LOCUS       NM_053366               3028 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus RAB6A, member RAS oncogene family (Rab6a),
            transcript variant 2, mRNA.
ACCESSION   NM_053366 XM_001062702 XM_001067160
VERSION     NM_053366.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3028)
  AUTHORS   Zahavi,E.E., Hummel,J.J.A., Han,Y., Bar,C., Stucchi,R., Altelaar,M.
            and Hoogenraad,C.C.
  TITLE     Combined kinesin-1 and kinesin-3 activity drives axonal trafficking
            of TrkB receptors in Rab6 carriers
  JOURNAL   Dev Cell 56 (4), 494-508 (2021)
   PUBMED   33571451
  REMARK    GeneRIF: Combined kinesin-1 and kinesin-3 activity drives axonal
            trafficking of TrkB receptors in Rab6 carriers.
            Erratum:[Dev Cell. 2021 May 17;56(10):1552-1554. doi:
            10.1016/j.devcel.2021.04.028.. PMID: 34004153]
REFERENCE   2  (bases 1 to 3028)
  AUTHORS   Matsuto,M., Kano,F. and Murata,M.
  TITLE     Reconstitution of the targeting of Rab6A to the Golgi apparatus in
            semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on
            Golgi membranes and a concerted role of Rab6A/BICD2 interactions in
            Golgi-to-ER retrograde transport
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2592-2609 (2015)
   PUBMED   25962623
REFERENCE   3  (bases 1 to 3028)
  AUTHORS   Stehbens,S.J., Paszek,M., Pemble,H., Ettinger,A., Gierke,S. and
            Wittmann,T.
  TITLE     CLASPs link focal-adhesion-associated microtubule capture to
            localized exocytosis and adhesion site turnover
  JOURNAL   Nat Cell Biol 16 (6), 561-573 (2014)
   PUBMED   24859005
REFERENCE   4  (bases 1 to 3028)
  AUTHORS   Lindsay,A.J., Jollivet,F., Horgan,C.P., Khan,A.R., Raposo,G.,
            McCaffrey,M.W. and Goud,B.
  TITLE     Identification and characterization of multiple novel Rab-myosin Va
            interactions
  JOURNAL   Mol Biol Cell 24 (21), 3420-3434 (2013)
   PUBMED   24006491
REFERENCE   5  (bases 1 to 3028)
  AUTHORS   Pusapati,G.V., Luchetti,G. and Pfeffer,S.R.
  TITLE     Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the
            late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B
            GTPase
  JOURNAL   J Biol Chem 287 (50), 42129-42137 (2012)
   PUBMED   23091056
REFERENCE   6  (bases 1 to 3028)
  AUTHORS   Matanis,T., Akhmanova,A., Wulf,P., Del Nery,E., Weide,T.,
            Stepanova,T., Galjart,N., Grosveld,F., Goud,B., De Zeeuw,C.I.,
            Barnekow,A. and Hoogenraad,C.C.
  TITLE     Bicaudal-D regulates COPI-independent Golgi-ER transport by
            recruiting the dynein-dynactin motor complex
  JOURNAL   Nat Cell Biol 4 (12), 986-992 (2002)
   PUBMED   12447383
  REMARK    Erratum:[Nat Cell Biol. 2003 Jan;5(1):84.]
REFERENCE   7  (bases 1 to 3028)
  AUTHORS   Bergo,M.O., Leung,G.K., Ambroziak,P., Otto,J.C., Casey,P.J.,
            Gomes,A.Q., Seabra,M.C. and Young,S.G.
  TITLE     Isoprenylcysteine carboxyl methyltransferase deficiency in mice
  JOURNAL   J Biol Chem 276 (8), 5841-5845 (2001)
   PUBMED   11121396
REFERENCE   8  (bases 1 to 3028)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   9  (bases 1 to 3028)
  AUTHORS   Han,S.Y., Park,D.Y., Park,S.D. and Hong,S.H.
