LOCUS       NM_001402314            4243 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus RAB3 GTPase activating protein catalytic subunit
            1 (Rab3gap1), transcript variant 1, mRNA.
ACCESSION   NM_001402314 XR_005492428
VERSION     NM_001402314.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4243)
  AUTHORS   Gerondopoulos,A., Bastos,R.N., Yoshimura,S., Anderson,R.,
            Carpanini,S., Aligianis,I., Handley,M.T. and Barr,F.A.
  TITLE     Rab18 and a Rab18 GEF complex are required for normal ER structure
  JOURNAL   J Cell Biol 205 (5), 707-720 (2014)
   PUBMED   24891604
REFERENCE   2  (bases 1 to 4243)
  AUTHORS   Spang,N., Feldmann,A., Huesmann,H., Bekbulat,F., Schmitt,V.,
            Hiebel,C., Koziollek-Drechsler,I., Clement,A.M., Moosmann,B.,
            Jung,J., Behrends,C., Dikic,I., Kern,A. and Behl,C.
  TITLE     RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced
            autophagy
  JOURNAL   Autophagy 10 (12), 2297-2309 (2014)
   PUBMED   25495476
REFERENCE   3  (bases 1 to 4243)
  AUTHORS   Liegel,R.P., Handley,M.T., Ronchetti,A., Brown,S., Langemeyer,L.,
            Linford,A., Chang,B., Morris-Rosendahl,D.J., Carpanini,S.,
            Posmyk,R., Harthill,V., Sheridan,E., Abdel-Salam,G.M., Terhal,P.A.,
            Faravelli,F., Accorsi,P., Giordano,L., Pinelli,L., Hartmann,B.,
            Ebert,A.D., Barr,F.A., Aligianis,I.A. and Sidjanin,D.J.
  TITLE     Loss-of-function mutations in TBC1D20 cause cataracts and male
            infertility in blind sterile mice and Warburg micro syndrome in
            humans
  JOURNAL   Am J Hum Genet 93 (6), 1001-1014 (2013)
   PUBMED   24239381
REFERENCE   4  (bases 1 to 4243)
  AUTHORS   Morris-Rosendahl,D.J., Segel,R., Born,A.P., Conrad,C., Loeys,B.,
            Brooks,S.S., Muller,L., Zeschnigk,C., Botti,C., Rabinowitz,R.,
            Uyanik,G., Crocq,M.A., Kraus,U., Degen,I. and Faes,F.
  TITLE     New RAB3GAP1 mutations in patients with Warburg Micro Syndrome from
            different ethnic backgrounds and a possible founder effect in the
            Danish
  JOURNAL   Eur J Hum Genet 18 (10), 1100-1106 (2010)
   PUBMED   20512159
REFERENCE   5  (bases 1 to 4243)
  AUTHORS   Ko,J., Zhang,C., Arac,D., Boucard,A.A., Brunger,A.T. and
            Sudhof,T.C.
  TITLE     Neuroligin-1 performs neurexin-dependent and neurexin-independent
            functions in synapse validation
  JOURNAL   EMBO J 28 (20), 3244-3255 (2009)
   PUBMED   19730411
REFERENCE   6  (bases 1 to 4243)
  AUTHORS   Sakane,A., Manabe,S., Ishizaki,H., Tanaka-Okamoto,M., Kiyokage,E.,
            Toida,K., Yoshida,T., Miyoshi,J., Kamiya,H., Takai,Y. and Sasaki,T.
  TITLE     Rab3 GTPase-activating protein regulates synaptic transmission and
            plasticity through the inactivation of Rab3
  JOURNAL   Proc Natl Acad Sci U S A 103 (26), 10029-10034 (2006)
   PUBMED   16782817
REFERENCE   7  (bases 1 to 4243)
  AUTHORS   Nagano,F., Kawabe,H., Nakanishi,H., Shinohara,M.,
            Deguchi-Tawarada,M., Takeuchi,M., Sasaki,T. and Takai,Y.
  TITLE     Rabconnectin-3, a novel protein that binds both GDP/GTP exchange
            protein and GTPase-activating protein for Rab3 small G protein
            family
  JOURNAL   J Biol Chem 277 (12), 9629-9632 (2002)
   PUBMED   11809763
REFERENCE   8  (bases 1 to 4243)
  AUTHORS   Clabecq,A., Henry,J.P. and Darchen,F.
