LOCUS       NM_019124               3467 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus rabaptin, RAB GTPase binding effector protein 1
            (Rabep1), mRNA.
ACCESSION   NM_019124
VERSION     NM_019124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3467)
  AUTHORS   Kim,H., Xu,H., Yao,Q., Li,W., Huang,Q., Outeda,P., Cebotaru,V.,
            Chiaravalli,M., Boletta,A., Piontek,K., Germino,G.G., Weinman,E.J.,
            Watnick,T. and Qian,F.
  TITLE     Ciliary membrane proteins traffic through the Golgi via a
            Rabep1/GGA1/Arl3-dependent mechanism
  JOURNAL   Nat Commun 5, 5482 (2014)
   PUBMED   25405894
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3467)
  AUTHORS   Ninkovic,M., Mitkovski,M., Kohl,T., Stuhmer,W. and Pardo,L.A.
  TITLE     Physical and functional interaction of KV10.1 with Rabaptin-5
            impacts ion channel trafficking
  JOURNAL   FEBS Lett 586 (19), 3077-3084 (2012)
   PUBMED   22841712
REFERENCE   3  (bases 1 to 3467)
  AUTHORS   Gorbea,C., Pratt,G., Ustrell,V., Bell,R., Sahasrabudhe,S.,
            Hughes,R.E. and Rechsteiner,M.
  TITLE     A protein interaction network for Ecm29 links the 26 S proteasome
            to molecular motors and endosomal components
  JOURNAL   J Biol Chem 285 (41), 31616-31633 (2010)
   PUBMED   20682791
REFERENCE   4  (bases 1 to 3467)
  AUTHORS   Brown,T.C., Tran,I.C., Backos,D.S. and Esteban,J.A.
  TITLE     NMDA receptor-dependent activation of the small GTPase Rab5 drives
            the removal of synaptic AMPA receptors during hippocampal LTD
  JOURNAL   Neuron 45 (1), 81-94 (2005)
   PUBMED   15629704
REFERENCE   5  (bases 1 to 3467)
  AUTHORS   Zhu,G., Zhai,P., Liu,J., Terzyan,S., Li,G. and Zhang,X.C.
  TITLE     Structural basis of Rab5-Rabaptin5 interaction in endocytosis
  JOURNAL   Nat Struct Mol Biol 11 (10), 975-983 (2004)
   PUBMED   15378032
REFERENCE   6  (bases 1 to 3467)
  AUTHORS   Cataldo,A.M., Petanceska,S., Peterhoff,C.M., Terio,N.B.,
            Epstein,C.J., Villar,A., Carlson,E.J., Staufenbiel,M. and
            Nixon,R.A.
  TITLE     App gene dosage modulates endosomal abnormalities of Alzheimer's
            disease in a segmental trisomy 16 mouse model of down syndrome
  JOURNAL   J Neurosci 23 (17), 6788-6792 (2003)
   PUBMED   12890772
REFERENCE   7  (bases 1 to 3467)
  AUTHORS   Zhu,G., Zhai,P., He,X., Terzyan,S., Zhang,R., Joachimiak,A.,
            Tang,J. and Zhang,X.C.
  TITLE     Crystal structure of the human GGA1 GAT domain
  JOURNAL   Biochemistry 42 (21), 6392-6399 (2003)
   PUBMED   12767220
REFERENCE   8  (bases 1 to 3467)
  AUTHORS   Mattera,R., Arighi,C.N., Lodge,R., Zerial,M. and Bonifacino,J.S.
  TITLE     Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5
            complex
  JOURNAL   EMBO J 22 (1), 78-88 (2003)
   PUBMED   12505986
REFERENCE   9  (bases 1 to 3467)
  AUTHORS   Neve,R.L., Coopersmith,R., McPhie,D.L., Santeufemio,C., Pratt,K.G.,
            Murphy,C.J. and Lynn,S.D.
