LOCUS       NM_001109005            4388 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus RAB23, member RAS oncogene family (Rab23), mRNA.
ACCESSION   NM_001109005 XM_001054063 XM_017596570 XM_346033
VERSION     NM_001109005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4388)
  AUTHORS   Nozawa,T., Aikawa,C., Goda,A., Maruyama,F., Hamada,S. and
            Nakagawa,I.
  TITLE     The small GTPases Rab9A and Rab23 function at distinct steps in
            autophagy during Group A Streptococcus infection
  JOURNAL   Cell Microbiol 14 (8), 1149-1165 (2012)
   PUBMED   22452336
REFERENCE   2  (bases 1 to 4388)
  AUTHORS   Chi,S., Xie,G., Liu,H., Chen,K., Zhang,X., Li,C. and Xie,J.
  TITLE     Rab23 negatively regulates Gli1 transcriptional factor in a
            Su(Fu)-dependent manner
  JOURNAL   Cell Signal 24 (6), 1222-1228 (2012)
   PUBMED   22365972
REFERENCE   3  (bases 1 to 4388)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   4  (bases 1 to 4388)
  AUTHORS   Hoover,A.N., Wynkoop,A., Zeng,H., Jia,J., Niswander,L.A. and Liu,A.
  TITLE     C2cd3 is required for cilia formation and Hedgehog signaling in
            mouse
  JOURNAL   Development 135 (24), 4049-4058 (2008)
   PUBMED   19004860
REFERENCE   5  (bases 1 to 4388)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   6  (bases 1 to 4388)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   7  (bases 1 to 4388)
  AUTHORS   Huangfu,D., Liu,A., Rakeman,A.S., Murcia,N.S., Niswander,L. and
            Anderson,K.V.
  TITLE     Hedgehog signalling in the mouse requires intraflagellar transport
            proteins
  JOURNAL   Nature 426 (6962), 83-87 (2003)
   PUBMED   14603322
REFERENCE   8  (bases 1 to 4388)
  AUTHORS   Eggenschwiler,J.T., Espinoza,E. and Anderson,K.V.
  TITLE     Rab23 is an essential negative regulator of the mouse Sonic
            hedgehog signalling pathway
  JOURNAL   Nature 412 (6843), 194-198 (2001)
   PUBMED   11449277
REFERENCE   9  (bases 1 to 4388)
  AUTHORS   Kasarskis,A., Manova,K. and Anderson,K.V.
  TITLE     A phenotype-based screen for embryonic lethal mutations in the
            mouse
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7485-7490 (1998)
   PUBMED   9636176
REFERENCE   10 (bases 1 to 4388)
  AUTHORS   Gunther,T., Struwe,M., Aguzzi,A. and Schughart,K.
  TITLE     Open brain, a new mouse mutant with severe neural tube defects,
            shows altered gene expression patterns in the developing spinal
            cord
  JOURNAL   Development 120 (11), 3119-3130 (1994)
   PUBMED   7720556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jul 26, 2021 this sequence version replaced
            XM_017596570.2, NM_001109005.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR21887620.942862.1, SRR22582416.597421.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000009.1  43440047-43440282
            237-329             JAXUCZ010000009.1  43441821-43441913
            330-549             JAXUCZ010000009.1  43443585-43443804
            550-635             JAXUCZ010000009.1  43444733-43444818
            636-792             JAXUCZ010000009.1  43455560-43455716
            793-875             JAXUCZ010000009.1  43457489-43457571
            876-968             JAXUCZ010000009.1  43458929-43459021
            969-4388            JAXUCZ010000009.1  43459908-43463327
FEATURES             Location/Qualifiers
     source          1..4388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..4388
                     /gene="Rab23"
