LOCUS       NM_153317               4708 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB8B, member RAS oncogene family (Rab8b), mRNA.
ACCESSION   NM_153317 XM_039080931
VERSION     NM_153317.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4708)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   2  (bases 1 to 4708)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   3  (bases 1 to 4708)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 4708)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   5  (bases 1 to 4708)
  AUTHORS   Pavlos,N.J., Gronborg,M., Riedel,D., Chua,J.J., Boyken,J.,
            Kloepper,T.H., Urlaub,H., Rizzoli,S.O. and Jahn,R.
  TITLE     Quantitative analysis of synaptic vesicle Rabs uncovers distinct
            yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered
            exocytosis
  JOURNAL   J Neurosci 30 (40), 13441-13453 (2010)
   PUBMED   20926670
REFERENCE   6  (bases 1 to 4708)
  AUTHORS   Fransen,M., Amery,L., Hartig,A., Brees,C., Rabijns,A.,
            Mannaerts,G.P. and Van Veldhoven,P.P.
  TITLE     Comparison of the PTS1- and Rab8b-binding properties of Pex5p and
            Pex5Rp/TRIP8b
  JOURNAL   Biochim Biophys Acta 1783 (5), 864-873 (2008)
   PUBMED   18346465
REFERENCE   7  (bases 1 to 4708)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   8  (bases 1 to 4708)
  AUTHORS   Lau,A.S. and Mruk,D.D.
  TITLE     Rab8B GTPase and junction dynamics in the testis
  JOURNAL   Endocrinology 144 (4), 1549-1563 (2003)
   PUBMED   12639940
  REMARK    GeneRIF: Rab8B participates in adherens junction dynamics in the
            testis.
REFERENCE   9  (bases 1 to 4708)
  AUTHORS   Chen,S., Liang,M.C., Chia,J.N., Ngsee,J.K. and Ting,A.E.
  TITLE     Rab8b and its interacting partner TRIP8b are involved in regulated
            secretion in AtT20 cells
  JOURNAL   J Biol Chem 276 (16), 13209-13216 (2001)
   PUBMED   11278749
REFERENCE   10 (bases 1 to 4708)
  AUTHORS   Armstrong,J., Thompson,N., Squire,J.H., Smith,J., Hayes,B. and
            Solari,R.
  TITLE     Identification of a novel member of the Rab8 family from the rat
            basophilic leukaemia cell line, RBL.2H3
  JOURNAL   J Cell Sci 109 (Pt 6), 1265-1274 (1996)
   PUBMED   8799816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 18, 2021 this sequence version replaced
            XM_039080931.1, NM_153317.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.11441.1,
                                           SRR26643288.34327.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760475,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000008.1  76417404-76417548   c
            146-206             JAXUCZ010000008.1  76359606-76359666   c
            207-267             JAXUCZ010000008.1  76356938-76356998   c
            268-345             JAXUCZ010000008.1  76350675-76350752   c
            346-435             JAXUCZ010000008.1  76349180-76349269   c
            436-501             JAXUCZ010000008.1  76347633-76347698   c
            502-552             JAXUCZ010000008.1  76345054-76345104   c
            553-4708            JAXUCZ010000008.1  76340106-76344261   c
FEATURES             Location/Qualifiers
     source          1..4708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4708
                     /gene="Rab8b"
                     /note="RAB8B, member RAS oncogene family"
                     /db_xref="GeneID:266688"
                     /db_xref="RGD:628764"
     exon            1..145
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..645
                     /gene="Rab8b"