  TITLE     Biochemical characterization of Rab3-GTPase-activating protein
            reveals a mechanism similar to that of Ras-GAP
  JOURNAL   J Biol Chem 275 (41), 31786-31791 (2000)
   PUBMED   10859313
REFERENCE   9  (bases 1 to 4243)
  AUTHORS   Nagano,F., Sasaki,T., Fukui,K., Asakura,T., Imazumi,K. and Takai,Y.
  TITLE     Molecular cloning and characterization of the noncatalytic subunit
            of the Rab3 subfamily-specific GTPase-activating protein
  JOURNAL   J Biol Chem 273 (38), 24781-24785 (1998)
   PUBMED   9733780
REFERENCE   10 (bases 1 to 4243)
  AUTHORS   Fukui,K., Sasaki,T., Imazumi,K., Matsuura,Y., Nakanishi,H. and
            Takai,Y.
  TITLE     Isolation and characterization of a GTPase activating protein
            specific for the Rab3 subfamily of small G proteins
  JOURNAL   J Biol Chem 272 (8), 4655-4658 (1997)
   PUBMED   9030515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 11, 2022 this sequence version replaced XR_005492428.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000013.1  41908217-41908254
            39-94               JAXUCZ010000013.1  41908350-41908405
            95-170              JAXUCZ010000013.1  41913980-41914055
            171-303             JAXUCZ010000013.1  41923782-41923914
            304-382             JAXUCZ010000013.1  41925467-41925545
            383-502             JAXUCZ010000013.1  41939141-41939260
            503-668             JAXUCZ010000013.1  41941446-41941611
            669-768             JAXUCZ010000013.1  41947055-41947154
            769-850             JAXUCZ010000013.1  41952196-41952277
            851-919             JAXUCZ010000013.1  41954293-41954361
            920-993             JAXUCZ010000013.1  41955811-41955884
            994-1086            JAXUCZ010000013.1  41960865-41960957
            1087-1253           JAXUCZ010000013.1  41961397-41961563
            1254-1343           JAXUCZ010000013.1  41963766-41963855
            1344-1516           JAXUCZ010000013.1  41964203-41964375
            1517-1571           JAXUCZ010000013.1  41966091-41966145
            1572-1943           JAXUCZ010000013.1  41966407-41966778
            1944-2081           JAXUCZ010000013.1  41970035-41970172
            2082-2309           JAXUCZ010000013.1  41973069-41973296
            2310-2406           JAXUCZ010000013.1  41975230-41975326
            2407-2510           JAXUCZ010000013.1  41975436-41975539
            2511-2626           JAXUCZ010000013.1  41976034-41976149
            2627-2729           JAXUCZ010000013.1  41976455-41976557
            2730-2750           JAXUCZ010000013.1  41979381-41979401
            2751-4243           JAXUCZ010000013.1  41980119-41981611
FEATURES             Location/Qualifiers
     source          1..4243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..4243
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /note="RAB3 GTPase activating protein catalytic subunit 1"
                     /db_xref="GeneID:304759"
                     /db_xref="RGD:1306487"
     exon            1..38
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2987
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /note="isoform 1 is encoded by transcript variant 1; RAB3
                     GTPase activating protein subunit 1; rab3-GAP p130; RAB3
                     GTPase-activating protein 130 kDa subunit; rab3
                     GTPase-activating protein catalytic subunit"
                     /codon_start=1
                     /product="rab3 GTPase-activating protein catalytic subunit
                     isoform 1"
                     /protein_id="NP_001389243.1"
                     /db_xref="GeneID:304759"
                     /db_xref="RGD:1306487"
                     /translation="MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGHSL
                     GKPLEKGIFTSGTWEERADEISFADFRFSVTHHYLVQESPDKEGKDEESEDAIPQSMQ
                     DLLCMNNDFPPRAHCLVRWYGLREFVVIAPAAHSDAVLSESKCNLLLSSISIALGNTG
                     CQVPLFVQIHHKWRRMYMGECQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGC
                     PLTPLPPVSIAIRFTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPI
                     SELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKI
                     CRRKESTDEILGRSTFEEEGRDVADITHALSKLTEPAPVPIHKLSVSNMVHTAKKKIR
                     KHRGEESPLNNDVLNTILLFLFPDAASEKPLDGTTSVDNSNPTAEAGDYTLYNQFKSA
                     PSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDLR
                     CCLLHQKLQMLNCCIERKKARDEGKKTSPSDSMTKAYPADAGKAGGQLGLDHLRDTEK
                     EKGEAGKSWDSWSDSEEEFFECLSDAEDLRGNGQESTKKGGPKDMAPLKPEGRLHQHG
                     KLTLLRNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSD
                     MESFKAANPGCCLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAW
                     ETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEESL
                     ENIPSVKKIIKQIIAHSSKVLRFPSPEDKKLEEIILQITTVEAIIARARSLKAKFGTE
                     KCEHEEEKEDLERFVSCLLEQPEVAVTGAGRGHAGRIIHKLFVNAQRLTESSDEAAAV
                     ALPEEELKRSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTK
                     EDFRLAGAFSSDTSFF"
     exon            39..94
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            95..170
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            171..303
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            304..382
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            383..502
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            503..668
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            669..768
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            769..850
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            851..919
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            920..993
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1086
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1253
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1343
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1516
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1571
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1943
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2081
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2309
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2406
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2510
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2626
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2729
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2750
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..4243
                     /gene="Rab3gap1"
                     /gene_synonym="Rab3-GAP; RGD1306487"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacgctcc gctctgcaag atggcggcgg acagtgagcc cgagtccgaa gtgtttgaga
       61 tcacagactt caccacagcc tcggagtggg aaaggtttat ttccaaagtt gaagaagtct
      121 tgaatgactg gaaactgatt ggacactctc tgggaaagcc actggaaaag ggtatattta
      181 cttccggcac atgggaagag cgagcagatg aaatttcctt tgctgacttc aggttttcag
      241 tcactcatca ctaccttgta caagaatctc ctgataaaga agggaaggat gaagaatcgg
      301 aggatgctat tcctcaatca atgcaagatt tgctatgtat gaataatgac tttcctccaa
      361 gagcacattg tctggtaaga tggtatggcc tgcgtgagtt tgtggtgatt gcccctgctg
      421 cacacagtga cgcggttctc agtgagtcca agtgtaacct cctcctcagt tccatctcta
      481 ttgccctggg aaacaccggc tgccaggtac cgctgtttgt ccagatacat cacaaatggc
      541 gccgaatgta catgggagaa tgccaaggtc caggcgtccg aactgacttt gaaatggttc
      601 atcttcgaaa ggtgccaaat cagtacactc atttgtcagg tctgctggac atcttcaaat
      661 caaaaatcgg ctgtcctcta actccattgc ctccagttag catcgctatc cggttcacat
      721 atgtgcttca ggattggcag cagtactttt ggcctcagca gcctccagat atagatgccc
      781 tcgtgggagg agaagttgga ggcctggagt tcggcaagtt gccgtttggt gcctgtgaag
      841 atcctatcag tgaactccat ttagcaacaa cgtggcctca tttgacagag gggatcattg
      901 tagacaacga tgtttattcc gatttggatc ctgttcaagc tccccactgg tctgttagag
      961 ttcgaaaagc tgataatccc cagtgcttac taggtgattt tgttactgaa tttttaaaaa
