LOCUS       NM_145094               3335 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB31, member RAS oncogene family (Rab31), mRNA.
ACCESSION   NM_145094
VERSION     NM_145094.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Yeo,J.C., Wall,A.A., Luo,L. and Stow,J.L.
  TITLE     Rab31 and APPL2 enhance FcgammaR-mediated phagocytosis through
            PI3K/Akt signaling in macrophages
  JOURNAL   Mol Biol Cell 26 (5), 952-965 (2015)
   PUBMED   25568335
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Wang,L., Liang,Z. and Li,G.
  TITLE     Rab22 controls NGF signaling and neurite outgrowth in PC12 cells
  JOURNAL   Mol Biol Cell 22 (20), 3853-3860 (2011)
   PUBMED   21849477
  REMARK    GeneRIF: The data provide the first evidence for Rab22 (also known
            as Rab22b, Rab31) as a positive regulator of nerve growth factor
            (NGF) signal transduction and cell differentiation.
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   4  (bases 1 to 3335)
  AUTHORS   Rodriguez-Gabin,A.G., Ortiz,E., Demoliner,K., Si,Q., Almazan,G. and
            Larocca,J.N.
  TITLE     Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in
            transport of mannose 6-phosphate receptors
  JOURNAL   J Neurosci Res 88 (3), 589-604 (2010)
   PUBMED   19795375
REFERENCE   5  (bases 1 to 3335)
  AUTHORS   Ng,E.L., Ng,J.J., Liang,F. and Tang,B.L.
  TITLE     Rab22B is expressed in the CNS astroglia lineage and plays a role
            in epidermal growth factor receptor trafficking in A431 cells
  JOURNAL   J Cell Physiol 221 (3), 716-728 (2009)
   PUBMED   19725050
  REMARK    GeneRIF: A developmental stage survey of the rat brain by Western
            immunoblot analysis indicated Rab22B presence at several stages of
            embryonic and postnatal development.
REFERENCE   6  (bases 1 to 3335)
  AUTHORS   Kong,S.L., Chui,P., Lim,B. and Salto-Tellez,M.
  TITLE     Elucidating the molecular physiopathology of acute respiratory
            distress syndrome in severe acute respiratory syndrome patients
  JOURNAL   Virus Res 145 (2), 260-269 (2009)
   PUBMED   19635508
REFERENCE   7  (bases 1 to 3335)
  AUTHORS   Rodriguez-Gabin,A.G., Yin,X., Si,Q. and Larocca,J.N.
  TITLE     Transport of mannose-6-phosphate receptors from the trans-Golgi
            network to endosomes requires Rab31
  JOURNAL   Exp Cell Res 315 (13), 2215-2230 (2009)
   PUBMED   19345684
  REMARK    GeneRIF: Data demonstrate that Rab31 is required for transport of
            mannose 6-phosphate receptors from the trans-Golgi network to
            endosomes and for the Golgi/TGN organization.
REFERENCE   8  (bases 1 to 3335)
  AUTHORS   Ng,E.L., Wang,Y. and Tang,B.L.
  TITLE     Rab22B's role in trans-Golgi network membrane dynamics
  JOURNAL   Biochem Biophys Res Commun 361 (3), 751-757 (2007)
   PUBMED   17678623
REFERENCE   9  (bases 1 to 3335)
  AUTHORS   Lodhi,I.J., Chiang,S.H., Chang,L., Vollenweider,D., Watson,R.T.,
            Inoue,M., Pessin,J.E. and Saltiel,A.R.
  TITLE     Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates
            Glut4 trafficking in adipocytes
  JOURNAL   Cell Metab 5 (1), 59-72 (2007)
   PUBMED   17189207
REFERENCE   10 (bases 1 to 3335)
  AUTHORS   Rodriguez-Gabin,A.G., Cammer,M., Almazan,G., Charron,M. and
            Larocca,J.N.
