LOCUS       NM_001040154            4283 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus RAB3 GTPase activating non-catalytic protein
            subunit 2 (Rab3gap2), mRNA.
ACCESSION   NM_001040154 XM_008769835 XM_573533
VERSION     NM_001040154.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4283)
  AUTHORS   Gerondopoulos,A., Bastos,R.N., Yoshimura,S., Anderson,R.,
            Carpanini,S., Aligianis,I., Handley,M.T. and Barr,F.A.
  TITLE     Rab18 and a Rab18 GEF complex are required for normal ER structure
  JOURNAL   J Cell Biol 205 (5), 707-720 (2014)
   PUBMED   24891604
REFERENCE   2  (bases 1 to 4283)
  AUTHORS   Spang,N., Feldmann,A., Huesmann,H., Bekbulat,F., Schmitt,V.,
            Hiebel,C., Koziollek-Drechsler,I., Clement,A.M., Moosmann,B.,
            Jung,J., Behrends,C., Dikic,I., Kern,A. and Behl,C.
  TITLE     RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced
            autophagy
  JOURNAL   Autophagy 10 (12), 2297-2309 (2014)
   PUBMED   25495476
REFERENCE   3  (bases 1 to 4283)
  AUTHORS   Nagano,F., Kawabe,H., Nakanishi,H., Shinohara,M.,
            Deguchi-Tawarada,M., Takeuchi,M., Sasaki,T. and Takai,Y.
  TITLE     Rabconnectin-3, a novel protein that binds both GDP/GTP exchange
            protein and GTPase-activating protein for Rab3 small G protein
            family
  JOURNAL   J Biol Chem 277 (12), 9629-9632 (2002)
   PUBMED   11809763
REFERENCE   4  (bases 1 to 4283)
  AUTHORS   Nagano,F., Sasaki,T., Fukui,K., Asakura,T., Imazumi,K. and Takai,Y.
  TITLE     Molecular cloning and characterization of the noncatalytic subunit
            of the Rab3 subfamily-specific GTPase-activating protein
  JOURNAL   J Biol Chem 273 (38), 24781-24785 (1998)
   PUBMED   9733780
REFERENCE   5  (bases 1 to 4283)
  AUTHORS   Lee,N.H., Weinstock,K.G., Kirkness,E.F., Earle-Hughes,J.A.,
            Fuldner,R.A., Marmaros,S., Glodek,A., Gocayne,J.D., Adams,M.D.,
            Kerlavage,A.R. et al.
  TITLE     Comparative expressed-sequence-tag analysis of differential gene
            expression profiles in PC-12 cells before and after nerve growth
            factor treatment
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8303-8307 (1995)
   PUBMED   7667285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 16, 2021 this sequence version replaced NM_001040154.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data from several strains because no single
            transcript was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.32534.1,
                                           SRR26643290.43479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000013.1  99289112-99289223
            113-177             JAXUCZ010000013.1  99303346-99303410
            178-301             JAXUCZ010000013.1  99314804-99314927
            302-383             JAXUCZ010000013.1  99316041-99316122
            384-431             JAXUCZ010000013.1  99317868-99317915
            432-507             JAXUCZ010000013.1  99317991-99318066
            508-609             JAXUCZ010000013.1  99319110-99319211
            610-709             JAXUCZ010000013.1  99321159-99321258
            710-808             JAXUCZ010000013.1  99322672-99322770
            809-957             JAXUCZ010000013.1  99326885-99327033
            958-1037            JAXUCZ010000013.1  99327762-99327841
            1038-1127           JAXUCZ010000013.1  99327952-99328041
            1128-1267           JAXUCZ010000013.1  99329748-99329887
            1268-1484           JAXUCZ010000013.1  99330878-99331094
            1485-1628           JAXUCZ010000013.1  99331614-99331757
            1629-1711           JAXUCZ010000013.1  99331991-99332073
            1712-1776           JAXUCZ010000013.1  99332360-99332424
            1777-1867           JAXUCZ010000013.1  99335339-99335429
            1868-1995           JAXUCZ010000013.1  99338157-99338284
