LOCUS       NM_145774               1395 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus RAB38, member RAS oncogene family (Rab38), mRNA.
ACCESSION   NM_145774
VERSION     NM_145774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Osanai,K., Nakase,K., Sakuma,T., Nishiki,K., Nojiri,M., Kato,R.,
            Saito,M., Fujimoto,Y., Mizuno,S. and Toga,H.
  TITLE     Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant
            lung surfactant homeostasis in Ruby rats
  JOURNAL   Respir Res 18 (1), 70 (2017)
   PUBMED   28438206
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Teumer,A., Tin,A., Sorice,R., Gorski,M., Yeo,N.C., Chu,A.Y., Li,M.,
            Li,Y., Mijatovic,V., Ko,Y.A., Taliun,D., Luciani,A., Chen,M.H.,
            Yang,Q., Foster,M.C., Olden,M., Hiraki,L.T., Tayo,B.O.,
            Fuchsberger,C., Dieffenbach,A.K., Shuldiner,A.R., Smith,A.V.,
            Zappa,A.M., Lupo,A., Kollerits,B., Ponte,B., Stengel,B.,
            Kramer,B.K., Paulweber,B., Mitchell,B.D., Hayward,C., Helmer,C.,
            Meisinger,C., Gieger,C., Shaffer,C.M., Muller,C., Langenberg,C.,
            Ackermann,D., Siscovick,D., Boerwinkle,E., Kronenberg,F.,
            Ehret,G.B., Homuth,G., Waeber,G., Navis,G., Gambaro,G., Malerba,G.,
            Eiriksdottir,G., Li,G., Wichmann,H.E., Grallert,H.,
            Wallaschofski,H., Volzke,H., Brenner,H., Kramer,H., Mateo Leach,I.,
            Rudan,I., Hillege,H.L., Beckmann,J.S., Lambert,J.C., Luan,J.,
            Zhao,J.H., Chalmers,J., Coresh,J., Denny,J.C., Butterbach,K.,
            Launer,L.J., Ferrucci,L., Kedenko,L., Haun,M., Metzger,M.,
            Woodward,M., Hoffman,M.J., Nauck,M., Waldenberger,M., Pruijm,M.,
            Bochud,M., Rheinberger,M., Verweij,N., Wareham,N.J., Endlich,N.,
            Soranzo,N., Polasek,O., van der Harst,P., Pramstaller,P.P.,
            Vollenweider,P., Wild,P.S., Gansevoort,R.T., Rettig,R., Biffar,R.,
            Carroll,R.J., Katz,R., Loos,R.J., Hwang,S.J., Coassin,S.,
            Bergmann,S., Rosas,S.E., Stracke,S., Harris,T.B., Corre,T.,
            Zeller,T., Illig,T., Aspelund,T., Tanaka,T., Lendeckel,U.,
            Volker,U., Gudnason,V., Chouraki,V., Koenig,W., Kutalik,Z.,
            O'Connell,J.R., Parsa,A., Heid,I.M., Paterson,A.D., de Boer,I.H.,
            Devuyst,O., Lazar,J., Endlich,K., Susztak,K., Tremblay,J.,
            Hamet,P., Jacob,H.J., Boger,C.A., Fox,C.S., Pattaro,C. and
            Kottgen,A.
  CONSRTM   DCCT/EDIC
  TITLE     Genome-wide Association Studies Identify Genetic Loci Associated
            With Albuminuria in Diabetes
  JOURNAL   Diabetes 65 (3), 803-817 (2016)
   PUBMED   26631737
  REMARK    GeneRIF: In an experimental diabetes model, Rab38 knockout rats
            showed higher urinary albumin concentrations and reduced amounts of
            megalin and cubilin at the proximal tubule cell surface compared to
            control rats.
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   Marubashi,S., Shimada,H., Fukuda,M. and Ohbayashi,N.
  TITLE     RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and
            Regulates Melanogenic Enzyme Trafficking in Melanocytes
  JOURNAL   J Biol Chem 291 (3), 1427-1440 (2016)
   PUBMED   26620560
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Ortiz-Sandoval,C.G., Hughes,S.C., Dacks,J.B. and Simmen,T.
  TITLE     Interaction with the effector dynamin-related protein 1 (Drp1) is
            an ancient function of Rab32 subfamily proteins
  JOURNAL   Cell Logist 4 (4), e986399 (2014)
   PUBMED   25767741
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Rangel-Filho,A., Lazar,J., Moreno,C., Geurts,A. and Jacob,H.J.
  TITLE     Rab38 modulates proteinuria in model of hypertension-associated
            renal disease
  JOURNAL   J Am Soc Nephrol 24 (2), 283-292 (2013)
   PUBMED   23291471
  REMARK    GeneRIF: Rab38 affects urinary protein excretion via effects in the
            proximal tubule.
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Rangel-Filho,A., Sharma,M., Datta,Y.H., Moreno,C., Roman,R.J.,
            Iwamoto,Y., Provoost,A.P., Lazar,J. and Jacob,H.J.
  TITLE     RF-2 gene modulates proteinuria and albuminuria independently of
            changes in glomerular permeability in the fawn-hooded hypertensive
            rat
  JOURNAL   J Am Soc Nephrol 16 (4), 852-856 (2005)
   PUBMED   15758045
  REMARK    GeneRIF: First report of gene responsible for quantitative trait
            locus linked to proteinuria in model of hypertension-associated
            ESRD. Rab38 influiences proteinuria independently of glomerular
            damage.
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   Osanai,K., Takahashi,K., Nakamura,K., Takahashi,M., Ishigaki,M.,
            Sakuma,T., Toga,H., Suzuki,T. and Voelker,D.R.
