LOCUS       NM_001012468            1776 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAB18, member RAS oncogene family (Rab18), mRNA.
ACCESSION   NM_001012468 XM_225453
VERSION     NM_001012468.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1776)
  AUTHORS   Nian,F.S., Li,L.L., Cheng,C.Y., Wu,P.C., Lin,Y.T., Tang,C.Y.,
            Ren,B.S., Tai,C.Y., Fann,M.J., Kao,L.S., Hong,C.J. and Tsai,J.W.
  TITLE     Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy
            Activities in the Nervous System: an Overlapping Mechanism for
            Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B
  JOURNAL   Mol Neurobiol 56 (9), 6095-6105 (2019)
   PUBMED   30721447
  REMARK    GeneRIF: the functions of RAB18 and RAB7 in lysosomal and
            autophagic activities may constitute an overlapping mechanism
            underlying Warburg micro syndrome and Charcot-Marie-Tooth
            Neuropathy Type 2B pathogenesis in the nervous system.
REFERENCE   2  (bases 1 to 1776)
  AUTHORS   Li,D., Zhao,Y.G., Li,D., Zhao,H., Huang,J., Miao,G., Feng,D.,
            Liu,P., Li,D. and Zhang,H.
  TITLE     The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact
            Formation
  JOURNAL   Cell Rep 27 (2), 343-358 (2019)
   PUBMED   30970241
REFERENCE   3  (bases 1 to 1776)
  AUTHORS   Dopie,J., Rajakyla,E.K., Joensuu,M.S., Huet,G., Ferrantelli,E.,
            Xie,T., Jaalinoja,H., Jokitalo,E. and Vartiainen,M.K.
  TITLE     Genome-wide RNAi screen for nuclear actin reveals a network of
            cofilin regulators
  JOURNAL   J Cell Sci 128 (13), 2388-2400 (2015)
   PUBMED   26021350
REFERENCE   4  (bases 1 to 1776)
  AUTHORS   Gerondopoulos,A., Bastos,R.N., Yoshimura,S., Anderson,R.,
            Carpanini,S., Aligianis,I., Handley,M.T. and Barr,F.A.
  TITLE     Rab18 and a Rab18 GEF complex are required for normal ER structure
  JOURNAL   J Cell Biol 205 (5), 707-720 (2014)
   PUBMED   24891604
REFERENCE   5  (bases 1 to 1776)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   6  (bases 1 to 1776)
  AUTHORS   Liegel,R.P., Handley,M.T., Ronchetti,A., Brown,S., Langemeyer,L.,
            Linford,A., Chang,B., Morris-Rosendahl,D.J., Carpanini,S.,
            Posmyk,R., Harthill,V., Sheridan,E., Abdel-Salam,G.M., Terhal,P.A.,
            Faravelli,F., Accorsi,P., Giordano,L., Pinelli,L., Hartmann,B.,
            Ebert,A.D., Barr,F.A., Aligianis,I.A. and Sidjanin,D.J.
  TITLE     Loss-of-function mutations in TBC1D20 cause cataracts and male
            infertility in blind sterile mice and Warburg micro syndrome in
            humans
  JOURNAL   Am J Hum Genet 93 (6), 1001-1014 (2013)
   PUBMED   24239381
REFERENCE   7  (bases 1 to 1776)
  AUTHORS   Gronemeyer,T., Wiese,S., Grinhagens,S., Schollenberger,L.,
            Satyagraha,A., Huber,L.A., Meyer,H.E., Warscheid,B. and Just,W.W.
  TITLE     Localization of Rab proteins to peroxisomes: a proteomics and
            immunofluorescence study
  JOURNAL   FEBS Lett 587 (4), 328-338 (2013)
   PUBMED   23333653
  REMARK    GeneRIF: Data suggest that overexpression of Rab18 in its GDP-bound
            state favors peroxisome proliferation in hepatocytes; Rab18 (as
            well as Rab6, Rab10, and Rab14) localizes to the peroxisomal
            compartment.
REFERENCE   8  (bases 1 to 1776)
  AUTHORS   Karthik,D. and Ravikumar,S.
  TITLE     Characterization of the brain proteome of rats with diabetes
            mellitus through two-dimensional electrophoresis and mass
            spectrometry
  JOURNAL   Brain Res 1371, 171-179 (2011)
   PUBMED   21112318
  REMARK    GeneRIF: Overexpression of brain RAB18 in alloxan diabetes leads to
            uneven distribution and function of intracellular-vesicular
            transport causing accumulation of protein inside the cell, this
            results in neurological disorder.
