LOCUS       NM_022692               2232 bp    mRNA    linear   ROD 03-MAY-2024
DEFINITION  Rattus norvegicus RAB5A, member RAS oncogene family (Rab5a), mRNA.
ACCESSION   NM_022692 XM_039084177
VERSION     NM_022692.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2232)
  AUTHORS   Guan,D.R., Fang,M., Zhu,M.Z., Wang,K., Cui,Y. and Bai,Y.P.
  TITLE     [The effects of different exercise modes on Rab5 protein and
            glucose metabolism in skeletal muscle of type 2 diabetic mellitus
            rats]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 38 (3), 207-211 (2022)
   PUBMED   36062786
  REMARK    GeneRIF: [The effects of different exercise modes on Rab5 protein
            and glucose metabolism in skeletal muscle of type 2 diabetic
            mellitus rats].
REFERENCE   2  (bases 1 to 2232)
  AUTHORS   Ackermann,F., Schink,K.O., Bruns,C., Izsvak,Z., Hamra,F.K.,
            Rosenmund,C. and Garner,C.C.
  TITLE     Critical role for Piccolo in synaptic vesicle retrieval
  JOURNAL   Elife 8, e46629 (2019)
   PUBMED   31074746
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2232)
  AUTHORS   Escudero,C.A., Cabeza,C., Moya-Alvarado,G., Maloney,M.T.,
            Flores,C.M., Wu,C., Court,F.A., Mobley,W.C. and Bronfman,F.C.
  TITLE     c-Jun N-terminal kinase (JNK)-dependent internalization and
            Rab5-dependent endocytic sorting mediate long-distance retrograde
            neuronal death induced by axonal BDNF-p75 signaling
  JOURNAL   Sci Rep 9 (1), 6070 (2019)
   PUBMED   30988348
  REMARK    GeneRIF: c-Jun N-terminal kinase (JNK)-dependent internalization
            and Rab5-dependent endocytic sorting mediate long-distance
            retrograde neuronal death induced by axonal BDNF-p75 signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2232)
  AUTHORS   Guo,X., Farias,G.G., Mattera,R. and Bonifacino,J.S.
  TITLE     Rab5 and its effector FHF contribute to neuronal polarity through
            dynein-dependent retrieval of somatodendritic proteins from the
            axon
  JOURNAL   Proc Natl Acad Sci U S A 113 (36), E5318-E5327 (2016)
   PUBMED   27559088
  REMARK    GeneRIF: Retrieval is also dependent on the Rab5 effector Fused
            Toes (FTS)-Hook-FTS and Hook-interacting protein (FHIP) (FHF)
            complex, which interacts with the minus-end-directed microtubule
            motor dynein and its activator dynactin to drive a population of
            axonal retrograde carriers containing somatodendritic proteins
            toward the soma.
REFERENCE   5  (bases 1 to 2232)
  AUTHORS   Tyrrell,B.J., Woodham,E.F., Spence,H.J., Strathdee,D., Insall,R.H.
            and Machesky,L.M.
  TITLE     Loss of strumpellin in the melanocytic lineage impairs the WASH
            Complex but does not affect coat colour
  JOURNAL   Pigment Cell Melanoma Res 29 (5), 559-571 (2016)
   PUBMED   27390154
REFERENCE   6  (bases 1 to 2232)
  AUTHORS   Gruenheid,S., Pinner,E., Desjardins,M. and Gros,P.
  TITLE     Natural resistance to infection with intracellular pathogens: the
            Nramp1 protein is recruited to the membrane of the phagosome
  JOURNAL   J Exp Med 185 (4), 717-730 (1997)
   PUBMED   9034150
REFERENCE   7  (bases 1 to 2232)
  AUTHORS   Ikin,A.F., Annaert,W.G., Takei,K., De Camilli,P., Jahn,R.,
            Greengard,P. and Buxbaum,J.D.
  TITLE     Alzheimer amyloid protein precursor is localized in nerve terminal
            preparations to Rab5-containing vesicular organelles distinct from
            those implicated in the synaptic vesicle pathway
  JOURNAL   J Biol Chem 271 (50), 31783-31786 (1996)
   PUBMED   8943215
REFERENCE   8  (bases 1 to 2232)
  AUTHORS   de Hoop,M.J., Huber,L.A., Stenmark,H., Williamson,E., Zerial,M.,
            Parton,R.G. and Dotti,C.G.
  TITLE     The involvement of the small GTP-binding protein Rab5a in neuronal
            endocytosis
  JOURNAL   Neuron 13 (1), 11-22 (1994)
   PUBMED   8043272
REFERENCE   9  (bases 1 to 2232)
  AUTHORS   Bucci,C., Wandinger-Ness,A., Lutcke,A., Chiariello,M., Bruni,C.B.
            and Zerial,M.
  TITLE     Rab5a is a common component of the apical and basolateral endocytic
            machinery in polarized epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 5061-5065 (1994)
   PUBMED   8197185
REFERENCE   10 (bases 1 to 2232)
  AUTHORS   Wagner,A.C., Strowski,M.Z. and Williams,J.A.