     1021 tttgccgtcg aaaggaatca accgatgaaa ttcttggacg gtccacattt gaggaagaag
     1081 gaagagacgt tgctgatata actcatgctt tgtcaaagct gactgaacca gcaccagttc
     1141 caattcataa attatcagtt tcaaacatgg tacacactgc caagaagaag atacggaagc
     1201 acagaggaga agaatcaccc ctgaacaacg atgttctcaa taccattctc ttgttcttgt
     1261 tcccagacgc tgcctctgag aagccgttgg atggaactac ttcagtagac aatagcaatc
     1321 ccacagcaga ggccggagac tacactctct acaatcagtt caagtctgcg ccctccgata
     1381 gtttgacata caaactggcc ttgtgtcttt gcatgatcaa cttctaccat ggcgggctga
     1441 agggcgtggc acatctctgg caggaatttg ttcttgaaat gcgtttcaga tgggaaaaca
     1501 actttttgat tccaggacta gcaagtggac caccagatct aagatgttgt ttactacatc
     1561 agaaactaca gatgttaaat tgttgtattg aaaggaagaa agctcgcgat gaagggaaaa
     1621 agacgagccc ctcagatagt atgactaagg catatccagc agatgctggg aaagctgggg
     1681 gccagcttgg cctggaccat ctccgagaca ccgagaagga gaagggagaa gcagggaagt
     1741 cctgggattc ctggagcgat agtgaagagg agttttttga gtgcctcagt gatgctgaag
     1801 accttagagg aaacgggcag gagagtacta agaaaggagg ccccaaggac atggcaccct
     1861 taaagccaga aggacgcctg caccagcatg ggaagctcac actgctgcgt aatggagagc
     1921 ctctctatat tccagtgact caggaaccag cacccatgac agaagatctg ctggaagagc
     1981 agtctgaggt cttagcaaaa ttagggacat ctgccgaggg ggcgcacctc cgagcacgca
     2041 tgcagagtgc ctgtctcctc tctgatatgg agtcttttaa ggcagctaat ccaggctgct
     2101 gtctggaaga ttttgtgagg tggtactcac caagggacta cattgaggag gaggtgactg
     2161 atgagaaggg caatgtggtc ctaaagggag agctaagtgc ccgtatgaag atccccagca
     2221 acatgtgggt agaagcctgg gaaactgcta agcctgttcc agcaagacgc cagaggagac
     2281 tgtttgatga tacccgagaa gctgagaagg tgctgcacta cctggccatg cagaagcctg
     2341 cagacctagc caggcacctc ctgccttgtg tgattcatgc agcagttctc aaggtaaagg
     2401 aagaagaaag tctggaaaac attccttctg ttaagaagat tataaagcaa atcatagccc
     2461 attccagcaa agtcctgcgc ttccccagtc ccgaagacaa gaagttggaa gagatcatcc
     2521 ttcaaattac tactgtggaa gccatcatag cccgagcccg gtccctgaag gccaagtttg
     2581 gaactgagaa atgtgagcac gaggaagaaa aggaagatct ggaaaggttt gtcagctgcc
     2641 tgctggagca gcctgaagta gcagtcactg gggcaggaag agggcatgct ggccgaatca
     2701 tccacaagct gtttgtgaat gctcagcggc tgactgaatc ttctgatgag gctgctgcag
     2761 tggctctgcc agaggaggag ctgaaaaggt caggctgccc agaggagaga agacagacct
     2821 tggtgtcaga cttcccacca cctgcaggcc gtgagctcat cctgagggcc actgtgccac
     2881 ggcctgcccc ctactccaaa gccctgcccc agcgcatgta cagcgtgctc accaaggagg
     2941 acttcagact tgcaggtgcc ttttcctcag acacctcctt cttctagggc aggatgagag
     3001 gcagctcctg ccatggacac ctgagacgac cttgtcgaac cagcagcagg agtcccacca
     3061 gcatccagag tcatctctag ttaccaagct tgagccggac ggatagttct gaggtgtcac
     3121 agacttccac ctgcgggagg tggcctgtat tgggggaacc acgcgtcagc aggcctctca
     3181 ccttggggga caatttgttc attctcctgt gacagtcatc tgtgtaagca cttagtggct
     3241 atctttatta gtattgcata tgcaagatag agtatctgtt aactcacctt ctggatattt
     3301 ggtgtagagc cttttagtcc cagagtctgt ttttaaactg ccatgtgaca ttccgtttct
     3361 tcagtcaccg ggtgatcagc tgtttgatga acatttgaat attctgggag aaagtctaga
     3421 atttcagttt tgtttttcca tgtcactaac cagatgtagt tcttctgatc aatctgtaca
     3481 tgaaatgtgg ctgcagatta gccctctctc tgtgtgtctg tctgtcttat aggatctctt
     3541 ggttgcaccc ctgcctttgc actttacttc tctgcattgc tggctaggga tggtatttag
     3601 tgacgtcaca ggagcacatg ttgaacacac atcctgggaa catagctcac cgtgcaggca
     3661 gagagtggtg tgtgctgagc ctccgagcca agcctgtgag tgggcagact ggacggctgc
     3721 tttgtgtctg tccagttggg gctgaagcac ctagtgcagg gtgacggcac tgtccttgtg
     3781 cagttcagag tgcattcagt tgttgctgca ggacctctct ttggtgattg taaattattt
     3841 tgggacctaa aattcccact ttaatccaaa gtaaaaaacg gttatgctaa agtgtaaatt
     3901 ctgcctgtgt gatttttaaa aattaataga actgcacaaa ccctgtgtta tttttgtaaa
     3961 agaaaaaaga gtatatatat atttatctgt atggtgtgca cagatgcgtg tctgcgtgtg
     4021 aataggagag ccaggggccg acccctaggc ttcacagtgt tcttttcttc tgaaacgctg
     4081 gacttcgctt cttagaaacc catagatgct agctgagacc caagggccag aacaagaaga
     4141 agacaggaca gtgtctgcct gctttcctgg gtattggtga cagaactcta gtgtggatgg
     4201 gctaaaatgg cattgtttat ctaataaaac ggactggcgt cta
//
