LOCUS       NM_013017               1984 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus RAB12, member RAS oncogene family (Rab12), mRNA.
ACCESSION   NM_013017 XM_001053530 XM_343639
VERSION     NM_013017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1984)
  AUTHORS   Efergan,A., Azouz,N.P., Klein,O., Noguchi,K., Rothenberg,M.E.,
            Fukuda,M. and Sagi-Eisenberg,R.
  TITLE     Rab12 Regulates Retrograde Transport of Mast Cell Secretory
            Granules by Interacting with the RILP-Dynein Complex
  JOURNAL   J Immunol 196 (3), 1091-1101 (2016)
   PUBMED   26740112
  REMARK    GeneRIF: we identified the small GTPase Rab12 as a novel regulator
            of mast cell secretory granule transport
REFERENCE   2  (bases 1 to 1984)
  AUTHORS   Sirohi,K., Chalasani,M.L., Sudhakar,C., Kumari,A., Radha,V. and
            Swarup,G.
  TITLE     M98K-OPTN induces transferrin receptor degradation and
            RAB12-mediated autophagic death in retinal ganglion cells
  JOURNAL   Autophagy 9 (4), 510-527 (2013)
   PUBMED   23357852
REFERENCE   3  (bases 1 to 1984)
  AUTHORS   Matsui,T., Itoh,T. and Fukuda,M.
  TITLE     Small GTPase Rab12 regulates constitutive degradation of
            transferrin receptor
  JOURNAL   Traffic 12 (10), 1432-1443 (2011)
   PUBMED   21718402
REFERENCE   4  (bases 1 to 1984)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   5  (bases 1 to 1984)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   6  (bases 1 to 1984)
  AUTHORS   Iida,H., Wang,L., Nishii,K., Ookuma,A. and Shibata,Y.
  TITLE     Identification of rab12 as a secretory granule-associated small
            GTP-binding protein in atrial myocytes
  JOURNAL   Circ Res 78 (2), 343-347 (1996)
   PUBMED   8575079
REFERENCE   7  (bases 1 to 1984)
  AUTHORS   Elferink,L.A., Anzai,K. and Scheller,R.H.
  TITLE     rab15, a novel low molecular weight GTP-binding protein
            specifically expressed in rat brain
  JOURNAL   J Biol Chem 267 (9), 5768-5775 (1992)
   PUBMED   1313420
  REMARK    Erratum:[J Biol Chem. 1992 Nov 5;267(31):22693.. PMID: 1429617]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB692926.1, M83676.1, DY310463.1, AI706856.1, CK841014.1 and
            AI029303.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_343639.3, XM_001053530.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               CB692926.1         1-205
            206-521             M83676.1           1-316
            522-1138            DY310463.1         43-659
            1139-1512           AI706856.1         14-387              c
            1513-1964           CK841014.1         18-469              c
            1965-1984           AI029303.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1984
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..1984
                     /gene="Rab12"
                     /note="RAB12, member RAS oncogene family"
                     /db_xref="GeneID:25530"
                     /db_xref="RGD:3527"
     exon            1..290
                     /gene="Rab12"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..799
                     /gene="Rab12"
                     /note="ras-related protein Rab-12-like"
                     /codon_start=1
                     /product="ras-related protein Rab-12"
                     /protein_id="NP_037149.1"
                     /db_xref="GeneID:25530"
                     /db_xref="RGD:3527"
