LOCUS       NM_031090               1413 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus RAB1A, member RAS oncogene family (Rab1a), mRNA.
ACCESSION   NM_031090
VERSION     NM_031090.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Lima,N.C.R., Melo,T.Q., Sakugawa,A.Y.S., Melo,K.P. and
            Ferrari,M.F.R.
  TITLE     Restoration of Rab1 Levels Prevents Endoplasmic Reticulum Stress in
            Hippocampal Cells during Protein Aggregation Triggered by Rotenone
  JOURNAL   Neuroscience 419, 5-13 (2019)
   PUBMED   31491505
  REMARK    GeneRIF: Restoration of Rab1 Levels Prevents Endoplasmic Reticulum
            Stress in Hippocampal Cells during Protein Aggregation Triggered by
            Rotenone.
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Liu,X., Wang,Z., Yang,Y., Li,Q., Zeng,R., Kang,J. and Wu,J.
  TITLE     Rab1A mediates proinsulin to insulin conversion in beta-cells by
            maintaining Golgi stability through interactions with golgin-84
  JOURNAL   Protein Cell 7 (9), 692-696 (2016)
   PUBMED   27502188
  REMARK    GeneRIF: Rab1A mediates proinsulin to insulin conversion in
            beta-cells by maintaining Golgi stability through interactions with
            golgin-84.
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Monteiro,A.C., Sumagin,R., Rankin,C.R., Leoni,G., Mina,M.J.,
            Reiter,D.M., Stehle,T., Dermody,T.S., Schaefer,S.A., Hall,R.A.,
            Nusrat,A. and Parkos,C.A.
  TITLE     JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c
            and regulate epithelial barrier function
  JOURNAL   Mol Biol Cell 24 (18), 2849-2860 (2013)
   PUBMED   23885123
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Preisinger,C., Korner,R., Wind,M., Lehmann,W.D., Kopajtich,R. and
            Barr,F.A.
  TITLE     Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism
            for Golgi checkpoint signalling
  JOURNAL   EMBO J 24 (4), 753-765 (2005)
   PUBMED   15678101
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Cussac,D., Leblanc,P., L'Heritier,A., Bertoglio,J., Lang,P.,
            Kordon,C., Enjalbert,A. and Saltarelli,D.
  TITLE     Rho proteins are localized with different membrane compartments
            involved in vesicular trafficking in anterior pituitary cells
  JOURNAL   Mol Cell Endocrinol 119 (2), 195-206 (1996)
   PUBMED   8807639
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Krijnse-Locker,J., Parton,R.G., Fuller,S.D., Griffiths,G. and
            Dotti,C.G.
  TITLE     The organization of the endoplasmic reticulum and the intermediate
            compartment in cultured rat hippocampal neurons
  JOURNAL   Mol Biol Cell 6 (10), 1315-1332 (1995)
   PUBMED   8573789
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     Four additional members of the ras gene superfamily isolated by an
            oligonucleotide strategy: molecular cloning of YPT-related cDNAs
            from a rat brain library
  JOURNAL   Proc Natl Acad Sci U S A 84 (23), 8210-8214 (1987)
   PUBMED   3317403
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031090.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066662.1, FQ214472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000014.1  98623677-98623876
            201-273             JAXUCZ010000014.1  98638000-98638072
            274-369             JAXUCZ010000014.1  98641510-98641605
            370-465             JAXUCZ010000014.1  98646300-98646395
            466-597             JAXUCZ010000014.1  98647658-98647789
            598-1413            JAXUCZ010000014.1  98647951-98648766
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1413
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /note="RAB1A, member RAS oncogene family"
                     /db_xref="GeneID:81754"
                     /db_xref="RGD:619736"
     exon            1..200
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..795
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /EC_number="3.6.5.2"
                     /note="RAB1, member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-1A"
                     /protein_id="NP_112352.2"
                     /db_xref="GeneID:81754"
                     /db_xref="RGD:619736"
                     /translation="MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTI
                     GVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNV
                     KQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATN
                     VEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC"
     exon            201..273
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /inference="alignment:Splign:2.1.0"
     exon            274..369
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /inference="alignment:Splign:2.1.0"
     exon            370..465
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /inference="alignment:Splign:2.1.0"
     exon            466..597
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1413
                     /gene="Rab1a"
                     /gene_synonym="Ac2-048; Rab1; Rab1r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcgatca ctgagtggcg gcggctgctg attgtgttct aagggtcgga gtggggtcga
       61 cgtttgctct accggaacag cttagctcat tcctcccctt cctttacccg tggcgcggag
      121 gcttggggcg gcggctgcgt cagcaagggc ggtggcggcg gcggcagctg cagtgacatg
      181 tccagcatga atcccgaata tgattattta ttcaagttac tcctgattgg cgactctggg
      241 gttggaaagt cttgccttct ccttaggttt gcggatgaca cgtatacgga aagctacatc
      301 agcacgattg gtgtggattt caagatacgg actatagagc tagacgggaa aacaatcaag
      361 cttcagatat gggacacagc aggccaggaa agatttcgaa caatcacctc cagttattac
      421 agaggagccc atggcatcat agttgtgtat gatgtgacag accaggagtc cttcaataac
      481 gtgaaacagt ggctgcagga gatcgatcgc tacgccagcg aaaatgtcaa caagttgttg
      541 gtagggaaca aatgtgacct gaccacaaag aaagtagtag actacacaac agccaaggaa
      601 tttgcagatt cccttggaat tccatttttg gaaaccagtg ctaagaacgc aacgaatgta
      661 gaacagtctt tcatgaccat ggcagcggag attaaaaagc ggatgggtcc tggagcaaca
      721 gctggaggtg cggagaagtc caatgttaaa atccagagca ctccagtcaa gcagtcaggt
      781 ggaggctgct gctaaaatcc gcctccgtcc ttttctcaca gcaatgaatt cgcaatctga
      841 acccaagtga aaaaacaaat tgcctgaatt gtactgtatg tagctgcact acaacagatt
      901 cttaccgttt ccacaaggtc agagattgta aatggtcaat actgactttt ttttttattc
      961 ccttgactca agacagctaa cttcattttc agaactgttt taaacctttg tgtgctggtt
     1021 tataaaataa tgtgtgtaat ccttgttgct ttcctgatac cagatcgttt cccgtggttg
     1081 gttagaatat attttgtttt gatgtttata ttggcatgtt tagatgttgg gtttagtctt
     1141 ctgaagatga agttcagcca ttttgtatca aacagcacaa ccagtgtctg tcagtttcca
     1201 tgcataaagt ttagtgagac gttatatgta agatctgatt tgctagttct tcctggtaga
     1261 gttataaatg gaaagattac actatctgat taatagtttc ttcatactct gcatataatt
     1321 tgtggctgca gaatattgta atttgttgca cactatgtaa caaaactgaa gatatgttta
     1381 ataaatattg tacttattgg aagtaatatc aaa
//