  TITLE     The neuronal growth-associated protein GAP-43 interacts with
            rabaptin-5 and participates in endocytosis
  JOURNAL   J Neurosci 18 (19), 7757-7767 (1998)
   PUBMED   9742146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019124.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85844.1, U70777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000010.1  56064917-56064996
            81-209              JAXUCZ010000010.1  56093644-56093772
            210-413             JAXUCZ010000010.1  56102339-56102542
            414-574             JAXUCZ010000010.1  56104691-56104851
            575-694             JAXUCZ010000010.1  56112208-56112327
            695-830             JAXUCZ010000010.1  56119948-56120083
            831-1009            JAXUCZ010000010.1  56122788-56122966
            1010-1141           JAXUCZ010000010.1  56126012-56126143
            1142-1609           JAXUCZ010000010.1  56134111-56134578
            1610-1714           JAXUCZ010000010.1  56136004-56136108
            1715-1831           JAXUCZ010000010.1  56137700-56137816
            1832-1930           JAXUCZ010000010.1  56142227-56142325
            1931-2071           JAXUCZ010000010.1  56148205-56148345
            2072-2261           JAXUCZ010000010.1  56157320-56157509
            2262-2317           JAXUCZ010000010.1  56158038-56158093
            2318-2416           JAXUCZ010000010.1  56160296-56160394
            2417-2533           JAXUCZ010000010.1  56163158-56163274
            2534-3467           JAXUCZ010000010.1  56163624-56164557
FEATURES             Location/Qualifiers
     source          1..3467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3467
                     /gene="Rabep1"
                     /note="rabaptin, RAB GTPase binding effector protein 1"
                     /db_xref="GeneID:54190"
                     /db_xref="RGD:708568"
     exon            1..80
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2635
                     /gene="Rabep1"
                     /note="rabaptin-5; rabaptin-5alpha"
                     /codon_start=1
                     /product="rab GTPase-binding effector protein 1"
                     /protein_id="NP_061997.2"
                     /db_xref="GeneID:54190"
                     /db_xref="RGD:708568"
                     /translation="MAQPGPAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRA
                     KFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA
                     IDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERAQWAQYRESADREIADLRRR
                     LSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVK
                     ELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQL
                     KHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRINKGKD
                     NKKIDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSK
                     SDNDMFKEGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSE
                     NFDTVSLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYL
                     LVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQ
                     ANDQLEKTMKEKQELEDFLRQSAEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDV
                     QEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVQVLRELVL
                     KYRENIVHVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS
                     ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKVNLEEQLKKETAAKATVEQLMF
                     EEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDI
                     NQLPET"
     exon            81..209
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..413
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..574
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..694
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..830
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1009
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1141
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1609
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1714
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1831
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1930
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2071
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2261
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2317
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2416
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2533