                     /note="GTPase Rab8b"
                     /codon_start=1
                     /product="ras-related protein Rab-8B"
                     /protein_id="NP_695229.1"
                     /db_xref="GeneID:266688"
                     /db_xref="RGD:628764"
                     /translation="MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGID
                     FKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNW
                     IRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSTNVEE
                     AFFTLARDIMTKLNRKMNDSNSSGAGGPVKITESRSKKTSFFRCSLL"
     exon            146..206
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
     exon            207..267
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
     exon            268..345
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
     exon            346..435
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
     exon            436..501
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
     exon            502..552
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
     exon            553..4708
                     /gene="Rab8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagggcc ggagcgagaa gatggcgaag acgtacgatt atctgttcaa gctgctgctc
       61 atcggcgact ccggcgttgg caagacctgc ctcctgttcc gcttctcaga ggacgccttc
      121 aacaccacct ttatctccac catcggaatt gattttaaaa tcagaacgat agaactcgac
      181 ggaaagaaaa ttaaacttca gatatgggac acggcgggcc aggaaagatt ccgaacaatt
      241 acaacagcat actatagagg agccatggga attatgctgg tctatgacat caccaatgaa
      301 aaatcctttg acaatattaa aaattggata agaaacattg aagagcatgc ctcttcagat
      361 gttgaaagaa tgatcctggg taacaaatgt gatatgaacg acaaaagaca agtgtcgaaa
      421 gaaagagggg agaagttagc aattgactat gggattaaat ttttggagac aagtgcaaaa
      481 tcgagtacaa atgtagaaga ggcatttttt acacttgcac gggatataat gacaaaactc
      541 aacagaaaaa tgaatgacag caattcatca ggagcaggtg ggccagtgaa aataacagaa
      601 agccggtcta agaagaccag tttcttccgg tgttctctgc tttgatgaac tcctcacttc
      661 tgagagactg cagaatacct agagggccct tccccgcctc tctgaaagca caggctaccc
      721 agcctcagag tcacctcacc cggctgctgc ggagagtacc ctggaactct gacctctcaa
      781 cacagaccgc caagtggatc ccagccttgt ggcctagcaa aagagcgggc tcctttcttt
      841 aaacatggaa gcaatgacgt ggagacacac gtaggaccta actggttttt ccttgtttta
      901 ctacctgtcc tggaagctgc tgtctttctt tgcacatgaa tgtcagcctt tccctgatac
      961 agcataatct cagactctta attgagcact ttagtggctt gaagttctag acttgtatat
     1021 ttggggatgt ttaaagatgg cagagcattg ggggttgggg atttagctca gtggtagagc
     1081 gcttgcctag caagcgcaag gccctgggtt cggtccccag ctccaaaaaa aaaaaaaaaa
     1141 aaaaaaagat ggcagagcat taaacagagg ttgacctgct aaaattaaag gatggttggc
     1201 ctgggtcacg tggccaaaag tccttctgtt ggtagcattt atcgaagggc tttgatttgt
     1261 agtattccta aaactcatta aatttgataa atgtttaaaa tttataaaaa cgcccatcta
     1321 tccagaggcc atgacattgt catcttgtca ggggtgatca gtcgggctca cccctgagtg
     1381 gctctgtccc tttgaagttg gctgctctgt gtcctctgtg gaaacagcct ctgcaaagca
     1441 cagcagcctc cctactcgag ggctgtttgc tgtccttctc ctgtgtgact tgctgtcctt
     1501 atttactatc taaagccggt ggtatatgca ggcacttctg tctgcctgtg agcttcatga
     1561 gcttcgatct cacatgggta gagatgtgat catcacagct ttctctccac atccgcctgc
     1621 ggtcttgtca cattacaacg tgtagtatat tctttcggag tttcacccat tagcttacat
     1681 tacccacttc ttaaccataa tccccatctg tgagagttaa caaaggttag ctttagattt
     1741 taatttgcag aaaactacat atatggagag agattaaaca tgttgatgta actttaaaag
     1801 acaactgtta gtaatgccca aagtaatgat tctttgttct atctggggtt taaaaaaata
