LOCUS       NM_053458               1273 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus RAB9A, member RAS oncogene family (Rab9a), mRNA.
ACCESSION   NM_053458
VERSION     NM_053458.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Huang,C.Y., Kuo,W.W., Ho,T.J., Chiang,S.F., Pai,P.Y., Lin,J.Y.,
            Lin,D.Y., Kuo,C.H. and Huang,C.Y.
  TITLE     Rab9-dependent autophagy is required for the IGF-IIR triggering
            mitophagy to eliminate damaged mitochondria
  JOURNAL   J Cell Physiol 233 (9), 7080-7091 (2018)
   PUBMED   29574782
  REMARK    GeneRIF: IGF-IIR predominantly induces mitophagy through the
            Rab9-dependent alternative autophagy.
            Erratum:[J Cell Physiol. 2020 Jan;235(1):619. doi:
            10.1002/jcp.28951.. PMID: 31587273]
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Marubashi,S., Shimada,H., Fukuda,M. and Ohbayashi,N.
  TITLE     RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and
            Regulates Melanogenic Enzyme Trafficking in Melanocytes
  JOURNAL   J Biol Chem 291 (3), 1427-1440 (2016)
   PUBMED   26620560
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Zhang,Z., Wang,S., Shen,T., Chen,J. and Ding,J.
  TITLE     Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the
            molecular basis for the binding specificity of Rab9A with RUTBC2
  JOURNAL   Structure 22 (10), 1408-1420 (2014)
   PUBMED   25220469
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Nottingham,R.M., Ganley,I.G., Barr,F.A., Lambright,D.G. and
            Pfeffer,S.R.
  TITLE     RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by
            Rab32 and Rab33B proteins
  JOURNAL   J Biol Chem 286 (38), 33213-33222 (2011)
   PUBMED   21808068
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   6  (bases 1 to 1273)
  AUTHORS   Ostrowski,M., Carmo,N.B., Krumeich,S., Fanget,I., Raposo,G.,
            Savina,A., Moita,C.F., Schauer,K., Hume,A.N., Freitas,R.P.,
            Goud,B., Benaroch,P., Hacohen,N., Fukuda,M., Desnos,C.,
            Seabra,M.C., Darchen,F., Amigorena,S., Moita,L.F. and Thery,C.
  TITLE     Rab27a and Rab27b control different steps of the exosome secretion
            pathway
  JOURNAL   Nat Cell Biol 12 (1), 19-30 (2010)
   PUBMED   19966785
REFERENCE   7  (bases 1 to 1273)
  AUTHORS   Jackson,L.K., Nawabi,P., Hentea,C., Roark,E.A. and Haldar,K.
  TITLE     The Salmonella virulence protein SifA is a G protein antagonist
  JOURNAL   Proc Natl Acad Sci U S A 105 (37), 14141-14146 (2008)
   PUBMED   18787122
REFERENCE   8  (bases 1 to 1273)
  AUTHORS   Chen,L., DiGiammarino,E., Zhou,X.E., Wang,Y., Toh,D., Hodge,T.W.
            and Meehan,E.J.
  TITLE     High resolution crystal structure of human Rab9 GTPase: a novel
            antiviral drug target
  JOURNAL   J Biol Chem 279 (38), 40204-40208 (2004)
   PUBMED   15263003
REFERENCE   9  (bases 1 to 1273)
  AUTHORS   Seaman,M.N.
  TITLE     Cargo-selective endosomal sorting for retrieval to the Golgi
            requires retromer
  JOURNAL   J Cell Biol 165 (1), 111-122 (2004)
   PUBMED   15078902
REFERENCE   10 (bases 1 to 1273)
  AUTHORS   Zhao,H., Ettala,O. and Vaananen,H.K.