            1996-2209           JAXUCZ010000013.1  99338984-99339197
            2210-2307           JAXUCZ010000013.1  99340092-99340189
            2308-2413           JAXUCZ010000013.1  99341109-99341214
            2414-2574           JAXUCZ010000013.1  99343040-99343200
            2575-2803           JAXUCZ010000013.1  99343952-99344180
            2804-2977           JAXUCZ010000013.1  99346871-99347044
            2978-3084           JAXUCZ010000013.1  99347134-99347240
            3085-3151           JAXUCZ010000013.1  99350397-99350463
            3152-3222           JAXUCZ010000013.1  99351394-99351464
            3223-3258           JAXUCZ010000013.1  99354299-99354334
            3259-3333           JAXUCZ010000013.1  99355584-99355658
            3334-3552           JAXUCZ010000013.1  99356077-99356295
            3553-3642           JAXUCZ010000013.1  99358211-99358300
            3643-3855           JAXUCZ010000013.1  99358856-99359068
            3856-4014           JAXUCZ010000013.1  99359897-99360055
            4015-4283           JAXUCZ010000013.1  99360213-99360481
FEATURES             Location/Qualifiers
     source          1..4283
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..4283
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /note="RAB3 GTPase activating non-catalytic protein
                     subunit 2"
                     /db_xref="GeneID:289350"
                     /db_xref="RGD:1311518"
     CDS             1..4164
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /note="RAB3-GAP150; rab3-GAP p150; rab3-GAP regulatory
                     subunit; rab3 GTPase-activating protein 150 kDa subunit;
                     RAB3 GTPase activating protein subunit 2"
                     /codon_start=1
                     /product="rab3 GTPase-activating protein non-catalytic
                     subunit"
                     /protein_id="NP_001035244.2"
                     /db_xref="GeneID:289350"
                     /db_xref="RGD:1311518"
                     /translation="MACSIVQFCSFQDLQSARDFLFPQLREETPGALRRDPSKTSNWE
                     DDSWGAWEETEPQEPEEEGNTSKTQKHSWLQECVLSLSPTSDLMVIAREQKAAFLVPK
                     WKHSDKGKEEMQFAVGWSGSVSAEEGEYVTSALCIPLASQKRSSTGRPDWTCIVVGFT
                     SGYVRFYTESGVLLLAQLLNEDRVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTI
                     DGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSP
                     FDQMKTASNIGGFNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVA
                     SKLTSALFSAASGWLGWKSKHEEETVQKQKPKMEPATPLAVRFGLPDSRRHGESICLS
                     PCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQIVEDLHERVPEKGDFSP
                     FGNTQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMGLNN
                     VTSQSWQPQTYQICLVDPVSASVKVVNVPFHLALSDKKSERAKDLHLVKKLAALLRAK
                     SPRPDSFEAEIKELILDIKYPATKKQALESILASDRVSFSCLRNVTQTSMDTLKNQEL
                     ESVDEGLLQFCASKLKLLHLYESVSQLNTLDFHSDTPFSDNDLAVLLRLDDKELLKLR
                     ALLEKYKQENTKATVRFSEDADGVLPVKTFLEYLDYEKDALSIRKTSEEECVALGSFF
                     FWKCLHGESSTEDMCHTLESAGLSPQQLLSLLLSVWLSKEKDILDKPQSVCCLHTMLS
                     LLSKMKVAIDETWDSQSVSPWWQQMRMACIQSENNGAALLSAHVGHSVAAQMSSSATD
                     KKFSQMVLDADAEALTDSWEALSLDTEYWKLLLRQLEDCLILQTLLHSRASPPAAKAS
                     SPQTEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDLSPELLKCANREKDVENPDEPRE
                     GIARSPPEVSEVETDLGAVPDLLRLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEA
                     RFLVRSIEHLRHILNPHVQNGISLMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDV
                     GMSDTALTSFLGSCLDLLQTSLEADISRDEVQVPVLDTEDAWLSVEGPTSIVELALEQ
                     KPIHYPLVEHHSILCSILYAAMSFSLKSVKPLALFDSKGKNAFFKDLTSIQLLPSGEM
                     DPNFISVRQQFLLKVVSAAVQAQHSKDRDPSARAADTHGQDLNWTALAVDLAHHLQVS
                     EDVIRRHYVGELYSYGADLLGEEAILQVQDKEVLASQLLVLTGQRLAHALFHTQTKEG
