LOCUS       NM_053998               1768 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus RAB8A, member RAS oncogene family (Rab8a), mRNA.
ACCESSION   NM_053998 XM_346486
VERSION     NM_053998.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1768)
  AUTHORS   Xiao,Y., Wang,G., He,G., Qin,W. and Shi,Y.
  TITLE     Rab8a/SNARE complex activation promotes vesicle anchoring and
            transport in spinal astrocytes to drive neuropathic pain
  JOURNAL   Biomol Biomed 24 (5), 1290-1300 (2024)
   PUBMED   38691557
  REMARK    GeneRIF: Rab8a/SNARE complex activation promotes vesicle anchoring
            and transport in spinal astrocytes to drive neuropathic pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1768)
  AUTHORS   Ouyang,Q., Chen,Q., Ke,S., Ding,L., Yang,X., Rong,P., Feng,W.,
            Cao,Y., Wang,Q., Li,M., Su,S., Wei,W., Liu,M., Liu,J., Zhang,X.,
            Li,J.Z., Wang,H.Y. and Chen,S.
  TITLE     Rab8a as a mitochondrial receptor for lipid droplets in skeletal
            muscle
  JOURNAL   Dev Cell 58 (4), 289-305 (2023)
   PUBMED   36800997
  REMARK    GeneRIF: Rab8a as a mitochondrial receptor for lipid droplets in
            skeletal muscle.
REFERENCE   3  (bases 1 to 1768)
  AUTHORS   Zhu,H., Xue,C., Xu,X., Guo,Y., Li,X., Lu,J., Ju,S., Wang,Y., Cao,Z.
            and Gu,X.
  TITLE     Rab8a/Rab11a regulate intercellular communications between neural
            cells via tunneling nanotubes
  JOURNAL   Cell Death Dis 7 (12), e2523 (2016)
   PUBMED   28005071
  REMARK    GeneRIF: Rab8a or Rab11a might be involved in the formation of
            tunneling nanotubes structures in the peripheral nerve system.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1768)
  AUTHORS   Sellier,C., Campanari,M.L., Julie Corbier,C., Gaucherot,A.,
            Kolb-Cheynel,I., Oulad-Abdelghani,M., Ruffenach,F., Page,A.,
            Ciura,S., Kabashi,E. and Charlet-Berguerand,N.
  TITLE     Loss of C9ORF72 impairs autophagy and synergizes with polyQ
            Ataxin-2 to induce motor neuron dysfunction and cell death
  JOURNAL   EMBO J 35 (12), 1276-1297 (2016)
   PUBMED   27103069
REFERENCE   5  (bases 1 to 1768)
  AUTHORS   Veleri,S., Manjunath,S.H., Fariss,R.N., May-Simera,H., Brooks,M.,
            Foskett,T.A., Gao,C., Longo,T.A., Liu,P., Nagashima,K.,
            Rachel,R.A., Li,T., Dong,L. and Swaroop,A.
  TITLE     Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal
            appendages on the mother centriole during cilia biogenesis
  JOURNAL   Nat Commun 5, 4207 (2014)
   PUBMED   24947469
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1768)
  AUTHORS   Gerges,N.Z., Backos,D.S. and Esteban,J.A.
  TITLE     Local control of AMPA receptor trafficking at the postsynaptic
            terminal by a small GTPase of the Rab family
  JOURNAL   J Biol Chem 279 (42), 43870-43878 (2004)
   PUBMED   15297461
REFERENCE   7  (bases 1 to 1768)
  AUTHORS   Chen,Y.M., Lee,N.P., Mruk,D.D., Lee,W.M. and Cheng,C.Y.
  TITLE     Fer kinase/FerT and adherens junction dynamics in the testis: an in
            vitro and in vivo study
  JOURNAL   Biol Reprod 69 (2), 656-672 (2003)
   PUBMED   12700184
REFERENCE   8  (bases 1 to 1768)
  AUTHORS   Huber,L.A., de Hoop,M.J., Dupree,P., Zerial,M., Simons,K. and
            Dotti,C.
  TITLE     Protein transport to the dendritic plasma membrane of cultured
            neurons is regulated by rab8p
  JOURNAL   J Cell Biol 123 (1), 47-55 (1993)
   PUBMED   8408204
REFERENCE   9  (bases 1 to 1768)
  AUTHORS   Cormont,M., Tanti,J.F., Zahraoui,A., Van Obberghen,E., Tavitian,A.
            and Le Marchand-Brustel,Y.
  TITLE     Insulin and okadaic acid induce Rab4 redistribution in adipocytes
  JOURNAL   J Biol Chem 268 (26), 19491-19497 (1993)
   PUBMED   8366094
REFERENCE   10 (bases 1 to 1768)
  AUTHORS   Elferink,L.A., Anzai,K. and Scheller,R.H.
