LOCUS       NM_001008848             839 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus RT1 class II, locus Ha (RT1-Ha), mRNA.
ACCESSION   NM_001008848 XM_579242
VERSION     NM_001008848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 839)
  AUTHORS   Ou G, Liu X, Yang L, Yu H, Ji X, Liu F, Xu H, Qian L, Wang J and
            Liu Z.
  TITLE     Relationship between HLA-DPA1 mRNA expression and susceptibility to
            hepatitis B
  JOURNAL   J Viral Hepat 26 (1), 155-161 (2019)
   PUBMED   30267609
REFERENCE   2  (bases 1 to 839)
  AUTHORS   Su TH, Yang HC, Tseng TC, Liou JM, Liu CH, Chen CL, Chen PJ, Chen
            DS, Liu CJ and Kao JH.
  TITLE     Distinct Relapse Rates and Risk Predictors After Discontinuing
            Tenofovir and Entecavir Therapy
  JOURNAL   J Infect Dis 217 (8), 1193-1201 (2018)
   PUBMED   29300980
REFERENCE   3  (bases 1 to 839)
  AUTHORS   Katrinli S, Enc FY, Ozdil K, Ozturk O, Tuncer I, Doganay GD and
            Doganay L.
  TITLE     Effect of HLA-DPA1 alleles on chronic hepatitis B prognosis and
            treatment response
  JOURNAL   North Clin Istanb 3 (3), 168-174 (2017)
   PUBMED   28275747
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 839)
  AUTHORS   Takejima P, Agondi RC, Rodrigues H, Aun MV, Kalil J and
            Giavina-Bianchi P.
  TITLE     Allergic and Nonallergic Asthma Have Distinct Phenotypic and
            Genotypic Features
  JOURNAL   Int Arch Allergy Immunol 172 (3), 150-160 (2017)
   PUBMED   28380482
REFERENCE   5  (bases 1 to 839)
  AUTHORS   Wasityastuti W, Yano Y, Ratnasari N, Triyono T, Triwikatmani C,
            Indrarti F, Heriyanto DS, Yamani LN, Liang Y, Utsumi T and Hayashi
            Y.
  TITLE     Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B
            virus infection in an Indonesian population
  JOURNAL   Infect Genet Evol 41, 177-184 (2016)
   PUBMED   27051043
REFERENCE   6  (bases 1 to 839)
  AUTHORS   Hirayama K, Chen H, Kikuchi M, Yin T, Gu X, Liu J, Zhang S and Yuan
            H.
  TITLE     HLA-DR-DQ alleles and HLA-DP alleles are independently associated
            with susceptibility to different stages of post-schistosomal
            hepatic fibrosis in the Chinese population
  JOURNAL   Tissue Antigens 53 (3), 269-274 (1999)
   PUBMED   10203020
REFERENCE   7  (bases 1 to 839)
  AUTHORS   Scholl T, Stevens MB, Mahanta S and Strominger JL.
  TITLE     A zinc finger protein that represses transcription of the human MHC
            class II gene, DPA
  JOURNAL   J Immunol 156 (4), 1448-1457 (1996)
   PUBMED   8568247
REFERENCE   8  (bases 1 to 839)
  AUTHORS   Meyer CG, Schnittger L and May J.
  TITLE     Met-11 of HLA class II DP alpha 1 first domain associated with
            onchocerciasis
  JOURNAL   Exp Clin Immunogenet 13 (1), 12-19 (1996)
   PUBMED   8854084
REFERENCE   9  (bases 1 to 839)
  AUTHORS   Balducci-Silano PL and Layrisse ZE.
  TITLE     HLA-DP and susceptibility to insulin-dependent diabetes mellitus in
            an ethnically mixed population. Associations with other HLA-alleles
  JOURNAL   J Autoimmun 8 (3), 425-437 (1995)
   PUBMED   7576003
REFERENCE   10 (bases 1 to 839)
  AUTHORS   Arimura Y, Tang WR, Koda T and Kakinuma M.
