LOCUS       NM_001008886            2682 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RT1 class Ib, locus S3 (RT1-S3), mRNA.
ACCESSION   NM_001008886 XM_001072449 XM_215303
VERSION     NM_001008886.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2682)
  AUTHORS   Rolle A, Meyer M, Calderazzo S, Jager D and Momburg F.
  TITLE     Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector
            Functions of Adaptive NK Cells
  JOURNAL   Cell Rep 24 (8), 1967-1976 (2018)
   PUBMED   30134159
REFERENCE   2  (bases 1 to 2682)
  AUTHORS   Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain
            V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha
            JB, Abdulhaqq S, Greene JM, Fruh K, Marshall E, Picker LJ, Jones
            EY, McMichael AJ and Gillespie GM.
  TITLE     Pathogen-derived HLA-E bound epitopes reveal broad primary anchor
            pocket tolerability and conformationally malleable peptide binding
  JOURNAL   Nat Commun 9 (1), 3137 (2018)
   PUBMED   30087334
  REMARK    Erratum:[Nat Commun. 2018 Nov 13;9(1):4833. PMID: 30420666]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2682)
  AUTHORS   Harriff MJ, Wolfe LM, Swarbrick G, Null M, Cansler ME, Canfield ET,
            Vogt T, Toren KG, Li W, Jackson M, Lewinsohn DA, Dobos KM and
            Lewinsohn DM.
  TITLE     HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis
            Protein MPT32 to Human CD8+ T cells
  JOURNAL   Sci Rep 7 (1), 4622 (2017)
   PUBMED   28676677
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2682)
  AUTHORS   Caccamo N, Pietra G, Sullivan LC, Brooks AG, Prezzemolo T, La Manna
            MP, Di Liberto D, Joosten SA, van Meijgaarden KE, Di Carlo P,
            Titone L, Moretta L, Mingari MC, Ottenhoff TH and Dieli F.
  TITLE     Human CD8 T lymphocytes recognize Mycobacterium tuberculosis
            antigens presented by HLA-E during active tuberculosis and express
            type 2 cytokines
  JOURNAL   Eur J Immunol 45 (4), 1069-1081 (2015)
   PUBMED   25631937
  REMARK    Erratum:[Eur J Immunol. 2019 Jun;49(6):971. PMID: 31161602]
REFERENCE   5  (bases 1 to 2682)
  AUTHORS   Yucesoy B, Johnson VJ, Lummus ZL, Kashon ML, Rao M,
            Bannerman-Thompson H, Frye B, Wang W, Gautrin D, Cartier A, Boulet
            LP, Sastre J, Quirce S, Tarlo SM, Germolec DR, Luster MI and
            Bernstein DI.
  TITLE     Genetic variants in the major histocompatibility complex class I
            and class II genes are associated with diisocyanate-induced Asthma
  JOURNAL   J Occup Environ Med 56 (4), 382-387 (2014)
   PUBMED   24709764
REFERENCE   6  (bases 1 to 2682)
  AUTHORS   Salgar SK, Kunz HW and Gill TJ 3rd.
  TITLE     Structural organization, sequence analysis, and physical mapping of
            the Grc-linked class Ib gene RT1.S3 in the rat
  JOURNAL   Immunogenetics 48 (1), 76-81 (1998)
   PUBMED   9601949
REFERENCE   7  (bases 1 to 2682)
  AUTHORS   Braud VM, Allan DS, O'Callaghan CA, Soderstrom K, D'Andrea A, Ogg
            GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL and
            McMichael AJ.
  TITLE     HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
  JOURNAL   Nature 391 (6669), 795-799 (1998)
   PUBMED   9486650
REFERENCE   8  (bases 1 to 2682)
  AUTHORS   Braud VM, Allan DS, Wilson D and McMichael AJ.