  TITLE     Expression and characterization of Rab38, a new member of the Rab
            small G protein family
  JOURNAL   Biol Chem 386 (2), 143-153 (2005)
   PUBMED   15843158
  REMARK    GeneRIF: results indicate that Rab38 is expressed non-ubiquitously
            in specific tissues & regulates early vesicle transport relating to
            the endoplasmic reticulum; suggested that Rab38 abnormality may
            cause multiple organ diseases as well as oculocutaneous albinism
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Oiso,N., Riddle,S.R., Serikawa,T., Kuramoto,T. and Spritz,R.A.
  TITLE     The rat Ruby (R) locus is Rab38: identical mutations in Fawn-hooded
            and Tester-Moriyama rats derived from an ancestral Long Evans rat
            sub-strain
  JOURNAL   Mamm Genome 15 (4), 307-314 (2004)
   PUBMED   15112108
REFERENCE   9  (bases 1 to 1395)
  AUTHORS   Osanai,K., Iguchi,M., Takahashi,K., Nambu,Y., Sakuma,T., Toga,H.,
            Ohya,N., Shimizu,H., Fisher,J.H. and Voelker,D.R.
  TITLE     Expression and localization of a novel Rab small G protein (Rab38)
            in the rat lung
  JOURNAL   Am J Pathol 158 (5), 1665-1675 (2001)
   PUBMED   11337364
REFERENCE   10 (bases 1 to 1395)
  AUTHORS   Hamada,S., Nishikawa,T., Yokoi,N. and Serikawa,T.
  TITLE     TM rats: a model for platelet storage pool deficiency
  JOURNAL   Exp Anim 46 (3), 235-239 (1997)
   PUBMED   9250486
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145774.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94043.1, BC070513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000001.1  151595153-151595400
            249-529             JAXUCZ010000001.1  151630232-151630512
            530-1395            JAXUCZ010000001.1  151674627-151675492
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1395
                     /gene="Rab38"
                     /gene_synonym="Ruby"
                     /note="RAB38, member RAS oncogene family"
                     /db_xref="GeneID:252916"
                     /db_xref="RGD:628752"
     exon            1..248
                     /gene="Rab38"
                     /gene_synonym="Ruby"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..682
                     /gene="Rab38"
                     /gene_synonym="Ruby"
                     /note="small GTP binding protein; ruby or red eyed
                     dilution; Rab38, member of RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-38"
                     /protein_id="NP_665717.1"
                     /db_xref="GeneID:252916"
                     /db_xref="RGD:628752"
                     /translation="MQTPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGV
                     DFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVA
                     KWKNDLDSKLTLPNGKPVSVVLLANKCDQGKDVLVNNGLKMDQFCKEHGFVGWFETSA
                     KENINIDEASRCLVKHILANECDFIESIEPDIVKPHLTSPKVVSCSGCAKS"
     exon            249..529
                     /gene="Rab38"
                     /gene_synonym="Ruby"
                     /inference="alignment:Splign:2.1.0"
     exon            530..1395
                     /gene="Rab38"
                     /gene_synonym="Ruby"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcccagggc aagctccagg ctccgcaaga cccgcgggcc tccaggatgc agacaccgca
       61 caaggagcac ctgtataagc tgctggtaat cggcgaccta ggtgtaggca agaccagcat
      121 catcaagcgc tacgtgcacc aaaacttctc ctcccactac cgggccacca ttggtgtgga
      181 cttcgcgctg aaggtgctcc actgggaccc agagacggtg gtgcgcctgc agctctggga
      241 catcgcaggt caagaaagat ttggtaacat gacaagagtc tattaccgag aagctatggg
      301 agcatttatt gtttttgatg tcaccagacc agccacattt gaagcagtgg caaaatggaa
      361 aaatgatttg gactcaaagt taactctccc taatggtaag ccagtatcag tggttttgtt
      421 ggccaacaaa tgtgaccaag ggaaggatgt gcttgtgaac aatggactca agatggacca
      481 gttctgcaag gagcatggtt tcgtaggatg gtttgaaaca tcagccaagg aaaatataaa
      541 cattgatgaa gcgtcaagat gcctggtcaa gcacatactt gcaaatgagt gcgacttcat
      601 agagtctata gaaccggaca ttgtgaagcc ccacctcaca tcacccaagg ttgtcagctg
      661 ctctggctgt gccaaatcct agaaggcacc tctgctggca tatgacagaa agaacccgtg
      721 gccctcatga atcgtgcttc agtttttcct tatccatttt gggtaagcat caggataggg
      781 aagcacatgt gacaagccaa agataatatg actctatgtt tcctgtcaaa gaggaacagc
      841 aaatgttctt tatgtgtttt tccccaccgt cagcacagtg tttacaagct tttaaaatat
      901 tagtctgttg caatatgctg ttttatcact gagcaaagtc actcagggac acagacagcc
      961 ttggtattca ttcctttaaa tcaacaaaag cttctggtct tcttgagaag gggactaaga
     1021 gagcaaggca gaggtcaagc taagtgtggg gatttatctt gccctggtgc gtctttgttc
     1081 aggtatcaat ttgttcctgg gtggtctgat aggtctatta aataggaaca ctattttttc
     1141 cattcatggc agacctaagg gttgcctgtg atgtttctct tcagagtcgt gtgcacaggc
     1201 agcctgggct tttgttgtta cttgctgtgc cctgaatgct ggtttaactg gaaactgtat
     1261 ggaaagatct gctccctgta tgtgcctttc tttcagcttt ctctgactca aactgcggga
     1321 ctgctctgta catgtaagat atattatata tatttttcac aagtgaaaaa taaaacatta
     1381 aaagtgttct ttccc
//
