LOCUS       NM_001107687            1082 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RAB25, member RAS oncogene family (Rab25), mRNA.
ACCESSION   NM_001107687 XM_001074095 XM_227404
VERSION     NM_001107687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Bannister JP, Bulley S, Leo MD, Kidd MW and Jaggar JH.
  TITLE     Rab25 influences functional Cav1.2 channel surface expression in
            arterial smooth muscle cells
  JOURNAL   Am J Physiol Cell Physiol 310 (11), C885-C893 (2016)
   PUBMED   27076616
  REMARK    GeneRIF: Rab25 is expressed in arterial myocytes where it promotes
            surface expression of CaV1.2 channels to control pressure- and
            depolarization-induced vasoconstriction.
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Lindsay AJ, Jollivet F, Horgan CP, Khan AR, Raposo G, McCaffrey MW
            and Goud B.
  TITLE     Identification and characterization of multiple novel Rab-myosin Va
            interactions
  JOURNAL   Mol Biol Cell 24 (21), 3420-3434 (2013)
   PUBMED   24006491
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Senga K, Mostov KE, Mitaka T, Miyajima A and Tanimizu N.
  TITLE     Grainyhead-like 2 regulates epithelial morphogenesis by
            establishing functional tight junctions through the organization of
            a molecular network among claudin3, claudin4, and Rab25
  JOURNAL   Mol Biol Cell 23 (15), 2845-2855 (2012)
   PUBMED   22696678
REFERENCE   4  (bases 1 to 1082)
  AUTHORS   Kessler D, Gruen GC, Heider D, Morgner J, Reis H, Schmid KW and
            Jendrossek V.
  TITLE     The action of small GTPases Rab11 and Rab25 in vesicle trafficking
            during cell migration
  JOURNAL   Cell Physiol Biochem 29 (5-6), 647-656 (2012)
   PUBMED   22613965
REFERENCE   5  (bases 1 to 1082)
  AUTHORS   Lapierre LA, Caldwell CM, Higginbotham JN, Avant KM, Hall J,
            Beauchamp RD and Goldenring JR.
  TITLE     Transformation of rat intestinal epithelial cells by overexpression
            of Rab25 is microtubule dependent
  JOURNAL   Cytoskeleton (Hoboken) 68 (2), 97-111 (2011)
   PUBMED   21246754
  REMARK    GeneRIF: up-regulation of Rab25 in RIE cells leads to
            microtubule-dependent transformation. Thus, depolymerization of
            microtubules may be a potent therapeutic target for cancer therapy
            through the reversal of the invasive phenotype of certain cancer
            cells.
REFERENCE   6  (bases 1 to 1082)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1082)
  AUTHORS   Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW,
            Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW,
            Ozanne BW and Norman JC.
  TITLE     Rab25 associates with alpha5beta1 integrin to promote invasive
            migration in 3D microenvironments
  JOURNAL   Dev Cell 13 (4), 496-510 (2007)
   PUBMED   17925226
REFERENCE   8  (bases 1 to 1082)
  AUTHORS   Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J,
            Smith-McCune K, Lu KH, Fishman D, Gray JW and Mills GB.
  TITLE     The RAB25 small GTPase determines aggressiveness of ovarian and
            breast cancers
  JOURNAL   Nat Med 10 (11), 1251-1256 (2004)
   PUBMED   15502842
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473976.2.
            
            On Jan 9, 2008 this sequence version replaced NM_001107687.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168745.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132269,
                                           SAMD00155324 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1082
                     /gene="Rab25"
                     /note="RAB25, member RAS oncogene family"
                     /db_xref="GeneID:310632"
                     /db_xref="RGD:1308447"
     exon            1..270
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..869
                     /gene="Rab25"
                     /codon_start=1
                     /product="ras-related protein Rab-25"
                     /protein_id="NP_001101157.2"
                     /db_xref="GeneID:310632"
                     /db_xref="RGD:1308447"
                     /translation="MGNRTDEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTT
                     IGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAV
                     VERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEACMFAENNGLLFLETSALDST
                     NVELAFETVLKEIFAKVSKQRQNSTRTSAITLGSAQAGQDPGPGEKRACCIGL"
     exon            271..466
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     exon            467..660
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     exon            661..741
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1082
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgttctc agcttccgtc ctctcagctc ccacagagta gcctaaagtg ccagagctga
       61 gcctccaggg ctcttcctgg cctcaactca gcctcttgtc ctttacccta atgagagagg
      121 agccaggtgc aggtctttca agagctgaga gtggaggcca tttaacctat aaacagactt
      181 gtgacctctg ttcctgcaaa cgccctcact ctccatgctg agccaagatg gggaatcgaa
      241 cagatgaaga ttataatttt gtctttaagg tggtactgat cggcgagtca ggcgtgggca
      301 agaccaatct gctgtcccgg ttcacccgca atgaattcag ccacgacagc cgcaccacca
      361 tcggggttga gttctccacc cgcactgtga tgctgggcac cgctgctgtc aaggcacaga
      421 tctgggacac agctggtctg gagcgatata gagccatcac ctctgcgtac tatcgcggag
      481 ccgtaggggc actcctggta tttgacctga ccaagcacca gacctatgct gtggtggagc
      541 gctggctaaa ggaactgtat gaccatgccg aagccacaat cgttgtcatg cttgtgggga
      601 acaaaagtga cctcagccag gcccgagagg tccccactga ggaggcgtgc atgtttgctg
      661 agaacaatgg cctgctattc ctggagacct cagccctgga ctccaccaat gttgagctag
      721 cctttgagac tgtcctcaaa gagatctttg caaaggtgtc caagcagagg cagaacagca
      781 cccggaccag tgccatcacc ctgggcagtg cccaagctgg acaggatcct ggacctgggg
      841 agaagagggc ctgttgcatt ggcctttgac ttcagctatg accaaccctg tgtcctgcct
      901 ttagccttcc ggtacatcca ccacccttac tgcaggactt ctccccaccc tcaagtccct
      961 gttcacaagc acccagggtc atcatgccct accatatgat ctatccacca catccctctc
     1021 catcacccga accccttaca ggtgagggcc tgcaaataaa actgttttgt atcatgcctg
     1081 gc
//