  TITLE     Identification of Rab6 as an N-ethylmaleimide-sensitive fusion
            protein-binding protein
  JOURNAL   Biochem J 352 Pt 1 (Pt 1), 165-173 (2000)
   PUBMED   11062069
REFERENCE   10 (bases 1 to 3028)
  AUTHORS   Cussac,D., Leblanc,P., L'Heritier,A., Bertoglio,J., Lang,P.,
            Kordon,C., Enjalbert,A. and Saltarelli,D.
  TITLE     Rho proteins are localized with different membrane compartments
            involved in vesicular trafficking in anterior pituitary cells
  JOURNAL   Mol Cell Endocrinol 119 (2), 195-206 (1996)
   PUBMED   8807639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 25, 2022 this sequence version replaced NM_053366.1.
            
            Transcript Variant: Variants 1 and 2 include either one of two
            duplicated, alternatively spliced coding exons and are the same
            length. The resulting proteins (isoforms 1 and 2, respectively) are
            the same length but differ at three amino acid positions. This
            variant (2) encodes isoform 2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.2127.1,
                                           SRR26643292.2959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               JAXUCZ010000001.1  164370033-164370572
            541-599             JAXUCZ010000001.1  164391265-164391323
            600-653             JAXUCZ010000001.1  164392835-164392888
            654-759             JAXUCZ010000001.1  164394110-164394215
            760-871             JAXUCZ010000001.1  164396320-164396431
            872-965             JAXUCZ010000001.1  164399222-164399315
            966-1032            JAXUCZ010000001.1  164404769-164404835
            1033-3028           JAXUCZ010000001.1  164406823-164408818
FEATURES             Location/Qualifiers
     source          1..3028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3028
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /note="RAB6A, member RAS oncogene family"
                     /db_xref="GeneID:84379"
                     /db_xref="RGD:619737"
     exon            1..540
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..1097
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ras-related protein Rab-6A; rab-6; RAB6, member RAS
                     oncogene family; RAB6B, member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-6A isoform 2"
                     /protein_id="NP_445818.1"
                     /db_xref="GeneID:84379"
                     /db_xref="RGD:619737"
                     /translation="MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQA
                     TIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQ
                     QTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAG
                     YNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVNEGGCSC"
     exon            541..599
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
     exon            600..653
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..759
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..871
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..965
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1032
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..3028
                     /gene="Rab6a"
                     /gene_synonym="Rab6; Rab6b; RCO4-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccgtgcca gaggctcgcg cactcagcgg gttgggctgc ggtggcggcg gcggcggctg
       61 ctgtgggagc ccgagcgctg cgcgtgctag gtcctagacg cgtctgcggc gctcgccccg
      121 ccaccctcct ctctcacctc agtctccgcg ccgcgttctg agggaaggaa cggcgctagg