  TITLE     TAP- and tapasin-dependent HLA-E surface expression correlates with
            the binding of an MHC class I leader peptide
  JOURNAL   Curr Biol 8 (1), 1-10 (1998)
   PUBMED   9427624
REFERENCE   9  (bases 1 to 2682)
  AUTHORS   Attaya M, Jameson S, Martinez CK, Hermel E, Aldrich C, Forman J,
            Lindahl KF, Bevan MJ and Monaco JJ.
  TITLE     Ham-2 corrects the class I antigen-processing defect in RMA-S cells
  JOURNAL   Nature 355 (6361), 647-649 (1992)
   PUBMED   1538753
REFERENCE   10 (bases 1 to 2682)
  AUTHORS   Parker KE, Carter CA and Fabre JW.
  TITLE     A rat class I cDNA clone with an Alu-like sequence and mapping to
            two genes in RT1.C/E
  JOURNAL   Immunogenetics 31 (3), 211-214 (1990)
   PUBMED   1969387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK599963.1, AJ243976.1 and BX883048.1.
            
            On Oct 23, 2009 this sequence version replaced NM_001008886.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029241.1, FQ209394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               CK599963.1         1-656
            657-1151            AJ243976.1         554-1048
            1152-2682           BX883048.1         299002-300532       c
FEATURES             Location/Qualifiers
     source          1..2682
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2682
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /note="RT1 class Ib, locus S3"
                     /db_xref="GeneID:294228"
                     /db_xref="RGD:735037"
     exon            1..106
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1137
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /note="RT1 class Ib, locus BM1; MHC class Ib RT1.S3;
                     histocompatibility 2, T region locus 23"
                     /codon_start=1
                     /product="RT1 class Ib, locus S3 precursor"
                     /protein_id="NP_001008886.2"
                     /db_xref="GeneID:294228"
                     /db_xref="RGD:735037"
                     /translation="MRMLPPAYLLQLLAGTMVLTQTSSHSLRYFYTALSRPGLGEPRF
                     IVVGYVDDTQFVRYDSDVENPRMEPRARWMEQEEPAYWERETRKARDTGRNFKVNLRT
                     LLRYYNQSDDESHTLQWMYGCDVGPDGHLLRGYCQEAYDGRDYISLNEDLRSWTATDM
                     ASQASKIKSEEVGEAHHQRAYLQGPCVEWLHTYLHLGKETLLRSDPPKAHVTLHPRPE
                     GDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWAAVVVPSGEE
                     LKYTCHVEHEGLPEPLALRWEPSPFTDSSMPVIVVLGAVAIIGAVAIIGAVAIIGAVV
                     RRRKRNTGEKGSYAHVLGSKAFQISDWPQKA"
     exon            107..376
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..652
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..928
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1063
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1093
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1141
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..2682
                     /gene="RT1-S3"
                     /gene_synonym="H2-T23; RT-BM1; RT1-BM1; RTBM1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacacaacc cacattcatg tttttcacag tccctgggca tgaggatgtt acctcctgcc
       61 tatttgctcc aactactggc aggcaccatg gtcctgaccc agactagctc acactcgctg
