LOCUS       NM_001108333            2826 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus RAB guanine nucleotide exchange factor 1
            (Rabgef1), mRNA.
ACCESSION   NM_001108333 XM_001072217 XM_341067
VERSION     NM_001108333.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2826)
  AUTHORS   Ackermann,F., Schink,K.O., Bruns,C., Izsvak,Z., Hamra,F.K.,
            Rosenmund,C. and Garner,C.C.
  TITLE     Critical role for Piccolo in synaptic vesicle retrieval
  JOURNAL   Elife 8, e46629 (2019)
   PUBMED   31074746
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2826)
  AUTHORS   Tam,S.Y., Lilla,J.N., Chen,C.C., Kalesnikoff,J. and Tsai,M.
  TITLE     RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and
            NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells
  JOURNAL   PLoS One 10 (11), e0142935 (2015)
   PUBMED   26588713
  REMARK    GeneRIF: Our data suggest that RabGEF1 is a negative regulator of
            TrkA-dependent neuronal differentiation and of NMDA
            receptor-mediated signaling activation in NGF-differentiated PC12
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2826)
  AUTHORS   Blumer,J., Rey,J., Dehmelt,L., Mazel,T., Wu,Y.W., Bastiaens,P.,
            Goody,R.S. and Itzen,A.
  TITLE     RabGEFs are a major determinant for specific Rab membrane targeting
  JOURNAL   J Cell Biol 200 (3), 287-300 (2013)
   PUBMED   23382462
REFERENCE   4  (bases 1 to 2826)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   5  (bases 1 to 2826)
  AUTHORS   Kalesnikoff,J., Rios,E.J., Chen,C.C., Alejandro Barbieri,M.,
            Tsai,M., Tam,S.Y. and Galli,S.J.
  TITLE     Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI
            surface expression and Fc epsilon RI-dependent responses in mast
            cells
  JOURNAL   Blood 109 (12), 5308-5317 (2007)
   PUBMED   17341663
REFERENCE   6  (bases 1 to 2826)
  AUTHORS   Kalesnikoff,J., Rios,E.J., Chen,C.C., Nakae,S., Zabel,B.A.,
            Butcher,E.C., Tsai,M., Tam,S.Y. and Galli,S.J.
  TITLE     RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events
            and biological responses in mast cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (8), 2659-2664 (2006)
   PUBMED   16533754
REFERENCE   7  (bases 1 to 2826)
  AUTHORS   Tam,S.Y., Tsai,M., Snouwaert,J.N., Kalesnikoff,J., Scherrer,D.,
            Nakae,S., Chatterjea,D., Bouley,D.M. and Galli,S.J.
  TITLE     RabGEF1 is a negative regulator of mast cell activation and skin
            inflammation
  JOURNAL   Nat Immunol 5 (8), 844-852 (2004)
   PUBMED   15235600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341067.3, XM_001072217.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2826
                     /gene="Rabgef1"
                     /note="RAB guanine nucleotide exchange factor 1"
                     /db_xref="GeneID:360797"
                     /db_xref="RGD:1307295"
     exon            1..413
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1710
                     /gene="Rabgef1"
                     /note="RAB guanine nucleotide exchange factor (GEF) 1"
                     /codon_start=1
                     /product="rab5 GDP/GTP exchange factor"
                     /protein_id="NP_001101803.1"
                     /db_xref="GeneID:360797"
                     /db_xref="RGD:1307295"
                     /translation="MLSHSLVIRKKMSLKSERRGIHVDQSELLCKKGCGYYGNPAWQG
                     FCSKCWREEYHKARQRQIQEDWELAERLQREEEEAFASSQSSQGAQSLTFSKFEEKKT
                     NEKTRKVTTVKKFFSASSRAGSKKEIQEAKAPSPSINRQTSIETDRVTKEFIDFLKTF
                     HKTGQEVYKQTKMFLEAMPYKRDLSIEEQSECTQDFYQNVAERLQTRGKVPPEKVEKM
                     MDQIEKHIMTRLYKFVFCPETTDDEKKDLAIQKRIRALHWVTPQMLCVPVNEEIPEVS
                     DMVVKAITDIIEMDSKRVPRDKLACITRCSKHIFNAIKITKNEPASADDFLPTLIYIV
                     LKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDF
                     DRYMSGQTSPRKQESESWSPEACLGVKQMYKNLDLLSQLNERQERIMTEAKKLEKDLI
                     DWTDGIAKEVQDIVEKYPLEIKPPNQPLAAIDSENVENDKLPPPLQPQVYAG"
