LOCUS       NM_023950               2087 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus RAB7A, member RAS oncogene family (Rab7a), mRNA.
ACCESSION   NM_023950 XM_346708
VERSION     NM_023950.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Sun,C., Peng,S., Lv,Z., Guo,T. and Zhang,L.
  TITLE     Research of STEAP3 interaction with Rab7A and RACK1 to modulate the
            MAPK and JAK/STAT signaling in Osteoarthritis
  JOURNAL   Int Immunopharmacol 124 (Pt B), 111034 (2023)
   PUBMED   37820423
  REMARK    GeneRIF: Research of STEAP3 interaction with Rab7A and RACK1 to
            modulate the MAPK and JAK/STAT signaling in Osteoarthritis.
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Liu,C., Wang,Q., Yuan,S., Li,S., Chen,X., Huang,X., Yan,J., Shan,H.
            and Zhang,M.
  TITLE     Upregulation of RAB7 is related to neuronal pyroptosis after spinal
            cord injury in rats
  JOURNAL   J Chem Neuroanat 128, 102229 (2023)
   PUBMED   36592695
  REMARK    GeneRIF: Upregulation of RAB7 is related to neuronal pyroptosis
            after spinal cord injury in rats.
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Yap,C.C., Digilio,L., McMahon,L.P., Wang,T. and Winckler,B.
  TITLE     Dynein Is Required for Rab7-Dependent Endosome Maturation,
            Retrograde Dendritic Transport, and Degradation
  JOURNAL   J Neurosci 42 (22), 4415-4434 (2022)
   PUBMED   35474277
  REMARK    GeneRIF: Dynein Is Required for Rab7-Dependent Endosome Maturation,
            Retrograde Dendritic Transport, and Degradation.
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Nian,F.S., Li,L.L., Cheng,C.Y., Wu,P.C., Lin,Y.T., Tang,C.Y.,
            Ren,B.S., Tai,C.Y., Fann,M.J., Kao,L.S., Hong,C.J. and Tsai,J.W.
  TITLE     Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy
            Activities in the Nervous System: an Overlapping Mechanism for
            Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B
  JOURNAL   Mol Neurobiol 56 (9), 6095-6105 (2019)
   PUBMED   30721447
  REMARK    GeneRIF: the functions of RAB18 and RAB7 in lysosomal and
            autophagic activities may constitute an overlapping mechanism
            underlying Warburg micro syndrome and Charcot-Marie-Tooth
            Neuropathy Type 2B pathogenesis in the nervous system.
REFERENCE   5  (bases 1 to 2087)
  AUTHORS   Ackermann,F., Schink,K.O., Bruns,C., Izsvak,Z., Hamra,F.K.,
            Rosenmund,C. and Garner,C.C.
  TITLE     Critical role for Piccolo in synaptic vesicle retrieval
  JOURNAL   Elife 8, e46629 (2019)
   PUBMED   31074746
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2087)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   7  (bases 1 to 2087)
  AUTHORS   Feng,Y., Press,B. and Wandinger-Ness,A.
  TITLE     Rab 7: an important regulator of late endocytic membrane traffic
  JOURNAL   J Cell Biol 131 (6 Pt 1), 1435-1452 (1995)
   PUBMED   8522602
REFERENCE   8  (bases 1 to 2087)
  AUTHORS   Meresse,S., Gorvel,J.P. and Chavrier,P.
  TITLE     The rab7 GTPase resides on a vesicular compartment connected to
            lysosomes
  JOURNAL   J Cell Sci 108 (Pt 11), 3349-3358 (1995)
   PUBMED   8586647
REFERENCE   9  (bases 1 to 2087)
  AUTHORS   Wasano,K. and Hirakawa,Y.
  TITLE     Lamellar bodies of rat alveolar type 2 cells have late endosomal
            marker proteins on their limiting membranes
  JOURNAL   Histochemistry 102 (5), 329-335 (1994)
   PUBMED   7868367
REFERENCE   10 (bases 1 to 2087)
  AUTHORS   Bucci,C., Frunzio,R., Chiariotti,L., Brown,A.L., Rechler,M.M. and
            Bruni,C.B.
