LOCUS       NM_030585               2191 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus rabaptin, RAB GTPase binding effector protein 2
            (Rabep2), mRNA.
ACCESSION   NM_030585
VERSION     NM_030585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Airik,R., Schueler,M., Airik,M., Cho,J., Ulanowicz,K.A.,
            Porath,J.D., Hurd,T.W., Bekker-Jensen,S., Schroder,J.M.,
            Andersen,J.S. and Hildebrandt,F.
  TITLE     SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is
            Required for Hedgehog Signaling
  JOURNAL   PLoS One 11 (5), e0156081 (2016)
   PUBMED   27224062
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Chang,W., Rewari,A., Centrella,M. and McCarthy,T.L.
  TITLE     Fos-related antigen 2 controls protein kinase A-induced
            CCAAT/enhancer-binding protein beta expression in osteoblasts
  JOURNAL   J Biol Chem 279 (41), 42438-42444 (2004)
   PUBMED   15299028
  REMARK    GeneRIF: Fos-related antigen 2 has a role in controlling protein
            kinase A-induced CCAAT/enhancer-binding protein beta expression in
            osteoblasts
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   Lerant,A.A., DeMaria,J.E. and Freeman,M.E.
  TITLE     Decreased expression of fos-related antigens (FRAs) in the
            hypothalamic dopaminergic neurons after immunoneutralization of
            endogenous prolactin
  JOURNAL   Endocrine 16 (3), 181-187 (2001)
   PUBMED   11954661
  REMARK    GeneRIF: effect of immunoneutralization of endogenous prolactin on
            expression of FRAs in the tuberoinfundibular dopaminergic,
            tuberohypophysial dopaminergic and periventricular hypothalamic
            dopaminergic subpopulations of the hypothalamic dopaminergic
            neurons
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Lerant,A., Kanyicska,B. and Freeman,M.E.
  TITLE     Nuclear translocation of STAT5 and increased expression of Fos
            related antigens (FRAs) in hypothalamic dopaminergic neurons after
            prolactin administration
  JOURNAL   Brain Res 904 (2), 259-269 (2001)
   PUBMED   11406124
  REMARK    GeneRIF: Expression of Fos-related antigens is an indicator of
            neuronal activation in hypothalamic dopaminergic neurons after
            prolactin administration.
REFERENCE   5  (bases 1 to 2191)
  AUTHORS   Feng,Z., Hong,J., Qi,Q., Han,Y., Wilson,B., Iadarola,M., Tiao,N.
            and Bing,G.
  TITLE     Cloning and expression of MP13 gene from rat hippocampus, a new
            factor related to guanosine triphosphate regulation
  JOURNAL   Neurosci Lett 296 (2-3), 129-132 (2000)
   PUBMED   11108998
REFERENCE   6  (bases 1 to 2191)
  AUTHORS   Pich,E.M., Chiamulera,C. and Tessari,M.
  TITLE     Neural substrate of nicotine addiction as defined by functional
            brain maps of gene expression
  JOURNAL   J Physiol Paris 92 (3-4), 225-228 (1998)
   PUBMED   9789813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 30, 2020 this sequence version replaced NM_030585.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089795.1, U34932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000001.1  190440872-190440942
            72-281              JAXUCZ010000001.1  190441354-190441563
            282-439             JAXUCZ010000001.1  190446909-190447066
            440-550             JAXUCZ010000001.1  190449567-190449677
            551-895             JAXUCZ010000001.1  190449760-190450104
            896-991             JAXUCZ010000001.1  190451065-190451160
            992-1090            JAXUCZ010000001.1  190451256-190451354
            1091-1246           JAXUCZ010000001.1  190453606-190453761
            1247-1424           JAXUCZ010000001.1  190455165-190455342
            1425-1436           JAXUCZ010000001.1  190455452-190455463
            1437-1492           JAXUCZ010000001.1  190455557-190455612
            1493-1609           JAXUCZ010000001.1  190455857-190455973
            1610-2191           JAXUCZ010000001.1  190456660-190457241
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2191
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /note="rabaptin, RAB GTPase binding effector protein 2"
                     /db_xref="GeneID:80754"
                     /db_xref="RGD:621416"
     exon            1..71
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1711
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /note="rabaptin-5beta; Fos-related antigen"
                     /codon_start=1
                     /product="rab GTPase-binding effector protein 2"
