LOCUS       NM_031092                760 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus RAB13, member RAS oncogene family (Rab13), mRNA.
ACCESSION   NM_031092
VERSION     NM_031092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 760)
  AUTHORS   Lindsay,L.A., Nasir,R.F., Dowland,S.N., Madawala,R.J. and
            Murphy,C.R.
  TITLE     Rab13 and Desmosome Redistribution in Uterine Epithelial Cells
            During Early Pregnancy
  JOURNAL   Reprod Sci 28 (7), 1981-1988 (2021)
   PUBMED   33527312
  REMARK    GeneRIF: Rab13 and Desmosome Redistribution in Uterine Epithelial
            Cells During Early Pregnancy.
REFERENCE   2  (bases 1 to 760)
  AUTHORS   Deng,B., Zhu,X., Zhao,Y., Zhang,D., Pannu,A., Chen,L. and Niu,W.
  TITLE     PKC and Rab13 mediate Ca2+ signal-regulated GLUT4 traffic
  JOURNAL   Biochem Biophys Res Commun 495 (2), 1956-1963 (2018)
   PUBMED   29247648
  REMARK    GeneRIF: In summary, ionomycin-promoted exocytosis of GLUT4 is
            partly reversed by siPKCtheta;, whereas ionomycin-inhibited
            endocytosis of GLUT4 requires both siPKCalpha and siPKCtheta;.
            PKCalpha and PKCtheta; contribute to ionomycin-induced
            phosphorylation of AS160 and TBC1D1. Rab13 is required for
            ionomycin-regulated GLUT4 exocytosis.
REFERENCE   3  (bases 1 to 760)
  AUTHORS   Sun,Y., Jaldin-Fincati,J., Liu,Z., Bilan,P.J. and Klip,A.
  TITLE     A complex of Rab13 with MICAL-L2 and alpha-actinin-4 is essential
            for insulin-dependent GLUT4 exocytosis
  JOURNAL   Mol Biol Cell 27 (1), 75-89 (2016)
   PUBMED   26538022
  REMARK    GeneRIF: Findings suggest that MICAL-L2 is an effector of
            insulin-activated Rab13, which links to GLUT4 through ACTN4,
            localizing GLUT4 vesicles at the muscle cell periphery to enable
            their fusion with the membrane.
REFERENCE   4  (bases 1 to 760)
  AUTHORS   Klip,A., Sun,Y., Chiu,T.T. and Foley,K.P.
  TITLE     Signal transduction meets vesicle traffic: the software and
            hardware of GLUT4 translocation
  JOURNAL   Am J Physiol Cell Physiol 306 (10), C879-C886 (2014)
   PUBMED   24598362
  REMARK    Review article
REFERENCE   5  (bases 1 to 760)
  AUTHORS   Hirvonen,M.J., Buki,K.G., Sun,Y., Mulari,M.T., Harkonen,P.L. and
            Vaananen,K.H.
  TITLE     Novel interaction of Rab13 and Rab8 with endospanins
  JOURNAL   FEBS Open Bio 3, 83-88 (2013)
   PUBMED   23772379
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 760)
  AUTHORS   Marzesco,A.M., Dunia,I., Pandjaitan,R., Recouvreur,M., Dauzonne,D.,
            Benedetti,E.L., Louvard,D. and Zahraoui,A.
  TITLE     The small GTPase Rab13 regulates assembly of functional tight
            junctions in epithelial cells
  JOURNAL   Mol Biol Cell 13 (6), 1819-1831 (2002)
   PUBMED   12058051
REFERENCE   7  (bases 1 to 760)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   8  (bases 1 to 760)
  AUTHORS   Sheth,B., Fontaine,J.J., Ponza,E., McCallum,A., Page,A., Citi,S.,
            Louvard,D., Zahraoui,A. and Fleming,T.P.