     exon            414..580
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..747
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..829
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..962
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1054
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1311
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..2826
                     /gene="Rabgef1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctgtgta tttcgggcct cagatgaagt ctttctttac tgtggctgta cttgaattcg
       61 ccgtgttgaa ctttggcgtt tgtactttct tctctccttc tgttctttct ttctcccctt
      121 atggcttgaa gagctcagac tcatttgaat tttgcttcat aagtgttgta ttttaatagt
      181 atggaagcaa gttaattttc aatgctttct cactccttgg ttatcaggaa gaagatgagc
      241 ctgaagtccg aacgccgggg aattcatgtg gatcagtcgg agctcctgtg caagaaagga
      301 tgtggttatt atggaaaccc tgcctggcag ggtttctgct ccaaatgctg gagggaggag
      361 taccacaagg cccggcagag gcagatccaa gaggactggg aactagcaga acgacttcag
      421 cgggaggagg aagaggcctt cgctagcagc cagagcagcc aaggagccca gtccctcacc
      481 ttctccaagt ttgaggagaa gaaaaccaat gagaaaactc gcaaagtcac cacagtgaag
      541 aagttcttca gcgcctcttc cagggctgga tccaagaagg aaattcagga agccaaagct
      601 cccagtccct ccataaaccg gcagaccagc attgagacgg accgagtgac taaggagttc
      661 atagactttc tcaagacctt ccacaagaca ggccaagaag tctataaaca gacgaagatg
      721 tttttggaag caatgcctta taaaagggat ttaagcatcg aggaacagtc agaatgtact
      781 caggactttt accagaatgt ggcggaaagg ttgcagaccc gcgggaaagt gcctccagag
      841 aaagtggaga agatgatgga tcagatcgaa aagcacatca tgacccgtct ctataaattt
      901 gtgttctgcc cagagacgac tgatgacgag aaaaaagatc tcgccattca aaagaggatc
      961 agggctctgc actgggtgac acctcagatg ctctgtgtcc cggtcaatga ggaaatcccg
     1021 gaagtgtctg acatggtggt gaaagcgatc acagacatca ttgagatgga ctcaaagcgt
     1081 gtgcctcggg acaagctggc ctgcatcacc aggtgtagca agcacatctt caatgccatc
     1141 aagatcacca agaatgagcc agcctctgcc gatgacttcc tgcccaccct tatctacatc
     1201 gtcctgaagg gcaacccccc tcgtctgcag tccaacatcc agtacatcac tcgcttctgc
     1261 aaccccagcc ggctcatgac gggcgaggat ggctactact tcaccaacct gtgctgtgct
     1321 gtggctttca ttgagaaact agacgctcag tctttgaatt taagtcagga ggattttgac
     1381 cggtacatgt ctggccagac gtcccccagg aagcaagagt ctgagagttg gtccccggag
     1441 gcctgcttag gtgtgaagca aatgtataag aacttggacc tcctgtctca gctgaatgaa
     1501 cggcaggaaa gaatcatgac tgaagccaag aaactcgaaa aagacttaat agactggaca
     1561 gatgggatcg ccaaggaagt tcaagacatt gttgagaagt accctcttga gattaagccc
     1621 ccaaaccaac ccttagcagc cattgactct gagaatgtgg agaacgacaa gctccctccc
     1681 cctctgcagc cgcaggtgta tgcagggtga tgtctcgctc acggccggct tgatttgggg
     1741 ctgatttcag ggagctgctg cgttccactg tttgggtctg gagtatgaat taactgctta
     1801 caatttcaaa gtatttttaa ggtacagatt tagggattgt ttattttctt ttttttttcc
     1861 tagcagggga agcttagtaa ataataatgt cctatttatt tgagttggtg aagtaggttt
     1921 gtgtgaattc tgtgtcaatc ttttatgtcc tttctgattc tcccacgggc ttcctctgtg
     1981 gtagacactg ttgttggttt tgggcaaaca ctgtctttta aaggataaaa cagatgctat
     2041 aaagtctatg ttgaaatgaa ttctatgttc ccacactctc ccagtgtgaa ataattttgt
     2101 aattgtaaag atagaagata atgttaataa gtaaatatgt aaaattgtaa atatgtaaaa
     2161 aaaaataggg ctgggagggg tggtatcagc gtgcatggca tttcatgagc tgattttttt
     2221 ttttaggtga aaatgaaata tattgaatgt ttgcctttag caccatttta tttggtttgt
     2281 ttgtcccact aaaaataatc taaaaataca tgagctttaa caggacacta gcactaactg
     2341 ccctaactct gaggtcctgg tacatgttaa tgaagttgtg acaccaactt ttaggtcaca
     2401 taaagaattg ttctgggacc ctggggtggt agctcaggca gtaaagtgct ttccacactg
     2461 gttcaaggac ctgagcttcc tgtccagccc cccatgtgaa aagccagaca tggtgacgca
     2521 cagttggaac agtgctgctg gaaggcacag atgggcaggt tcctggggga atgtcctcct
     2581 gaccctgatt aaacaaagga accaagatgg acagctcctg agaaatgata gccaaggttg
     2641 acctctggct tccacatgcc tacatctgtg cctgtgtacc tctacacaca tgtgtaccac
     2701 atacacatga acacactgtt gctaattagt acggttgact ttgaactgtg ctcatagctt
     2761 cctttcccta attcatccaa taaacttccc ccacaatgtt atgggggcta ttgccttttt
     2821 gaattg
//