      181 ctagcgaagc ccgagcgcac cgctggctgc ctccgacacc gccctgcgtc ccttcgcggt
      241 cgcgggcctg gctgggtgct aggcgactct gcggggaggc ggcggcgacg gctgccggtc
      301 ggtggagtca ctctcccttc agcctcgccc ctctgctcgg ccctgcaggg gccgagagga
      361 ctccgaggct gccccttccg ctcggccctc ttcgtcagcg ggttggagct gcagcggtct
      421 ggaagaggtc tttgagctga ggcggcggcg gcggctcctc cggctccatc atgtccgcgg
      481 gcggagactt cgggaatccg ctgaggaaat tcaagctggt gttcctagga gagcagagcg
      541 ttggaaagac atccttgatc accagattca tgtatgatag ttttgacaac acctatcagg
      601 caacaattgg cattgacttc ttatcaaaaa caatgtactt ggaggatcga accatcaggc
      661 tgcagctgtg ggacactgcg ggtcaggaac gtttccgtag cctcattccc agttacatcc
      721 gtgactctgc tgcagccgta gtagtttacg atatcacaaa tgttaactca ttccagcaga
      781 ctacaaaatg gattgatgat gtcagaacag aaagaggaag tgatgtcatc atcatgctag
      841 taggaaataa aacagatctt gctgataaga ggcaagtgtc aattgaggag ggagagagga
      901 aagccaaaga gctgaatgtt atgtttattg aaaccagtgc aaaagcagga tacaatgtaa
      961 agcagctttt ccggcgtgtc gctgcagctt tacctggaat ggaaagcaca caggacagaa
     1021 gcagagaaga catgattgac ataaaactgg aaaagcctca ggagcagcca gtcaatgaag
     1081 gtggctgttc ctgctaatgc ccctggcatc ctacaaccct ttaacagaag ctcactgctt
     1141 tggccccata ctttcattga ctgcagtgtg aatattggct tgaacctttt cccttcagta
     1201 ataacgtatt gcaattcatc attgctgcct gtttcgtgga gatgctctat tagcttcaca
     1261 agcacaaaaa agtcagtgtc ttcattattt atatttttta aaagccaaac aattccagca
     1321 tactcgtgat aactttgagg attagataca ttttcttaac attttttccc tttttaatgt
     1381 tatgataatg tactttaaaa tgatgaaaat ctcagcagta tgtgtgtggc ttgtaaagag
     1441 cagtgtgttc acagcagcat ttgcctacct tcttgctgtc tcccagcttt tcttgcctct
     1501 tccttctccc ctttcctgtc cttaccttcc ccaaacaaac aagagatggc aaacagcagt
     1561 ataaccaagc cctttggaat tatctgtagt tttacagata ccttttagct cctggccatg
     1621 agccataatg tccaaaatta ctcttgagca ctgatataag tcacttagac cttctttgag
     1681 gtcagaactc agctgttgct atcatgatgg gcagtgcctg agtaaggaaa gggttctggt
     1741 atgtcttcaa aatgaatctt aacgagttta ctgagtggtt acaggtaaag gaacataaac
     1801 tattatttct gatcagaaca ggtacccctt ttacatgagc tttactagac tctgggagag
     1861 aaaagtggcc aaggacttct caactgtttt ttaatacttg tttagtcatg gtgaaattga
     1921 taaaagttct agcagttctc cccaaatttt ttaattgtca aaatactgtc tttttttagg
     1981 aaaaaaaaat cagcaccttt taaagcaata gatttcactt gggtttcttt tccaaaaaat
     2041 gctacataga caaggcattg taaaaatcag tttcctttaa gaaccagcag aataaaaatt
     2101 tgacgtgaag aaaacttctg tgtctagtag aaataatatc taaagtttac caactatagt
     2161 accctcacag aatagcaaat acccttctgc tctggacgtt ggttcagatt tgaatttgga
     2221 agtaatttcc ttggaagtcc ctgtggcagg tcagagaaat ggaaataaaa gttactataa
     2281 ttcagattta tgccttattt tttagcattt tttaaatgtt gggtctttca agctgttttt
     2341 tgctttttat tagatctata taaataagtt aactagcaat ttagttttgt atttaagcta
     2401 caattaatct ttttcctttg gtgatattta tttctttgct tttttttaac ttcaaatttt
     2461 taggtgtttt gttgaatgtt tagagcttca tcaccatggc aatatgtatt tcccttgaaa
     2521 cattgcaaac aaatatgcta tgagtgcacc cttttaatct tcactagtta ttgtgagatt
     2581 gctgtgtaag ttaataaaca catttgtaaa tacattattt gcagggaaaa aattctgagt
     2641 tctaactcag aagaagcctg cgggggttta tgttgtaagc attacttaac acagtataaa
     2701 gatgaaaagg taacaaaaat aacttcatac ttcctcacct cctcattgca acaaaattcc
     2761 taactggaaa gcccgactcc cctccctgtc ctcctccact tctacgtact gtcaccttgt
     2821 aacacttgga gagcacttgg attatggatc tgaatagaga aatactttca gataatcatt
     2881 agcccacata ccctgtaact tatactcaaa catgggatag agttgtaaag tgcttttata
     2941 atacatatta ttgttaaaag caaggattga ctcttttgtt ttattttgac atggcatgtc
     3001 ctgaaataaa tatcaattca atatggca
//
