LOCUS       NM_017359               2738 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus RAB10, member RAS oncogene family (Rab10), mRNA.
ACCESSION   NM_017359 XM_346787
VERSION     NM_017359.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Bruno,J., Brumfield,A., Chaudhary,N., Iaea,D. and McGraw,T.E.
  TITLE     SEC16A is a RAB10 effector required for insulin-stimulated GLUT4
            trafficking in adipocytes
  JOURNAL   J Cell Biol 214 (1), 61-76 (2016)
   PUBMED   27354378
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Gerondopoulos,A., Bastos,R.N., Yoshimura,S., Anderson,R.,
            Carpanini,S., Aligianis,I., Handley,M.T. and Barr,F.A.
  TITLE     Rab18 and a Rab18 GEF complex are required for normal ER structure
  JOURNAL   J Cell Biol 205 (5), 707-720 (2014)
   PUBMED   24891604
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Xu,X.H., Deng,C.Y., Liu,Y., He,M., Peng,J., Wang,T., Yuan,L.,
            Zheng,Z.S., Blackshear,P.J. and Luo,Z.G.
  TITLE     MARCKS regulates membrane targeting of Rab10 vesicles to promote
            axon development
  JOURNAL   Cell Res 24 (5), 576-594 (2014)
   PUBMED   24662485
  REMARK    GeneRIF: Either genetic silencing of MARCKS or disruption of its
            interaction with Rab10 inhibited axon growth of cortical neurons.
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Babbey,C.M., Ahktar,N., Wang,E., Chen,C.C., Grant,B.D. and
            Dunn,K.W.
  TITLE     Rab10 regulates membrane transport through early endosomes of
            polarized Madin-Darby canine kidney cells
  JOURNAL   Mol Biol Cell 17 (7), 3156-3175 (2006)
   PUBMED   16641372
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Chen,Y.T., Holcomb,C. and Moore,H.P.
  TITLE     Expression and localization of two low molecular weight GTP-binding
            proteins, Rab8 and Rab10, by epitope tag
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6508-6512 (1993)
   PUBMED   7688123
REFERENCE   9  (bases 1 to 2738)
  AUTHORS   Elferink,L.A., Anzai,K. and Scheller,R.H.
  TITLE     rab15, a novel low molecular weight GTP-binding protein
            specifically expressed in rat brain
  JOURNAL   J Biol Chem 267 (9), 5768-5775 (1992)
   PUBMED   1313420
  REMARK    Erratum:[J Biol Chem. 1992 Nov 5;267(31):22693.. PMID: 1429617]
REFERENCE   10 (bases 1 to 2738)
  AUTHORS   Araki,W., Ohno,K., Matsunaga,K., Nakamura,H., Sugimoto,C. and
            Shimada,T.
  TITLE     [Two sisters with pseudoidiopathic hypoparathyroidism presenting
            extensive intracranial calcification]
  JOURNAL   Nihon Naika Gakkai Zasshi 78 (1), 81-82 (1989)
   PUBMED   2732579
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085744.1.
            
            On Mar 27, 2005 this sequence version replaced NM_017359.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085744.1, BC070518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2738
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /note="RAB10, member RAS oncogene family"
                     /db_xref="GeneID:50993"
                     /db_xref="RGD:620879"
     exon            1..175
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..651
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /EC_number="3.6.5.2"
                     /note="ras-related protein rab10"
                     /codon_start=1
                     /product="ras-related protein Rab-10"
                     /protein_id="NP_059055.2"
                     /db_xref="GeneID:50993"
                     /db_xref="RGD:620879"
                     /translation="MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGI
                     DFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISK
                     WLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIE
                     KAFLTLAEDILRKTPVKEPNSENVDISSGGGVTGWKSKCC"
     exon            176..236
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /inference="alignment:Splign:2.1.0"