                     MELLARLPPTLCTWLKAMNPQDLQNTGVPVAATAKLVHKVMELLPEKHGQYSLALHLI
                     EAVEAMATL"
     exon            1..112
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            113..177
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            178..301
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            302..383
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            384..431
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            432..507
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            508..609
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            610..709
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            710..808
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            809..957
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1037
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1127
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1267
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1484
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1628
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1711
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1776
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1867
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1995
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2209
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2307
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2413
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2574
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2803
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2977
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3084
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3151
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3222
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3258
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3333
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3552
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3642
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3855
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..4014
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4283
                     /gene="Rab3gap2"
                     /gene_synonym="RGD1311518"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcctgct ccatcgtcca gttctgctcc tttcaggacc tgcagtccgc gcgcgacttc
       61 ctattccctc agctgcggga ggagaccccc ggagccctga gaagggaccc cagtaaaaca
      121 tcaaactggg aagatgatag ttggggagca tgggaagaaa cagagcccca agaacctgaa
      181 gaagaaggaa atacttctaa aacacaaaaa cattcctggc ttcaagaatg tgttttatcc
      241 ctctctccaa ccagtgacct tatggtcata gcccgggagc agaaggccgc atttctagtg
      301 ccaaaatgga agcacagtga taaagggaag gaggaaatgc agttcgctgt cggttggagc
      361 ggctccgtaa gtgcagagga aggggagtat gtaaccagtg ctctgtgcat cccgctggca
      421 agtcagaaga ggagttccac tgggcgccct gactggacct gcattgtagt gggctttacg
      481 tctggttatg tgcggttcta cactgagagt ggagtgcttt tgcttgcaca actattgaat
      541 gaggacagag tgcttcagct taaatgtagg acctatgaaa tcccaagaca ccctggagtg
      601 actgagcaga atgaagagct gagcatctta tatccggctg ccattgtgac cattgacgga
      661 tttagtcttt ttcagtctct tcgagcttgt cgaaaccagg tagcaaaagc tgcagcatca
      721 ggcaatgaga acatacaacc accaccgtta gcttataaga aatggggtct acaagatatt
      781 gacaccatta tcgatcatgc tagtattggc attatgactc tgtcgccgtt tgatcaaatg
      841 aagactgctt ccaatatagg tggatttaat gcagcaatta aaaacagtcc gcccgccatg
      901 tcccagtaca tcactgtggg ctccagtccg ttcactggct tcttctatgc tctagaggga
      961 agcactcagc ctctgctgtc tcacgttgca cttgctgttg caagtaagct gacctccgcc
     1021 ctcttcagtg ccgctagtgg ttggcttggt tggaaaagca agcacgaaga agaaactgtc
     1081 cagaagcaga agcccaagat ggagccagcc accccgctgg ctgtgagatt tggacttccg
     1141 gattctagac gccacggcga aagcatatgc ctgtctcctt gtaacactct ggccgcagtc