REFERENCE   9  (bases 1 to 1776)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   10 (bases 1 to 1776)
  AUTHORS   Vazquez-Martinez,R., Cruz-Garcia,D., Duran-Prado,M., Peinado,J.R.,
            Castano,J.P. and Malagon,M.M.
  TITLE     Rab18 inhibits secretory activity in neuroendocrine cells by
            interacting with secretory granules
  JOURNAL   Traffic 8 (7), 867-882 (2007)
   PUBMED   17488286
  REMARK    GeneRIF: in neuroendocrine cells, Rab18 acts as a negative
            regulator of secretory activity, likely by impairing secretory
            granule transport
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089957.1.
            
            On Apr 20, 2005 this sequence version replaced XM_225453.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089957.1, EV775276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..1776
                     /gene="Rab18"
                     /note="RAB18, member RAS oncogene family"
                     /db_xref="GeneID:307039"
                     /db_xref="RGD:1308905"
     exon            1..112
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..665
                     /gene="Rab18"
                     /codon_start=1
                     /product="ras-related protein Rab-18"
                     /protein_id="NP_001012486.1"
                     /db_xref="GeneID:307039"
                     /db_xref="RGD:1308905"
                     /translation="MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVD
                     FKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNW
                     LNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQC
                     AFEELVEKIIQTPGLWESENQNKGVKLSPREESHGGGACGGYCSVL"
     exon            113..168
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            169..230
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            231..303
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            304..422
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            423..489
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1746
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactgactgg caccgaggca gggtcggagt agagcgggtg caggatggac gaggacgtgc
       61 tgaccactct gaagatcctc atcattggcg agagtggggt gggcaagtcc agcctgctcc
      121 tgaggttcac agacgacacc tttgatccag aacttgcagc aacaataggt gttgacttta
      181 aggtgaaaac gatttcagtg gatggaaata aggctaaact tgcaatatgg gatacagctg
      241 gtcaagaaag gttcagaaca ttaactccca gctattatag aggtgcacag ggagttatat
      301 tagtctatga tgtcacaaga agagacacct ttgttaaact ggataattgg ttaaatgaat
      361 tggaaacata ctgtacaaga aatgacatag taaacatgct agttggaaat aaaattgata
      421 aggaaaaccg tgaagtcgat agaaatgaag gcttgaaatt tgcacgcaag cattctatgt
      481 tgttcataga ggcaagtgca aaaacctgtg atggtgttca gtgtgccttt gaggagctgg
      541 ttgaaaagat catccagaca cctggactgt gggaaagtga gaaccagaac aaaggagtca
      601 agctgtcccc cagggaggag agccacgggg gaggagcctg tggcggttac tgttctgtgc
      661 tataaactct gggaagccgt ctcttgcata ttggatcgga tagtgatatc tctctgtata
      721 taaactctta actgctaata gggaccttgc agtttgcaca taattgtttt tatcatggca
      781 gtgagtattt gcaagaaacc cctcgttggc tttcccaggt gaagcggtgt ggtaagcatg
      841 cagtttgcag tctatggggt tttttgaggg gggggttgtt tttgtttttg tttttggtgt
      901 tttttgtttt gggtttttat gtaacgtaaa atagatgtac cttcatgagt acatttgatt
      961 ttatgattta catttatcat gtcattttaa aaacatctgt ctagtatgtg ttgctgcaag
     1021 tctgcttttg ttttcccttt tgcttaatta ctgaattact tggtatgtag aactagaacc
     1081 atggggaggt tccccttgag gaataacaaa gcatgattca cagcttttct aggatgtttt
     1141 agagtcttag tactaagtaa aattctcagt tcagaatata gcccaggcca attcctaatt
     1201 aaatctctat ttgttctgat gatgcttcca aaatagtatt gctaatttaa ggaagtttgg
     1261 tatttacttt actccatgat tagctcagtt atccagacat taaccccgtg ttgcacacac
     1321 tgggttcctg gtcttggtgc agtgttttgg ttacatggca tcaggcaggc tttcctccat
     1381 ttgggtttca gaagaacata aacagtgtat tacagctcct ttaatactcc actttaaaac
     1441 caacgtgctt tttcacacgt gttggtagtg tttgtccagg tgcctcagtt gtaacttgtt
     1501 gtgtaatgac tgtctgtatc ttatggcttc cataaatggc tagttgctat tcagaaacac
     1561 atttttgtga tttgaagatg gggaagggaa acactataaa tgacaatttg agaaatgtct
     1621 gttgttccaa actctgactg gcggggagat gctattgcag tgagatcgtt gataagttac
     1681 tgtaacaagt agccactagt ttgttaaaaa ccaacctgta cagattaata aactttttcc
     1741 acaataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
