LOCUS       NM_013019               1445 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB4A, member RAS oncogene family (Rab4a), mRNA.
ACCESSION   NM_013019
VERSION     NM_013019.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1445)
  AUTHORS   Jackson,T.C., Kotermanski,S.E. and Kochanek,P.M.
  TITLE     Whole-transcriptome microarray analysis reveals regulation of Rab4
            by RBM5 in neurons
  JOURNAL   Neuroscience 361, 93-107 (2017)
   PUBMED   28818525
  REMARK    GeneRIF: Rab4a is involved in the regulation of endocytosis and
            protein trafficking in cells
REFERENCE   2  (bases 1 to 1445)
  AUTHORS   Chichger,H., Braza,J., Duong,H., Stark,M. and Harrington,E.O.
  TITLE     Neovascularization in the pulmonary endothelium is regulated by the
            endosome: Rab4-mediated trafficking and p18-dependent signaling
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 309 (7), L700-L709 (2015)
   PUBMED   26254426
  REMARK    GeneRIF: This study shows for the first time that
            neovascularization within the pulmonary vasculature is dependent on
            the prorecycling endocytic proteins Rab4 and p18.
REFERENCE   3  (bases 1 to 1445)
  AUTHORS   Schindler,C., Chen,Y., Pu,J., Guo,X. and Bonifacino,J.S.
  TITLE     EARP is a multisubunit tethering complex involved in endocytic
            recycling
  JOURNAL   Nat Cell Biol 17 (5), 639-650 (2015)
   PUBMED   25799061
REFERENCE   4  (bases 1 to 1445)
  AUTHORS   Kuijl,C., Pilli,M., Alahari,S.K., Janssen,H., Khoo,P.S.,
            Ervin,K.E., Calero,M., Jonnalagadda,S., Scheller,R.H., Neefjes,J.
            and Junutula,J.R.
  TITLE     Rac and Rab GTPases dual effector Nischarin regulates vesicle
            maturation to facilitate survival of intracellular bacteria
  JOURNAL   EMBO J 32 (5), 713-727 (2013)
   PUBMED   23386062
REFERENCE   5  (bases 1 to 1445)
  AUTHORS   Peng,H.Y., Chen,G.D., Hsieh,M.C., Lai,C.Y., Huang,Y.P. and Lin,T.B.
  TITLE     Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's
            adjuvant-induced inflammatory pain via regulating dorsal horn
            GluR1-containing AMPA receptor trafficking in rats
  JOURNAL   Pain 153 (12), 2380-2392 (2012)
   PUBMED   22980744
  REMARK    GeneRIF: Our results suggest that spinal SGK1 phosphorylation,
            which subsequently triggers the GRASP-1/Rab4 cascade, plays a
            pivotal role in CFA-induced inflammatory pain by regulating
            GluR1-containing AMPAR recycling in the dorsal horn.
REFERENCE   6  (bases 1 to 1445)
  AUTHORS   Uphues,I., Kolter,T., Goud,B. and Eckel,J.
  TITLE     Failure of insulin-regulated recruitment of the glucose transporter
            GLUT4 in cardiac muscle of obese Zucker rats is associated with
            alterations of small-molecular-mass GTP-binding proteins
  JOURNAL   Biochem J 311 (Pt 1) (Pt 1), 161-166 (1995)
   PUBMED   7575448
REFERENCE   7  (bases 1 to 1445)
  AUTHORS   Uphues,I., Kolter,T., Goud,B. and Eckel,J.
  TITLE     Insulin-induced translocation of the glucose transporter GLUT4 in
            cardiac muscle: studies on the role of small-molecular-mass
            GTP-binding proteins
  JOURNAL   Biochem J 301 (Pt 1) (Pt 1), 177-182 (1994)
   PUBMED   8037667
REFERENCE   8  (bases 1 to 1445)
  AUTHORS   Ricort,J.M., Tanti,J.F., Cormont,M., Van Obberghen,E. and Le
            Marchand-Brustel,Y.
