LOCUS       NM_031654               1940 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus Rab geranylgeranyltransferase subunit alpha
            (Rabggta), mRNA.
ACCESSION   NM_031654 NM_013020
VERSION     NM_031654.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Lubelwana Hafver,T., Wanichawan,P., Manfra,O., de Souza,G.A.,
            Lunde,M., Martinsen,M., Louch,W.E., Sejersted,O.M. and Carlson,C.R.
  TITLE     Mapping the in vitro interactome of cardiac sodium (Na+)-calcium
            (Ca2+) exchanger 1 (NCX1)
  JOURNAL   Proteomics 17 (17-18) (2017)
   PUBMED   28755400
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Arora,D.K., Syed,I., Machhadieh,B., McKenna,C.E. and Kowluru,A.
  TITLE     Rab-geranylgeranyl transferase regulates glucose-stimulated insulin
            secretion from pancreatic beta cells
  JOURNAL   Islets 4 (5), 354-358 (2012)
   PUBMED   23114750
  REMARK    GeneRIF: siRNA-mediated knockdown of alpha- or beta-subunits of
            RGGT and REP1 markedly attenuates glucose-stimulated insulin
            secretion in insulin 832/13 cells
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Guo,Z., Wu,Y.W., Das,D., Delon,C., Cramer,J., Yu,S., Thuns,S.,
            Lupilova,N., Waldmann,H., Brunsveld,L., Goody,R.S., Alexandrov,K.
            and Blankenfeldt,W.
  TITLE     Structures of RabGGTase-substrate/product complexes provide
            insights into the evolution of protein prenylation
  JOURNAL   EMBO J 27 (18), 2444-2456 (2008)
   PUBMED   18756270
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Guo,Z., Wu,Y.W., Tan,K.T., Bon,R.S., Guiu-Rozas,E., Delon,C.,
            Nguyen,T.U., Wetzel,S., Arndt,S., Goody,R.S., Blankenfeldt,W.,
            Alexandrov,K. and Waldmann,H.
  TITLE     Development of selective RabGGTase inhibitors and crystal structure
            of a RabGGTase-inhibitor complex
  JOURNAL   Angew Chem Int Ed Engl 47 (20), 3747-3750 (2008)
   PUBMED   18399557
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Pylypenko,O., Rak,A., Reents,R., Niculae,A., Sidorovitch,V.,
            Cioaca,M.D., Bessolitsyna,E., Thoma,N.H., Waldmann,H.,
            Schlichting,I., Goody,R.S. and Alexandrov,K.
  TITLE     Structure of Rab escort protein-1 in complex with Rab
            geranylgeranyltransferase
  JOURNAL   Mol Cell 11 (2), 483-494 (2003)
   PUBMED   12620235
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Detter,J.C., Zhang,Q., Mules,E.H., Novak,E.K., Mishra,V.S., Li,W.,
            McMurtrie,E.B., Tchernev,V.T., Wallace,M.R., Seabra,M.C.,
            Swank,R.T. and Kingsmore,S.F.
  TITLE     Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse
            reduces Rab prenylation and platelet synthesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4144-4149 (2000)
   PUBMED   10737774
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Zhang,H., Seabra,M.C. and Deisenhofer,J.
  TITLE     Crystal structure of Rab geranylgeranyltransferase at 2.0 A
            resolution
  JOURNAL   Structure 8 (3), 241-251 (2000)
   PUBMED   10745007
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Armstrong,S.A., Seabra,M.C., Sudhof,T.C., Goldstein,J.L. and
            Brown,M.S.
