LOCUS       NM_001108944            3356 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB33B, member RAS oncogene family (Rab33b),
            mRNA.
ACCESSION   NM_001108944 XM_001054246 XM_001054312 XM_345208
VERSION     NM_001108944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3356)
  AUTHORS   Dupuis,N., Lebon,S., Kumar,M., Drunat,S., Graul-Neumann,L.M.,
            Gressens,P. and El Ghouzzi,V.
  TITLE     A novel RAB33B mutation in Smith-McCort dysplasia
  JOURNAL   Hum Mutat 34 (2), 283-286 (2013)
   PUBMED   23042644
REFERENCE   2  (bases 1 to 3356)
  AUTHORS   Zografou,S., Basagiannis,D., Papafotika,A., Shirakawa,R.,
            Horiuchi,H., Auerbach,D., Fukuda,M. and Christoforidis,S.
  TITLE     A complete Rab screening reveals novel insights in Weibel-Palade
            body exocytosis
  JOURNAL   J Cell Sci 125 (Pt 20), 4780-4790 (2012)
   PUBMED   22899725
REFERENCE   3  (bases 1 to 3356)
  AUTHORS   Nottingham,R.M., Ganley,I.G., Barr,F.A., Lambright,D.G. and
            Pfeffer,S.R.
  TITLE     RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by
            Rab32 and Rab33B proteins
  JOURNAL   J Biol Chem 286 (38), 33213-33222 (2011)
   PUBMED   21808068
REFERENCE   4  (bases 1 to 3356)
  AUTHORS   Pavlos,N.J., Gronborg,M., Riedel,D., Chua,J.J., Boyken,J.,
            Kloepper,T.H., Urlaub,H., Rizzoli,S.O. and Jahn,R.
  TITLE     Quantitative analysis of synaptic vesicle Rabs uncovers distinct
            yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered
            exocytosis
  JOURNAL   J Neurosci 30 (40), 13441-13453 (2010)
   PUBMED   20926670
REFERENCE   5  (bases 1 to 3356)
  AUTHORS   Mehrpour,M., Esclatine,A., Beau,I. and Codogno,P.
  TITLE     Overview of macroautophagy regulation in mammalian cells
  JOURNAL   Cell Res 20 (7), 748-762 (2010)
   PUBMED   20548331
  REMARK    Review article
REFERENCE   6  (bases 1 to 3356)
  AUTHORS   Starr,T., Sun,Y., Wilkins,N. and Storrie,B.
  TITLE     Rab33b and Rab6 are functionally overlapping regulators of Golgi
            homeostasis and trafficking
  JOURNAL   Traffic 11 (5), 626-636 (2010)
   PUBMED   20163571
REFERENCE   7  (bases 1 to 3356)
  AUTHORS   Itoh,T., Fujita,N., Kanno,E., Yamamoto,A., Yoshimori,T. and
            Fukuda,M.
  TITLE     Golgi-resident small GTPase Rab33B interacts with Atg16L and
            modulates autophagosome formation
  JOURNAL   Mol Biol Cell 19 (7), 2916-2925 (2008)
   PUBMED   18448665
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474003.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345208.3, XM_001054312.1, XM_001054246.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV764768.1, FQ090842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..3356
                     /gene="Rab33b"
                     /note="RAB33B, member RAS oncogene family"
                     /db_xref="GeneID:365793"
                     /db_xref="RGD:1308353"
     exon            1..654
                     /gene="Rab33b"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1095
                     /gene="Rab33b"
                     /note="RAB33B, member of RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-33B"
                     /protein_id="NP_001102414.1"
                     /db_xref="GeneID:365793"
                     /db_xref="RGD:1308353"
                     /translation="MASEMESSLEVSFSSSCAVSGASGCLPPARSRIFKIIVIGDSNV
                     GKTCLTYRFCAGRFPDRTEATIGVDFRERAVDIDGERIKIQLWDTAGQERFRKSMVQH
                     YYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPT
                     DLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQLPDNRISLK
                     PETKPAVTCWC"
     exon            655..3356
                     /gene="Rab33b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggccgca cctccttcct ctctggtgtc tctctccccg cccccaagag ctgcgccgct
       61 tcctccagag cttgggaacc tgggacgtgg cgaggcggtc caaggttgga gcgccgcaca
      121 cagaggtccc tcaggcggac cttctgcgcc gcagtccagt cagggatcgc cgacgcatct