  TITLE     Identification of Rab 5 but not Rab 3A in rat pancreatic zymogen
            granule membranes
  JOURNAL   Biochem Biophys Res Commun 200 (1), 542-548 (1994)
   PUBMED   8166729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Mar 9, 2021 this sequence version replaced
            XM_039084177.1, NM_022692.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161848.1, SRR22582424.642958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000009.1  6721127-6721361
            236-490             JAXUCZ010000009.1  6725165-6725419
            491-642             JAXUCZ010000009.1  6738654-6738805
            643-765             JAXUCZ010000009.1  6739285-6739407
            766-859             JAXUCZ010000009.1  6741368-6741461
            860-2232            JAXUCZ010000009.1  6748084-6749456
FEATURES             Location/Qualifiers
     source          1..2232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2232
                     /gene="Rab5a"
                     /note="RAB5A, member RAS oncogene family"
                     /db_xref="GeneID:64633"
                     /db_xref="RGD:620936"
     exon            1..235
                     /gene="Rab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            236..490
                     /gene="Rab5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..975
                     /gene="Rab5a"
                     /EC_number="3.6.5.2"
                     /function="role in vesicle transport"
                     /note="small GTP-binding protein rab5"
                     /codon_start=1
                     /product="ras-related protein Rab-5A"
                     /protein_id="NP_073183.1"
                     /db_xref="GeneID:64633"
                     /db_xref="RGD:620936"
                     /translation="MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQ
                     FHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDI
                     TNEESFSRAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFM
                     ETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPAQPARSQCCSN"
     exon            491..642
                     /gene="Rab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            643..765
                     /gene="Rab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            766..859
                     /gene="Rab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            860..2232
                     /gene="Rab5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagaggac gacgacgagg aggaagaagt cctcggaact cgagcccggc gactctggag
       61 gaggagagag gaaggcggag cagagaggcg gagacgcagc ccggcagggg cggcacggcg
      121 ctcggagtcc cgcgtcggcc agtgtgagaa gcagcgagta ggcgacgccg ctgcaactgc
      181 ggcgcgtcgg atctccgggc cgtgcgtggc ctcactgccg ggaaccgcgc cccaggtatt
      241 ttctccagaa agaagaaaac attgatacct tgcatcctgg aagttcattt aggaatctga
      301 aatcagggac ttctttataa tttggacatg gctaatcgag gagcaacaag acccaacggg
      361 ccaaatactg gaaataaaat atgccagttc aaactggttc ttctaggaga gtctgctgtt
      421 ggcaaatcaa gtctggtgct tcgctttgtg aaaggccaat ttcatgagtt tcaagagagt
      481 accattgggg ctgcctttct aacccaaact gtgtgtcttg atgacacaac agtaaaattt
      541 gaaatatggg atacagctgg ccaagaacgg tatcatagcc tagcaccaat gtactaccga
      601 ggagcacaag ccgccatagt tgtgtatgat attacaaatg aggagtcctt ttcgagagca
      661 aaaaactggg ttaaagaact tcaaaggcaa gcaagtccta atattgtgat agctttgtca
      721 ggaaacaagg ctgacttagc aaataaaaga gctgttgact tccaggaagc acagtcctat
      781 gcagatgaca acagcttatt atttatggag acatcagcta agacatcaat gaatgtaaat
      841 gaaatattta tggcaatagc taaaaagctg ccaaagaacg aaccacaaaa tccaggcgca
      901 aactcagcca gaggacgagg agtagacctt actgagcctg cacagccagc cagaagccag
      961 tgttgtagta actgaactcc agtgtcaact tcctaaatgg caaaaaccat ggaattggga
     1021 gcatttagcc ggcccagtgt gacttccaaa aagagactat ggtagaatca agtttctaat
     1081 actgaattat tttgagtgtt ttgaacttaa tttttaataa catgcatgtg ttcctccagc
     1141 agtagaaagg aaaatgagaa ctgtgtatac acttgttcca tgggaaagtg caggggaaca
     1201 gttcatctcc agtgggtatg gacccactct taacccaccc agtctctaaa ctgggatgat
     1261 agtcaggtat ggaagattca aaattactaa tgtatgcttt agaaaaacat ttttagaaga
     1321 ctaaaaatat ttatgcttag caacaaaagc caagcaaatg gtaattttct ttgattgtct
     1381 taaaaagcct acatttcaca tattaataaa gtaatcccaa gaaaacagtc ctatatctcc
     1441 agaaagaagg aatattggtg gcatcttaat tttattcagt catgttactt cttaaaattt
     1501 aattgaagaa aaaaaagtca catgtaaccc catcctgttt taggaatata aaaactgata
     1561 agtgcatttt aatggatagt ggtcctttca taggagcttc tttttaagac aaagtggaaa
     1621 caaaccaggt atctgctttc tatttaatca ctgttggcta ttacatagag gtctgtctag
     1681 aacagggagg gggctctgct tccctttgga catgattagt cagtgcacta accattatgt
     1741 acattcaaac ttgattattt taaatattca gctgtactgt aaatagagta ctgcattgta
     1801 gtctccatat gtttattatt tcctgtaata tttaagaatt gcctaaacat acaaaatgta
     1861 cagttactaa aacagctaat tatttctttc tccccctatg aaaggaaggg gctttgctgt
     1921 tcttacatgc tagaaccata ataaacaccg tacttgcaat ttgtaacata agtattacaa
     1981 tgttattagt aatcttgaag cctttttttt tgaagtccat tttattttaa tcagtatatt
     2041 gcactaatta ttttaggtat tttcattata tgaaatctac catgtgtcag atgatttaat
     2101 ctatttaagt gttgatctgc tagcagaatg tgtacatttt acagtaactc aaaattagta
     2161 aggagaacag ctcaccagtg tttagtttta tattgaggtg ctcaggttgg aataaagtgg
     2221 tgtaaaaagc aa
//
