LOCUS       NM_053978               1483 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB28, member RAS oncogene family (Rab28), mRNA.
ACCESSION   NM_053978
VERSION     NM_053978.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Roosing,S., Rohrschneider,K., Beryozkin,A., Sharon,D.,
            Weisschuh,N., Staller,J., Kohl,S., Zelinger,L., Peters,T.A.,
            Neveling,K., Strom,T.M., van den Born,L.I., Hoyng,C.B.,
            Klaver,C.C., Roepman,R., Wissinger,B., Banin,E., Cremers,F.P. and
            den Hollander,A.I.
  CONSRTM   European Retinal Disease Consortium
  TITLE     Mutations in RAB28, encoding a farnesylated small GTPase, are
            associated with autosomal-recessive cone-rod dystrophy
  JOURNAL   Am J Hum Genet 93 (1), 110-117 (2013)
   PUBMED   23746546
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Jiang,J., Qi,Y.X., Zhang,P., Gu,W.T., Yan,Z.Q., Shen,B.R.,
            Yao,Q.P., Kong,H., Chien,S. and Jiang,Z.L.
  TITLE     Involvement of Rab28 in NF-kappaB nuclear transport in endothelial
            cells
  JOURNAL   PLoS One 8 (2), e56076 (2013)
   PUBMED   23457503
  REMARK    GeneRIF: Rab28 is novel regulator of NFkB nuclear transport in
            endothelial cells.
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Lee,S.H., Baek,K. and Dominguez,R.
  TITLE     Large nucleotide-dependent conformational change in Rab28
  JOURNAL   FEBS Lett 582 (29), 4107-4111 (2008)
   PUBMED   19026641
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Brauers,A., Schurmann,A., Massmann,S., Muhl-Zurbes,P., Becker,W.,
            Kainulainen,H., Lie,C. and Joost,H.G.
  TITLE     Alternative mRNA splicing of the novel GTPase Rab28 generates
            isoforms with different C-termini
  JOURNAL   Eur J Biochem 237 (3), 833-840 (1996)
   PUBMED   8647132
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X78606.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X78606.1, FM073792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1483
                     /gene="Rab28"
                     /note="RAB28, member RAS oncogene family"
                     /db_xref="GeneID:117049"
                     /db_xref="RGD:620891"
     exon            1..93
                     /gene="Rab28"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..684
                     /gene="Rab28"
                     /note="rab-26"
                     /codon_start=1
                     /product="ras-related protein Rab-28"
                     /protein_id="NP_446430.1"
                     /db_xref="GeneID:117049"
                     /db_xref="RGD:620891"
                     /translation="MSDSEEESQDRQLKIVVLGDGTSGKTSLATCFAQETFGKQYKQT
                     IGLDFFLRRITLPGNLNVTLQVWDIGGQTIGGKMLDKYIYGAQGILLVYDITNYQSFE
                     NLEDWYSVVKTVSEESETQPLVALVGNKIDLEHMRTVKPDKHLRFCQENGFSSHFVSA
                     KTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVNYNQEPMSRTVNPPRSSMC
                     AVQ"
     exon            94..190
                     /gene="Rab28"
                     /inference="alignment:Splign:2.1.0"
     exon            191..279
                     /gene="Rab28"
                     /inference="alignment:Splign:2.1.0"
     exon            280..409
                     /gene="Rab28"
                     /inference="alignment:Splign:2.1.0"
     exon            410..513
                     /gene="Rab28"
                     /inference="alignment:Splign:2.1.0"
     exon            514..591
                     /gene="Rab28"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1473
                     /gene="Rab28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcatcct cggacaccat gtcagactct gaggaggaga gccaggaccg gcaactgaaa
       61 atcgtcgtgc tgggggacgg cacctccggg aagacttcct tagctacgtg ttttgctcaa
      121 gagacatttg ggaaacagta caagcagact ataggactgg atttcttttt gagaaggatt
      181 accttaccag gaaatttgaa tgttactctt caagtttggg atataggagg gcagacaata
      241 ggtggcaaga tgttggataa atacatctat ggagcacagg gaatcctctt ggtatatgat
      301 attacaaact accaaagctt tgagaatttg gaagattggt attctgtggt gaagacagta
      361 agcgaagagt cagaaactca gcccctggtt gctttagtag gcaataaaat tgacttggag
      421 catatgcgaa cagtaaaacc tgataaacac ttacgatttt gccaggaaaa tggttttagt
      481 agccactttg tttcagccaa gacgggagac tctgtcttcc tgtgttttca gaaagttgcg
      541 gcagaaatcc tgggaatcaa gttaaacaaa gcagaaatag aacagtcaca gagagtggtg
      601 aaggcagata ttgtaaacta caaccaggag cccatgtcaa gaactgttaa tccacctcgg
      661 agctccatgt gtgcagttca gtgagcacac actgtattga tagttctggc tgctcttccc
      721 tggattgggc ccaagctgcc taggaacatg ttttatcagt gactgtctct gtagtcagct
      781 cacacttcct cctgctctgc tccttcatcc cttagtcgcc tcagagtatc gggcagctcc
      841 ctggacagga aggaattcag atttggaacc acatgttttg aaatctgaat ggaaagtcca
      901 ttctctggat tgagactgcc tcctcgctcc agaagaacca tgttgcttct ttatctcttc
      961 ttttttccca gatttaaaaa atttaaacag atatgaagat gctccacgct ttgatcatca
     1021 ttttctattt gaacttgtat atgtgaacgt gtacttgaga gcactgatgg tggaagttat
     1081 caagaaggtg ttcctttgct ggctattaag agtaaactat acaaagctgc atctgattga
     1141 aagtgcttca aatgaggctg caatagaaat attttttcat ttttaaaagg agcctaatgt
     1201 gtttatattg tagtttataa ctcacaagta ctgagtattt gatattgtat ttttattact
     1261 gtatcatggt cattgcatat tttatcatat ttggcttaga tggctttatg aattttgata
     1321 aatggttcag ctgatcctcc acatggaatt tctcctacag gctgtatgag agtgcttcca
     1381 gatgagtcat gatatccttg gatcattgtg gatcgatcac actgtacctg atgttctgat
     1441 gtttttctca cataaataaa tttatttaaa ttaaaaaaaa aaa
//
