LOCUS       NM_013018               1404 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus RAB3A, member RAS oncogene family (Rab3a), mRNA.
ACCESSION   NM_013018
VERSION     NM_013018.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1404)
  AUTHORS   Yang,Y., Liu,Z., Lu,Y., Yu,X., Zhu,R., Cai,X., Lin,J., Wang,Z. and
            Zha,D.
  TITLE     Rab3a attenuates spinal cord injury by mediating vesicle release
  JOURNAL   Brain Res Bull 208, 110884 (2024)
   PUBMED   38253132
  REMARK    GeneRIF: Rab3a attenuates spinal cord injury by mediating vesicle
            release.
REFERENCE   2  (bases 1 to 1404)
  AUTHORS   Yang,Y., Yang,J., Liang,Y., Zhang,G., Cai,Z., Zhang,Y., Lin,H. and
            Tan,M.
  TITLE     Rab3A interacts with spastin to regulate neurite outgrowth in
            hippocampal neurons
  JOURNAL   Biochem Biophys Res Commun 643, 77-87 (2023)
   PUBMED   36587525
  REMARK    GeneRIF: Rab3A interacts with spastin to regulate neurite outgrowth
            in hippocampal neurons.
REFERENCE   3  (bases 1 to 1404)
  AUTHORS   Dai,Z., Tang,X., Chen,J., Tang,X. and Wang,X.
  TITLE     Rab3A Inhibition of Ca2+ -Dependent Dopamine Release From PC12
            Cells Involves Interaction With Synaptotagmin I
  JOURNAL   J Cell Biochem 118 (11), 3696-3705 (2017)
   PUBMED   28370453
  REMARK    GeneRIF: This work has shed new light on the molecular mechanism
            for Rab3 and synaptotamin regulation of neurotransmitter release.
REFERENCE   4  (bases 1 to 1404)
  AUTHORS   Ferrer-Orta,C., Perez-Sanchez,M.D., Coronado-Parra,T., Silva,C.,
            Lopez-Martinez,D., Baltanas-Copado,J., Gomez-Fernandez,J.C.,
            Corbalan-Garcia,S. and Verdaguer,N.
  TITLE     Structural characterization of the Rabphilin-3A-SNAP25 interaction
  JOURNAL   Proc Natl Acad Sci U S A 114 (27), E5343-E5351 (2017)
   PUBMED   28634303
  REMARK    GeneRIF: analysis of crystal structures and biochemical analyses of
            Rabphilin-3A C2B-SNAP25 and C2B-phosphatidylinositol
            4,5-bisphosphate (PIP2) complexes, revealing how Rabphilin-3A C2
            domains operate in cooperation with PIP2/Ca(2+) and SNAP25 to bind
            the plasma membrane, adopting a conformation compatible to interact
            with the complete SNARE complex
REFERENCE   5  (bases 1 to 1404)
  AUTHORS   Tang,X., Xie,C., Wang,Y. and Wang,X.
  TITLE     Localization of Rab3A-binding site on C2A domain of synaptotagmin I
            to reveal its regulatory mechanism
  JOURNAL   Int J Biol Macromol 96, 736-742 (2017)
   PUBMED   28057568
  REMARK    GeneRIF: Rab3A-binding site on C2A domain of synaptotagmin I
REFERENCE   6  (bases 1 to 1404)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
REFERENCE   7  (bases 1 to 1404)
  AUTHORS   de Hoop,M.J., Huber,L.A., Stenmark,H., Williamson,E., Zerial,M.,
            Parton,R.G. and Dotti,C.G.
  TITLE     The involvement of the small GTP-binding protein Rab5a in neuronal
            endocytosis
  JOURNAL   Neuron 13 (1), 11-22 (1994)
   PUBMED   8043272
REFERENCE   8  (bases 1 to 1404)
  AUTHORS   Araki,W., Ohno,K., Matsunaga,K., Nakamura,H., Sugimoto,C. and
            Shimada,T.