  TITLE     Role of rRAB22b, an oligodendrocyte protein, in regulation of
            transport of vesicles from trans Golgi to endocytic compartments
  JOURNAL   J Neurosci Res 66 (6), 1149-1160 (2001)
   PUBMED   11746448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072698.1.
            
            On Oct 8, 2005 this sequence version replaced NM_145094.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072698.1, CK359937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..3335
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /note="RAB31, member RAS oncogene family"
                     /db_xref="GeneID:246324"
                     /db_xref="RGD:628598"
     exon            1..129
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..678
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /note="monomeric GTP-binding protein; GTP-binding protein
                     Rab0"
                     /codon_start=1
                     /product="ras-related protein Rab-31"
                     /protein_id="NP_659562.2"
                     /db_xref="GeneID:246324"
                     /db_xref="RGD:628598"
                     /translation="MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFM
                     TKTVPCGNELHKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFHTLKKWVK
                     ELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGALVVETSAKNAINIEELF
                     QGISRQIPPLDPHENGNSGGIKLGNQSLQAGRRCC"
     exon            130..209
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /inference="alignment:Splign:2.1.0"
     exon            210..291
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /inference="alignment:Splign:2.1.0"
     exon            292..363
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /inference="alignment:Splign:2.1.0"
     exon            364..470
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /inference="alignment:Splign:2.1.0"
     exon            471..580
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /inference="alignment:Splign:2.1.0"
     exon            581..3307
                     /gene="Rab31"
                     /gene_synonym="Rab0"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagagccct gggagacggc tggacgcagg ctgggcgcgg tgcggcccgg acgatgctgc
       61 tgagccccgg cccggcccga cccagagcac atgatggcga tacgggagct caaagtgtgt
      121 cttctcgggg acacgggagt tgggaaatca agcattgtgt gtcggtttgt ccaggaccac
      181 tttgaccaca acatcagccc caccattggg gcatctttca tgaccaaaac tgtgccttgt
      241 ggaaatgaac ttcacaaatt cctcatctgg gacaccgctg gtcaggagcg gttccattcc
      301 ctggctccca tgtattaccg aggctcggcc gcagccgtca tagtctatga catcactaag
      361 caggattcat ttcatacctt gaaaaaatgg gttaaggagc tgaaggagca tggcccagag
      421 aacatcgtga tggcgattgc cgggaacaag tgtgacctat cagatattag ggaggtgccc
      481 ctgaaggatg ctaaggagta cgctgaatcc ataggtgccc tcgtggtgga gacaagtgcg
      541 aagaatgcca ttaacatcga ggagctcttt caggggatca gccggcagat cccacccttg
      601 gacccccatg aaaacggaaa cagtggcggg atcaaactgg ggaaccagag cttgcaagcc
      661 ggccggcggt gctgctgagc cgagggcgtg gcatacagag catgacagaa ggagccagag
      721 acctctcctg tgtccagggc acacagaagg accccaccca cggggctaac tctgcctgct
