LOCUS       NM_001012140            1326 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus RAB34, member RAS oncogene family (Rab34), mRNA.
ACCESSION   NM_001012140 XM_340849
VERSION     NM_001012140.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Pusapati,G.V., Kong,J.H., Patel,B.B., Krishnan,A., Sagner,A.,
            Kinnebrew,M., Briscoe,J., Aravind,L. and Rohatgi,R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi:
            10.1016/j.devcel.2018.01.002.. PMID: 29401421]
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Kasmapour,B., Gronow,A., Bleck,C.K., Hong,W. and Gutierrez,M.G.
  TITLE     Size-dependent mechanism of cargo sorting during lysosome-phagosome
            fusion is controlled by Rab34
  JOURNAL   Proc Natl Acad Sci U S A 109 (50), 20485-20490 (2012)
   PUBMED   23197834
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Goldenberg,N.M. and Silverman,M.
  TITLE     Rab34 and its effector munc13-2 constitute a new pathway modulating
            protein secretion in the cellular response to hyperglycemia
  JOURNAL   Am J Physiol Cell Physiol 297 (4), C1053-C1058 (2009)
   PUBMED   19641095
  REMARK    GeneRIF: mechanistic basis for high glucose-induced protein
            secretion is through interaction of munc13 and rab34, indicating a
            potentially critical role for this newly described pathway in the
            pathogenesis of DN.
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Zou,L., Zhou,J., Zhang,J., Li,J., Liu,N., Chai,L., Li,N., Liu,T.,
            Li,L., Xie,Z., Liu,H., Wan,Y. and Wu,Y.
  TITLE     The GTPase Rab3b/3c-positive recycling vesicles are involved in
            cross-presentation in dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15801-15806 (2009)
   PUBMED   19717423
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Goldenberg,N.M., Grinstein,S. and Silverman,M.
  TITLE     Golgi-bound Rab34 is a novel member of the secretory pathway
  JOURNAL   Mol Biol Cell 18 (12), 4762-4771 (2007)
   PUBMED   17881736
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Speight,P. and Silverman,M.
  TITLE     Diacylglycerol-activated Hmunc13 serves as an effector of the
            GTPase Rab34
  JOURNAL   Traffic 6 (10), 858-865 (2005)
   PUBMED   16138900
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   Sun,P., Yamamoto,H., Suetsugu,S., Miki,H., Takenawa,T. and Endo,T.
  TITLE     Small GTPase Rah/Rab34 is associated with membrane ruffles and
            macropinosomes and promotes macropinosome formation
  JOURNAL   J Biol Chem 278 (6), 4063-4071 (2003)
   PUBMED   12446704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086400.1.
            
            On Feb 11, 2005 this sequence version replaced XM_340849.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086400.1, FQ212591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1326
                     /gene="Rab34"
                     /note="RAB34, member RAS oncogene family"
                     /db_xref="GeneID:360571"
                     /db_xref="RGD:1305058"
     exon            1..8
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            9..221
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..947
                     /gene="Rab34"
                     /note="Ras-related protein RAB34; RAB34, member of RAS
                     oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-34"
                     /protein_id="NP_001012140.1"
                     /db_xref="GeneID:360571"
                     /db_xref="RGD:1305058"
                     /translation="MNILAPVRRDRVLAELPQCLKKEAALHVRKDFHPRVTCACQEHR
                     TGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFS
                     LQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHSKQWLADALKENDPSNVL
                     LFLVGSKKDLSTPAQYSLMEKDALKVAQEIKAEYWSVSSLTGENVREFFFRVAALTFE
                     ANVLAELEKSGSRHIGDVVRINSDDKNLYLTASKKKATCCP"
     exon            222..313
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            314..379
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            380..481
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            482..546
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            547..598
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            599..680
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            681..771
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            772..879
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1306
                     /gene="Rab34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgttggcg tctccaaggc ccagggctcc cacaggctct tcgtggcccc gggtgattgt
       61 cggtaccccg cggccgcgaa taatcgtcgg gtccccacgg gtcccggccg ccggggtgga
      121 tcaggaccct gagtctttcc ggggagcccc gcaaggccgc agacaagatg aacattctgg
      181 cccccgtgcg gagggaccgc gtcctggcgg agctgcccca gtgcctgaag aaggaggccg
      241 ctttgcacgt gcgcaaagac ttccaccccc gggtcacttg cgcctgccag gagcaccgga
      301 caggcaccgt gggatttaaa atatccaagg tcatcgttgt gggggaccta tctgtgggga
      361 agacctgtct tattaatagg ttctgcaaag acaccttcga taagaattac aaggctacca
      421 tcggagtgga ttttgagatg gaacgatttg aagtcttggg tgtccccttc agtctccaac
      481 tttgggacac tgctggtcag gagaggttca agtgcatcgc ttccacctac tacagaggag
      541 cacaagccat catcattgtc ttcaacctga atgacgtggc atccctggaa cactccaagc
      601 agtggctcgc tgatgccctc aaggagaatg acccttccaa cgtgcttctc ttccttgtgg
      661 gttccaagaa ggatctgagt actcctgctc agtattccct aatggagaag gatgccctca
      721 aggtggccca agagattaag gctgagtatt ggtcagtgtc ctccctcaca ggtgagaacg
      781 tccgggaatt cttcttccgt gtggcagcgc taacctttga ggccaatgtc ctggctgaac
      841 tggagaaatc gggatctcgg cacattgggg atgttgttcg catcaacagc gatgacaaaa
      901 acctgtacct aactgccagc aagaaaaagg ccacatgttg tccctgagca ctgaggatgg
      961 tccagagact tcacattccc ggggttaccg tgccaccccc aactgctcca gaactcaacc
     1021 cctgggtatt tgcactgact ttccccagac caaagagctc ccggttgatg tcagtgcccc
     1081 cagagggtag ctgggaccat gctagtcatt tcctgccccc aggcaccatg ccaaagactg
     1141 gatgaccctt tattcctctg gggctctcca gggtgcctga tttgtggggg ggagggtgtc
     1201 agtgttctcg ctgtttttgc tcagcctgat gggcctttta tgtatgaaga tgcttactga
     1261 ttccagcctt atactgtgcc ttatgcatta aaatccgtta ttagcaaaaa aaaaaaaaaa
     1321 aaaaaa
//
