LOCUS       NM_001109363            1580 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RAB17, member RAS oncogene family (Rab17), mRNA.
ACCESSION   NM_001109363 XM_001066796 XM_578804
VERSION     NM_001109363.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Striz AC, Stephan AP, Lopez-Coral A and Tuma PL.
  TITLE     Rab17 regulates apical delivery of hepatic transcytotic vesicles
  JOURNAL   Mol Biol Cell 29 (23), 2887-2897 (2018)
   PUBMED   30256711
  REMARK    GeneRIF: Authors determined that transcytosis of three classes of
            newly synthesized apical residents showed similar responses to
            rab17 mutant expression, indicating that rab17 is a general
            component of the transcytotic machinery required for apically
            destined vesicle docking and fusion.
REFERENCE   2  (bases 1 to 1580)
  AUTHORS   Mori,Y., Fukuda,M. and Henley,J.M.
  TITLE     Small GTPase Rab17 regulates the surface expression of kainate
            receptors but not
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            receptors in hippocampal neurons via dendritic trafficking of
            Syntaxin-4 protein
  JOURNAL   J Biol Chem 289 (30), 20773-20787 (2014)
   PUBMED   24895134
  REMARK    GeneRIF: These data suggest that Rab17 mediates the dendritic
            trafficking of Syntaxin-4 to selectively regulate dendritic surface
            insertion of GluK2-containing KARs in rat hippocampal neurons.
REFERENCE   3  (bases 1 to 1580)
  AUTHORS   Mori Y, Matsui T, Furutani Y, Yoshihara Y and Fukuda M.
  TITLE     Small GTPase Rab17 regulates dendritic morphogenesis and
            postsynaptic development of hippocampal neurons
  JOURNAL   J Biol Chem 287 (12), 8963-8973 (2012)
   PUBMED   22291024
REFERENCE   4  (bases 1 to 1580)
  AUTHORS   Beaumont KA, Hamilton NA, Moores MT, Brown DL, Ohbayashi N,
            Cairncross O, Cook AL, Smith AG, Misaki R, Fukuda M, Taguchi T,
            Sturm RA and Stow JL.
  TITLE     The recycling endosome protein Rab17 regulates melanocytic
            filopodia formation and melanosome trafficking
  JOURNAL   Traffic 12 (5), 627-643 (2011)
   PUBMED   21291502
REFERENCE   5  (bases 1 to 1580)
  AUTHORS   Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ and Barr FA.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   6  (bases 1 to 1580)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1580)
  AUTHORS   Yoshimura S, Egerer J, Fuchs E, Haas AK and Barr FA.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   8  (bases 1 to 1580)
  AUTHORS   Hunziker W and Peters PJ.
  TITLE     Rab17 localizes to recycling endosomes and regulates
            receptor-mediated transcytosis in epithelial cells
  JOURNAL   J Biol Chem 273 (25), 15734-15741 (1998)
   PUBMED   9624171
REFERENCE   9  (bases 1 to 1580)
  AUTHORS   Zacchi P, Stenmark H, Parton RG, Orioli D, Lim F, Giner A, Mellman
            I, Zerial M and Murphy C.
  TITLE     Rab17 regulates membrane trafficking through apical recycling
            endosomes in polarized epithelial cells
  JOURNAL   J Cell Biol 140 (5), 1039-1053 (1998)
   PUBMED   9490718
REFERENCE   10 (bases 1 to 1580)
  AUTHORS   Lutcke A, Jansson S, Parton RG, Chavrier P, Valencia A, Huber LA,
            Lehtonen E and Zerial M.
  TITLE     Rab17, a novel small GTPase, is specific for epithelial cells and
            is induced during cell polarization
  JOURNAL   J Cell Biol 121 (3), 553-564 (1993)
   PUBMED   8486736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC167022.1.