      121 cggtatttct acaccgccct gtcccggccc ggcctcgggg agcccaggtt cattgtcgtt
      181 ggctacgtgg acgacacgca gttcgtgcgc tatgacagcg atgtggagaa tccgaggatg
      241 gagccacggg cgcggtggat ggagcaggag gagccggcat attgggagcg ggagactcgg
      301 aaagccaggg acaccgggag gaacttcaaa gtgaatctga ggaccctgct ccgctactac
      361 aatcagagtg acgacgaatc tcacacgctg cagtggatgt acggctgcga cgtggggccc
      421 gatgggcacc tgctccgcgg ttattgtcag gaggcttatg acggccggga ttatatctcc
      481 ttgaacgagg acctgcgctc ctggaccgcg actgacatgg cctcacaggc ctctaagatc
      541 aagtcagagg aagttggtga ggcccatcac cagagggcct acctgcaagg tccttgcgtg
      601 gagtggctcc acacatacct acatctggga aaggagacgc tgctgcgctc agacccccca
      661 aaggcacatg tgacccttca ccccagacct gaaggtgatg tcaccctgag gtgctgggcc
      721 ctgggcttct accctgctga catcaccttg acctggcaat tgaatgggga ggacctgacc
      781 caggacatgg agcttgtgga gaccaggcct gcaggggatg gaaccttcca gaagtgggca
      841 gctgtggtag tgccttctgg ggaggagctg aagtacacat gccatgtgga gcatgaggga
      901 ctgcctgaac ctctcgccct gagatgggag ccttctccat tcaccgactc cagcatgcca
      961 gtgattgttg tccttggagc tgtggccatc attggagctg tggccatcat tggagctgtg
     1021 gccatcattg gagctgttgt gaggaggagg aagagaaaca caggtgaaaa aggcagctat
     1081 gctcatgttc taggcagcaa ggctttccag atctctgact ggcctcagaa ggcatgaaaa
     1141 gacagttgcc tcgtggggct gagcgacaag ttctgactaa acatctgagg gagctgcttc
     1201 ccctgaggac aatgtgaaga actggcaatc ccagaccttc ttgcctccct ggacacctga
     1261 cttcacaaca gaaaataatc tgactctggg ctgggtgttt cctattgctt ttatctgcac
     1321 tgagtggaaa tgcggtttcc aacagtgtaa cgcagtaccg ttgtgtggtg gtagtgacat
     1381 tgcacacagg tttgtgagct gggggtgtga tgtgcttttg ttactgtagg cagaacaagc
     1441 tagaagtcca ccattcctct tatggtcatt gttttaaaac aaaacaaatg ctggagagat
     1501 ggctcagtgt taagagcact gacttctctt acagaggtcc tggttcaaat cccagcaacc
     1561 acatggtggc tcacaaccat atgtaatgag atctgatgct ctcttctgat gtgtctgaac
     1621 acagctatat atgataaata aatctaaaaa atatttttta aatgaatagg gcacaccatg
     1681 gtcaactctg ctgtctgttt atctctagac atccagtgtc tttagagtcc acacaaggtc
     1741 attaaaagga ctggggtgga tggtgactgg agagatagct cagtggttaa gagtgtttgc
     1801 tgcttcatgg gtggtggtgg tggcacaagc ctttaatcca aacactcagg aggcagaggc
     1861 aggtggatct ctgagttcaa ggccagcctg gcctataagg caagttccaa gatagccaag
     1921 gatacacaga gaaaccctgt ttgaaaaaac ccaagcctag acctagagag ttggctcaat
     1981 ggttaagagc actgactgct tttccagagg tcctgagttc aaggcccagc aaaggcacat
     2041 ggtggctcac aaccatctgt aatgggatct gatgcacttt tctggtgtgt ctaaagcgac
     2101 atggtaactc gctgtctgta actagtagca aacagttcat atctcacaca gacatgaatg
     2161 cagatagagc accaacacat ataaaattaa atctttaaaa aatgaaaggt ctgggggctg
     2221 gatgaatggt gtttgtcttt gcaaatgtct gacagtggct gtgactcaca gcctcatagc
     2281 agctcctatt gcctggtgtt caccatctgt cttggttata aaaaggtttc gtaatgtgaa
     2341 acccttcaaa tgagctggtg cccttctcac cagtttgcat cttacaggat tcctgaaggg
     2401 cttatattct gggccgtccc attgtggagg attaggtttt acacaacgta tccactctag
     2461 cattgcaatt tccctgagcc ttaaaatccc ttcatcgacg ctgagccaag ggatatctgg
     2521 catctgcaac tccttttccg taggccgtca tttgatgaac gcttcagcca accattcaaa
     2581 caaacttctg acactttttt ttaactgtgt ggccttccat attaaaccta gaatctccac
     2641 tcagagagac catgtcaata aattcagcct gatctatttt aa
//