                     /note="RAB23, member RAS oncogene family"
                     /db_xref="GeneID:367242"
                     /db_xref="RGD:1306867"
     exon            1..236
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
     exon            237..329
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
     exon            330..549
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1108
                     /gene="Rab23"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-23"
                     /protein_id="NP_001102475.1"
                     /db_xref="GeneID:367242"
                     /db_xref="RGD:1306867"
                     /translation="MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGV
                     DFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISS
                     WREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEGLAKRLKLRFYRTSVKEDLNVNE
                     VFKYLAEKHLQKLKQQVADEPEQTHSSSNKIGVFNASVGSHLGQNSSSLNGGDVINLR
                     PNKQRTKKTRNPFSSCSVP"
     exon            550..635
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
     exon            636..792
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
     exon            793..875
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
     exon            876..968
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
     exon            969..4388
                     /gene="Rab23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtcggcg acgagtggct ccgtgaaccc ggatactaat aaagttcgct agagactctt
       61 aatcgttctg aaagagcgga gcgggtgcga ggcgtctgcg gggaggaacc gggctcagtg
      121 ctgcgggctg tgcgttccgg gctcggtgct gcgggctgtg cattccgggc tgggtgctgc
      181 ggttgtgcgt tccgggttgc gggctccgct ctgagggttc cgggctgtgg gcagagggcg
      241 aagaattgtt tagatagaga agaggaagtt gacttcccag aactgagcca gtgtgagccc
      301 acaagctgga tgaacacggt cagatcttgg tctgagggag agggtctgac ctcctggagt
      361 tagagctggt ccagaaaccg ttcctgtttc aaaaatgctg gaggaagaca tggaagtggc
      421 catcaagatg gtggtggtag ggaatggggc tgttgggaag tcaagcatga ttcagcgcta
      481 ctgcaaaggc atttttacaa aagactacaa gaaaaccatc ggcgttgact ttttggagcg
      541 gcagattcaa gttaatgatg aagacgtgag gctaatgctg tgggacactg caggtcaaga
      601 ggagtttgat gcgataacga aggcctacta tcgaggagcc caggcttgtg tgcttgtgtt
      661 ttctaccaca gacagggagt cttttgaagc aatttccagc tggagagaaa aggtagtagc
      721 agaagttgga gatataccaa ccgcgcttgt acagaacaag atcgatcttc tggatgattc
      781 atgtatcaaa aatgaggaag ctgagggact ggccaaaagg ctaaagctga gattctacag
      841 gacgtctgtg aaggaggatc taaatgtgaa cgaagttttt aaatatttgg ctgagaaaca
      901 cctacaaaaa ctcaaacaac aagtagcgga cgagccggag cagacacatt cgagcagtaa
      961 caagataggt gtctttaatg cgtctgttgg aagtcacttg ggtcagaatt caagttccct
     1021 taacggtgga gatgtcatca accttagacc taacaaacaa aggaccaaga aaaccagaaa
     1081 tcctttcagc agctgtagtg taccctaatt gttttaggga ggagaaagct gaattgcacc
     1141 gtgcagttaa ccgcaccgag tgtggggtgt cccgagtgtg tcggcaggcc tcgcacctcg
     1201 ctctgaaagc tgacattgta atgttgctct gccgtgcttc tcagaatgta gacggagccc
     1261 tctgctggaa attactgccc tgtgaactca ctctagtttt ttacattaga cgaagcttct
     1321 cctgtttttg aaggaacacc ataggaaatg tcaaaaacag gttttgctga atttgcaacg
     1381 ctgaacacta gaacaacatg actaactaca ttggtaactg tttaccctga tggaccaagg
     1441 agagatggcc ggcattcttg ttctgaaact ggtcgtcgag cttttctgga atgttcaacc
     1501 tgaatgctta aagaacatac tgcaggggaa acgcggcctc ctgagacagc agcacagcgc
     1561 gtgtcgtcag tggtactcgt gcaatatctg taaagtgtgg actatggggt gagcatacag
