LOCUS       NM_001013046            2151 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB35, member RAS oncogene family (Rab35), mRNA.
ACCESSION   NM_001013046 XM_222241
VERSION     NM_001013046.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Sheehan,P., Zhu,M., Beskow,A., Vollmer,C. and Waites,C.L.
  TITLE     Activity-Dependent Degradation of Synaptic Vesicle Proteins
            Requires Rab35 and the ESCRT Pathway
  JOURNAL   J Neurosci 36 (33), 8668-8686 (2016)
   PUBMED   27535913
  REMARK    GeneRIF: The findings of this study demonstrated that the
            Rab35/ESCRT pathway mediates the use-dependent degradation of a
            subset of Synaptic Vesicle membrane proteins in mammalian neurons.
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Etoh,K. and Fukuda,M.
  TITLE     Structure-function analyses of the small GTPase Rab35 and its
            effector protein centaurin-beta2/ACAP2 during neurite outgrowth of
            PC12 cells
  JOURNAL   J Biol Chem 290 (14), 9064-9074 (2015)
   PUBMED   25694427
  REMARK    GeneRIF: showed by knockdown-rescue approaches that neither a
            centaurin-beta2 binding-deficient Rab35(T76S/T81A) mutant nor a
            Rab35 binding-deficient centaurin-beta2(N610A/N691A) mutant
            supported neurite outgrowth of PC12 cells
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Miyamoto,Y., Yamamori,N., Torii,T., Tanoue,A. and Yamauchi,J.
  TITLE     Rab35, acting through ACAP2 switching off Arf6, negatively
            regulates oligodendrocyte differentiation and myelination
  JOURNAL   Mol Biol Cell 25 (9), 1532-1542 (2014)
   PUBMED   24600047
  REMARK    GeneRIF: Rab35/ACAP2 and cytohesin-2 antagonistically control
            oligodendrocyte differentiation and myelination through Arf6
            regulation.
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Kobayashi,H., Etoh,K. and Fukuda,M.
  TITLE     Rab35 is translocated from Arf6-positive perinuclear recycling
            endosomes to neurite tips during neurite outgrowth
  JOURNAL   Small GTPases 5, e29290 (2014)
   PUBMED   24852758
  REMARK    GeneRIF: Rab35 is translocated from recycling endosomes to neurite
            tips in a late phase of NGF stimulation.
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Kobayashi,H. and Fukuda,M.
  TITLE     Rab35 establishes the EHD1-association site by coordinating two
            distinct effectors during neurite outgrowth
  JOURNAL   J Cell Sci 126 (Pt 11), 2424-2435 (2013)
   PUBMED   23572513
  REMARK    GeneRIF: Rab35 regulates the formation of an EHD1-association site
            on Arf6-positive endosomes by integrating the functions of two
            distinct Rab35 effectors for successful neurite outgrowth.
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Zou,L., Zhou,J., Zhang,J., Li,J., Liu,N., Chai,L., Li,N., Liu,T.,
            Li,L., Xie,Z., Liu,H., Wan,Y. and Wu,Y.
  TITLE     The GTPase Rab3b/3c-positive recycling vesicles are involved in
            cross-presentation in dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15801-15806 (2009)
   PUBMED   19717423
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Chevallier,J., Koop,C., Srivastava,A., Petrie,R.J.,
            Lamarche-Vane,N. and Presley,J.F.
  TITLE     Rab35 regulates neurite outgrowth and cell shape
  JOURNAL   FEBS Lett 583 (7), 1096-1101 (2009)
   PUBMED   19289122
  REMARK    GeneRIF: Rab35 colocalizes with actin filaments and with Cdc42,
            Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and
            in vitro
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Kouranti,I., Sachse,M., Arouche,N., Goud,B. and Echard,A.
  TITLE     Rab35 regulates an endocytic recycling pathway essential for the
            terminal steps of cytokinesis
  JOURNAL   Curr Biol 16 (17), 1719-1725 (2006)
   PUBMED   16950109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085769.1.