  TITLE     [Two sisters with pseudoidiopathic hypoparathyroidism presenting
            extensive intracranial calcification]
  JOURNAL   Nihon Naika Gakkai Zasshi 78 (1), 81-82 (1989)
   PUBMED   2732579
REFERENCE   9  (bases 1 to 1404)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     Complete coding sequences of the ras related rab 3 and 4 cDNAs
  JOURNAL   Nucleic Acids Res 16 (3), 1204 (1988)
   PUBMED   3344209
REFERENCE   10 (bases 1 to 1404)
  AUTHORS   Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     Four additional members of the ras gene superfamily isolated by an
            oligonucleotide strategy: molecular cloning of YPT-related cDNAs
            from a rat brain library
  JOURNAL   Proc Natl Acad Sci U S A 84 (23), 8210-8214 (1987)
   PUBMED   3317403
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087580.1.
            
            On Mar 13, 2005 this sequence version replaced NM_013018.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087580.1, FQ214465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155309, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1404
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1404
                     /gene="Rab3a"
                     /gene_synonym="RAB3"
                     /note="RAB3A, member RAS oncogene family"
                     /db_xref="GeneID:25531"
                     /db_xref="RGD:3528"
     exon            1..108
                     /gene="Rab3a"
                     /gene_synonym="RAB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..771
                     /gene="Rab3a"
                     /gene_synonym="RAB3"
                     /note="Ras-related small GTP binding protein 3A"
                     /codon_start=1
                     /product="ras-related protein Rab-3A"
                     /protein_id="NP_037150.2"
                     /db_xref="GeneID:25531"
                     /db_xref="RGD:3528"
                     /translation="MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYAD
                     DSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMY
                     DITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFE
                     FFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDC
                     AC"
     exon            109..336
                     /gene="Rab3a"
                     /gene_synonym="RAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            337..455
                     /gene="Rab3a"
                     /gene_synonym="RAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..580
                     /gene="Rab3a"
                     /gene_synonym="RAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            581..1379
                     /gene="Rab3a"
                     /gene_synonym="RAB3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcctccac cgccgcctgc agcccccgca tcttcttctg gggcccggtc gccagcgcag
       61 tcgcctcggt cgctgtcgcc agcgttgtct cagtttagag agggcaagat ggcctcagcc
      121 acagactctc gatatgggca gaaggagtcc tcagaccaga acttcgacta tatgttcaag
      181 atcctgatca ttggtaacag cagtgtgggc aaaacctcat tccttttccg ctacgcagac
      241 gactctttta ctccagcctt tgtcagcact gtgggcatag acttcaaggt caaaaccatc
      301 taccgcaatg acaagaggat caagctgcag atctgggaca cagcaggaca agagcggtac
      361 cgaaccatca ccacagccta ctaccggggc gccatgggct tcattctaat gtatgacatc
      421 accaatgagg agtccttcaa tgcagtgcag gactggtcca ctcagatcaa aacttactca
      481 tgggacaatg cccaggtgct gctggtgggg aacaagtgcg acatggagga cgagcgagtg
      541 gtgtcctcag aacgaggccg gcagctggcc gaccacctgg gctttgagtt ctttgaggcc
      601 agcgccaagg acaacattaa tgtcaagcag acctttgaac gtctggtgga cgtgatctgt
      661 gagaagatgt cggagtccct agatactgca gaccctgcag tcacgggtgc caagcagggc
      721 ccacagctca ccgaccagca ggcaccacct catcaggatt gcgcctgctg aaccacactt
      781 cccttcccca ccgccagggg cgcgtccccc atccctgtca ccctatttat tattgtagct
      841 atttatttat ttattgagga tgcgccgcga gcgcaccccc ttcccgccct gtacataccc
      901 ccacccagct ctgccgtggt atattgtggt cagtgctgct tcctctcctt ttagaaacac
      961 ccccccccct tcccactttt gtttttgtaa accgtcccat ccacagttgt cagttgtgaa
     1021 gaggggacca gatgtcactc tgcagcaggc tgatgggaga tggcgggcct gccagccctc
     1081 aggctggggg atgtgccacg tggaccactt ggttgacaga ctggcttcct gcttgcctgg
     1141 gccttctgcc ctatactttg ggatagatgg ggtaaagggg gatatagtca actactttgt
     1201 aatacccccc aaactgttct tacgtcatga gtgtcaaatg tgtcccccca cctccctaga
     1261 agttatgaac actatacaca gtcaataaag cgaatggaac ttgctgagac ccagccggcc
     1321 cagcccctgc acccacccca caaggcagtc cttgacatta aagagagaat ttaatgaaaa
     1381 aaaaaaaaaa aaaaaaaaaa aaaa
//
