LOCUS       NM_001004238            1515 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB21, member RAS oncogene family (Rab21), mRNA.
ACCESSION   NM_001004238 XM_216895
VERSION     NM_001004238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Burgo,A., Proux-Gillardeaux,V., Sotirakis,E., Bun,P., Casano,A.,
            Verraes,A., Liem,R.K., Formstecher,E., Coppey-Moisan,M. and
            Galli,T.
  TITLE     A molecular network for the transport of the TI-VAMP/VAMP7 vesicles
            from cell center to periphery
  JOURNAL   Dev Cell 23 (1), 166-180 (2012)
   PUBMED   22705394
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Ohbayashi,N., Yatsu,A., Tamura,K. and Fukuda,M.
  TITLE     The Rab21-GEF activity of Varp, but not its Rab32/38 effector
            function, is required for dendrite formation in melanocytes
  JOURNAL   Mol Biol Cell 23 (4), 669-678 (2012)
   PUBMED   22171327
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   6  (bases 1 to 1515)
  AUTHORS   Burgo,A., Sotirakis,E., Simmler,M.C., Verraes,A., Chamot,C.,
            Simpson,J.C., Lanzetti,L., Proux-Gillardeaux,V. and Galli,T.
  TITLE     Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in
            neurite growth
  JOURNAL   EMBO Rep 10 (10), 1117-1124 (2009)
   PUBMED   19745841
REFERENCE   7  (bases 1 to 1515)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1515)
  AUTHORS   Eathiraj,S., Pan,X., Ritacco,C. and Lambright,D.G.
  TITLE     Structural basis of family-wide Rab GTPase recognition by
            rabenosyn-5
  JOURNAL   Nature 436 (7049), 415-419 (2005)
   PUBMED   16034420
REFERENCE   9  (bases 1 to 1515)
  AUTHORS   Simpson,J.C., Griffiths,G., Wessling-Resnick,M., Fransen,J.A.,
            Bennett,H. and Jones,A.T.
  TITLE     A role for the small GTPase Rab21 in the early endocytic pathway
  JOURNAL   J Cell Sci 117 (Pt 26), 6297-6311 (2004)
   PUBMED   15561770
REFERENCE   10 (bases 1 to 1515)
  AUTHORS   Opdam,F.J., Kamps,G., Croes,H., van Bokhoven,H., Ginsel,L.A. and
            Fransen,J.A.
  TITLE     Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21
            is an apically located GTP-binding protein in polarised intestinal
            epithelial cells
  JOURNAL   Eur J Cell Biol 79 (5), 308-316 (2000)
   PUBMED   10887961
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079323.1.
            
            On Sep 10, 2004 this sequence version replaced XM_216895.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079323.1, CF111792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1515
                     /gene="Rab21"
                     /note="RAB21, member RAS oncogene family"
                     /db_xref="GeneID:299799"
                     /db_xref="RGD:1303150"
     exon            1..373
                     /gene="Rab21"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..892
                     /gene="Rab21"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-21"
                     /protein_id="NP_001004238.1"
                     /db_xref="GeneID:299799"
                     /db_xref="RGD:1303150"
                     /translation="MAAAGGGAAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFND
                     KHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDVTDE
                     DSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTS
                     AKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQAGAARRGVQIIDDEPQAQSGSGG
                     CCSSG"
     exon            374..433
                     /gene="Rab21"
                     /inference="alignment:Splign:2.1.0"
     exon            434..541
                     /gene="Rab21"
                     /inference="alignment:Splign:2.1.0"
     exon            542..605
                     /gene="Rab21"
                     /inference="alignment:Splign:2.1.0"
     exon            606..660
                     /gene="Rab21"
                     /inference="alignment:Splign:2.1.0"
     exon            661..749
                     /gene="Rab21"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1490
                     /gene="Rab21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtagctc tctcctagcc tcgggtccct gacgtggtag ccggggccct tcattctggg
       61 actttctctc ggccctcgca ggcctcgccc gctggaggac gcggcgggca ccgggctcgg
      121 cggggcgtga gagagccggg cccgggagga gcgggcgccg cggcggcggt ggtgcggggc
      181 tcggcgcggc gctgggctcg ggcggcgggg cagcggcggg atggctgcgg ccggcggcgg
      241 ggcggcggcg gcggcgggcc gagcctactc ttttaaggtg gtgctgctcg gagaaggctg
      301 cgtggggaag acgtcgctgg tgctgcgcta ctgcgagaac aagttcaacg acaagcacat
      361 caccaccctg caggcttctt tcttaacaaa gaagttaaat attggtggga agagagtaaa
      421 ccttgctata tgggatacag ccggtcaaga gagattccat gcattgggtc caatttacta
      481 ccgagattcg aatggagcta ttttagttta tgatgtaaca gatgaagatt cttttcagaa
      541 ggtaaaaaac tgggtcaaag aattacggaa aatgttggga aatgaaatct gtttgtgtat
      601 agttggtaat aaaatagact tggaaaagga gaggcacgtc tccattcaag aagcagaatc
      661 gtatgcagag tctgtgggag caaagcatta ccatacttct gctaaacaaa acaaaggcat
      721 tgaggaactc tttcttgacc tttgtaaaag gatgatagaa acggcccagg tggatgagag
      781 ggcgaagggc aatggctcga gtcaagcagg ggctgcgagg cgcggcgtgc agatcatcga
      841 cgacgaacct caagcccaga gtggcagtgg agggtgctgt tcttctgggt aacggctcac
      901 gcctgcgaac taaacaaaat ggaactgtgg atcatccctc aacatgaaga ctgccatatt
      961 ccaagtcacg tcattttacc aatggagtta gagaattaac agtatttcca attacgtttg
     1021 taacactgca gagaccttaa gtgctaaact tagtggggtt tgtgacagag gattggcatt
     1081 ttctacaaat gttaacaaag caattaccaa tggccttttt acatattttt tctttaatga
     1141 ggaataatat gcatgtagaa aagacctact taaaggcttc atttctattc ttttaaatca
     1201 gatctttatt taataactta tatatgatgt tggaatggta tacatttttg cagtcctttg
     1261 tattttgtgg tagtttgaat tgtatcactt ctaaacagca tactgttttt gtttttgttt
     1321 tttgattagc agatacgtga agttctattt ttgcagggtt tgcacaggcc cctaactgtc
     1381 tactactttg atataatcta taaacatcct gtatgctgag ctgataaaat acattgtaaa
     1441 ttacatatta aatattttat ctgcttttac aagcgcaagg tgcaaaaata aaaaaaaaaa
     1501 aaaaaaaaaa aaaaa
//