            
            On May 11, 2008 this sequence version replaced NM_001109363.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167022.1, FM059624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..1580
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /note="RAB17, member RAS oncogene family"
                     /db_xref="GeneID:503269"
                     /db_xref="RGD:1562478"
     exon            1..182
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /inference="alignment:Splign:2.1.0"
     exon            183..342
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..827
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /codon_start=1
                     /product="ras-related protein Rab-17"
                     /protein_id="NP_001102833.1"
                     /db_xref="GeneID:503269"
                     /db_xref="RGD:1562478"
                     /translation="MAQAGGLPQASPSSGQPYVSKLVLLGSSSVGKTSLALRYMKQDF
                     SNVLPTVGCAFFTKVVDLGSSSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITR
                     KDSFHKAQQWLEDLEKEFHPGEVVVMLVGNKTDLGEEREVTFQEGKEFAESKSLLFME
                     SSAKLNYQVSEIFNTIAQELLQRAGDGQSSSPQEGEAVVLNQGPTVRPRQCCA"
     exon            343..494
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /inference="alignment:Splign:2.1.0"
     exon            495..620
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /inference="alignment:Splign:2.1.0"
     exon            621..714
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1557
                     /gene="Rab17"
                     /gene_synonym="RGD1562478"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggcctg cccacttcct ttgctgggct gctggtggtc agtgtgcacg gctcctcccg
       61 ccctgcccct ggcaggactc tgaccactca tccagcaccc aggagaagcc tagccagggg
      121 aagaaagggg agccagcggc cctgtgggat gatggtctgt ggaacttttt caaagtgaac
      181 aggccatggc acaggctggc gggctgccac aggccagccc ttcttctggc cagccctacg
      241 tgagcaagct ggttctgctt ggaagcagtt ctgtgggcaa gaccagcctg gccctccggt
      301 acatgaagca ggacttcagc aacgtcttgc caactgtggg gtgtgccttc ttcacaaagg
      361 tggtggactt gggttcctcg tctctgaagc ttgagatctg ggacacagcc ggccaggaga
      421 agtaccacag cgtctgccac ctctacttcc ggggtgctaa tgctgcgctc ctggtttatg
      481 acatcactag gaaggattcc tttcacaagg cccagcagtg gctggaggac ctggagaagg
      541 agttccatcc aggagaggtg gtggtgatgc tggtcggcaa caaaacggat ctcggcgagg
      601 agcgggaagt gaccttccag gaaggaaaag agtttgcgga gagcaaaagc ctgctgttca
      661 tggaatcctc tgccaagctg aactaccagg tatccgagat cttcaacacc attgcccagg
      721 agctgctaca gagagcagga gatgggcaga gcagcagccc acaggagggt gaggctgtgg
      781 ttctgaacca gggacctaca gtcaggccgc gccagtgctg tgcatgacag ccgctgccac
      841 tgcaggagag cgagtggagg atagctcagc ctgtgcttcc gagggtcccc agcccaagct
      901 acatcttcaa gagtctgctg gctctttgtc cattcatgtt ctctgtcgaa gatggcttgt
      961 gggtgagctc tggaggctac cagaagttgc tttcctttgt aataaccgct tgccaaagct
     1021 gatgggaact gtctcaggga ggatccagtg tcaagtggct tccagaagac tgtcagccct
     1081 accttaccag atacacagat acctgaatgc tctgagccaa gtgtgcctgc cccgcctggg
     1141 ctgtcccttt cagcttcttt acagccatcg cagaagaatt aaaggaagca gagcggtgtg
     1201 gactggaaca attctttgat ccatggaata ggacgacaga tgcttcatcc cgggtcagct
     1261 ggtccgtaat gacaccactt tcgttctggg aactgtcagg ggaagagaag ggacatcaat
     1321 gcaaggaaaa atgtagagat gagccaagga aaaaatgagc ccaaggtact aagtctcagt
     1381 gaggtggcgc tggagacaga gtctggaagg gtggctggga tggatggtcc tttccatctg
     1441 tggctgggca gagccaggtt tctctctcgt gattcgagga ctctgaaacc cctgtcctga
     1501 gatcaacacc gggctgtctc accttctctc caaatattaa atgtcttgac aatctgaaaa
     1561 aaaaaaaaaa aaaaaaaaaa
//