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..3467
                     /gene="Rabep1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgctgcttc cccgcccatc cccgttctcc aggccgccca ctggccatgg cgcagccggg
       61 cccggctccc cagcctgacg tttctcttca gcaacgggta gcagaattgg aaaaaattaa
      121 tgcagaattt ttacgtgcac agcagcagct tgagcaagaa tttaatcaaa agagagcaaa
      181 atttaaggag ctgtatttgg ctaaagagga ggatctgaag cggcaaaatg cagtattgca
      241 agctgcgcag gatgacttgg gtcaccttcg gacacagctg tgggaggcgc aggcagaaat
      301 ggagaatatc aaggcgatcg ccacagtctc tgagaacact aagcaagaag ctatagatga
      361 agttaaaagg cagtggagag aagaagttgc ttcacttcag gctgtaatga aagagactgt
      421 gcgtgactat gagcatcagt ttcacctgag gctggagcag gaacgagcgc agtgggcaca
      481 gtatcgagag tctgcagacc gggagatagc tgacctaaga agaaggttgt ctgaaggtca
      541 agaggaagaa aatttagaaa atgaaatgaa aaaggcccaa gaggatgccg agaagcttcg
      601 ctctgtcgtg atgcccatgg agaaggaaat tgcagccctg aaagataaac tgacagaagc
      661 tgaagacaag attaaagagc tggaggcctc aaaggttaag gaactgaatc attatctgga
      721 ggccgagaag tcttgcagga ctgatctgga gatgtatgta gctgttttga acacccagaa
      781 atctgttcta caggaagatg ctgagaaatt gaggaaagaa ctgcatgaag tttgccatct
      841 cttggagcaa gagcgacaac aacacaacca gttaaaacac acgtggcaga aggccaacga
      901 ccagtttttg gaatctcagc gcttgctgat gagagacatg cagcgaatgg agatcgtgtt
      961 aacttcagaa cagctacgac aagttgaaga actgaagaag aaagatcagg aggaggatga
     1021 acaacaaagg atcaataagg gaaaagataa caagaaaata gacactgaag aagaagtaaa
     1081 aataccagta gtatgtgctt taactcaaga agaatcttca accccactat caaatgaaga
     1141 ggagcattta gacagcaccc atgggtcagt ccattcctta gatgcagact tgctgttacc
     1201 atctggagat ccattcagta aatcggacaa tgacatgttt aaagagggac tccggagagc
     1261 tcagtctaca gacagcttgg gaacctcaag ctcattgcaa tccaaagctt taggctataa
     1321 ctacaaagca aaatctgctg gaaatttgga tgagtcggat tttggaccac tggttggagc
     1381 agattctgtg tctgagaact ttgatactgt gtcccttggg tcactgcaga tgccaagtgg
     1441 atttatgtta accaaagatc aagaaagagc aattaaggca atgacacctg aacaggagga
     1501 gacagcatcc ctcctctcaa gtgtcacaca gggtatggag agtgcatatg tctctcctag
     1561 tggttacctc ttagtgagtg aaacggaatg gaatctcctg cagaaagagg tacataatgc
     1621 tggaaataag cttggtagac gttgtgatat gtgttccaat tatgaaaaac agttacaagg
     1681 aattcagatt caggaagctg agacaagaga ccaggtgaaa aaactgcagt taatgctcag
     1741 gcaagctaat gaccagctag agaagacaat gaaagagaaa caggagctag aggacttcct
     1801 caggcagagt gccgaggact caagccacca gatatctgca cttgttttaa gagcccaagc
     1861 ctctgaggta ttacttgaag agttacaaca gagtttttcc caagcaaaga gggatgttca
     1921 ggagcagatg gcagtgctga tgcagtcacg tgaacaggtc tcagaagagc tggtgaggtt
     1981 acagaaagac aatgacagcc tccagggaaa gcatagcttg catgtgtcat tacaactagc
     2041 agaagacttc attcttccag atactgtgca ggtgctccgg gaactggttt taaaatatcg
     2101 tgagaacatt gttcatgtgc ggacagcagc agaccacatg gaagagaagc tgaaggctga
     2161 aatacttttt ctaaaagagc aaattcaggc ggaacagtgt ttaaaagaaa accttgaaga
     2221 gacattacag ctggaaattg aaaactgcaa ggaggaaata gcttccattt ctagtctaaa
     2281 agctgaatta gaaagaataa aagttgaaaa gggacagttg gaatctacat taagagagaa
     2341 gtcgcaacaa cttgagagcc tccaagaaat aaaagttaat ttagaggaac agttaaagaa
     2401 ggaaactgct gctaaggcca ctgttgaaca gctcatgttt gaagagaaga acaaagctca
     2461 gaggttgcag acagaattag atgtcagtga acaagtccag agagattttg taaaactttc
     2521 tcagactctt caggtgcagt tagagaggat ccggcaagca gactccctgg agaggatccg
     2581 ggcaattctg aatgatacca aactgacaga cattaaccag ctccctgaga catgacaccc
     2641 tgatggcagg attctgacct gcattttggg tttttaactc atctttagaa taacattaat
     2701 tattatttaa ctcttaatgg aagaagtcac agcaaaagga ggactggaga aatgcagttc
     2761 tggagggaga aggctgctgt gtgcagggac agccaacaga cgtttcaaag ggaacactaa
     2821 tgagacactg gactcgattc caacaggcgt gggatcagat tgggtgccag aaaagtgctg
     2881 tttccttgcc tgcttcctcc agcgtggact ctggaacata attcctgcca tgaaagcaac
     2941 ttcccaatag tgtttggaat tacgttttct gttcatacaa actgggagag aaaagtttct
     3001 ttctcctgtg gtctggggct catcagtagc agtgttcagc tagcagagag gtgtagtgcg
     3061 ctgtgtgagt attttatatt aaaatgtgga gtgagagcag gccattggct attgattgtg
     3121 tttcccttgc tcaatgcatt ttgtttcctt tttaaccatt ccttctattg gaagacctta
     3181 aatgctattg taacttgctt gagaactata ggaccatggc aaacaaaagc aattaaaatt
     3241 aggagaatct gaatctttgg ctgaggccaa tatatattat atatatatat caatttatgg
     3301 aaaaaaagca caaataacct tggaagcact ttgtctgcac accatgatga acttcctggg
     3361 cccaaaggta ccagggcaaa taactggcac catctaccct ttcgaagtgt tttagttact
     3421 ggatcagtgg aaaataatac taataaaaca agctatctct gacatct
//
