LOCUS       NM_001398945            6997 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB22A, member RAS oncogene family (Rab22a),
            mRNA.
ACCESSION   NM_001398945 XM_006235705
VERSION     NM_001398945.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6997)
  AUTHORS   Yuan,F., Snapp,E.L., Novikoff,P.M., Suadicani,S.O., Spray,D.C.,
            Potvin,B., Wolkoff,A.W. and Stanley,P.
  TITLE     Human liver cell trafficking mutants: characterization and whole
            exome sequencing
  JOURNAL   PLoS One 9 (1), e87043 (2014)
   PUBMED   24466322
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6997)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
REFERENCE   3  (bases 1 to 6997)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   4  (bases 1 to 6997)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   5  (bases 1 to 6997)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 6997)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 6997)
  AUTHORS   Eathiraj,S., Pan,X., Ritacco,C. and Lambright,D.G.
  TITLE     Structural basis of family-wide Rab GTPase recognition by
            rabenosyn-5
  JOURNAL   Nature 436 (7049), 415-419 (2005)
   PUBMED   16034420
REFERENCE   8  (bases 1 to 6997)
  AUTHORS   Kauppi,M., Simonsen,A., Bremnes,B., Vieira,A., Callaghan,J.,
            Stenmark,H. and Olkkonen,V.M.
  TITLE     The small GTPase Rab22 interacts with EEA1 and controls endosomal
            membrane trafficking
  JOURNAL   J Cell Sci 115 (Pt 5), 899-911 (2002)
   PUBMED   11870209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 28, 2021 this sequence version replaced XM_006235705.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.20564.1,
                                           SRR26643290.14451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               JAXUCZ010000003.1  182877998-182878290
            294-373             JAXUCZ010000003.1  182879579-182879658
            374-455             JAXUCZ010000003.1  182907868-182907949
            456-527             JAXUCZ010000003.1  182914402-182914473
            528-634             JAXUCZ010000003.1  182914549-182914655
            635-744             JAXUCZ010000003.1  182915179-182915288
            745-6997            JAXUCZ010000003.1  182918148-182924400
FEATURES             Location/Qualifiers
     source          1..6997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..6997
                     /gene="Rab22a"
                     /note="RAB22A, member RAS oncogene family"
                     /db_xref="GeneID:366265"
                     /db_xref="RGD:1311959"
     exon            1..293
                     /gene="Rab22a"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..842
                     /gene="Rab22a"
                     /codon_start=1
                     /product="ras-related protein Rab-22A"
                     /protein_id="NP_001385874.1"
                     /db_xref="GeneID:366265"
                     /db_xref="RGD:1311959"
                     /translation="MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMT
                     KTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVRE
                     LRQHGPPSIVVAIAGNKCDLTDVREVMERDAKDYADSIHAIFVETSAKNAININELFI
                     EISRRLPSTDASPASGGKGFKLRRQPSEPKRSCC"
     exon            294..373
                     /gene="Rab22a"
                     /inference="alignment:Splign:2.1.0"
     exon            374..455
                     /gene="Rab22a"
                     /inference="alignment:Splign:2.1.0"
     exon            456..527
                     /gene="Rab22a"
                     /inference="alignment:Splign:2.1.0"
     exon            528..634
                     /gene="Rab22a"
                     /inference="alignment:Splign:2.1.0"
     exon            635..744
                     /gene="Rab22a"
                     /inference="alignment:Splign:2.1.0"
     exon            745..6997
                     /gene="Rab22a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgaccca gctggcgtcc caagatggcg gcgtcggtgg cgcccggtag gccaaggcgg
       61 tgtccgggct gttgaggtga ctccgcggga caagtgacgg gtcggccgga ccgaagggcg
      121 gcggcggaca cacggccgcc cggagtgcgc agcagggact tggcgaggca gcggcgccgg
      181 gggatgctgg tgctgggccg ggcctctccc tcctcaactt agggcggcgg cgggcccgca
      241 cccctggttc ccgggccatg gcgctgaggg aacttaaagt gtgcctactt ggggacacgg
      301 gtgtgggtaa atcaagcatc gtgtggcggt ttgtggaaga cagctttgac ccgaatatca
      361 atccaaccat aggggcatct tttatgacca agactgtcca gtaccaaaat gagctacata
      421 aattcctaat ctgggataca gctggacaag aacgattccg cgcgttggca cccatgtact
      481 accgagggtc agcagcagcc atcatcgtct atgacatcac aaaagaagag acgttctcaa
      541 ctttgaagaa ctgggtgaga gagctccgtc agcacggccc ccctagcatt gttgttgcca
      601 ttgcagggaa caagtgcgat cttactgatg tcagagaagt catggagaga gatgccaagg
      661 actacgccga ttccattcat gccatctttg tagaaaccag cgcaaaaaat gcaataaaca
      721 taaatgaact ctttatagaa attagtcgaa gacttccatc cactgacgcc agcccggcat
      781 ctggcggcaa gggcttcaaa ctccgaagac agccgtcgga gccaaagcgt agctgctgct
      841 gaccacccag ggcctgacct ggacgaagaa gcgggtggac ctggatgctg caggagagcc
      901 gtgccctgcc actgcctctg ccgcccgccg cctcatgctc tttatgcaat aaggactcag
      961 agaaccgtct gtgtggttct cttggaagac tgcagcaggt gtctctgtct gcagactatg
     1021 acggtggact ccggctggca tgcagaggga ccatgctcgt ccccggctgt ttacctagct
     1081 ggaaggagcg tctgatgcct gggtggtagg actgcaatgc tggggctttg gtaatcagga
     1141 ttcatgtatc attgtaaagg gaaacaagca ctttcacgga tcttaaggga aaggcttaga
     1201 gatggtcgtc tccttggtcc tcatctctag tgtcagagtc gtgtcattta gctgtgggaa
     1261 gtgatcacaa gtagatgggt ggatgtccct gggacagttc tcaccgtctc taaagcactt
     1321 tgacgcacag tagactcacg caggccgcca ttgctgcggc tgctggttca cctttggttt
     1381 gcttctgacc ctgtatgtgt cagagcccgc cgtgcacatt agctctggcc acctttctac
     1441 ataagctctc ctggtccagg ccatggggtg gacaggctgc ctggagccag cagagttgca
     1501 tgtacctaaa ctgatgagca gtggtttata aagaagagga gaggacagga caaagcaaat
     1561 gagtcttttg gtgggatggg ttttgtttct ggtttttgcc cagtttgttt tggtgggaaa
     1621 aacaactgtg ctgcctggca tatgtaaatt tgtagtctat atttatgata ccattgctta
     1681 aaattataaa ttatgtaaat acattaataa cttctgagtt cccttcagta ctcatttagt
     1741 cctgtgccca gtctcctgtg tgcccacccg tttttcagcc tatcccacag gaaactctga
     1801 agccccattt accttgtgta gaagaagcat ggagcactta gctcgaagct tccttcctcc
     1861 tcccctcacc gtctgcatcc catctggaaa tggtaataaa gacatatgcc ttcctgacaa