      781 ggagtgtgag cagctttgta ccctgggaga cccgcaggat gctgaacgag gaagtttcct
      841 gaaaagaaat gatagaaaac tctggaaaac tcaccatccc accgcaacac ggcctccggt
      901 ttatgagatg cacatggcga gcttgtactt gctaggtaat aggtataggt tgccgtcttt
      961 tgttaaagaa ttgttaggga ggttttagat ttgtccgcaa acctcagagt gctgttcttc
     1021 actgatttcc tacgtcacct agtcaggttc caataacgtc tccagggcca ggaccttcct
     1081 ttctggccag tccatcaaaa ggcaaaggca gtatatagta ggttagctct tagctggctt
     1141 tggcaggaag cctttcttag ttttctgagg gaaatcagag atgcatagct ggaccgttgc
     1201 tcaaactgag aagtaatctc ctcaaagaga gacaaacatt ggattagaaa ccgccatccc
     1261 tgtctttttt tgtttatccg atgaccattt ttctaaggtg tggccatccg tgaaccaacc
     1321 aaatcagact agaacgttat atataattta ggggtccaga gagttaaatt gttgctatgt
     1381 aagcagtggg ggagggaggg tataaatggc atttagggta cccccagcat gcataccccc
     1441 ccattgcagt gagtttctac ttatgggaat gattacttta cagagcatta ggagacaatg
     1501 tcacgatgcc acatctaggg atgtttgagc ctaaattgta gggcagactt ctattcatag
     1561 tggctaatca tgggttacag ccaaccaggc agaggaacgt taccacccca aaattctgga
     1621 ctcctaaagg tgtaaaatag gaagaagtcc cttaaacttt gcccgcattg gagaaaaaag
     1681 gttgtcaagc agtcggtgcc aagtcccagt cacagacggt gcttgtcaac ttcgggatgc
     1741 cagcttcaac atggtcttcc tgcttctccc aactcggaag ctaattaaat cttagaatac
     1801 agaggagagc aaacacttgt cttgattcaa gaatgtccct agatatccta tagcagacgt
     1861 ctcaaacact gttagcaagt ggcatctctg tctcgtgcca gggtcttctc aagaccgtca
     1921 gagcctgtcc caacatcaga cgtccaacat cactgttaca ggattccacg ggctggcaaa
     1981 gatgttcatc ctctcactgc aggtcaaaca cacaaacaaa gaacaattga gttgaagttg
     2041 aagtggcctc tctcgactag tatcaagctt atttttgaac ctctccccat tggggggtaa
     2101 acttttgctg agggcttgta tttacctgtc tgtctgtcca ttcccagggg agaatgccac
     2161 agctttgggt gggttttgca gtggtcgagt tttgcatgaa ctgtctgggc ttcaccttga
     2221 gagtgagctg ccctgggatt ggagaagcat gcaagggtag gataccttgc tcttcccagg
     2281 ctgcattgac attgatatcc aagccatgca gaggacaagt atgcctgagt gccaccagca
     2341 tgagggaagg gagatgtggc atgtgggcac acgaatattc acgccgtttg gggccttctc
     2401 tgcagatggt gctgaggcct ttggtgcttc tctccccttg gcttggcgtt cctcttggga
     2461 cgttttaacc attgacccta aacaaagacc tagaaatgac aattgctcca gacataggat
     2521 gtagtggcct tatggttact ctccaaattc ccttcccaac ccctattttc ctctctcaca
     2581 ggtggcaggt ttgtatatgt gtaaatatga tttttatgtc agccacaccc acacgtaatc
     2641 tacttcagag tggctgtgtt tggctcatga ccttgtgtcc ataagggagg cacaggttgt
     2701 caaagggatt ctttctcagc agacgtcccg aaggaccgtg taagggttgt gcaaatgttc
     2761 tatacaggta cagaatcgac tagccatttt tttcattaga agtggtgtat cagggtactg
     2821 gatatgacgt catcttgcag actaacctac attctagcca acagcaaggg ctgtgcccca
     2881 gtgggaaccc cattctttcc tgaggaaggc ttgaaggatc caagtgtttc ctctgcaatc
     2941 atggactctg gcttcttgct gctccacagc gttctttctg ggtgaggagt aaggagccag
     3001 tggtcagctg agggttctgg ctgtgctcac atgtgatcat gcctttcacc atcgtcgtga
     3061 cgcccagcaa ctcagcagtc acgaggtcac atagactgtc accctttctg gtgtttctgt
     3121 aaagggtttc cacttgggct ggacccaggt tttgcaccta gaagatccct ctgcagacac
     3181 ctaggaccct cgagtcttat actccgttct atgataaggc ggtgtttccg tccgagctca
     3241 tttgtatcag tcgcttttga ttttaaccca ttggtatgat tcatactaat aaatattcta
     3301 aggtttaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