  TITLE     rab15, a novel low molecular weight GTP-binding protein
            specifically expressed in rat brain
  JOURNAL   J Biol Chem 267 (9), 5768-5775 (1992)
   PUBMED   1313420
  REMARK    Erratum:[J Biol Chem. 1992 Nov 5;267(31):22693.. PMID: 1429617]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105863.1.
            
            On Dec 11, 2007 this sequence version replaced NM_053998.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105863.1, BC071176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1768
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1768
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /note="RAB8A, member RAS oncogene family"
                     /db_xref="GeneID:117103"
                     /db_xref="RGD:621144"
     exon            1..129
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..629
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /EC_number="3.6.5.2"
                     /note="mel transforming oncogene (derived from cell line
                     NK14)- RAB8 homolog"
                     /codon_start=1
                     /product="ras-related protein Rab-8A"
                     /protein_id="NP_446450.2"
                     /db_xref="GeneID:117103"
                     /db_xref="RGD:621144"
                     /translation="MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGID
                     FKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNW
                     IRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVEN
                     AFFTLARDIKAKMDKKLEGNSPQGSSHGVKITVEQQKRTSFFRCSLL"
     exon            130..190
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
     exon            191..251
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
     exon            252..329
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
     exon            330..419
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
     exon            420..485
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
     exon            486..536
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1744
                     /gene="Rab8a"
                     /gene_synonym="Mel; Rab8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaatatggc gaagacctac gattacctgt tcaagctgct gctgatcggg gactcggggg
       61 tagggaagac ctgtgtcctg ttccgcttct ccgaggacgc cttcaattcc acgttcatct
      121 ctaccatagg aattgacttt aaaattagga ccatagagct cgatggcaag aggattaaac
      181 tgcagatatg ggacacagcc ggccaggagc ggtttcggac aatcacgaca gcctactaca
      241 ggggtgccat gggtatcatg ctggtctacg acattaccaa tgagaagtcc ttcgacaaca
      301 tccggaattg gattcggaac attgaggagc atgcctctgc agatgtggag aagatgatac
      361 tggggaataa gtgtgatgtg aacgacaaga ggcaggtgtc caaggaacgg ggagaaaagc
      421 tggcactcga ctatgggatc aagttcatgg agaccagcgc gaaggccaac atcaatgtgg
      481 agaacgcatt tttcactctc gccagggata tcaaagcaaa aatggacaaa aaattggaag
      541 ggaacagccc acaggggagc agccatggag tcaagatcac agtggagcag cagaagagga
      601 ccagcttctt ccggtgcagt ctcctgtgag gacaaggtct ctgcccattt gagcctgcgc
      661 tcagcccagc tgactgtgcc tgccccgggc gagcctccac ctccgatgct cggacacagc
      721 tgcccggact caattgagaa attgattatt ttagtaaccg tctgatcttt tccaccttca
      781 gagatggacc aagttagaat tttgctgttt ttcctgtgtc atctgccagt caggcctatc
      841 cgtcccctgc cgcattgcca tagatggaga gaggtgggtt ggggcaaggc agcctccatc
      901 tccagccttc tgcccctcca ccacagaagg gaggtcagtg gcagtgccca gcctgcctgg
      961 ccccatactc caagcaccac caccagggcc actgagggcc aagcctggca cctgccttca
     1021 cccgttctca gttgtggaca agtgacaacc ttgtccactg tctccttacg tgtcaaacca
     1081 aagggaagca caaactaagg aaagcccact tagaggactt tggaagaagt ggctggctcc
     1141 catgaccaga gcaggatggg agtctgcagt ccagactgag gtgacatcac caccactctc
     1201 ccatgaccca ctgcctcagt gggccccaaa accggctccc tcatcttctc ctcctctgcc
     1261 tggctctaat cggatgttcc ttttctagct aagatgattt tttatttttt cagattccta
     1321 acaccatgaa atgattctgt cattgatttt ctagcagcat acctgggaga ttcagaacca
     1381 gcgtggttgc cctgcgccca cagggcacct ggtccctgag acccagacaa gcattccatg
     1441 gcacagtgct accctgcagt cttcacccag ttgtgttgtg acagctctgt cctcctggaa
     1501 agactgattg ggaccagatg tcctgtggga ggggtgtcat ctgagagcac cttccttttc
     1561 actctaaccc ttccccgatg ctgctgtcag tcaagctgtc agcatcaaaa tctctccctt
     1621 ttttgaaatt aaaaccaacg taccagcaat agtcatccgc cctcccctgg agtctctgat
     1681 gtaccatgtt tacactgacc agtgcactca gaaaatcaga ttaaagtgta tttaagagga
     1741 agcaaaaaaa aaaaaaaaaa aaaaaaaa
//