     1921 gcctgactag tccttcctgc ctggggccag agtgagccca gcacccgtcc gtccctccgt
     1981 catgcaccta gggccagagt gagcctctct tagctcctcc agagagcttg gaccaactgt
     2041 tttaagagtg ctttgcttat taacagcccg gctcaccctc cctcctttat tttctcttgc
     2101 ttctgttagt actgcacact cttttccctc aggagcctga tgagggttta atataatcta
     2161 aaataaagca gccaagtgaa gctgctggag atctgttcct ggcctgattt ggctcccttc
     2221 cagcccgcgt attgtaaggg aaggacattt acaagattaa ataggaaatg aaacagcttg
     2281 aatttcaaac caaattgtgt tttcagagct gtccttaact gaacagtcaa aacttttaaa
     2341 aacaattgtt actagtttat gccccttccc catatgcgta aaatggagac ggtttaacag
     2401 agtggcaacc caggtgacac tagacctgag cgaggccttg taaccatctc aagttgccta
     2461 tcattaccaa agtcagactt tggctcatgt ggacaaggct gccctctgcg catccaatgg
     2521 ctgctctctt ctgcagctcc tggcccctac tgccttccct catgtgtcac acaaagggaa
     2581 tgactggcca cggcttcttg tctatttgac aggatgagaa gcatagactc tgtgttcatg
     2641 tcttccgcac cctctctgtc accagccttc tctagaaaca gggttgtcct gcttatgata
     2701 ctgtgctgta gtcagtgaca gcagactttc gtcagggtga gcacagggag cgtcctattc
     2761 ggtgagcgtc actccctcct cttccccccc ctcctcctcc cctcttcctc cccccttcct
     2821 cctctccccc tcctcctcct tcagaatgca tatgaaaatg cactcacagt gctttttgac
     2881 cacattttag atgaagcagg aatctattat acattcctta tttccctggc tgtttcttaa
     2941 gagaaatagc ctcactccaa aggcgtcaag acatggcccc tccctaaaaa tctttggttc
     3001 ccttgtgacg cagggccatt ttttaaaact ttgaagaatg aacggaaggg aagctcttta
     3061 attaactgcc ggtgtgtatt gatctctctc agaggagctg gaataagccc ctcgcaggtg
     3121 tccggtccga ggaaccactg tctctccacg tctccctcta cataagtgtt tttctgattc
     3181 cgcgataact aattaaccat catttggtga ttaaaggaac atagtgggag agcctgatta
     3241 agtgtccttc agtgtaaact ctgagaagtg attgggagga gtacctacta caagcccttc
     3301 tgcctcccag tgaaacgccg tccgtccgtc cgccgcccgc ctgtcagctg cctccaagac
     3361 aagtgctgga catgggagct gagagcttta ttcctcttaa aacaacccag tccttgctcc
     3421 catcgatgat ggcgtttgaa gtgtccgcct cctctcattg tgctcctgtc ccttaactgc
     3481 ctacccaggt cagagcttga gattttctta tgagaggctt gactacttga agaggccggc
     3541 atccttgttg agattagctg ccctgtggaa tttttaatag atgaaaggga gggagggagc
     3601 ctttaatttt aggacttctc tgtaagtctc atatgtattc cttgtctcca ggaggaaaat
     3661 aggttcgggg tctttctaaa gctctaagag acagagtact gaagatgttt tgtagtaagt
     3721 agctgtctct tggcaccccg ggctgccaga ccagagggcc tggtgctata tttcaagggt
     3781 tccatgtttg gatgggtggg tttggtttgg ggtacactgc atgccagcac atcagcctcc
     3841 acatcccaga aggcaacggt tcattgcctt ctgtctcttt ctgctgcaaa gacattgatg
     3901 gggcacagct cagcatgtct tcatacacat cctttcagaa tccacagaga cccccgtgtg
     3961 tctgtaagac cctgcaggag tcaggaaaga agccttacct gggaccccta agccaacctg
     4021 caacctgctt cagaacatgg ctgccaaaga ggctggcttt tatcattaaa cttagcaggc
     4081 tgtcaccttg accagtgagc acagaatgac cgtgggagct agctcccgga agtcttcact
     4141 taaacttgtt ctgaagggac aagcaacata ctcatcagtt gtttgatttc aagacatgtt
     4201 ccacctctta acagctcatc tgtttctaag gaataaatgg ggtgtacctt caggattcaa
     4261 ggtgtcaact acatcttgct tggtctcctt gacttctcaa aaaaaaggcc aatgatgcca
     4321 aacattgggg ttggcatctg ctatgaaggc tggtaacaca tgttccatcc ctgggtccta
     4381 tgtaatggaa ggagaagaat tccacaggtc gtcctctgat acacacacac acacacacac