     1201 acagatgact ttggcagagt tatcttgttg gatgtagcca gaggaattgc aatacggatg
     1261 tggaaagggt atcgggatgc acaaattgga tggattcaga ttgtagagga cctccatgaa
     1321 cgagtaccag aaaaggggga cttctccccc tttggaaata ctcaagggcc cagtcgagta
     1381 gctcagttcc ttgtgatcta tgcaccacga aggggaattc tggaagtgtg gagcacacag
     1441 caaggaccta gagtgggagc tttcaacgtg ggcaaacact gcaggctgct gtatcctggc
     1501 tacaaaatca tgggcttaaa caatgtgaca agtcagagtt ggcaacctca gacttaccag
     1561 atctgccttg ttgaccctgt gtctgcaagt gtgaaggtgg tgaacgtgcc tttccactta
     1621 gcactgagtg acaagaagag tgaaagagcc aaggacctgc acttagtgaa gaagctggcc
     1681 gccctgctga gagcaaagtc ccctaggccg gattcatttg aagcggaaat aaaggagttg
     1741 attcttgaca ttaagtatcc tgcaaccaag aaacaagctc tggaaagcat tttggccagt
     1801 gaccgtgtgt cattttcctg ccttagaaat gttactcaga cttcaatgga cactttaaaa
     1861 aaccaagagc ttgagtctgt cgatgaagga ctgttacagt tttgtgccag taaattgaaa
     1921 ttactacatc tttatgagtc tgtcagtcag ttaaatactc ttgactttca ctcagataca
     1981 ccgttctctg ataatgattt ggctgtgttg ctaaggctgg atgataaaga actcctgaag
     2041 ctccgggcct tattagagaa atacaaacaa gaaaacacca aggccactgt gcggttctct
     2101 gaggatgcag atggagtgct gcctgttaag accttccttg aatatctaga ctatgagaag
     2161 gatgcactga gcataaggaa gaccagtgaa gaggaatgtg tggccctagg cagtttcttc
     2221 ttttggaagt gtttgcatgg agaaagctcc actgaagaca tgtgccacac tctggagtct
     2281 gctggactta gcccacagca gttactgtct ctgctcctaa gtgtttggct ttcgaaggaa
     2341 aaagatattt tggacaaacc acaatctgtc tgctgtcttc ataccatgct gtccctgctg
     2401 agcaagatga aagtggccat cgatgagaca tgggattctc agtctgtgtc cccgtggtgg
     2461 cagcagatgc gcatggcctg cattcagtca gagaacaacg gagctgccct gctgtctgca
     2521 cacgttgggc attctgttgc tgcgcagatg tccagcagtg ccacagataa gaaattttcc
     2581 cagatggttt tggatgctga tgcagaagcc ctcacagact cctgggaagc cctttctttg
     2641 gacaccgagt actggaagct cctgctgaga cagctggagg actgcctcat actccagact
     2701 ctgctgcata gcagagcaag ccctccagct gccaaagcgt catctccaca gacagagcca
     2761 cttcctaggc tttctgttaa gaaactgtta gaagggggga aaggtggtat tgcagacagc
     2821 gtggccaagt ggatatttaa acaggacctc agccctgaat tgttgaaatg tgccaacaga
     2881 gaaaaagacg tagagaatcc agacgagccc agagaaggta ttgcccgaag tccccctgag
     2941 gtgtcagagg tggagacaga cctaggagcc gtaccagact tgctccgcct agcctacgag
     3001 cagttccctt gtagccttga gcttgacgtg ctgcatgcgc actgctgctg ggaatatgtg
     3061 gttcagtgga acaaagaccc agaggaagct cgctttttgg ttagatccat agagcacctg
     3121 aggcacattc ttaatccgca tgttcaaaat ggcatctcgt tgatgatgtg gaacacattc
     3181 ctggtgaaaa ggttttctgc tgctacctac ttaatggata aggttgggaa atctccaaag
     3241 gataggttgt gtcgaaggga cgtagggatg agcgacacgg cactgacctc cttcctcggc
     3301 tcctgcctgg accttcttca gacgtcattg gaggctgaca ttagcaggga tgaagtccag
     3361 gtgccagtcc tggacactga ggatgcctgg ctgtcggtgg aaggccccac ctctatagtg
     3421 gaactggcgc tggagcagaa gcctatccac tacccgctgg tagagcatca ttccatcctg
     3481 tgctccatcc tgtacgccgc catgagcttt tctctgaaga gtgtgaagcc tcttgccctt
     3541 tttgacagca agggaaagaa tgcatttttt aaggatttaa cttcaattca gttattacct
     3601 agtggggaaa tggatccaaa ctttatttct gtaagacaac agttcttact gaaagttgtc
     3661 agtgcagccg ttcaggccca gcactccaag gacagagacc cctctgcacg agcagcagac
     3721 actcacggcc aagacctcaa ctggacagct ctggctgtgg acttagccca ccaccttcaa
     3781 gtgagcgaag acgtcattcg acggcattat gtgggagagt tgtacagcta tggagctgac
     3841 ctcttaggag aggaggccat tcttcaagtt caggacaaag aggttctggc gtctcagctg
     3901 ctagtgttga cgggacaaag gctggctcat gcacttttcc acacccagac gaaagaaggc
     3961 atggagctgc tggccagact cccgcccaca ctctgcacct ggctgaaggc aatgaacccc
     4021 caggatcttc agaacactgg tgtacctgtg gcagcaacag ccaaactcgt gcataaagtg
     4081 atggagctcc tgccagagaa gcacgggcag tacagcctcg ccttacacct catcgaggct
     4141 gtggaagcca tggctacctt atgacagtag cccacacttc ggtgaccaca tgaaccactg
     4201 catgtccttt tacatagtga gatctggaac tttggaaggt ttctaggttt tttgtataat
     4261 aaataaatat attactttaa aaa
//