  TITLE     cDNA cloning and expression of the alpha and beta subunits of rat
            Rab geranylgeranyl transferase
  JOURNAL   J Biol Chem 268 (16), 12221-12229 (1993)
   PUBMED   8505342
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086547.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031654.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086547.1, SRR8487226.35907.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1940
                     /gene="Rabggta"
                     /note="Rab geranylgeranyltransferase subunit alpha"
                     /db_xref="GeneID:58983"
                     /db_xref="RGD:621697"
     exon            1..35
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            36..93
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1794
                     /gene="Rabggta"
                     /EC_number="2.5.1.60"
                     /note="Rab geranylgeranyltransferase alpha; rab GGTase
                     alpha; rab GG transferase alpha; rab
                     geranyl-geranyltransferase subunit alpha; geranylgeranyl
                     transferase type II subunit alpha; Rab geranylgeranyl
                     transferase, a subunit; Rab geranylgeranyltransferase,
                     alpha subunit"
                     /codon_start=1
                     /product="geranylgeranyl transferase type-2 subunit alpha"
                     /protein_id="NP_113842.1"
                     /db_xref="GeneID:58983"
                     /db_xref="RGD:621697"
                     /translation="MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGEL
                     DESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRV
                     NPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAP
                     AEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNA
                     FFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLL
                     MVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLL
                     KDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLM
                     RALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAH
                     KDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLP
                     RLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSIL
                     T"
     exon            94..204
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            205..329
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            330..517
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            518..721
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            722..805
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            806..888
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            889..990
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1096
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1148
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1237
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1326
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1443
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1557
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1645
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1872
                     /gene="Rabggta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttgcac gtcctggcac ctcctccctg agtagattga acggactacc tctggacccc
       61 ctcccctgtc cccaacgctg agccgaaacc atgcatgggc gcctgaaggt gaagacgtcg
      121 gaagagcagg cagaggccaa aaggctagaa cgagagcaga agctaaagct ctaccagtca
      181 gccactcaag ctgtcttcca gaagcgtcag gctggtgagc tggatgaatc agtgctagaa
      241 ctgacaagcc agattctggg agccaaccct gattttgcca ccctctggaa ctgtcgaaga
      301 gaagtactcc agcacctgga aaccgagaag tcccctgagg agtcagctgc tcttgtgaag
      361 gcagaactgg gcttcctaga gagctgtctt cgtgtgaacc ctaagtccta tggcacttgg
      421 caccaccgct gctggctgct gagtcgcctg cctgagccca actgggcccg ggagctggag
      481 ctatgcgctc gcttcctcga ggccgatgag cggaactttc attgctggga ctatcggcga
      541 tttgtagccg cacaggctgc tgttgcccct gcagaggaac tagccttcac tgacagcctc
      601 atcacccgta acttctccaa ctattcctcc tggcattatc gctcctgcct cttgccacag
      661 ctgcaccccc agccagactc tggcccacag ggtcggctcc ctgaaaatgt actgctgaaa
      721 gagctggagt tggtgcagaa tgccttcttt actgacccca acgatcagag tgcctggttc
      781 tatcaccgct ggctcctggg tcgggcggag ccccacgatg ttctatgctg tgtgcatgtg
      841 agccgggagg aggcctgtct gtcggtctgc ttttctcgtc ccctgacagt gggctccaga
      901 atggggacct tgctactcat ggttgatgag gcacctttga gtgtggagtg gaggactcca
      961 gatggcagga accggcccag ccatgtctgg ctctgtgacc tgcctgctgc ctctctcaat
     1021 gaccagttgc cccagcacac gtttcgtgtc atctggacag gaagtgatag ccagaaggag
     1081 tgtgtgcttt taaaagaccg cccagaatgc tggtgccgag actcagccac tgatgaacag
     1141 ctattcaggt gtgagctgtc agtggaaaag tccacagtgc tgcagtctga gcttgaatcc
     1201 tgtaaggagc tgcaggaact agagcctgag aataaatggt gcctgctgac catcatcctg
     1261 ctgatgcgag cactggaccc cctcctctat gagaaggaaa cactgcagta cttcagtacc
     1321 ctcaaagctg tggacccaat gagagcagct tacttggatg acctgcgcag caagttcttg
     1381 ctggagaaca gtgttctcaa gatggagtac gctgatgtac gcgtgctgca cctggctcac
     1441 aaggatctca cagtgctctg ccacctggaa caactgctct tggtcactca tcttgacctg
     1501 tcccataatc gactccgagc cttaccccca gccctggctg ctctgcgctg tcttgaggtg
     1561 ctgcaggcca gtgacaatgc cctggagaac gtggatggtg tggctaacct tccccggcta
     1621 caagagctgt tactatgtaa taaccgcctc caacagtctg cagcaatcca gcctcttgtc
     1681 tcctgcccca ggctagtcct cctcaacctg cagggcaact cgctgtgcca agaagagggc
     1741 atccaggagc gtttggctga gatgctaccg tctgtcagca gcatcctcac ctaggaggcc
     1801 ctgcctcatc ctcaccttta acttactggg actgaataaa gtgtggagag gcccctctac
     1861 cacttgaccg ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa
//