     4441 acacacacac acacacacac cccaccacac cacatcagta aatgtcatag tttttaaaaa
     4501 aagtattctg aacatcagag cagggagagc ataaacagag caccatgcag ctttagaaaa
     4561 ggagggtcag atagaattta gcccgagact cagagggatg acctcagtga atttcccgtg
     4621 gcagcagaaa ggcttgtctc gacttccagt aatagaaaac cgggcaattt gattatctga
     4681 ttttcgagaa atgttaatgg agttccaggg catttgtcct gttttatgtg caaatgaaaa
     4741 tctaaaaaat attagaagga cacacaccac agtcctcagg agcctcccta ccacatcttg
     4801 gaaggtgaca agcgaggggc ctgccgagac aaggttcctt agatgtgctg caaagggcgg
     4861 gtggatagag cttgggatga ccaagtttct cctcgtcctt cagggtgctc ttagcaggga
     4921 ggagagtgat ttactctctg gagctaggac ttccaccagc atgcatcaca tttaatttga
     4981 tggtctgtac tatcagaaat aactaatatc tgtgttcttt cctctcggag agcaatcaat
     5041 tatagatgtg ctagaatatt ttggcttcaa aacaaaagga ttcagaagtt taataatgat
     5101 aaaaaaaaaa agtcccaggc cttccatcgg tgccttttat tatgttgaac atttttgata
     5161 gcaagattag accatataaa tagtagacgg tgagattaaa atcataatgt ctaacaaact
     5221 taagaaaaaa tgttttaatt tgctgtgagt tcattttatg gtgcccagtg cctcatcaaa
     5281 atgcttcata attacaacaa gcaaaaaccc gggtagctct ccacagacag gccttaagtg
     5341 ccaagctcta tctgccaatt aatggagagt cctaagacag caatgatttt ttttaaagag
     5401 cctcctttaa ttgacagttt tcaactacgg gtcttaatgt cctccttaat cgcacagtag
     5461 aagcagcccg ctggctccgg catgcggcct ctcgaccagg aactttccag ggtctggaag
     5521 caggttgttt accacggtct gttggaggga atcgtcttta aaatagcaca ttgcacacgg
     5581 ggcccatggt ctttactcag aactagcatc gccaaagagg ccccaagtgt caaacaacgg
     5641 caagctgtgt gctctctcca ctgctccatg aagcaggact tgtgctcccc tccttcaggc
     5701 tgtggtcagg cctgcccaca acactgtttg ccttgaggac taatcctaac atcgctgggc
     5761 catcattatc acttggcatt tataccgaag taatccattt ccccccccct cggaaaaggc
     5821 tggaattcca tcccctctcc ccctcaaccc ccacccctat ttgaagttta ctgcatggtg
     5881 catgaaagtc tctcaacttg ggtcacgccc atgacatgac caagacgaac cagtcagcgt
     5941 ggtaggtgag gatgattggc agctgggtag tcagagccgc tgactggagc tctattttta
     6001 aagccatttg ttaggccgtc atagccagag ctttattgcc ctgggaagga tccttttttt
     6061 ctttttaact caccccactc agtctctcca tcatcttaca tcgtgagtca cacacaccat
     6121 catcaatcac caccctgacc ttcagaaatt accgcctgcc ttccacagga ttggtgggga
     6181 attctccctc aggccccagc cacctcggca cgcgtgacgc acccttctct caggggcaaa
     6241 gagcccccag gacttgtaga agggcagtgg gcagcattga gccggagagg tagacagtga
     6301 ccacactgac agaatgtgat cggttgctag tgataggagg acgggcttga agggtcagaa
     6361 ctccacggag tctataagag agcacttgtc agagagttta aaagtccaat tcagatatct
     6421 agatagaaaa gacattctaa gcccttgtac cagcaatcct tttttttccc cctcccaaga
     6481 gtgccatccc tcgtcaagac ccaacgccgg gagtaagtga ccggtgcctt tcacaacagc
     6541 atctatgtgg aaatggagtt gcccctggtt tcccaagcct ggcagcactc taaaccgcct
     6601 gaactgaaag ccgccgcggc ttcacagtgc tgacatactg cctgcttacc tacatgtaac
     6661 tcagtcctgg gatgaggact tgccaagcct gtatagatgc tcgatgacca tttttgcagt
     6721 ccgaccttgg gcaggaccta agtctatgta aaccgtgtga tatccgtttt gtttgtaaat
     6781 gcggagaaaa gaaaactcgg ctgtttgctc tttgttgtaa gatttctctt ttgtgcactt
     6841 ctgtttgcag acagtaggtc tggcacactc tggaagagtg tttcttcagc gtgactctgc
     6901 tcgtacgctc tcatagagtg tgcatgctct gtcactaaaa aactcatatg aagaatggca
     6961 tgtgaacatt ttgctaataa aatgctacgt ttacaga
//
