LOCUS       NM_133580               1391 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus RAB26, member RAS oncogene family (Rab26), mRNA.
ACCESSION   NM_133580
VERSION     NM_133580.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1391)
  AUTHORS   Luningschror,P., Binotti,B., Dombert,B., Heimann,P., Perez-Lara,A.,
            Slotta,C., Thau-Habermann,N., R von Collenberg,C., Karl,F.,
            Damme,M., Horowitz,A., Maystadt,I., Fuchtbauer,A., Fuchtbauer,E.M.,
            Jablonka,S., Blum,R., Uceyler,N., Petri,S., Kaltschmidt,B.,
            Jahn,R., Kaltschmidt,C. and Sendtner,M.
  TITLE     Plekhg5-regulated autophagy of synaptic vesicles reveals a
            pathogenic mechanism in motoneuron disease
  JOURNAL   Nat Commun 8 (1), 678 (2017)
   PUBMED   29084947
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1391)
  AUTHORS   Binotti,B., Pavlos,N.J., Riedel,D., Wenzel,D., Vorbruggen,G.,
            Schalk,A.M., Kuhnel,K., Boyken,J., Erck,C., Martens,H., Chua,J.J.
            and Jahn,R.
  TITLE     The GTPase Rab26 links synaptic vesicles to the autophagy pathway
  JOURNAL   Elife 4, e05597 (2015)
   PUBMED   25643395
  REMARK    GeneRIF: Rab26 selectively directs synaptic and secretory vesicles
            into preautophagosomal structures.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1391)
  AUTHORS   Li,C., Fan,Y., Lan,T.H., Lambert,N.A. and Wu,G.
  TITLE     Rab26 modulates the cell surface transport of alpha2-adrenergic
            receptors from the Golgi
  JOURNAL   J Biol Chem 287 (51), 42784-42794 (2012)
   PUBMED   23105096
REFERENCE   4  (bases 1 to 1391)
  AUTHORS   Tian,X., Jin,R.U., Bredemeyer,A.J., Oates,E.J., Blazewska,K.M.,
            McKenna,C.E. and Mills,J.C.
  TITLE     RAB26 and RAB3D are direct transcriptional targets of MIST1 that
            regulate exocrine granule maturation
  JOURNAL   Mol Cell Biol 30 (5), 1269-1284 (2010)
   PUBMED   20038531
REFERENCE   5  (bases 1 to 1391)
  AUTHORS   Yoshie,S., Imai,A., Nashida,T. and Shimomura,H.
  TITLE     Expression, characterization, and localization of Rab26, a low
            molecular weight GTP-binding protein, in the rat parotid gland
  JOURNAL   Histochem Cell Biol 113 (4), 259-263 (2000)
   PUBMED   10857477
REFERENCE   6  (bases 1 to 1391)
  AUTHORS   Wagner,A.C., Strowski,M.Z., Goke,B. and Williams,J.A.
  TITLE     Molecular cloning of a new member of the Rab protein family, Rab
            26, from rat pancreas
  JOURNAL   Biochem Biophys Res Commun 207 (3), 950-956 (1995)
   PUBMED   7864900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 25, 2020 this sequence version replaced NM_133580.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061984.1, SRR26643298.59218.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               JAXUCZ010000010.1  14062241-14062577   c
            338-448             JAXUCZ010000010.1  14061050-14061160   c
            449-490             JAXUCZ010000010.1  14059602-14059643   c
            491-557             JAXUCZ010000010.1  14059461-14059527   c
            558-610             JAXUCZ010000010.1  14059239-14059291   c
            611-676             JAXUCZ010000010.1  14058941-14059006   c
            677-733             JAXUCZ010000010.1  14058798-14058854   c
            734-810             JAXUCZ010000010.1  14058622-14058698   c
            811-1391            JAXUCZ010000010.1  14057942-14058522   c
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1391
                     /gene="Rab26"
                     /note="RAB26, member RAS oncogene family"
                     /db_xref="GeneID:171111"
                     /db_xref="RGD:620890"
     exon            1..337
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..913
                     /gene="Rab26"
                     /codon_start=1
                     /product="ras-related protein Rab-26"
                     /protein_id="NP_598264.2"
                     /db_xref="GeneID:171111"
                     /db_xref="RGD:620890"
                     /translation="MSRKKTPKSKGGSVPAASTLPAAANGPRLAHPRTARPGPEAPPN
                     GPPQSGRPSLGGTGDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDF
                     RNKVLDVDGMKVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDITNKDSFDNIQAWL
                     TEIQEYAQQDVVLMLLGNKVDSTQERVVKREDGEKLAKEYGLPFMETSAKSGLNVDLA
                     FTAIAKELKQRSTKAPSEPRFRLHDYVKREGRGVSCCRL"
     exon            338..448
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     exon            449..490
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     exon            491..557
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     exon            558..610
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     exon            611..676
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     exon            677..733
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     exon            734..810
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1391
                     /gene="Rab26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgagtgct ggagatgctg ctgctgccgc cgctgccgct gctgctgtgg gacgggttcg
       61 ggtccgagtc tgccttggcg ggcacggagc gtgggacgac ctgggacccg gtggtagcag
      121 caggagcaca ctgagaacca tgtccaggaa gaagaccccc aaaagcaagg gggggagtgt
      181 gccggctgcc tctacgctgc ccgccgccgc caacgggcca cgtctggcac atcccaggac
      241 tgcgcgccct ggcccagagg caccgcccaa cgggcccccg cagtccggcc ggccctcact
      301 tggtggcact ggagacttct acgacgttgc tttcaaggtc atgctggtgg gggattccgg
      361 tgtggggaag acgtgcctgc tcgtgcgctt caaggatggg gctttcctgg ctggtacctt
      421 catctccact gtgggcatcg acttccggaa taaagttctg gatgtggatg gcatgaaggt
      481 gaagctgcag atctgggaca cggctggtca ggagcggttc cgaagtgtca cccatgccta
      541 ctaccgggat gctcacgcac tgttgctgct ctacgacatc accaacaaag attccttcga
      601 caacatccag gcctggttga cagaaatcca ggaatatgcc cagcaggacg tggtgctcat
      661 gctgttgggg aacaaggttg actctactca agaacgagtg gtaaagaggg aagatgggga
      721 gaaattagcc aaggagtatg ggctgccatt catggagacc agcgccaaga gcggcctcaa
      781 tgtggacttg gcttttacag ccatagcaaa ggagctgaaa caaagatcca ccaaggctcc
      841 cagtgagccg cgcttcaggc tgcatgacta tgtgaagagg gagggccgag gggtctcctg
      901 ctgtcgactc tgaacctggc tgaattttgg ttctacgctg gaggcagctg tttgggatac
      961 cataggtgat ggatgccaga atgtcttcct tttcaagaca cctgaggctg atgctcttca
     1021 gccccttggc ctcaggggcc atcacagaaa gcatacaaac cacactatgg cctgtggctg
     1081 ccctcttctg ggcactccca gcaggaagga tggcaccaca tcgtgcctcc tatgaaaagc
     1141 catgcttact gcacacggcc tgggaaggac cccacacacg accaaaggct acaagaatca
     1201 tgttgtccat ttgttgggtt gcttccaagt caactagtag gctctgatgt aggaaaccac
     1261 aggaagattg ggctgataga accaggtcac tacttagcag gctggcccag tccttcccac
     1321 cttgtactaa agtcaccaga ctacaaatgt tgtgtgaaaa cctgtcccca ttaataaagg
     1381 tgtttctgga g
//
