LOCUS       NM_080580               2226 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus RAB3D, member RAS oncogene family (Rab3d), mRNA.
ACCESSION   NM_080580
VERSION     NM_080580.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Lindsay,A.J., Jollivet,F., Horgan,C.P., Khan,A.R., Raposo,G.,
            McCaffrey,M.W. and Goud,B.
  TITLE     Identification and characterization of multiple novel Rab-myosin Va
            interactions
  JOURNAL   Mol Biol Cell 24 (21), 3420-3434 (2013)
   PUBMED   24006491
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Zografou,S., Basagiannis,D., Papafotika,A., Shirakawa,R.,
            Horiuchi,H., Auerbach,D., Fukuda,M. and Christoforidis,S.
  TITLE     A complete Rab screening reveals novel insights in Weibel-Palade
            body exocytosis
  JOURNAL   J Cell Sci 125 (Pt 20), 4780-4790 (2012)
   PUBMED   22899725
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Limi,S., Ojakian,G. and Raffaniello,R.
  TITLE     Rab3D regulates amylase levels, not agonist-induced amylase
            release, in AR42J cells
  JOURNAL   Cell Mol Biol Lett 17 (2), 258-273 (2012)
   PUBMED   22367855
  REMARK    GeneRIF: Rab3D is not involved in agonist-induced exocytosis in
            AR42J cells. Instead, Rab3D may regulate amylase content in these
            cells.
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Pavlos,N.J., Cheng,T.S., Qin,A., Ng,P.Y., Feng,H.T., Ang,E.S.,
            Carrello,A., Sung,C.H., Jahn,R., Zheng,M.H. and Xu,J.
  TITLE     Tctex-1, a novel interaction partner of Rab3D, is required for
            osteoclastic bone resorption
  JOURNAL   Mol Cell Biol 31 (7), 1551-1564 (2011)
   PUBMED   21262767
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Kogel,T. and Gerdes,H.H.
  TITLE     Roles of myosin Va and Rab3D in membrane remodeling of immature
            secretory granules
  JOURNAL   Cell Mol Neurobiol 30 (8), 1303-1308 (2010)
   PUBMED   21080055
  REMARK    GeneRIF: These data suggest an implication of myosin Va and Rab3D
            in the maturation of SGs where they participate in overlapping but
            not identical tasks.
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Valentijn,J.A. and Jamieson,J.D.
  TITLE     Carboxyl methylation of rab3D is developmentally regulated in the
            rat pancreas: correlation with exocrine function
  JOURNAL   Eur J Cell Biol 76 (3), 204-211 (1998)
   PUBMED   9716267
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Roa,M., Paumet,F., Le Mao,J., David,B. and Blank,U.
  TITLE     Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell
            exocytosis following stimulation via high affinity IgE receptors
            (Fc epsilonRI)
  JOURNAL   J Immunol 159 (6), 2815-2823 (1997)
   PUBMED   9300704
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Oberhauser,A.F., Balan,V., Fernandez-Badilla,C.L. and
            Fernandez,J.M.
  TITLE     RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells
  JOURNAL   FEBS Lett 339 (1-2), 171-174 (1994)
   PUBMED   7508866
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Elferink,L.A., Anzai,K. and Scheller,R.H.
  TITLE     rab15, a novel low molecular weight GTP-binding protein
            specifically expressed in rat brain
  JOURNAL   J Biol Chem 267 (9), 5768-5775 (1992)
   PUBMED   1313420
  REMARK    Erratum:[J Biol Chem. 1992 Nov 5;267(31):22693.. PMID: 1429617]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081741.1.