  TITLE     Differentiation of the epithelial apical junctional complex during
            mouse preimplantation development: a role for rab13 in the early
            maturation of the tight junction
  JOURNAL   Mech Dev 97 (1-2), 93-104 (2000)
   PUBMED   11025210
REFERENCE   9  (bases 1 to 760)
  AUTHORS   Zahraoui,A., Joberty,G., Arpin,M., Fontaine,J.J., Hellio,R.,
            Tavitian,A. and Louvard,D.
  TITLE     A small rab GTPase is distributed in cytoplasmic vesicles in non
            polarized cells but colocalizes with the tight junction marker ZO-1
            in polarized epithelial cells
  JOURNAL   J Cell Biol 124 (1-2), 101-115 (1994)
   PUBMED   8294494
REFERENCE   10 (bases 1 to 760)
  AUTHORS   Elferink,L.A., Anzai,K. and Scheller,R.H.
  TITLE     rab15, a novel low molecular weight GTP-binding protein
            specifically expressed in rat brain
  JOURNAL   J Biol Chem 267 (9), 5768-5775 (1992)
   PUBMED   1313420
  REMARK    Erratum:[J Biol Chem. 1992 Nov 5;267(31):22693.. PMID: 1429617]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031092.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF525280.1, FQ222701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000002.1  177972970-177973178
            210-270             JAXUCZ010000002.1  177974324-177974384
            271-331             JAXUCZ010000002.1  177975617-177975677
            332-409             JAXUCZ010000002.1  177975894-177975971
            410-499             JAXUCZ010000002.1  177976418-177976507
            500-565             JAXUCZ010000002.1  177976591-177976656
            566-619             JAXUCZ010000002.1  177976737-177976790
            620-760             JAXUCZ010000002.1  177977225-177977365
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..760
                     /gene="Rab13"
                     /note="RAB13, member RAS oncogene family"
                     /db_xref="GeneID:81756"
                     /db_xref="RGD:620880"
     exon            1..209
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..697
                     /gene="Rab13"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-13"
                     /protein_id="NP_112354.1"
                     /db_xref="GeneID:81756"
                     /db_xref="RGD:620880"
                     /translation="MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNSTYISTIGID
                     FKIRTVEIEGKRIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNW
                     MKSIKENASAGVERLLLGNKCDMEAKRKVQREQAERLAREHRIRFFETSAKSSVNVDE
                     AFSSLARDILLKTGGRRSGNSSKPSSTDLKVSDKKNSNKCSLG"
     exon            210..270
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
     exon            271..331
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
     exon            332..409
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
     exon            410..499
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
     exon            500..565
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
     exon            566..619
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
     exon            620..760
                     /gene="Rab13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggtttct gcctgccaac cctccgatcc cgcctaccag cgttggctct tcccgacccc
       61 tcccccggcg cccccagtgt ccgccatggc caaagcctac gaccacctct tcaagttgct
      121 gctgatcggg gactcggggg tgggcaagac ttgtctcatc attcgctttg cagaggacaa
      181 cttcaacagc acttacatct ccaccatcgg aattgatttc aagatccgaa ctgtggaaat
      241 agaggggaag agaatcaaac tgcaagtctg ggacacagct ggccaagaac gattcaagac
      301 aataaccacc gcctattacc gtggagccat gggcattatc ctagtatatg acatcacaga
      361 tgagaaatcc ttcgagaata ttcagaactg gatgaaaagc atcaaagaga acgcgtctgc
      421 tggagtggag cgccttctgc tggggaacaa atgtgacatg gaagccaagc ggaaggtgca
      481 gagagagcag gctgagaggt tggcccgaga gcacagaatc cgattttttg agacaagtgc
      541 caaatccagt gtgaatgtgg atgaggcttt cagttccctg gcccgtgaca tcttgctcaa
      601 gacaggaggc cggagatcgg gaaacagcag caagccctca agcactgacc tgaaagtatc
      661 tgacaagaag aacagcaaca agtgctcctt gggctgagga acatttcttg cctcctattc
      721 accctgaacc tggaggctag acctgaggga ggtggactga
//
