LOCUS       NM_001079936            3289 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RAB5B, member RAS oncogene family (Rab5b), mRNA.
ACCESSION   NM_001079936 XM_001071247 XM_213824
VERSION     NM_001079936.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3289)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 3289)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   3  (bases 1 to 3289)
  AUTHORS   Pavlos,N.J., Gronborg,M., Riedel,D., Chua,J.J., Boyken,J.,
            Kloepper,T.H., Urlaub,H., Rizzoli,S.O. and Jahn,R.
  TITLE     Quantitative analysis of synaptic vesicle Rabs uncovers distinct
            yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered
            exocytosis
  JOURNAL   J Neurosci 30 (40), 13441-13453 (2010)
   PUBMED   20926670
REFERENCE   4  (bases 1 to 3289)
  AUTHORS   Zou,L., Zhou,J., Zhang,J., Li,J., Liu,N., Chai,L., Li,N., Liu,T.,
            Li,L., Xie,Z., Liu,H., Wan,Y. and Wu,Y.
  TITLE     The GTPase Rab3b/3c-positive recycling vesicles are involved in
            cross-presentation in dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15801-15806 (2009)
   PUBMED   19717423
REFERENCE   5  (bases 1 to 3289)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3289)
  AUTHORS   Shin,N., Jeong,H., Kwon,J., Heo,H.Y., Kwon,J.J., Yun,H.J.,
            Kim,C.H., Han,B.S., Tong,Y., Shen,J., Hatano,T., Hattori,N.,
            Kim,K.S., Chang,S. and Seol,W.
  TITLE     LRRK2 regulates synaptic vesicle endocytosis
  JOURNAL   Exp Cell Res 314 (10), 2055-2065 (2008)
   PUBMED   18445495
  REMARK    GeneRIF: Results suggest that LRRK2, in conjunction with its
            interaction with Rab5b, plays an important role in synaptic
            function by modulating the endocytosis of synaptic vesicles.
REFERENCE   7  (bases 1 to 3289)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   8  (bases 1 to 3289)
  AUTHORS   Pisitkun,T., Shen,R.F. and Knepper,M.A.
  TITLE     Identification and proteomic profiling of exosomes in human urine
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13368-13373 (2004)
   PUBMED   15326289
REFERENCE   9  (bases 1 to 3289)
  AUTHORS   Callaghan,J., Nixon,S., Bucci,C., Toh,B.H. and Stenmark,H.
  TITLE     Direct interaction of EEA1 with Rab5b
  JOURNAL   Eur J Biochem 265 (1), 361-366 (1999)
   PUBMED   10491193
REFERENCE   10 (bases 1 to 3289)
  AUTHORS   Bucci,C., Lutcke,A., Steele-Mortimer,O., Olkkonen,V.M., Dupree,P.,
            Chiariello,M., Bruni,C.B., Simons,K. and Zerial,M.
  TITLE     Co-operative regulation of endocytosis by three Rab5 isoforms
  JOURNAL   FEBS Lett 366 (1), 65-71 (1995)
   PUBMED   7789520
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129101.1.
            
            On or before Jan 11, 2007 this sequence version replaced
            XM_213824.4, XM_001071247.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129101.1, SRR8487227.333628.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3289
                     /gene="Rab5b"
                     /note="RAB5B, member RAS oncogene family"
                     /db_xref="GeneID:288779"
                     /db_xref="RGD:1306489"
     exon            1..168
                     /gene="Rab5b"
                     /inference="alignment:Splign:2.1.0"
     exon            169..429
                     /gene="Rab5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..914
                     /gene="Rab5b"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-5B"
                     /protein_id="NP_001073405.1"
                     /db_xref="GeneID:288779"
                     /db_xref="RGD:1306489"
                     /translation="MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQ
                     FHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDI
                     TNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFM
                     ETSAKTAMNVNDLFLAIAKKLPKSEPQNPGGAAGRSRGVDLHEQAQQNKSQCCSN"
     exon            430..581
                     /gene="Rab5b"
                     /inference="alignment:Splign:2.1.0"
     exon            582..704
                     /gene="Rab5b"
                     /inference="alignment:Splign:2.1.0"
     exon            705..798
                     /gene="Rab5b"
                     /inference="alignment:Splign:2.1.0"