                     /translation="MDPSAALHRRPAGGGLGAVSPALSGGQARRRKQPPRPADFKLQV
                     IIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQER
                     FNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCET
                     DREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDVLRSELSN
                     SILSLQPEPEIPPELPPPRPHVRCC"
     exon            291..351
                     /gene="Rab12"
                     /inference="alignment:Splign:2.1.0"
     exon            352..490
                     /gene="Rab12"
                     /inference="alignment:Splign:2.1.0"
     exon            491..580
                     /gene="Rab12"
                     /inference="alignment:Splign:2.1.0"
     exon            581..685
                     /gene="Rab12"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1967
                     /gene="Rab12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggtggag ggtgcgcggg ggcccggggc gcgcggacgg cggcccgagc gcgagccgta
       61 tgcgtgcatg gatccgagcg ccgcgctgca ccggcggccc gcgggcggcg gcctgggcgc
      121 ggtctccccg gcgctgtccg gcggccaggc ccgtcggagg aagcagcccc ccaggccggc
      181 cgacttcaag ctgcaggtca tcatcatcgg ctcccgcggc gtgggcaaga ccagcctgat
      241 ggagcgcttc accgacgaca cgttctgcga ggcctgcaag tccaccgtgg gtgttgactt
      301 taaaatcaag actgtagaac taagagggaa gaaaattaga ttacagatct gggacacagc
      361 agggcaggag cgattcaaca gcattacctc agcctattac agaagtgcca aggggatcat
      421 actcgtgtat gacatcacca agaaagagac gttcgatgac ttgccaaagt ggatgaagat
      481 gatcgataag tatgcttcag aagacgctga gcttctcctg gtcggaaata agctggactg
      541 tgaaacagac agagaaatct ccaggcagca aggagaaaag tttgcacagc agataaccgg
      601 gatgcggttc tgcgaagcca gtgccaagga caatttcaac gtggatgaga tctttctgaa
      661 actcgttgat gatattttga aaaagatgcc tctcgatgtt ttgagaagcg agttatccaa
      721 tagcatcctc tctctacaac cagagcctga gatcccacca gagctgcctc cacccagacc
      781 acacgtccga tgctgttgat ttgatacttt ggagatggtg caagccattg ctagaagggg
      841 aaagcattct gctctgcact acaatcacgt gacaacttcc tttcgcactt tgtaacccaa
      901 gtcagctaca cactaacttg taaatatgca aatatgcaat cctgggtgag gtcgggttat
      961 aggttacaca cgtcccttca gattatattt cctccttatc ccagtgtcta gtgtacatac
     1021 actgggagac gtagtacttc taatatgaag aatgggagag aaacgtcctt gttaactaca
     1081 ctataaggca gacactccga tgagaagaca ggacctggtg cttcgcttgc tgtttcaacg
     1141 aaaatctaca aaaactgaag atttttttga aaaggaagac aagacaactg ccttttcttt
     1201 atttatgagg ctttctccat gtagcatctc aaggtttgga gtgtctctgc cccaaagcaa
     1261 agcttccttc acagccacca gtgagattac atatggctat gaattgagaa ggttttccta
     1321 gataggggac tggattggac ttggtcctgc ggctgcagaa cctggggttt tcccactggc
     1381 tgcaaccttc ttttaagaat gaaaaagatt caatcgagaa agacctgaag ggctgggatt
     1441 gtagctcagt aattgagcat ttttccagcg tacgtgaggc tctgggttca atccctgtca
     1501 tcacaaggaa aggaaaaaga gaaagaaaaa gaagcatttt gaaaactata gaaaagattt
     1561 taaaatcata ctgctgtcct acagaaatcc tgtttaaagg gattttaaga gttacatttt
     1621 agtatatcaa agaatacaca tgcatttgcc taaacactct gtatctttgt aacgataaac
     1681 ttctcccctt ggtggtgaag cttatgccta tttagcctag actgtgttca agttttcttg
     1741 ttttgttttg tttttttctt gagggttttt tttcctggtc tgataaggaa tttgtgaact
     1801 ctatctttgg tatacctttt attaaactgc accgttttgt ttagtcgagg taaataagta
     1861 tgtatttgaa taacttggcg tgtcctgagt gttgtggtat gagaagcatc gtggtctttc
     1921 tacactaatg aagtgcaaat aaagttttgt atttatgaat gacagttaaa aaaaaaaaaa
     1981 aaaa
//