            
            On Mar 26, 2005 this sequence version replaced XM_222241.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085769.1, DN931342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2151
                     /gene="Rab35"
                     /note="RAB35, member RAS oncogene family"
                     /db_xref="GeneID:288700"
                     /db_xref="RGD:1306362"
     exon            1..156
                     /gene="Rab35"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..710
                     /gene="Rab35"
                     /codon_start=1
                     /product="ras-related protein Rab-35"
                     /protein_id="NP_001013064.1"
                     /db_xref="GeneID:288700"
                     /db_xref="RGD:1306362"
                     /translation="MARDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVD
                     FKIRTVEINGEKVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRW
                     LHEINQNCDDVCRILVGNKNDDPERKVVETEDAYKFAGQMGIQLFETSAKENVNVEEM
                     FNCITELVLRAKKDNLAKQQQQQQNDVVKLTKNSKRKKRCC"
     exon            157..207
                     /gene="Rab35"
                     /inference="alignment:Splign:2.1.0"
     exon            208..331
                     /gene="Rab35"
                     /inference="alignment:Splign:2.1.0"
     exon            332..456
                     /gene="Rab35"
                     /inference="alignment:Splign:2.1.0"
     exon            457..581
                     /gene="Rab35"
                     /inference="alignment:Splign:2.1.0"
     exon            582..2089
                     /gene="Rab35"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaagtgg atccgccgct gccggagcag ccgggaggga gctgcggatc ccgaggccag
       61 taccgacccc gcccgcccgc gcgcgcgcgc cgcccccgcc cgccatggcc cgggactacg
      121 accacctctt caagctgctc atcatcggcg acagcggtgt gggcaagagc agcttgctgt
      181 tacgatttgc agacaacacc ttctcaggca gctacatcac cacaatcgga gtggatttca
      241 agatccggac tgtggagatc aacggggaga aggtgaagct gcagatctgg gacactgcag
      301 ggcaggagcg cttccgcacc atcacctcta cgtattatcg ggggacccac ggggtcattg
      361 tggtttacga tgtcactagt gccgagtcct ttgtcaatgt caagcgatgg cttcatgaaa
      421 tcaaccagaa ctgtgacgat gtgtgccgaa tattagtggg caataagaat gacgaccctg
      481 agcggaaggt ggtagagaca gaagacgcct acaaatttgc cgggcagatg gggatccagc
      541 tctttgagac cagtgccaag gagaacgtca atgtggaaga gatgttcaac tgcatcacag
      601 agctggttct acgggcaaag aaagacaact tggccaaaca gcagcagcag caacagaacg
      661 atgtggtgaa gctcaccaaa aacagtaaac gaaagaaacg ctgctgctaa tgccccgccc
      721 acccaccgca gagactgcac tgcacctccc agcctgaggc ctcggcggct ctcggggaca
      781 gtctcagtct agtgccgtta tttaaagaat tctctccacg ttttttgtat cgggaggcgc
      841 catcggcact tcctctcctt tccccttgag tgccaagaag gtgttggacg agcctgccct
      901 tccccacggt gcccttttcc ctgccgaggc gcctggacct ggtgaggacg ctgccagctg
      961 agtggaccga ttaaccagtt tgtacatagt gtatattgca ttaaccagct gcacaccctc
     1021 agcctgctct ggcttttggc tccttccgcc aacctgctgc aacagaccct cccgagccct
     1081 ccacacccat ctcgacggca gcttcctgag gagccaacct cgtgtcctag ctgagtcctt
     1141 ggccatccct ggcccatgga gtgcactcca catggctcct acctacagct gctctgggaa
     1201 cctggcctcc acacaggccc taggtcttca gttccacgag gaactcagtc ctgccctttt
     1261 ggacaacagg tttctcattc tgccttctag atgcctctgc tacaaaccca gggggagccg
     1321 cggcttctca cttacccacc atgtttcagt tcctgcagaa aggtagtggc acacctgtag
     1381 agatggagct tgcgaggcgg aggggggagc attctcttaa caaatacagc caatgaggcc
     1441 aaatcaaaca aagttcctca cagttatttc cccgagatgt gattggctca gcagtcagca
     1501 aacgttgtga ctgtcccact ttgggctcag tatttttaga aaaggtgatg gcttctattc
     1561 agtgcagggc caggctctct cccttctgtg gtaaaggaag gctttgcacc ctcgtccctg
     1621 tgctcgagag cctcccgctg gagacagttt gtaatggagc accaggcacc tgtggcagag
     1681 ccagggggtt gctgggctat gggaagacac tcccaggctg ggacaggtag cttttgcatt
     1741 actgacagat ctgtttttag ttatgaaggt ggtaggaaga tttcttagcc actgggaagt
     1801 ggtagtgggg ttggggcagc cagtattcac ctacccccgc ccccagcaga gtaatctgca
     1861 tttgattact tcccccttcc ccgggacact tggttggttc cctttcccct aaaggatcac
     1921 gtaactcgga agaactgatt tggacatcat aatgtgtttt attagacttc ctttcctagg
     1981 cgatttccag gcacagtcct gactggacaa tcatcacaga atactgcaga ttttccatgt
     2041 taacactgtg gatggggttt caatcaataa aactggggct ttcttctcaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