  TITLE     Intracellular membrane trafficking pathways in bone-resorbing
            osteoclasts revealed by cloning and subcellular localization
            studies of small GTP-binding rab proteins
  JOURNAL   Biochem Biophys Res Commun 293 (3), 1060-1065 (2002)
   PUBMED   12051767
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053458.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF325692.1, FQ212962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000021.1  31610089-31610216
            129-156             JAXUCZ010000021.1  31627308-31627335
            157-1273            JAXUCZ010000021.1  31631012-31632128
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..1273
                     /gene="Rab9a"
                     /gene_synonym="Rab9"
                     /note="RAB9A, member RAS oncogene family"
                     /db_xref="GeneID:84589"
                     /db_xref="RGD:619740"
     exon            1..128
                     /gene="Rab9a"
                     /gene_synonym="Rab9"
                     /inference="alignment:Splign:2.1.0"
     exon            129..156
                     /gene="Rab9a"
                     /gene_synonym="Rab9"
                     /inference="alignment:Splign:2.1.0"
     exon            157..1273
                     /gene="Rab9a"
                     /gene_synonym="Rab9"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..793
                     /gene="Rab9a"
                     /gene_synonym="Rab9"
                     /note="rab-9A; RAB9, member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-9A"
                     /protein_id="NP_445910.2"
                     /db_xref="GeneID:84589"
                     /db_xref="RGD:619740"
                     /translation="MAGKSSLFKIILLGDGGVGKSSLMNRYVTNKFDSQLFHTIGVEF
                     LNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWK
                     KEFIYYADVKEPESFPFVILGNKTDIKERQVSTEEAQAWCKDNGDYPYFETSAKDSTN
                     VAAAFEEAVRRILATEDRSDHLIQTDTVNLHRKPKPNSSCC"
ORIGIN      
        1 cttctgccca agtcgctccc tgctggaagt gctctcgaca ttcccgactc tctggccctc
       61 tttctgccct ggttgtaccc aggtgtgttg gcgaatagct cccaggacgt cctgtgtgtg
      121 tctgcaagat aatgatgttt gaactgaact actaaggatt ctgaaatcaa aacttacact
      181 attaatcatg gcaggaaaat cgtctctttt taaaataatt ctccttggag atggtggagt
      241 tggcaagagt tctcttatga acagatatgt aaccaataaa tttgattccc agctcttcca
      301 cacaataggt gtggaatttt taaataaaga tttggaggtg gatggacatt ttgttaccat
      361 gcagatttgg gacacagctg gtcaagaacg attccgaagc ctgaggacac cattttaccg
      421 aggttctgac tgttgcctgc ttacatttag tgtcgatgat tcacaaagct tccagaatct
      481 gagcaactgg aagaaagagt tcatatatta tgcagatgtg aaagagcctg aaagctttcc
      541 ttttgtgatt ttgggcaaca agactgacat aaaagaacgg caggtatcta cagaagaagc
      601 ccaagcctgg tgcaaggaca acggcgacta tccttacttc gaaacaagtg caaaagattc
      661 caccaatgtt gctgctgcct ttgaggaggc agttcgaaga attctggcta cagaagatag
      721 gtcagatcac ctgattcaaa cagacacagt caatctgcac cgaaagccca agccaaactc
      781 ttcttgctgt tgatggcatt aaagggatag ctggtgcatt ttaaccaacc aacacacaca
      841 cacacacaca cacacacaca cacacacaca cacacagaca cacgaatgag agtggagaac
      901 aaaattagta tgcagaagag ttcatctact aataaaattc aattaacgca tattgttgcc
      961 tcattagtcc atgggagaag ggacacactc actctgaagg aatctattta ctcagtaatg
     1021 gcacattaca tttataaact gtaatggttg tctattgttt cttaaaatta aaacattagt
     1081 gctaataaga tgaccaagaa ttgacttaat tgtaattcag acataaatct tgactattct
     1141 tagattgttt tgccccacaa gaaaatggag aattactttt atatgtgtat atttttatgt
     1201 aatgagcatt ctattcttgg tccaggaaag taaattccta cagcaatact attaaagatt
     1261 aaaatctaat gca
//
