LOCUS       NM_053459                890 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus RAB27B, member RAS oncogene family (Rab27b),
            mRNA.
ACCESSION   NM_053459
VERSION     NM_053459.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Zhang,J., Zhang,K., Qi,L., Hu,Q., Shen,Z., Liu,B., Deng,J.,
            Zhang,C. and Zhang,Y.
  TITLE     DENN domain-containing protein FAM45A regulates the homeostasis of
            late/multivesicular endosomes
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (5), 916-929 (2019)
   PUBMED   30771381
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Gallo,L.I., Dalghi,M.G., Clayton,D.R., Ruiz,W.G., Khandelwal,P. and
            Apodaca,G.
  TITLE     RAB27B requirement for stretch-induced exocytosis in bladder
            umbrella cells
  JOURNAL   Am J Physiol Cell Physiol 314 (3), C349-C365 (2018)
   PUBMED   29167152
  REMARK    GeneRIF: RAB27B regulates discoidal- and/or fusiform-shaped vesicle
            exocytosis in bladder umbrella cells.
REFERENCE   3  (bases 1 to 890)
  AUTHORS   Shen,Y.T., Gu,Y., Su,W.F., Zhong,J.F., Jin,Z.H., Gu,X.S. and
            Chen,G.
  TITLE     Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein
            Trafficking in Oligodendrocytes
  JOURNAL   Neurosci Bull 32 (4), 331-340 (2016)
   PUBMED   27325508
  REMARK    GeneRIF: The data of this study suggested that Rab27b is involved
            in myelin biogenesis by regulating PLP transport from late
            endosomes/lysosomes to the cell membrane in oligodendrocytes.
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Ejlerskov,P., Christensen,D.P., Beyaie,D., Burritt,J.B.,
            Paclet,M.H., Gorlach,A., van Deurs,B. and Vilhardt,F.
  TITLE     NADPH oxidase is internalized by clathrin-coated pits and localizes
            to a Rab27A/B GTPase-regulated secretory compartment in activated
            macrophages
  JOURNAL   J Biol Chem 287 (7), 4835-4852 (2012)
   PUBMED   22157766
  REMARK    GeneRIF: cyt b(558) depends on clathrin for internalization, and in
            activated macrophages NADPH oxidase occupies a Rab27A/B-regulated
            secretory compartment
REFERENCE   5  (bases 1 to 890)
  AUTHORS   Huang,S.H., Duan,S., Sun,T., Wang,J., Zhao,L., Geng,Z., Yan,J.,
            Sun,H.J. and Chen,Z.Y.
  TITLE     JIP3 mediates TrkB axonal anterograde transport and enhances BDNF
            signaling by directly bridging TrkB with kinesin-1
  JOURNAL   J Neurosci 31 (29), 10602-10614 (2011)
   PUBMED   21775604
REFERENCE   6  (bases 1 to 890)
  AUTHORS   Chen,X., Li,C., Izumi,T., Ernst,S.A., Andrews,P.C. and
            Williams,J.A.
  TITLE     Rab27b localizes to zymogen granules and regulates pancreatic
            acinar exocytosis
  JOURNAL   Biochem Biophys Res Commun 323 (4), 1157-1162 (2004)
   PUBMED   15451418
  REMARK    GeneRIF: These results demonstrate that Rab27b is present on ZGs
            and plays an important role in regulating acinar exocytosis.
REFERENCE   7  (bases 1 to 890)
  AUTHORS   Westbroek,W., Lambert,J., De Schepper,S., Kleta,R., Van Den
            Bossche,K., Seabra,M.C., Huizing,M., Mommaas,M. and Naeyaert,J.M.
  TITLE     Rab27b is up-regulated in human Griscelli syndrome type II
            melanocytes and linked to the actin cytoskeleton via exon F-Myosin
            Va transcripts
  JOURNAL   Pigment Cell Res 17 (5), 498-505 (2004)
   PUBMED   15357836
REFERENCE   8  (bases 1 to 890)
  AUTHORS   Kierszenbaum,A.L., Tres,L.L., Rivkin,E., Kang-Decker,N. and van
            Deursen,J.M.