     1621 acgcctggct ggagcaggtc tgtgccctgg gaaagggtgt gcagattcta attcactccc
     1681 tcagacgacc attgtgtatg tttctggtct cacatgagcc ctcagacata ctctacagaa
     1741 cgaatttcta caaaagtgta ccgtgtgcca aacactaccc ctaattttta cagtgctttc
     1801 ctattagaat ttgcatttac ggcatcttgt agaggcctgt gacagtgtag gtgaagggaa
     1861 tgtaaacatc tgaatgttag ggcctctccc tcaggggagt tctcccagcg tcttctcagg
     1921 gccgccgtaa gcacagtggg ctttatgctg ttatgtgctt agcttgtgtc cagtacacac
     1981 agcagcctgc ggccactcag aagacctgtg gagcatgcgc acactagctt ctgtcaggct
     2041 gctaacttga gaccaaactc tgaacttcgg agctgaaggg acccgtcttc tcagagtgac
     2101 ggtctttggc cctgatccag gttagagatt tcctgaagcc ttgcagctcg tcaggcagcc
     2161 ctttgctcac acgtggtata gccttcacca ctagtgcttc agtttttccg tggccttggg
     2221 tctacatggc accttatcaa gacctatcgg tcagaggcat ctgcaaggat gtgacctagt
     2281 gtgtaatgaa ggtcggaagc atgtgagtcg gactcacact gcctgccaaa gagatgatgt
     2341 catgaactcc actaaaaact cttcatcagt agttttgttt ttaaagtatc gataacccgt
     2401 ttccagagtc ttggttttca tgtggcttta aaatatatga aagtgatttt tcttggaata
     2461 tatgctataa agtccttttt tttttaacta aaatataaaa tagttcttgt atttctcttg
     2521 tccctttttt aagttaccct gacacaccac cccatgctgc cccgattcct ggtgtgagca
     2581 cagaggttcc ggcgtccttg ctccacggtg gcccacgctt gcccttcaca ctacatccca
     2641 agccggccac gcaggccgct cctctgtgta ctctgctgtt agagccccca ctgccggggt
     2701 gaggtgggga cttggttccc cacagtggtg ctgctgtgag ccaccattgt tctctttgaa
     2761 tacagactct tcagattttg cactaatttg ttggcaaata aatgagttgc cacttttaat
     2821 gacattggca gaaaatgcat tccttataga gtattgtagc tttcttcata gtcactaaat
     2881 gcatggtaga aaggcgtgtg gtatgtctct gtaaaagtgt ctgctgatgg ctgcactttc
     2941 cttaatattt gttcttttgt cttccccctt ccccaacccc ctcaccccac cacaccccag
     3001 agctgaggac caaacccagg gccttgcgcc tgctaggcaa gcgctctacc actgagctaa
     3061 atcccaaccc cttccctact atttgtaaca gaagtttatg tgttttgctt tatccatttt
     3121 tttaatggaa gtgtttgtta cacatttgaa cttttacttt gcattactgt attttatacc
     3181 taactttaaa aggtctaaaa tcatccacaa gtaatattaa tttatcattg tagtcaattc
     3241 tgagaccttt aggtcacatt gtgggtttct tctgtaaccg taacgcttaa gaacttcagt
     3301 atgaaattct agagacgccc cctgtcgatg aacgctgtcc aggacttggg gccatgggac
     3361 agttgtgctc tggttaactg ttttgcagtg tcaccgtttt tagtgtcagg cacgtagctg
     3421 tggagtagtt gacgtatcta agagttcctc aggtttcttc cagtctctgc ctgtgaacta
     3481 aatagtacat aagacagccc acatacggcc gtgcaaataa aagcaggttg aactgctgct
     3541 ttttgtccac tcaaggtgac agcacacgtg gagatttcaa attacagcta gcgctaccac
     3601 agagaggatg tgtgacccct tccctgccag tgaagtcggg cagtgcagag aactcagggt
     3661 gtggccccac tgtgcctgcc actagggacc agggtctttg agaggattag gatgagctgt
     3721 tggcctttta gcctgatgta gcaccctgaa gtgctcttgt aatctgagat gtctcttgcc
     3781 ttccgaggat tctggtgact gctatgaggc gagcacctca cagagacttg gtcacagcca
     3841 gcgctgatat gcagggagcc cataaggggg tgcgggggtg gggggtgggg ggctgtgacc
     3901 tccacagcct taggtgagca ggtgacttta cccacactaa cagctactac aaacatcatg
     3961 ttgctcttaa gagtttcaca tacaaaacct aaaaatccgt cctagaaatg aagttatctg
     4021 cacacaggtg aacgaaaccc cagcagggtc tgcccagcag ccagcccaga taggaggatg
     4081 atttggccac aagagttttt gttactacta ctttttctgt tgtctcttga aatatctata
     4141 gcaggatgtt gataaaatgg tattttaaaa ataaaatctt tgaatcaaag gaaaaactta
     4201 acccctccta tatttttgtt actaataaat aatgcttttg taaatccgaa tggaaaacta
     4261 cttgtatgta ttcatattga gtggtactta atacctttgg ggttaattta aaaatgtact
     4321 acttgattaa aatttccaaa aagataaatt ccaataacca aaaagaataa agcatttcaa
     4381 agctagaa
//