  TITLE     A new member of the ras gene superfamily identified in a rat liver
            cell line
  JOURNAL   Nucleic Acids Res 16 (21), 9979-9993 (1988)
   PUBMED   3057452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_023950.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072470.1, SRR26643429.17179.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000004.1  122064026-122064185 c
            161-221             JAXUCZ010000004.1  122036464-122036524 c
            222-348             JAXUCZ010000004.1  122033284-122033410 c
            349-567             JAXUCZ010000004.1  122025372-122025590 c
            568-696             JAXUCZ010000004.1  122024575-122024703 c
            697-2087            JAXUCZ010000004.1  122019284-122020674 c
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2087
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /note="RAB7A, member RAS oncogene family"
                     /db_xref="GeneID:29448"
                     /db_xref="RGD:61908"
     exon            1..160
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /inference="alignment:Splign:2.1.0"
     exon            161..221
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..792
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /EC_number="3.6.5.2"
                     /note="RAB7, member RAS oncogene family; ras-related
                     protein p23; ras-related protein BRL-RAS"
                     /codon_start=1
                     /product="ras-related protein Rab-7a"
                     /protein_id="NP_076440.1"
                     /db_xref="GeneID:29448"
                     /db_xref="RGD:61908"
                     /translation="MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGAD
                     FLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSW
                     RDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAI
                     NVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNERAKASAESCSC"
     exon            222..348
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /inference="alignment:Splign:2.1.0"
     exon            349..567
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /inference="alignment:Splign:2.1.0"
     exon            568..696
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /inference="alignment:Splign:2.1.0"
     exon            697..2087
                     /gene="Rab7a"
                     /gene_synonym="Rab7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggaagtg ggagcaaggc cggagctttg accataaagc ccaaggcggc ggcgttggcg
       61 acggtgtttg gggctgggca gctccgagga gcctgctgga gccggagtcg aacctctctg
      121 tcgcggcctg cgttgtgtct cctcctctgt tgaccctgcg cttcaaggat gacctctagg
      181 aagaaagtgt tgctgaaggt catcatcctg ggagactctg gtgttggaaa gacatcgctc
      241 atgaaccagt atgtgaataa gaagttcagt aaccagtaca aagccacaat aggagcagac
      301 tttctgacca aggaggtgat ggtggatgac agacttgtta ccatgcagat ctgggacaca
      361 gctggtcaag aacggttcca gtctcttggt gtggccttct acagaggtgc agattgctgc
      421 gttctggtgt ttgatgtgac tgcccccaac acattcaaaa cccttgacag ctggagagac
      481 gagtttctca tccaggccag cccccgggat cctgagaact tcccttttgt tgtgttggga
      541 aacaagattg acctggaaaa cagacaagtg gccacaaaga gggcacaggc ttggtgctac
      601 agcaaaaaca acattcctta cttcgagacc agtgccaagg aggccatcaa tgtggaacag
      661 gccttccaga caattgctcg gaatgccctt aaacaggaaa cggaagtgga gctgtacaat
      721 gaattccctg aacccatcaa actggacaag aacgagcggg ccaaggcctc cgcagagagc
      781 tgcagctgtt gaagaggcag tgagcacaga gcacagagtc cttcacagac caagaacaca
      841 cacgtaggcc ttcaacacgc gtccctcctc ctctaaacag accagaacgt gagctctcac
      901 atccagctgc caaaagaaac tccacacaca cacatacaca catgcacaca cacacagaca
      961 tacacacaca gcaagcaaac tccagcctgt gcctgtcagg gctcctgggg cagctgtcca
     1021 ccgtgagccc tgtgtatggc atatggcgga gaccctgggt gctctggggt gcagtgggcg
     1081 tggaaagctt actctttttg tccactggaa agtgagagaa ctgttcacag ttcatctgtg
     1141 tctaattatc tgattttttt ttttaacggt cttgtggtct tttaccccta ccctccttga
     1201 aggtcctgtg ggaaggctgg tgcccaggct ccgttctgag caggctgttt tgtatgtatc
     1261 tgttaatgct tgttactttt aactaatcag atctttttac agtatccatt tattatgtaa
     1321 tgcttcttag aaaagaatct tatagtacat gttaatatat gcaaccaatt aaaatgtata
     1381 aattagtgta aggaattcct gggttgtgtg tttaagtcct ctaacgcagg cgtgcaaggt
     1441 ggagggttga accctgtctg gattacagag tgttagagac tcaaatttgg aagtccagct
     1501 agcggcagta ttctgtacag tagacacaag aattatgtac gccttttatc acagacttaa
     1561 gagccaaaaa gcttttcatc tctccagagg gaaaactgaa tgagacagtt cccttctgtg
     1621 tctaaatttt ccaaaaggtt gatttgcata atacagtagt gtatacaatg gataaattgc
     1681 tgttacttca gaaattaaaa ttatcatttt ctccctttct gtttttcttc tgttcaacac
     1741 ttcccaatgc ccttagatca ctgtcctact caaagaggaa aggagaaccc caccagacct
     1801 gtcccagtca gtgactctac ctttgttcta gaaggcgctc ctttcagggt tgtggtacct
     1861 gtaggttagc agatcccctc ctttcccacc caccctagtg tggcccagca ctaacccaca
     1921 gtctcttggg ttgagccctg gcagttctgt cccctcctga ggtcctgccc tgcatcatgg
     1981 cttgcttccc ggagcacttc ccctccagaa gtctacattc tagggtgtag gctgagttct
     2041 tctgtaaaga gatgagcgtg atgccaataa aatttaacaa gaacaaa
//
