LOCUS       NM_001168353            1074 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RT1 class Ib, locus M5 (RT1-M5), transcript
            variant 1, mRNA.
ACCESSION   NM_001168353
VERSION     NM_001168353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Acar,M., Cora,T., Tunc,R. and Acar,H.
  TITLE     HLA-B27 subtypes in Turkish patients with ankylosing spondylitis
            and healthy controls
  JOURNAL   Rheumatol Int 32 (10), 3103-3105 (2012)
   PUBMED   21927904
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Lambracht-Washington,D., Moore,Y.F., Wonigeit,K. and Lindahl,K.F.
  TITLE     Structure and expression of MHC class Ib genes of the central M
            region in rat and mouse: M4, M5, and M6
  JOURNAL   Immunogenetics 60 (3-4), 131-145 (2008)
   PUBMED   18324395
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Shankarkumar,U., Ghosh,K. and Mohanty,D.
  TITLE     Novel HLA B*2714 and B*2708 allele associations in seronegative
            spondarthritis patients and haemophilia patients with chronic
            synovitis in India
  JOURNAL   Tissue Antigens 62 (2), 175-178 (2003)
   PUBMED   12889998
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Gunther,E. and Walter,L.
  TITLE     The major histocompatibility complex of the rat (Rattus norvegicus)
  JOURNAL   Immunogenetics 53 (7), 520-542 (2001)
   PUBMED   11685465
  REMARK    Review article
REFERENCE   6  (bases 1 to 1074)
  AUTHORS   Gul,A., Uyar,F.A., Inanc,M., Ocal,L., Tugal-Tutkun,I., Aral,O.,
            Konice,M. and Saruhan-Direskeneli,G.
  TITLE     Lack of association of HLA-B*51 with a severe disease course in
            Behcet's disease
  JOURNAL   Rheumatology (Oxford) 40 (6), 668-672 (2001)
   PUBMED   11426025
REFERENCE   7  (bases 1 to 1074)
  AUTHORS   Orchard,T.R., Thiyagaraja,S., Welsh,K.I., Wordsworth,B.P., Hill
            Gaston,J.S. and Jewell,D.P.
  TITLE     Clinical phenotype is related to HLA genotype in the peripheral
            arthropathies of inflammatory bowel disease
  JOURNAL   Gastroenterology 118 (2), 274-278 (2000)
   PUBMED   10648455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883052.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BX883052.1         51901-51976
            77-346              BX883052.1         52227-52496
            347-622             BX883052.1         52646-52921
            623-898             BX883052.1         53507-53782
            899-1006            BX883052.1         53908-54015
            1007-1074           BX883052.1         54098-54165
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1074
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /note="RT1 class Ib, locus M5"
                     /db_xref="GeneID:499400"
                     /db_xref="RGD:1595816"
     CDS             1..1074
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; major histocompatibility complex, class I, F;
                     MHC class Ib antigen RT1.M5 long isoform; MHC class Ib
                     antigen RT1.M5 short isoform"
                     /codon_start=1
                     /product="RT1 class Ib, locus M5 isoform 1 precursor"
                     /protein_id="NP_001161825.1"
                     /db_xref="GeneID:499400"
                     /db_xref="RGD:1595816"
                     /translation="MGSSVFSVLLPLLLSRAWALNQVGAGIHSLQFFATAVTQPSSRE
                     HSFIFVGFVDDTQFLCYNNQGESQRMEPRALWVKNMGPGYWERQTRMVKDISKNSLVN
                     LREAMSVYNHSEDGTHVFQCVSGCDVGPDGLFLRGHEQHAYDGRDYLALNKDLHSWTA
                     GDTAAQITRRKWEEAGVAEQRRTYLKGECVESLRTYLEIGKETLLGADPPKAHVTHHP
                     SPEGDNTLRCWALGFYPSDITLTWQRDGEDLTQDMELVETRPGGDGTFQKWAAVVVPS
                     GEEHRYTCCVEHEGLTEPLLLKWDPSKHTIPIMGITAGLVFLGVAFTGAVVAIAMRKQ
                     RGCRVLTPSKAHLERSDKYLTWT"
     exon            1..76
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /inference="alignment:Splign:2.1.0"
     exon            77..346
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /inference="alignment:Splign:2.1.0"
     exon            347..622
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /inference="alignment:Splign:2.1.0"
     exon            623..898
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1006
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1074
                     /gene="RT1-M5"
                     /gene_synonym="Hla-f; RGD1560260; RT1.M5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaagct ccgttttctc tgtcctccta ccattgctgc tcagccgagc ttgggcattg
       61 aaccaggtcg gcgcaggcat ccattccttg cagttttttg ccactgctgt gacccagcct
      121 agttcgaggg agcattcctt catctttgtc ggctttgtgg acgacacaca gttcctgtgc
      181 tacaacaatc agggggaaag tcagagaatg gagccgcgcg ctctgtgggt aaagaatatg
      241 gggcccggat attgggagcg gcagactagg atggtcaagg acatttccaa gaattcccta
      301 gtgaacttgc gggaggccat gagtgtctac aaccacagcg aggatggcac tcatgtcttt
      361 cagtgtgtgt ctggctgtga cgtggggcca gatggactct tcctccgtgg gcacgagcag
      421 cacgcatacg acggccgcga ctacctcgct ctaaacaagg acctgcactc ctggacggca
      481 ggtgacacag cagcgcagat cacgcggcgc aagtgggagg aagctggtgt cgcggagcaa
      541 aggcgaacct acctgaaggg cgagtgtgtg gagtcgctcc gcacatacct ggagataggg
      601 aaggagactc tgctaggagc agatcctcca aaagcacatg tgacccatca ccccagccct
      661 gaaggtgata acaccctgag gtgctgggcc ctgggcttct acccttctga catcaccctg
      721 acctggcagc gggatggaga agacctgacc caggacatgg agcttgtgga gacaagacct
      781 gggggtgatg gaaccttcca gaagtgggca gctgtggtgg tgccttctgg ggaggagcat
      841 agatacacat gctgtgtgga gcatgagggg ctaactgagc ctctccttct gaaatgggac
      901 ccttctaagc acaccatccc catcatggga atcactgctg gcctggtttt ccttggagtt
      961 gccttcactg gagctgtggt tgccatagcg atgaggaagc agagaggatg tcgtgttcta
     1021 actccttcta aagcacattt ggaaagaagt gacaaatacc tcacatggac atga
//