      181 ttccaggtac actgcgccgg caggcagaga tctactgcgc acgcgccggg gccttagtgg
      241 ggcgccacac ctgggtgggc aagagctgct cgcgcacgcg cgctgtggtg cctgcgggct
      301 gtggggagct gggcgttgtg tatcactgcc agggagcgct gtcgctggcg tggcgccatt
      361 cccgcggctt ctctgctccg gctcagctcc gggcggggcg ggaggatggc ttcggagatg
      421 gagtcgtcgc tggaggtcag cttctcatcc agctgtgcag tgtcaggggc atctggatgt
      481 ttgcctcccg cccgctcccg catcttcaag atcatagtaa tcggtgactc gaacgtgggc
      541 aagacgtgcc tgacttaccg cttctgcgcc ggccgcttcc ccgaccgcac cgaggccacg
      601 atcggggtgg acttccgaga gcgagccgtg gatatcgatg gagaacgcat taagatccag
      661 ttgtgggaca ctgcgggaca agagcggttc aggaagagca tggtccagca ctactacagg
      721 aacgtgcatg ctgtggtctt tgtgtatgac atgaccaaca tggccagctt ccacagcctg
      781 ccatcttgga tagaggaatg caaacagcat ttgctggcaa atgacatacc tcgaattctg
      841 gtgggaaata aatgtgactt gagaagtgcc attcaggtgc ccacagactt ggcacaaaag
      901 tttgctgaca cacacagtat gcctttgttt gagacctctg ctaaaaaccc caatgataat
      961 gaccacgtag aagctatatt tatgacgttg gctcataaac taaagagcca caaaccattg
     1021 atgctcagcc agctgcccga taacagaatc agcctgaaac ctgagacaaa acctgcggtg
     1081 acgtgctggt gctaagttgt aggcgtagcc atcaccggct gacttacctg aagagaagct
     1141 tgtgaagtgt gacagtgatt aagttcctca gagtaaatct taaatgtaat ggatcatcct
     1201 gctgttacca ttgttccgat gccttttgta ttttgcatcc tcttaatcaa gtttgtcact
     1261 gagacaacac atggagagag ccgctcaaca gctggaacaa aaagggaagc aaaggcagga
     1321 tgaccagagc catctttcca gttccagcca gatgaagcaa catcaagtga gcatggtgga
     1381 acttcaaggg tcagtcttgc tccactctgt gttcctggga cagcaaaaga catgctgtgc
     1441 agtgcacacg tgctgaccgg tgcacacgtg ctgagcagag ctggagcgag cagcacgtta
     1501 atagggtgct ttattttact ctgtgtcttt aagcactaaa agctaatcaa aagaattcaa
     1561 gcggttgtaa caggagttta ttttagctgt gacatttagt taaaatatca aatgtctaca
     1621 aagctagttt ctggtacccc ttgtcctctg ttcacagatg gctgggtgac tcggagctgg
     1681 tatcagtcaa catccatttg gctgggggct ctacatgtgt tcctgttgga tgagttttgt
     1741 ttttaaatgc ctgaatttta tgaccttggt ataaaaattg gtaaacaaac tgttacttgg
     1801 tatcaaaatg agttaaatat tgaaaaatat cttacctgtc tctcaatgat gaaagaaata
     1861 gtttagaaag attatttttt tcgccctaag tacttgtagt ttgaatttaa gactttgcac
     1921 aaaggaaata gcacgcttac atatgaagat gttagcagag tggtgcgtaa gccacgctca
     1981 gcctgagttg cacatccttg ttgtgacagc ttgcaaccct tggcaatttt agaggaaatg
     2041 aagccaaaat atgttttact taaatatttt cgtaatgtgg gaaacaaaca taatccaacc
     2101 tagttttaga ttttgtttca tttattctga aggtctcaac tggacaattc agttatgaaa
     2161 gcaaaatttt tctatttaat aaactaagta aaagtaactt aagggataat tgtaaaattt
     2221 aaatattaat tcagtaaata caatgaaata aagattagcg cctagattgg ctttctttgc
     2281 agttagaaag atcctccttc ctccctccct ccctccttcc ctcccttcct tcctgacttt
     2341 ttaaatacaa ggcctcactt cgtaggcccg actggcctgg gaccagggtg gtcacagact
     2401 tagccatacc aacctgcccc atcttccaag ggctgggcat gagagcccct gtcaccagga
     2461 ctggtccaat acattttcct taatcgtact agaattaaag attaaagatt cttttgtccg
     2521 aatgaatgct gacttgtgaa ctacttccta gtgaaagccg gctgtggtga caggcggctg
     2581 aggatgtctc cacagaggag cgtctgtctg ttcactgttc ttcagcgctc tctctgtaca
     2641 cggggaggcc gctatgtttt cctagcatac ctatggcttt cttcctgctg tttcaagatt
     2701 gttttctcaa tactgttaat taataatttt ctttttaaag taactttttt taatgagcat
     2761 tctttacata attttttcat tttagtattt attaatcaaa acatatttgt atctcatttg
     2821 taacgaccta ccactttagt gttttttatt ttaaacagat acatatcagg tgagcaagga
     2881 taatgtcttt cgacgtagtc caaagtgtct gtaaagcact ttattgactg ttgaccaaaa
     2941 cgacggtgag ctgacatcca gttttttttt ttaaggacaa atcacacatt ttgtacatct
     3001 gggaatttat tttggctgac atttaattgg aagtctcaga tgttttagaa aaaagatctt
     3061 aatttgcaga cagcaaagca aactcctttg gcatccgctg tggttggctc cagacagctt
     3121 gatgacagtg taaggtcttt gacgttttct cagccaggtt agtagctttg ctgcgaaaca
     3181 gtcactcttg atatttctcc cacaatgtac aataaatcat cttttccatg agcaatggta
     3241 ttcctttctt ttgtttactg ggttgaatat aaaattaaag aacatacctc ctcctgacta
     3301 ctgtgctttt caggaaatat gtacaacctg cagttcattc acttgaaaat ccaaaa
//