     exon            237..375
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /inference="alignment:Splign:2.1.0"
     exon            376..465
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /inference="alignment:Splign:2.1.0"
     exon            466..567
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /inference="alignment:Splign:2.1.0"
     exon            568..2729
                     /gene="Rab10"
                     /gene_synonym="Ac1075"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgatccctt ggggctaccg gcggcgagcg cccgagccgc tcctcccaat ggcgaagaag
       61 acgtacgacc tgcttttcaa gctgctcctg atcggggact cgggagtggg caagacctgc
      121 gtcctttttc gtttttcgga tgatgccttc aataccacct ttatttccac cataggaata
      181 gactttaaga tcaaaacagt ggaactacaa ggaaagaaga tcaagctaca gatatgggac
      241 acagcaggcc aggaacgatt tcacaccatc acaacctcct actacagagg agcaatgggc
      301 atcatgctag tgtatgacat caccaacggt aaaagttttg aaaacatcag caagtggctt
      361 agaaacatag atgagcatgc caatgaagat gtggaaagga tgttactagg gaacaagtgt
      421 gacatggacg acaagagagt tgtaccgaaa ggcaaaggag agcagattgc aagggagcat
      481 ggtattaggt tttttgagac tagtgcaaaa gcaaatataa acatcgaaaa ggcgttcctc
      541 acattagctg aagacatcct ccgaaagacc cctgtaaaag aacccaacag tgaaaacgta
      601 gatatcagca gtggaggagg tgtgacgggc tggaagagca aatgctgctg agcgctctcc
      661 cgtccatctg ttgccatcca ccatccgttt ctcttcttgc tgcaaaataa aacactctgt
      721 ccatttttaa ctctaaacag atatttttgt tcctcatctt aactattcag tccacctatt
      781 ttatttgttc tttcatctgt gactgcttgc ggactattat aattttcttc aaacaaaaaa
      841 aatgtataga gaaatcatgt ccgacttcat tttcagatgt tcttgctcag ctcaccactg
      901 cacttctgtt gtattatagt ccagctctta tcaacattaa ctacagcaat catttcaact
      961 ctattctgca aattgtataa gaataaaagt tagaattaac aattttattt tgtacaacag
     1021 tgggattttc tgtcatgaat aatgtgcttg agtcctataa cctatagatg tgatagcaaa
     1081 gaaacacaag ccaggaaaac attcatttcc cctgaatcag tacgtggggt taattttgtc
     1141 ctgtgcctta tgtggaaagg aactactttg gtttctcttt tttgttcggt ggaagcatgt
     1201 gcaggagaca tttcatccca acataaaccc gttcagatgc ttgtggtttg cttggctgta
     1261 tctttcacag tagttaaccg aggacaaagg gtaatgcaga agtgatactt gatttccagt
     1321 ctcattccca gtggccttga tatttaaact gattcccgcc accaggtcct tgggccactc
     1381 tgtccctgcg tctcatcttt ctgcatgctg ctttgtttgc ccccactact cctggtatga
     1441 gttatttaaa aatgaaaggt ttgtcaagtt taacataaag cactgattta ccttgctaag
     1501 taaacagaaa gataaattct aactgcctat atcagatgtc agttaatcgg tgtcagcccc
     1561 tcatttactc tctcctaaaa cctgacccgc agtttgcctt ctgttcccct cccccctcct
     1621 gtctatccat ggagtttatg aaatggaaga gttattgcat gcactagtgt ttggagggtg
     1681 ttgtggtttg tctctaatta ggtgtatatc ctattcactt tcctagaata agcctcttaa
     1741 cctgaatgtg actagtctcc attatggcga ctcctctggc agttcagtag cccaggaaag
     1801 actggtttta aaaagaccat aaagagcaag gaggagtggt cttagcgttt gccaaatgta
     1861 ttgagatttg gcctctgaag aacactttcg gtattgtctt tactgtaaga tttagaaata
     1921 catcataata ttattaattt caagtcctat ctttacatcc tctcagaaaa cttattaccg
     1981 tgaatttttt aaaaaagaaa aaggacagca aaaggcttct cgtgtaaagc tgagctctct
     2041 ggctctgtcc gaccccatcc ttctttctct gttctagttt ggcttcattg cttctcatta
     2101 ggatagggta ggcgaagttc cctatgctgc tagcatccta agatgatacc tttgtggaaa
     2161 taattgtgaa tagcatgatt catttcaagc agaggctgag tttaggacag cagctaccat
     2221 tgagaagatg tctgtgacac gcattttaat gacctcttgg ctcacataaa caatataggg
     2281 acatatctgc taaaagagcc catggtcttt tcagatagtg ccctaaagac aattttatat
     2341 gcctcactgg tggttcttag ggtccccctc acttgactct atcattgttt actagtaaaa
     2401 agcagcattg ccaaataatc cctgattttc cactatgaaa aatgcaatgt ctaagctttt
     2461 gaagtttgta ggttaaacct actgttgtta gttagatctt tgctgtttgt gttgcttccc
     2521 tctatctgga ttgtggcggt cgcctcttta ctttaaactt tgtttaaccc ttaattcagt
     2581 gacttaaggt ttggagatac acactgggat tttggctaac agactgacag ttttgttgtt
     2641 tgcataatta taatcggcac tgtacagaga aaagatatgg cctcctttgt taaatctgca
     2701 ctttctgaat atcaaaaaaa aaaaaaaaaa aaaaaaaa
//