                     /protein_id="NP_085074.2"
                     /db_xref="GeneID:80754"
                     /db_xref="RGD:621416"
                     /translation="MAAAPAALALDPQPQEEQKDASESSELSRLRAELAGALAEMETM
                     KAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYETQIAALKQERQQQQQDS
                     EEKERELGHLKQLLARAHPLDSLEKQMEKAHEDSEKLREIVLPMEQEIAELKVKLLRA
                     EELIQEIQRRPRQPASLHGSTELLPLSRNPSPPLEPSEEPSGDAGPAAEAFAHNCDDS
                     ASISSFSLGGAAGSVSLRGPQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDSQ
                     WEQLQVEGRQLQKELESVRRERDELQEGLSRSNEDCAKQMQVLLAQVQNSEQLLRTLQ
                     GIVSQAQERVQRQMAELATSHKCLSQEVKRLNEENRGLRAEQLPSSALQGSEQQEDQD
                     EALPSSIQELHQLVRHTRQQARARQQAQEHEAERLRIEIVKLREALDEETAAKASLEG
                     QLRVQREETDVLEASLCSLRIETERVQQEHHKAQLTDLLSEQRAKALRLQAELETSEQ
                     VQRDFVRLSQALQVRLEQIRQADTLEQVRSILDEAPLRDIKDIKDS"
     exon            72..281
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            282..439
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            440..550
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            551..895
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            896..991
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1090
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1246
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1424
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1436
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1492
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1609
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..2191
                     /gene="Rabep2"
                     /gene_synonym="Fra; MP13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccatcac cagtgagtgc gggaatccgc cgtttgggct gagacgatgg cagctgcgcc
       61 agcagcccta gcgctggatc cccagcccca agaggagcaa aaggatgcat ccgaatcaag
      121 tgagctcagt aggcttcgtg ccgaactggc cggtgcactg gcagaaatgg aaaccatgaa
      181 ggctgtagct gaggtgagcg agagcaccaa ggcagaggcg gtggctgcag tgcagagaca
      241 gtgccaagag gaggtggctt ccctgcaggc catcctgaaa gactccatca gcagctacga
      301 gacccagatc gcagccctga aacaggagcg gcagcagcag caacaggact ctgaggagaa
      361 ggagcgagag ctgggccacc tcaaacagct gctggcccgg gcccaccctt tggactcctt
      421 ggagaagcaa atggaaaagg ctcacgaaga ctcagaaaag cttcgggaga tcgtgttgcc
      481 catggagcag gagattgcag agctgaaggt gaagctgctg agggcggaag agctgatcca
      541 agagatccag agacgaccaa ggcagcctgc ctccctgcat ggctccacag agttgcttcc
      601 actatcaagg aacccctcac caccactgga accctcggag gaaccaagtg gagacgcagg
      661 cccagctgct gaggccttcg cccacaactg tgatgacagt gcctccatct cttccttctc
      721 cctcggtggg gccgccggta gtgtctccct acgaggtccc caaggcctca gccctgagca
      781 ggaagagaca gcttctctgg tgtctactgg cactctggtc cccgagggca tctacctacc
      841 ccctccgggg taccagcttg ttccagacag ccagtgggag caactgcagg tagaggggcg
      901 gcagctgcag aaggagctgg aaagtgtccg ccgtgagcgg gatgaactgc aggaaggact
      961 gagccggagc aatgaggact gtgccaagca gatgcaggtg ctcctggccc aggtccagaa
     1021 ctcagagcag ctgctccgaa ctctgcaggg aatcgtgagc caggcccagg agcgggtgca
     1081 gcggcagatg gcagaactgg ccacttctca caagtgcctg agccaagagg ttaaaagact
     1141 gaatgaagaa aatcgaggac tccgggctga gcagctgcca tcctccgccc tccagggctc
     1201 agagcagcag gaggaccagg acgaggccct gccaagctcc atacaggagc tacaccagct
     1261 ggtgcggcac acccggcagc aggctcgggc caggcagcag gcacaggagc atgaggctga
     1321 gcgcctgcgc attgaaattg tgaagctgcg ggaggcacta gacgaggaga cagcagccaa
     1381 ggccagtctg gagggacagc tgagggtgca gcgagaagag acagatgtgc tggaggcctc
     1441 cctgtgcagc ctgagaatag agacagagcg ggtccaacaa gagcatcaca aggcccagct
     1501 cacagatctc ctctccgaac agagagccaa ggcactacgg ctgcaggctg agctggagac
     1561 cagtgaacag gtgcagaggg acttcgtacg gctgtcccag gccctacagg tgcgcctgga
     1621 gcagatccgc caagcagaca ctctggagca agtacgtagc attctggacg aggcacccct
     1681 cagggacatt aaggacatta aggactcgtg aggggccagg cgagaggcct ccctgctggg
     1741 gaagctgccc cattctctac cagaactgtg aggtgtggac tgcaggtctc agaatggagt
     1801 ccgtcagctg caaacctgga cagtggtgtc ccgggccact acttccaccc agggtggctg
     1861 gccctgccct cagggatgat acctggaaga gggtcctagc ctcctcccag aaccaaagct
     1921 ttcaggctgc catgctccct catggatcca gttctcccac cccatcacct cgggccagca
     1981 gccagtccca ctctctgcgt acccagctta tggctagaag ctgttggatt cagtggctcc
     2041 tcacatagag gccctgggac acacagctgc tttctggact gtatgacact aaggtttttg
     2101 tccataggta cccgaaatag gccccaagac ataaggaagc aaggccagac ttttctgtca
     2161 tttattttca ataaataagc agtcagctag t
//
