl transferase
  JOURNAL   J Biol Chem 268 (16), 12221-12229 (1993)
   PUBMED   8505342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 26, 2021 this sequence version replaced NM_138708.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216744.1, FQ229109.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345330,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                JAXUCZ010000002.1  245510761-245510779 c
            20-127              JAXUCZ010000002.1  245509743-245509850 c
            128-325             JAXUCZ010000002.1  245508600-245508797 c
            326-431             JAXUCZ010000002.1  245508135-245508240 c
            432-484             JAXUCZ010000002.1  245507390-245507442 c
            485-595             JAXUCZ010000002.1  245507194-245507304 c
            596-721             JAXUCZ010000002.1  245506632-245506757 c
            722-871             JAXUCZ010000002.1  245505534-245505683 c
            872-1342            JAXUCZ010000002.1  245504586-245505056 c
FEATURES             Location/Qualifiers
     source          1..1342
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..1342
                     /gene="Rabggtb"
                     /note="Rab geranylgeranyltransferase subunit beta"
                     /db_xref="GeneID:25533"
                     /db_xref="RGD:3530"
     exon            1..19
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1012
                     /gene="Rabggtb"
                     /EC_number="2.5.1.60"
                     /note="GGTase-II-beta; rab GGTase beta; rab GG transferase
                     beta; Rab geranylgeranyltransferase, beta subunit; rab
                     geranyl-geranyltransferase subunit beta; geranylgeranyl
                     transferase type II subunit beta; type II protein
                     geranyl-geranyltransferase subunit beta; Rab
                     geranylgeranyl transferase componenet, subunit beta"
                     /codon_start=1
                     /product="geranylgeranyl transferase type-2 subunit beta"
                     /protein_id="NP_619715.2"
                     /db_xref="GeneID:25533"
                     /db_xref="RGD:3530"
                     /translation="MGTQQKDVTIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEY
                     LRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAV
                     QILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLD
                     AINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWW
                     LCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETG
                     GFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEDVLQRVNVQPELVS"
     exon            20..127
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     exon            128..325
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     exon            326..431
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     exon            432..484
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     exon            485..595
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     exon            596..721
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     exon            722..871
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1342
                     /gene="Rabggtb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttcggcgg tcggacatgg gcacacagca gaaggacgtc accatcaagt cagatgcgcc
       61 tgacaccctg ctgctcgaga agcatgctga ttatatcgcc tcgtacggct caaagaaaga
      121 tgattatgaa tactgcatgt ccgaatactt gagaatgagc ggcgtctact ggggcctgac
      181 agtgatggac ctcatggggc agcttcatcg gatgaataaa gaggagatac tggtgtttat
      241 caagtcgtgc cagcatgagt gtgggggagt cagtgccagc atcgggcacg acccccacct
      301 tctctacacg ctcagtgctg tccagattct cactctgtat gatagcatcc atgtaatcaa
      361 cgtagacaaa gtggtagcct atgttcagag tctacagaaa gaagatggtt cctttgctgg
      421 agacatctgg ggagaaatcg atacaagatt ctcattttgt gcagtggcaa ctttggctct
      481 cttgggcaaa cttgatgcta ttaatgtgga aaaggccatt gaatttgttt tgtcctgtat
      541 gaactttgat ggtggatttg ggtgcagacc aggctctgaa tctcacgccg gacagatcta
      601 ttgttgcaca ggattcctgg ccataactag tcagttgcat caagtgaact ccgacctact
      661 tggttggtgg ctttgtgaac gacagttgcc ctctggcgga ctcaatggaa gacccgagaa
      721 gttaccagat gtgtgctatt cctggtgggt gttggcctcc ttaaagataa tcgggagact
      781 tcattggatt gacagagaaa agcttcgaag cttcatcttg gcatgtcaag atgaagagac
      841 aggagggttt gcagacaggc caggagacat ggtggatccc tttcacacct tgtttggcat
      901 tgctggattg tcacttctgg gggaagagca gatcaagcct gtcagccctg tcttttgcat
      961 gcctgaagac gtgctgcaga gggtgaatgt ccagcctgaa ctagtgagct agtccgaggg
     1021 gaagagcctt cggtgtgcag tatcagttac tgtggttatc aaacccagaa gtgacttaat
     1081 attttgtata tcatatgtca atgataaaat tatataagta ttgtaaaata aatgtcgtat
     1141 ttagatcttt agtgttctga gtacagtttc tgtcaatact gtttgttaat gtctaacagc
     1201 aacaaactta aaaagctagt atttaactgc cacctccctg tgtccttttg acctgtaaca
     1261 atgacgggaa atgatttctg ttaataaaga tgatcaaagt gagtgaaact catgatttaa
     1321 ataaaagatg cataaaattg ag
//