            
            On Oct 17, 2004 this sequence version replaced NM_080580.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081741.1, FQ075728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680420
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2226
                     /gene="Rab3d"
                     /note="RAB3D, member RAS oncogene family"
                     /db_xref="GeneID:140665"
                     /db_xref="RGD:620924"
     exon            1..98
                     /gene="Rab3d"
                     /inference="alignment:Splign:2.1.0"
     exon            99..337
                     /gene="Rab3d"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..769
                     /gene="Rab3d"
                     /codon_start=1
                     /product="GTP-binding protein Rab-3D"
                     /protein_id="NP_542147.1"
                     /db_xref="GeneID:140665"
                     /db_xref="RGD:620924"
                     /translation="MASASEPPASPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYAD
                     DSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMY
                     DIANQESFTAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVSAEDGQRLAGDLGFE
                     FFEASAKENINVKQVFERLVDIICDKMNESLEPSSSPGSNGKGPALGDTPPPQPSSCG
                     C"
     exon            338..456
                     /gene="Rab3d"
                     /inference="alignment:Splign:2.1.0"
     exon            457..581
                     /gene="Rab3d"
                     /inference="alignment:Splign:2.1.0"
     exon            582..2206
                     /gene="Rab3d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgctggcag cagcggcagc tgtggggcga gggtcgcagc cctgtgcggg ccatagcaac
       61 ttcgtgggcg gatccttgtg tgcgaggcgg gacccgagat cccaccaaga tggcatccgc
      121 tagtgagccc cctgccagcc cacgggacgc tgccgaccag aactttgact acatgttcaa
      181 actgcttttg atcgggaaca gcagcgtagg caagacctcc ttcctgttcc gctatgccga
      241 tgactccttc acccccgcct tcgtgagcac agtgggcatt gacttcaagg tcaagacagt
      301 ctacagacat gacaagagga tcaagctgca gatctgggac acagcaggcc aggagcgcta
      361 ccggacaatc accacggcct actaccgtgg agccatgggc ttcctgctga tgtatgacat
      421 cgccaaccag gagtccttca cagctgtgca ggactgggct acgcagatta aaacctattc
      481 ctgggacaac gcccaggtca tccttgtggg gaacaagtgt gacctggagg atgaacgggt
      541 cgtatctgct gaggatggcc agaggctcgc tggtgatctt ggttttgagt tcttcgaggc
      601 cagcgccaag gagaacatca acgtgaagca ggtgttcgag cgcctggtgg atatcatctg
      661 tgacaagatg aatgagtccc tggaacccag ctccagccca ggcagcaatg ggaaaggccc
      721 agccctcggg gataccccac cccctcagcc gagcagctgc ggctgttagg ttcggccctt
      781 gacctcccca cacctgtcct tcttgcctct tcatgggcag cggccaaggt gtgagctatg
      841 gggactgtct caaagctcag ggcaccccct tgcctctggt ccacgtaccc ctcctcttgc
      901 acaagttcag ctccctttct ctccatgtca gaatgctcag acagtcctgg ttagagccca
      961 cgccccgggg ctctgctcag cattgtctgg ggttggcaca cccacacagg cattcaatgg
     1021 aggtagctat aggtgccatg gcctttcctg atgatggaag gatgtcccat gccttccgcc
     1081 tcagaaccat ttcccaggtg tgtgatctac tcctctgttg ttggctgaag atgtcacctg
     1141 gtgtgggtcg ctgtccaact tagtcctggt agcctctcca tctcaggtcc accagtttgg
     1201 ccttgaaatc tgcctatgaa ctggccgctg ccaaggatac aggcagatct gccatctcca
     1261 tctctgcctc tctggcatcg actggaaagc ctgctttccc gttatagagg gatagagtca
     1321 gagcccctga cacccgggac tctccaaagt gccttccaag cttctcctga atccatgcca
     1381 ctcccagaat taaattttgg attattcagg gccctatcca tggaggctga gaattgcctc
     1441 accctttaca gtacagcttt ctgtcagttt acctcagagc cagggaactg aggctgccca
     1501 gccaggtccc catctgtccc gtgttttaag caagagtttt acaaacctta catcctgtgt
     1561 agaaacggaa gtgaagaaag caacccacag agggcgtgcc cttgctagtc ggtttctcat
     1621 ggcaggattt gggcttctcc acccgaggac tcatgtatag acccagcgtt ggcatcattg
     1681 tcaccatcag ttggcccagg gacactgggg ttgtggggaa ggattgggga gaaggcatca
     1741 gtgggcaacc cagtgttttt gtttgtacat catgggagca acaggccctc ctgtgagtta
     1801 gggatgggct tcgggtgtga ttgatgtctc tacaaagctt gagacttagc ccctaggata
     1861 ctcgactcac tccagctagg aagtcttttg actcaccgac caaactcccc taaacgccat
     1921 ctgacatgct tggtccaggt gacagacggt cgctcagagt cacatacccc tgattctgta
     1981 tcagtgtgtc ctccttcagt ccccagagcc aaaatcattc tgcagcccta ctgagcacag
     2041 cctcttcctg gggtgcgtac gacctacggt gcctgcttca ggtccagatg tgtttctagg
     2101 cctgccagtg gctgtcttca tacaaagtga gggcgtctga ctactgggag gaaagagtca
     2161 ttttttttta tgttgcttta tcattaaata gtcaaaacaa tgaaaaaaaa aaaaaaaaaa
     2221 aaaaaa
//