     1861 aaagtaatta gacctagcat atcctccagg aatcttgtct tttcagtaga gcacataatt
     1921 caggtctcag ctttcaaata gccattgttg ggtgtctaaa acctagccct gtgcatttcg
     1981 gtttgtcatt agagaagtgg tgtggccatc caggccaaag cccaccaaag gcttcactgc
     2041 ctttctcacc aaattctggt tctgatgttt cttctctagg tgaaaccacc acactgggga
     2101 cggggggggg gtatatagtg ttaacttttg tgccaactgc agatcataat gtcactgctc
     2161 ttctagcctt acgtgtccta acacagcagg cataagaaca ggtgacagga cagtcactcc
     2221 cctctcttgt gccacacctt aaggtggacg tggtcatgga gagctggtca cacagacaat
     2281 tctgcctggg ccagccaggc cttcccatca gtggctgcat ataccagcgt tatttttggt
     2341 ggatatgctg actttactgt tgaaaaactt tagccttttc ttctttttcc ctagttacct
     2401 atcggcttaa aatcacacat tactgccctt gtgcaagctg ttcactcact gagaactaat
     2461 tacaagtcta acatcatgac attaaataca ttttgaaaag aaccagtatt ttcttaaaaa
     2521 tgtcttatca ctacttttct ggaaaaaagt tcaagcagtt aaattggtca caaagtactt
     2581 cgcagaaagc acaggtcgtg acactacata tgaatgtaat tctcttagca tttacctctg
     2641 actgtttggt gtcttaacac ttcggtttct atctcagggg ttgtctgcaa accaaaactg
     2701 acatgctctg tggtcagcct tttcttcttt ttcttctttt cctttttttt ttctctcttt
     2761 taaagcaaaa ccagaatact ttgcttttgg agtctctact ctccttgtgt cttttgtggg
     2821 ttaaccgtct ccatgaacat tgaaagagcc tgtaagtgtt aggcgagtct aacagtgctc
     2881 tttgaagcag cagcaatcgg ggagtgtatc cttgttatat agaaatacat tgtcctggct
     2941 attttcttac atttaacttt gctaaactgt atataattga gctcagacca taggaattca
     3001 ctttttgcat ggtagaaacg acccaacata tagtctactt tgcttatagt gtacatatgg
     3061 tgcgttattt tttctatttg tagatgaatt tagtgacaga taattgtctg ttccctgctg
     3121 agactgaaga tatctagggg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgag
     3181 agggggggga gcatgtctgt ggtcttctgg gtagggtaca tagagatttt tactgcagta
     3241 ttagtggttc agtggctgca ctttattact gtgctaattt ttgatgattg gactcaaaat
     3301 ttcagctaga gcctgagggt atcagacagt gaaatgtact gtaactaaat aggatgtgga
     3361 tcgggcgatt gtcaactgtt ctgctgggag ctcatcctag cctcttgcgc ttcaggcaga
     3421 tgagagcaga gcagtctacc tgcgcatcag gtgctgccgg gccttcttcc tgttcctgtg
     3481 gacattttat gcagcctttg ttataagttt cccgaagact atgctcttta cgttgaagga
     3541 ctattacttt aattatacct catttagcta atattctaat aaccagtagg aaacaatgag
     3601 ccggcctcta agcacccaac aaattcaggc tgtgtgtttt gtctcgtctg gttttgaact
     3661 ggaggaagag agagatactt tcaaataaag catgatgtcc atacccagta gcagaccaaa
     3721 atatgacttt cctgtccctc cattaaagaa ttcagttgtg caacatacat gggttgttct
     3781 gcggtttacg agtaagaaat tgtaattgtg tttttcaggc tccaatgctg agaatctgta
     3841 ttgtggtgta taaagtgtct tcctaagagc agtaaaagga caaattaagc agactttctt
     3901 ttcaagctta tgacttagat tcttttagaa atatagttct taatctttaa agatgagatt
     3961 ctaagcctag aattttaaac cacatttcat tatggtggct tactgatctc aaattttcta
     4021 caatttggtt tttttagact taaaaacagc taaacaaaac cttcctttat ctttctcatc
     4081 acatccagtg gcagagggga ctgtctgaga gtaaagtccc atgattcaga aggacatagc
     4141 aggtcaggat gtaccaataa aagttatgaa tgtgatgttc attagaaaga aactgaacaa
     4201 ctgagtacag aaatgaatat cagcaagaat ttgttttaag gattttccag attttacttt
     4261 gtatcttgaa gtgtgtgcca tatgccaaga actaacagaa cttcctgttc catctctgta
     4321 ccttcttctt ttttaaaagt gaacttatgg tcgttcattc ctgtggcctt atggatgggt
     4381 tgtcttgact gtttgcaact gatgctgcag ttcctttaat gcaaaaacgc catgaattgt
     4441 ctgactgaag tcatgcccca ccatgggaac tatggagttt cttcatagac ttctccttgt
     4501 gtgcttaagc gtattttgtt ttgcttcagt ggctcactgt ggaaagcttc tgtggatagt
     4561 atgggcctgc catgtggctg gtctgttgaa gccagttcat taactggact gatactgatg
     4621 ttgtgttttt taaaaatgaa ttttattcca ggtgaacttt tttttacaat actgttcatc
     4681 taaaataaaa actacatgat gaaaaatg
//