  TITLE     Parallel changes in Glut 4 and Rab4 movements in two
            insulin-resistant states
  JOURNAL   FEBS Lett 347 (1), 42-44 (1994)
   PUBMED   8013658
REFERENCE   9  (bases 1 to 1445)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     Complete coding sequences of the ras related rab 3 and 4 cDNAs
  JOURNAL   Nucleic Acids Res 16 (3), 1204 (1988)
   PUBMED   3344209
REFERENCE   10 (bases 1 to 1445)
  AUTHORS   Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     Four additional members of the ras gene superfamily isolated by an
            oligonucleotide strategy: molecular cloning of YPT-related cDNAs
            from a rat brain library
  JOURNAL   Proc Natl Acad Sci U S A 84 (23), 8210-8214 (1987)
   PUBMED   3317403
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062016.1.
            
            On Oct 8, 2005 this sequence version replaced NM_013019.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062016.1, SRR8487227.246293.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1445
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /note="RAB4A, member RAS oncogene family"
                     /db_xref="GeneID:25532"
                     /db_xref="RGD:3529"
     exon            1..153
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..779
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /EC_number="3.6.5.2"
                     /note="Ras-related small GTP binding protein 4"
                     /codon_start=1
                     /product="ras-related protein Rab-4A"
                     /protein_id="NP_037151.2"
                     /db_xref="GeneID:25532"
                     /db_xref="RGD:3529"
                     /translation="MAQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNH
                     TIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYN
                     ALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTG
                     ENVEEAFMQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRTQAPSAQECGC
                     "
     exon            154..234
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            235..349
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            350..412
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            413..567
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            568..663
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            664..796
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1413
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagtcccgc tgggccgcag ccggtggccg gctcgccgtg ggcccgtacc cggctctcca
       61 cactcggttc ctctcgctct gcggagactg gaggacgaac cccgtggagc tgtggcggca
      121 ggatggcgca gaccgccatg tccgagactt acgatttctt gtttaagttc ttggtcattg
      181 gaaatgcggg aactggcaaa tcctgcttgc tccatcagtt cattgagaag aaattcaaag
      241 atgactcaaa tcataccata ggagtggaat tcggctcaaa gataataaat gttggtggta
      301 aatatgtgaa gttacagata tgggacacgg ctggacagga gcggttcagg tctgtgacga
      361 gaagctacta cagaggtgcg gctggggcac tcctcgtcta tgacatcacc agccgagaaa
      421 cctacaatgc gcttactaat tggttaacag atgccagaat gctggcgagc cagaacatcg
      481 tcatcattct ctgcgggaac aagaaggacc tggatgccga ccgggaagtc accttccttg
      541 aagcctccag gttcgcacaa gagaatgagc tcatgttcct ggaaaccagt gcactgactg
      601 gcgagaacgt cgaagaggct ttcatgcagt gcgcaaggaa gatacttaac aaaattgaat
      661 caggtgagct ggaccccgag aggatgggct ctggtatcca gtatggagac gccgccttga
      721 gacagctacg gtcaccccga cgtacacagg ctccaagtgc acaggagtgt ggctgctagg
      781 caccccagca acacaggttc agtggtggtt tctggagcac agccgcagga gcccgaagag
      841 ctgaagattt tactaccatc tactactctg cacagaagta gatctccacg ggaacggtgc
      901 acgccggcag ccagggctca gcagccgttc tgcaaactaa ctcagaggac agacagtacc
      961 tttacatgcc acacgtatgc agatccccgc cccacacgta cccttcatgt tccgttaaat
     1021 ccagcttgtg ctgcacacag cccagcacgt tcccacacag cacagagcca gtgtgacatg
     1081 ataggatccc acacccaatg agcttttttt atttaaactc acgggaaatg cagttgtgaa
     1141 tgagagagag agcgagcgcg tgtttctcat tgtgtcggtt aactcccagg agatgccagt
     1201 ttgtgaaagt ggagcgtgct tttctcattg tgtcagttac acgcgtgact cagtatgaaa
     1261 ggactctggt gtgaacagcc agtgcgtttc ttatttaatc cctctcaccc acttttacac
     1321 tgtttctgta attccacacc tgaaatgcta aacccacagg actcgttaac agcctggaaa
     1381 taaagtggaa ccgagtttct catgcacagt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaa
//
