LOCUS       NP_113842                567 aa            linear   ROD 22-MAY-2025
DEFINITION  geranylgeranyl transferase type-2 subunit alpha [Rattus
            norvegicus].
ACCESSION   NP_113842 NP_037152
VERSION     NP_113842.1
DBSOURCE    REFSEQ: accession NM_031654.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 567)
  AUTHORS   Lubelwana Hafver,T., Wanichawan,P., Manfra,O., de Souza,G.A.,
            Lunde,M., Martinsen,M., Louch,W.E., Sejersted,O.M. and Carlson,C.R.
  TITLE     Mapping the in vitro interactome of cardiac sodium (Na+)-calcium
            (Ca2+) exchanger 1 (NCX1)
  JOURNAL   Proteomics 17 (17-18) (2017)
   PUBMED   28755400
REFERENCE   2  (residues 1 to 567)
  AUTHORS   Arora,D.K., Syed,I., Machhadieh,B., McKenna,C.E. and Kowluru,A.
  TITLE     Rab-geranylgeranyl transferase regulates glucose-stimulated insulin
            secretion from pancreatic beta cells
  JOURNAL   Islets 4 (5), 354-358 (2012)
   PUBMED   23114750
  REMARK    GeneRIF: siRNA-mediated knockdown of alpha- or beta-subunits of
            RGGT and REP1 markedly attenuates glucose-stimulated insulin
            secretion in insulin 832/13 cells
REFERENCE   3  (residues 1 to 567)
  AUTHORS   Guo,Z., Wu,Y.W., Das,D., Delon,C., Cramer,J., Yu,S., Thuns,S.,
            Lupilova,N., Waldmann,H., Brunsveld,L., Goody,R.S., Alexandrov,K.
            and Blankenfeldt,W.
  TITLE     Structures of RabGGTase-substrate/product complexes provide
            insights into the evolution of protein prenylation
  JOURNAL   EMBO J 27 (18), 2444-2456 (2008)
   PUBMED   18756270
REFERENCE   4  (residues 1 to 567)
  AUTHORS   Guo,Z., Wu,Y.W., Tan,K.T., Bon,R.S., Guiu-Rozas,E., Delon,C.,
            Nguyen,T.U., Wetzel,S., Arndt,S., Goody,R.S., Blankenfeldt,W.,
            Alexandrov,K. and Waldmann,H.
  TITLE     Development of selective RabGGTase inhibitors and crystal structure
            of a RabGGTase-inhibitor complex
  JOURNAL   Angew Chem Int Ed Engl 47 (20), 3747-3750 (2008)
   PUBMED   18399557
REFERENCE   5  (residues 1 to 567)
  AUTHORS   Pylypenko,O., Rak,A., Reents,R., Niculae,A., Sidorovitch,V.,
            Cioaca,M.D., Bessolitsyna,E., Thoma,N.H., Waldmann,H.,
            Schlichting,I., Goody,R.S. and Alexandrov,K.
  TITLE     Structure of Rab escort protein-1 in complex with Rab
            geranylgeranyltransferase
  JOURNAL   Mol Cell 11 (2), 483-494 (2003)
   PUBMED   12620235
REFERENCE   6  (residues 1 to 567)
  AUTHORS   Detter,J.C., Zhang,Q., Mules,E.H., Novak,E.K., Mishra,V.S., Li,W.,
            McMurtrie,E.B., Tchernev,V.T., Wallace,M.R., Seabra,M.C.,
            Swank,R.T. and Kingsmore,S.F.
  TITLE     Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse
            reduces Rab prenylation and platelet synthesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4144-4149 (2000)
   PUBMED   10737774
REFERENCE   7  (residues 1 to 567)
  AUTHORS   Zhang,H., Seabra,M.C. and Deisenhofer,J.
  TITLE     Crystal structure of Rab geranylgeranyltransferase at 2.0 A
            resolution
  JOURNAL   Structure 8 (3), 241-251 (2000)
   PUBMED   10745007
REFERENCE   8  (residues 1 to 567)
  AUTHORS   Armstrong,S.A., Seabra,M.C., Sudhof,T.C., Goldstein,J.L. and
            Brown,M.S.
  TITLE     cDNA cloning and expression of the alpha and beta subunits of rat
            Rab geranylgeranyl transferase
  JOURNAL   J Biol Chem 268 (16), 12221-12229 (1993)
   PUBMED   8505342
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086547.1.
            
            On Nov 4, 2002 this sequence version replaced NP_037152.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086547.1, SRR8487226.35907.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     Protein         1..567
                     /product="geranylgeranyl transferase type-2 subunit alpha"
                     /EC_number="2.5.1.60"
                     /note="Rab geranylgeranyltransferase alpha; rab GGTase
                     alpha; rab GG transferase alpha; rab
                     geranyl-geranyltransferase subunit alpha; geranylgeranyl
                     transferase type II subunit alpha; Rab geranylgeranyl
                     transferase, a subunit; Rab geranylgeranyltransferase,
                     alpha subunit"
                     /calculated_mol_wt=64774
     Region          1..>237
                     /region_name="BET4"
                     /note="Protein prenyltransferase, alpha subunit
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5536"
                     /db_xref="CDD:227823"
     Region          44..78
                     /region_name="PFTA 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          88..122
                     /region_name="PFTA 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Site            98
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JHK4; propagated from
                     UniProtKB/Swiss-Prot (Q08602.1)"
     Region          124..158
                     /region_name="PFTA 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          159..193
                     /region_name="PFTA 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          207..241
                     /region_name="PFTA 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          247..346
                     /region_name="RabGGT_insert"
                     /note="Rab geranylgeranyl transferase alpha-subunit,
                     insert domain; pfam07711"
                     /db_xref="CDD:462239"
     Region          363..397
                     /region_name="PFTA 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          442..463
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          443..461
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          <444..547
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          462..487
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          464..486
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          487..508
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          488..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          509..530
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     Region          510..534
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          534..555
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08602.1)"
     CDS             1..567
                     /gene="Rabggta"
                     /coded_by="NM_031654.2:91..1794"
                     /db_xref="GeneID:58983"
                     /db_xref="RGD:621697"
ORIGIN      
        1 mhgrlkvkts eeqaeakrle reqklklyqs atqavfqkrq ageldesvle ltsqilganp
       61 dfatlwncrr evlqhletek speesaalvk aelgflescl rvnpksygtw hhrcwllsrl
      121 pepnwarele lcarfleade rnfhcwdyrr fvaaqaavap aeelaftdsl itrnfsnyss
      181 whyrscllpq lhpqpdsgpq grlpenvllk elelvqnaff tdpndqsawf yhrwllgrae
      241 phdvlccvhv sreeaclsvc fsrpltvgsr mgtlllmvde aplsvewrtp dgrnrpshvw
      301 lcdlpaasln dqlpqhtfrv iwtgsdsqke cvllkdrpec wcrdsatdeq lfrcelsvek
      361 stvlqseles ckelqelepe nkwclltiil lmraldplly eketlqyfst lkavdpmraa
      421 ylddlrskfl lensvlkmey advrvlhlah kdltvlchle qlllvthldl shnrlralpp
      481 alaalrclev lqasdnalen vdgvanlprl qelllcnnrl qqsaaiqplv scprlvllnl
      541 qgnslcqeeg iqerlaemlp svssilt
//