  TITLE     Structure of novel rat major histocompatibility complex class II
            genes RT1.Ha and Hb
  JOURNAL   Immunogenetics 41 (5), 320-325 (1995)
   PUBMED   7721355
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883042.1.
            
            On Oct 21, 2009 this sequence version replaced NM_001008848.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO561954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680421, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               BX883042.1         290666-290797
            133-378             BX883042.1         294876-295121
            379-660             BX883042.1         295423-295704
            661-839             BX883042.1         295797-295975
FEATURES             Location/Qualifiers
     source          1..839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..839
                     /gene="RT1-Ha"
                     /gene_synonym="RT1.Ha"
                     /note="RT1 class II, locus Ha"
                     /db_xref="GeneID:24986"
                     /db_xref="RGD:1595921"
     exon            1..132
                     /gene="RT1-Ha"
                     /gene_synonym="RT1.Ha"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..815
                     /gene="RT1-Ha"
                     /gene_synonym="RT1.Ha"
                     /note="major histocompatibility complex class II H-alpha;
                     HLA class II histocompatibility antigen, DP alpha 1
                     chain-like; RLA class II histocompatibility antigen, DP
                     alpha-1 chain-like"
                     /codon_start=1
                     /product="RT1 class II, locus Ha precursor"
                     /protein_id="NP_001008848.1"
                     /db_xref="GeneID:24986"
                     /db_xref="RGD:1595921"
                     /translation="MFQTKAEALRASFLAFLLSLPGSGAIKAEHVATYDIFVQTQHPS
                     GECMYAFDGDEQFYVDLDREETVWDLPEFSKVYAFDAQEALPYIDSLKNNLRALIQRY
                     NVTQDPSEPPEVTVFPKNPVELGQPNVLICHIDRLFPPVLNVTWLRNGQPVTEGTSET
                     VFLASTELRFHKFHYLTFIPTAQDVYDCRVEHWSLDQPSLSHWEMQEPVQVSETMETT
                     VCALGLVVGLVGSVVGSALIVRAPHGGHNPRTQEPL"
     exon            133..378
                     /gene="RT1-Ha"
                     /gene_synonym="RT1.Ha"
                     /inference="alignment:Splign:2.1.0"
     exon            379..660
                     /gene="RT1-Ha"
                     /gene_synonym="RT1.Ha"
                     /inference="alignment:Splign:2.1.0"
     exon            661..839
                     /gene="RT1-Ha"
                     /gene_synonym="RT1.Ha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgattacggt catcagccgt agattccctg acctgtgctc tgaagagaga atgttccaga
       61 ctaaagctga ggccctgaga gcctccttcc tggccttcct gctgagtctc ccaggatctg
      121 gggccatcaa agcggagcac gtagcaacgt acgacatatt tgtgcagacg cagcacccgt
      181 ctggtgaatg catgtacgcg tttgacggtg atgagcagtt ctacgtggat cttgacaggg
      241 aggagacggt ctgggacctg ccggagttca gcaaggtgta tgcgtttgac gcccaggagg
      301 ctcttcccta catcgacagc ctgaagaaca acttgagagc cttgatccag agatacaacg
      361 tcacccagga ccccagcgag cctcccgagg tgaccgtgtt ccctaagaac ccggtagagc
      421 tgggccagcc caatgtcctc atctgccaca tcgacaggct ctttccccca gtgctcaatg
      481 tcacatggct acgtaacggg cagccggtca ccgaaggaac ttcagagacc gtctttctgg
      541 ccagcacaga actcagattt cacaagttcc actacctgac cttcattccc acagcgcagg
      601 atgtgtatga ctgcagggtg gagcactgga gcctggacca gccgagtctc agtcactggg
      661 aaatgcagga gccagtccag gtgtccgaga caatggagac cacggtctgc gccctgggcc
      721 tggtggtggg cctggtgggc tccgtggttg gtagtgcgct catcgtaagg gctccgcatg
      781 gcggccataa ccctcggacc caggaacccc tgtgagtaac tgtggaggta gggatgcta
//
