LOCUS       NM_001105840            1893 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RAB5C, member RAS oncogene family (Rab5c), mRNA.
ACCESSION   NM_001105840 XM_001081435 XM_213463
VERSION     NM_001105840.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ and Barr FA.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Pavlos NJ, Gronborg M, Riedel D, Chua JJ, Boyken J, Kloepper TH,
            Urlaub H, Rizzoli SO and Jahn R.
  TITLE     Quantitative analysis of synaptic vesicle Rabs uncovers distinct
            yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered
            exocytosis
  JOURNAL   J Neurosci 30 (40), 13441-13453 (2010)
   PUBMED   20926670
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Schroder B, Wrocklage C, Pan C, Jager R, Kosters B, Schafer H,
            Elsasser HP, Mann M and Hasilik A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 1893)
  AUTHORS   Fuchs E, Haas AK, Spooner RA, Yoshimura S, Lord JM and Barr FA.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   8  (bases 1 to 1893)
  AUTHORS   Fujimoto Y, Itabe H, Sakai J, Makita M, Noda J, Mori M, Higashi Y,
            Kojima S and Takano T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   9  (bases 1 to 1893)
  AUTHORS   Zhao H, Ettala O and Vaananen HK.
  TITLE     Intracellular membrane trafficking pathways in bone-resorbing
            osteoclasts revealed by cloning and subcellular localization
            studies of small GTP-binding rab proteins
  JOURNAL   Biochem Biophys Res Commun 293 (3), 1060-1065 (2002)
   PUBMED   12051767
REFERENCE   10 (bases 1 to 1893)
  AUTHORS   Bucci C, Lutcke A, Steele-Mortimer O, Olkkonen VM, Dupree P,
            Chiariello M, Bruni CB, Simons K and Zerial M.
  TITLE     Co-operative regulation of endocytosis by three Rab5 isoforms
  JOURNAL   FEBS Lett 366 (1), 65-71 (1995)
   PUBMED   7789520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB719595.1, BC158856.1, DV715536.1, BP465087.1 and CV797230.1.
            
            On Sep 27, 2011 this sequence version replaced NM_001105840.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158856.1, CO564237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               CB719595.1         1-528
            529-1225            BC158856.1         511-1207
            1226-1516           DV715536.1         394-684
            1517-1856           BP465087.1         14-353              c
            1857-1893           CV797230.1         1-37                c
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1893
                     /gene="Rab5c"
                     /note="RAB5C, member RAS oncogene family"
                     /db_xref="GeneID:287709"
                     /db_xref="RGD:1307095"
     exon            1..107
                     /gene="Rab5c"
                     /inference="alignment:Splign:2.1.0"
     exon            108..361
                     /gene="Rab5c"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..846
                     /gene="Rab5c"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-5C"
                     /protein_id="NP_001099310.2"
                     /db_xref="GeneID:287709"
                     /db_xref="RGD:1307095"
                     /translation="MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKG
                     QFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYD
                     ITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLF
                     METSAKTAMNVNEIFMAIAKKLPKNEPQNAAGAPGRNRGVDLQESNPASRSQCCSN"
     exon            362..513
                     /gene="Rab5c"
                     /inference="alignment:Splign:2.1.0"
     exon            514..636
                     /gene="Rab5c"
                     /inference="alignment:Splign:2.1.0"
     exon            637..730
                     /gene="Rab5c"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1876
                     /gene="Rab5c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaggcgga agtggaggcc ggagcctggg acaccgccgg ggcgggggga gaggagcgga
       61 gtctgtggga gccccggccc aagtaacgct gctgccccgg agccgcgttg gaggcctccc
      121 ttcccattaa gtgcctcttt gcaaagcacc gaccccaccc ccacgctcac tggtactact
      181 acagagcatc gcaccatggc gggtcgagga ggtgcagcac gacccaatgg accagctgca
      241 ggcaacaaga tctgtcagtt taagctggtc ctcttgggcg agtctgcagt gggcaaatcc
      301 agcctggtcc tccgctttgt caaggggcag ttccatgagt accaggagag cacaattgga
      361 gcggctttcc tcacacagac tgtctgctta gacgacacaa cggtcaagtt tgagatctgg
      421 gacacagctg ggcaagagcg atatcacagc ctggccccga tgtactatcg gggggcccaa
      481 gcagccattg tggtctatga catcaccaac acagatacat ttgcacgggc taagaactgg
      541 gtgaaggagt tacagaggca ggccagcccc aacatcgtca ttgcactagc gggtaacaaa
      601 gcagacctgg ccagcaagag agccgtggag tttcaggaag cacaagccta cgcagatgac
      661 aacagtttgc tgttcatgga gacgtccgca aagactgcaa tgaacgtgaa tgaaattttc
      721 atggcgatag ctaagaagct tcccaagaat gagccccaga atgcagctgg tgctccaggc
      781 cgaaacagag gtgtggatct gcaggagagc aacccagcca gccggagcca gtgctgcagc
      841 aactgagccc cttacctgcc actgccccca ctcctccagc agaatgacct gactggaatc
      901 tactctaacc aatcgcactt aacaactcgg gccaccactg ggggcagggg aagggtccat
      961 catgaattct ccgcataact ttgatcctag gccggaggga gttattccac ctgcaccttt
     1021 ctgtacaaat actaattcaa ttttaagtct taagtcactt ttttaatata tatgatcttc
     1081 tgctcttccc tgttcccttt ctactgctcc cccacttgcc ctttgctggt agtagccatg
     1141 ctcctgtgct cttcatcctg ggacagggct tggagcagct accctttcct tccttcttgc
     1201 tggagagcag actcagcaag aacacccaca tcgaccttgt tgggagccgt cttgggctgg
     1261 ggcagtgggc aggccctggg ctggggaagg gacaggcagc tctttcctca gctggctgtc
     1321 aatcaggctg cagccccctc cccatctgac tcccagctgg gagagaaacc gcagcattac
     1381 ttaagcatca tttgtgacag ccacacccat ggcccaggcc tcctccaccc ttagtcaccc
     1441 tgacctctgg ctctgagccc tgttctgacc aaatcacgat gatgagtatt cgggggtggg
     1501 tgggtaaggg gggggagtgg gagggatgga accaactttt tctgtatttt gtattgtatg
     1561 ttttcttcaa catgtaacca atcagtatct tgtcaatata gtcagccgat cgatcgacct
     1621 cacacttgtc ttcctcgtct ttctctggca gtttatcagg ccatacatat cctctcaatt
     1681 tttcctgaag ttaatttaaa atgaatcatc aatctgatta aatggctcta ctccatgtgt
     1741 gtgagaggat gctgctggtc atggtaacca aaagaaagag gccctgctgt tggcagctct
     1801 gatggtggag gataggactg acctggggct gacacctggc tcccctcggc ttacattaaa
     1861 gaatatgcaa cctgtaaaaa aaaaaaaaaa aaa
//
