LOCUS       NM_031718               2043 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RAB2A, member RAS oncogene family (Rab2a), mRNA.
ACCESSION   NM_031718 XM_006237846 XM_008763556
VERSION     NM_031718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2043)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 2043)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 2043)
  AUTHORS   Pavlos,N.J., Gronborg,M., Riedel,D., Chua,J.J., Boyken,J.,
            Kloepper,T.H., Urlaub,H., Rizzoli,S.O. and Jahn,R.
  TITLE     Quantitative analysis of synaptic vesicle Rabs uncovers distinct
            yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered
            exocytosis
  JOURNAL   J Neurosci 30 (40), 13441-13453 (2010)
   PUBMED   20926670
REFERENCE   5  (bases 1 to 2043)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2043)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 2043)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   8  (bases 1 to 2043)
  AUTHORS   Cussac,D., Leblanc,P., L'Heritier,A., Bertoglio,J., Lang,P.,
            Kordon,C., Enjalbert,A. and Saltarelli,D.
  TITLE     Rho proteins are localized with different membrane compartments
            involved in vesicular trafficking in anterior pituitary cells
  JOURNAL   Mol Cell Endocrinol 119 (2), 195-206 (1996)
   PUBMED   8807639
REFERENCE   9  (bases 1 to 2043)
  AUTHORS   Krijnse-Locker,J., Parton,R.G., Fuller,S.D., Griffiths,G. and
            Dotti,C.G.
  TITLE     The organization of the endoplasmic reticulum and the intermediate
            compartment in cultured rat hippocampal neurons
  JOURNAL   Mol Biol Cell 6 (10), 1315-1332 (1995)
   PUBMED   8573789
REFERENCE   10 (bases 1 to 2043)
  AUTHORS   Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     Four additional members of the ras gene superfamily isolated by an
            oligonucleotide strategy: molecular cloning of YPT-related cDNAs
            from a rat brain library
  JOURNAL   Proc Natl Acad Sci U S A 84 (23), 8210-8214 (1987)
   PUBMED   3317403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 6, 2022 this sequence version replaced NM_031718.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229541.1, SRR26643295.20562.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000005.1  26473424-26473671
            249-320             JAXUCZ010000005.1  26493994-26494065
            321-388             JAXUCZ010000005.1  26504663-26504730
            389-471             JAXUCZ010000005.1  26511566-26511648
            472-564             JAXUCZ010000005.1  26512151-26512243
            565-676             JAXUCZ010000005.1  26513641-26513752
            677-745             JAXUCZ010000005.1  26534064-26534132
            746-2043            JAXUCZ010000005.1  26536144-26537441
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..2043
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /note="RAB2A, member RAS oncogene family"
                     /db_xref="GeneID:65158"
                     /db_xref="RGD:68323"
     exon            1..248
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..841
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /EC_number="3.6.5.2"
                     /note="RAB2, member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-2A"
                     /protein_id="NP_113906.2"
                     /db_xref="GeneID:65158"
                     /db_xref="RGD:68323"
                     /translation="MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFG
                     ARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLE
                     DARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAF
                     INTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNASHGGNQGGQQAGGGCC"
     exon            249..320
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..388
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..471
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..564
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..676
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..745
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..2043
                     /gene="Rab2a"
                     /gene_synonym="Rab2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgttccga agggctgggc cgctgcgatc cgcgctcggc gctgtcagtt cgtcccgctg
       61 cccctcggcc cttgctgctg gctctgacgg cgaccgacgg cgggcggggc ccgggttcgc
      121 ggccgagcgg cgccggtgag ggcgcggagg aggcgcacag cgggaggagg agccgtgagc
      181 ctggcacgga gcggccgcgg ccatggcgta cgcctatctc ttcaagtaca tcatcatcgg
      241 cgacacaggt gttggtaaat cgtgcttatt gctacagttt acagacaaga ggtttcagcc
      301 ggtgcatgac ctcacaattg gtgtagagtt tggtgctcga atgataacca ttgatgggaa
      361 acagataaaa ctccagatct gggatacagc agggcaggag tcctttcgtt ctatcacaag
      421 gtcatattac agaggtgcag cgggggcttt actagtgtat gatattacaa ggagagacac
      481 gttcaaccac ttgacaacct ggttagaaga cgcccgtcag cattccaatt ccaacatggt
      541 catcatgctt attggaaata aaagtgactt agaatctagg agagaagtga aaaaggaaga
      601 aggtgaagct tttgcacgag agcatggact tatcttcatg gaaacttctg ccaagactgc
      661 ttctaatgta gaggaggcat ttattaacac agcaaaagaa atttatgaaa aaatccaaga
      721 aggggtcttt gacattaata atgaggcaaa cggcatcaaa attggccctc agcatgctgc
      781 taccaatgca tctcacggag gcaaccaagg agggcagcag gcagggggag gctgctgctg
      841 agtctgctgt tgccggctag ctgcccagtg gagccacgca ctctgtcacc ctctctcctc
      901 atgctcagct gagacatgaa actattgaaa tggctttgtg tcacaggaga ctttaatcct
      961 tcagattctt gtataacttt gaataaatgg ttaatgttca cttaaaaaga cagattttgg
     1021 agattgtatt catatctatt tgcatttgat ttctaggtca attgatgtga ttatttttgt
     1081 taaatgttgt cttgtgccct taactacgag ctgaattgta ttaaaacact acaaagtcat
     1141 ggtgagtatt ttaaatcagt ttgtgtagtt aggtctcccg acacccgtgg ttacctaatg
     1201 tttaatatta taggactgtc ctcaaaaggt ttgtcaactt tcaaggatgt aaggaaaagc
     1261 agaactcttt gaattctgta tttatcattt gctttctgta tatatagttt aataacctgc
     1321 ttgggtgtga tttgccaagc ttgaactcta atgcatttgc ataaattcta ccactgttcg
     1381 gagcttaaag ctacagaagc attgttagga attgcttgga cactgacttt taaacttttt
     1441 gacatcgtta acgagcatgt tcatcttttc ttgtcactag tccaagaaac tgcgcttcct
     1501 gtgtactact aaggctgtgt gtgttaacct gtgttaatgc caaaagtttg ctctttgtcc
     1561 acagtttctt gagaccactt cataaaagga tttgtttgcc ttaatgagtg ctgttgggta
     1621 aaacacggtg taatgagtgg gaagggcaga cacaaactcc aacactacgc aactccctag
     1681 agcgaggacc acggagaggg cacgccatgc cacttaacct tcccttagat acaataatgt
     1741 tcccttttat tcacacagtt tctaagtata ttttcatgca gggcagtttg tcaaccttga
     1801 tgtacagtga ctgtgtaaaa ttttttcttt cagtggcaac ctatctataa tctttaaaat
     1861 atggtaagct tactgtctgt ttgaggggga tacgaaaata aatctaccag atggaaaatc
     1921 ctgttcaaag tagaaaagtt ttagttgttt actcactgtg gtggttttat cctttctttt
     1981 tctcccttgg tctagaatga aattgttcca gcagtgcaaa ataaaatcct atgtataaaa
     2041 gtg
//