     exon            799..3268
                     /gene="Rab5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagcccca ggtaccgagc tgatggagcc cacaagggca gaggcggagg tcccgagagg
       61 agcgcagcct tgcctgcggc agaggcgggt cgggccgacg ccagggctcg agagcctcct
      121 ggagcgggca aaaggggctg tcccgcaggc ctagtgggcg ccgaggagga ctgttgaggc
      181 ctggaagtcc ctccctttcc cctcccccct ttgccaattt gtggcattcc cctccctcta
      241 ccttctccta ctttgataac ctggctatga ctagcagaag tacagccagg cccaatgggc
      301 agccccaggc cagcaaaata tgccagttca aattggtcct gctgggagaa tctgcagtgg
      361 ggaagtcgag cctggtgtta cgttttgtca aaggacagtt ccatgaatac caggaaagta
      421 ccattggagc ggccttcctc acccagtcgg tgtgtctaga tgacacaaca gtcaagtttg
      481 agatctggga cacagctggg caggaacgat accacagttt agcccccatg tactacaggg
      541 gtgcccaggc tgccatcgtg gtctatgata tcactaatca ggaaacgttt gcccgggcaa
      601 agacatgggt aaaggaacta cagcggcaag ccagccctag catcgtcatt gccttggcag
      661 ggaacaaagc tgaccttgcc aacaagcgca tggtggagta tgaagaggct caggcatatg
      721 cagatgacaa cagcttatta tttatggaga cttcagctaa gactgctatg aacgtgaatg
      781 atctcttcct ggcaatagca aagaagttgc caaagagtga accccagaat ccagggggtg
      841 cagcaggccg aagtcggggc gtggatcttc atgagcaggc ccagcagaac aagagccagt
      901 gttgtagcaa ctgagggagg ggtggctagc agcaaatacg tatggaatta gcacgaaagc
      961 taagacataa cctccatccc cgcccctcag cacacagccc ctacggtgac agcacactga
     1021 gccctggctc ccaagggctg cctcctgaca gctccgtcat ggcacttttt aatgcttcag
     1081 caaccaacac caggcagctg ttgccactac tatgccctac tctggggctt ggggtcaaat
     1141 ctccccagga ccttccttcc aaaacaaact ttctttactt catgttctcg gtgcaagaca
     1201 gtgacttcct cattgtccca tcacccccca ccccttcccc tccatgtttt cccagtgttt
     1261 cagagaagac ttttgtctcc tgcctccctc tcccacctct cagcactccc tcctctagat
     1321 cctgtttcct cctctttaca agatgatgaa gggtattccc aggtactgag aagggaggaa
     1381 tatactttta gttacattaa aaaccttgcc gggagagtaa ggctcagagc aggagggagt
     1441 aaggaaacat ttcctttcat tttatctggt gagagtttct tgtctatgaa acactgcggc
     1501 accaatcagt ggacttgtgg agggtgtcct aggtaggagt gagatcgggg aggtgagctc
     1561 gcaggcactg aatggagttt attagttaat aggacacaga tggagatgca gtgtcatctg
     1621 tggctctaac tcgtcccaag gctgctttcc ttcttgtccc catccactaa ccccaccgag
     1681 tgtggggatt ggacctcaga gtgctccaaa gaatcttcac tggttgcctg cacccttagt
     1741 ctgctgtgat ctaattggag gaggtaccag tctctgatgc cgtcctctga agcctgtgta
     1801 tacataggca tttccctacc ctggccttga gatggcctta accccagaca ccatgcccct
     1861 gcagtttgca ctttaattga tggtagttca gtcaagatac atgtttttct tggggggggg
     1921 ggtgattgat ttacctatcc ttcaaccttt ttaattaaat ggaatctaca atgaatgagg
     1981 tttggagagg ccctatagac aacagtcaca gtggcagcta ctcacaccca gtgtccactg
     2041 ctagcttcct ctgactgatt cacacctcta ttcttgggta taggtttgtc tgagcaactg
     2101 gggagtggcc tcagagtagc acgggccatg gtggtggagt aaagaaaggt caggaaaagg
     2161 gagtgctcta tcttcccagg gttcacattc gatttgctac gtcttaccat gtcttttcta
     2221 cttccctgta aatacgtgta agtcttgatt ctctgtacag tcagttctgc ctcctggttc
     2281 ccattagccc ccttttcttc tcccttttgt taatatcttg ggtttagttc ctccttcatt
     2341 cccccactca ctcttactta atccatgtac cactagaggc tcctcccaca gaggccgttt
     2401 gtccagtgac agggcaacta gaactgaagg tgcctcacag ctgccttgta tcatcagagg
     2461 gccttggtcc tttctgaatc tctggcttct ctacatccta cattagatgt ttgagggtgt
     2521 ctgtgagaag ccatcaaagc aagaaggaat ttgatatttc agccagagtt tgggggtaat
     2581 tttcagaaga aaggaaagac cacagtagcc tagagttgag cctttctgcc cctttggctt
     2641 agacactgac ttgtattcca gctgaggaat ccatgaagcc aagattctca aggacccaac
     2701 ttaggttctt ccacttagaa ctcaattctc ttccttttcc aggggcagcc ttagttctca
     2761 cggccctgaa acatacatat ttacttttct agaacctgtt catctgcaaa acacccaggc
     2821 acatcctttt tgcaagtgga gactctgagt gaagctctct aagtctctta gggacttaac
     2881 tccttctctg caaaaatgaa gatgttttat tgccttgggg ctgggaagcc atctcccagg
     2941 ctttcacttc ctcccttcct cccttcttag gaacagtatt ggccttagtt ccggggcctg
     3001 tctgctgcct tccctctcct cctgccagct cttctgcctt tgtttgagct ctgttgggct
     3061 tgaggggttt ggttctctcc ccacctccct gtcacccttt ttcttctgat cagtttttag
     3121 gggagggctc atcttttctg cctttatatt ttttttccta agaaagtgtt tgcctttctt
     3181 tcactctcct aacataacaa tcgtggtaac agaatgcaac tgctgattta tcgatgtatt
     3241 taatgtaagt aaaaaaggaa aaaagaaaaa aaaaaaaaaa aaaaaaaaa
//