  TITLE     The acroplaxome is the docking site of Golgi-derived myosin
            Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb
            mutant mouse spermatids
  JOURNAL   Biol Reprod 70 (5), 1400-1410 (2004)
   PUBMED   14724135
REFERENCE   9  (bases 1 to 890)
  AUTHORS   Imai,A., Yoshie,S., Nashida,T., Shimomura,H. and Fukuda,M.
  TITLE     The small GTPase Rab27B regulates amylase release from rat parotid
            acinar cells
  JOURNAL   J Cell Sci 117 (Pt 10), 1945-1953 (2004)
   PUBMED   15039459
  REMARK    GeneRIF: the Rab27B-Slac2-c complex is an important constituent of
            secretory granule exocytosis in parotid acinar cells
REFERENCE   10 (bases 1 to 890)
  AUTHORS   Chen,D., Guo,J., Miki,T., Tachibana,M. and Gahl,W.A.
  TITLE     Molecular cloning and characterization of rab27a and rab27b, novel
            human rab proteins shared by melanocytes and platelets
  JOURNAL   Biochem Mol Med 60 (1), 27-37 (1997)
   PUBMED   9066979
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF325693.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF325693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..890
                     /gene="Rab27b"
                     /note="RAB27B, member RAS oncogene family"
                     /db_xref="GeneID:84590"
                     /db_xref="RGD:620114"
     exon            1..212
                     /gene="Rab27b"
                     /inference="alignment:Splign:2.1.0"
     exon            213..384
                     /gene="Rab27b"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..888
                     /gene="Rab27b"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-27B"
                     /protein_id="NP_445911.1"
                     /db_xref="GeneID:84590"
                     /db_xref="RGD:620114"
                     /translation="MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGI
                     DFREKRVVYDTQGADGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLT
                     SQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLLDQREVNERQARELAEKYGIPYF
                     ETSAATGQNVEKSVETLLDLIMKRMEKCVEKTQVPDTVNGVNSGKVDGEKPAEKKCAC
                     "
     exon            385..470
                     /gene="Rab27b"
                     /inference="alignment:Splign:2.1.0"
     exon            471..574
                     /gene="Rab27b"
                     /inference="alignment:Splign:2.1.0"
     exon            575..698
                     /gene="Rab27b"
                     /inference="alignment:Splign:2.1.0"
     exon            699..890
                     /gene="Rab27b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagtcttg acaggcagag gttggcctta caccgatcgg gagccacagg ttgcagactg
       61 cagagagccg tgcccatgac tgtgactctg tgaggctggc tgcctgcgcg ccttggttgc
      121 tggcttgctg gcgggtcccc ggagctcgag aagactagag tgggccccga aacctgatac
      181 cagcgccctc actgccgccg ctctgcgggc tggcccgcca agaccctcac tatgactgat
      241 ggagactatg actacctgat taaactcctg gcccttggag actcaggagt agggaagaca
      301 acatttcttt accgatacac agacaataaa ttcaatccca aattcatcac tacagtagga
      361 attgattttc gggaaaaacg tgtggtttat gacacacaag gagcagatgg atcttcaggg
      421 aaagccttta aggtacatct gcagctttgg gacactgctg gacaagagcg gttccggagt
      481 ctcaccaccg ccttcttcag agatgccatg ggcttcttac taatgtttga cctcaccagt
      541 caacagagtt tcttgaatgt cagaaactgg atgagtcaac tgcaggcaaa tgcttactgt
      601 gaaaacccag atatagtatt aattggcaac aaggcagacc tgctggacca aagggaagtc
      661 aacgagcgac aagcacgaga gctggctgaa aaatatggca taccatactt tgaaacaagt
      721 gcggcgacag gacagaatgt agagaagtca gtggaaaccc ttctggactt aatcatgaag
      781 agaatggaga agtgtgtaga gaagacgcag gttccggaca ctgtcaatgg tgtgaattct
      841 gggaaggtcg atggggagaa gccagcagag aagaaatgtg cctgctagac
//
