LOCUS       NM_001164826            1134 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RT1 class II, locus Db2 (RT1-Db2), mRNA.
ACCESSION   NM_001164826
VERSION     NM_001164826.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Monzon-Casanova E, Rudolf R, Starick L, Muller I, Sollner C, Muller
            N, Westphal N, Miyoshi-Akiyama T, Uchiyama T, Berberich I, Walter L
            and Herrmann T.
  TITLE     The Forgotten: Identification and Functional Characterization of
            MHC Class II Molecules H2-Eb2 and RT1-Db2
  JOURNAL   J Immunol 196 (3), 988-999 (2016)
   PUBMED   26740108
  REMARK    GeneRIF: our findings suggest that the H2-E2 or RT1-D2 molecules
            could function as Ag-presenting molecules for a particular class of
            Ags, as modulators of Ag presentation like nonclassical
            nonpolymorphic class II molecules
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Tuncel J, Haag S, Yau AC, Norin U, Baud A, Lonnblom E, Maratou K,
            Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A,
            Stridh P, Jagodic M, Olsson T, Fernandez-Teruel A, Zubarev RA, Mott
            R, Aitman TJ, Flint J and Holmdahl R.
  CONSRTM   EURATRANS Consortium
  TITLE     Natural polymorphisms in Tap2 influence negative selection and
            CD4ratioCD8 lineage commitment in the rat
  JOURNAL   PLoS Genet 10 (2), e1004151 (2014)
   PUBMED   24586191
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Walter L, Hurt P, Himmelbauer H, Sudbrak R and Gunther E.
  TITLE     Physical mapping of the major histocompatibility complex class II
            and class III regions of the rat
  JOURNAL   Immunogenetics 54 (4), 268-275 (2002)
   PUBMED   12136338
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   De Palma,J.
  TITLE     Cause & effect, or ... there are lies, damn lies, and statistics
  JOURNAL   Nephrol News Issues 6 (11), 27-57 (1992)
   PUBMED   1300424
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883043.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BX883043.1         172349-172448
            101-367             BX883043.1         183101-183367
            368-649             BX883043.1         184385-184666
            650-760             BX883043.1         186170-186280
            761-1134            BX883043.1         190593-190966
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1134
                     /gene="RT1-Db2"
                     /gene_synonym="Db2"
                     /note="RT1 class II, locus Db2"
                     /db_xref="GeneID:24981"
                     /db_xref="RGD:1595922"
     CDS             1..861
                     /gene="RT1-Db2"
                     /gene_synonym="Db2"
                     /note="MHC class II beta chain"
                     /codon_start=1
                     /product="RT1 class II, locus Db2 precursor"
                     /protein_id="NP_001158298.1"
                     /db_xref="GeneID:24981"
                     /db_xref="RGD:1595922"
                     /translation="MVCLWLPRDPCVAAVVLSLLMLSPPVALVRDPRPRFLEQLKAEC
                     HYVKGREHVWSVTRFIYNQEEFARFDSVFGKFLAVTELGRPIAEYLNTQKDMLDNYRA
                     SVDRCRNNYDLVDIFMSNLKAKPKVTVYPSKTQPLEYHNLLVCSVSDFYPGTIEIRWF
                     RNGEEEKTGVVSTDLISNGDWTYQTLVMLETVPQGGEVYTCQVEHPSLTSPVRVEWRA
                     RSTSAQNKMLSGAMGMALGLFILAVGLFIYLRNLRGSVSHGAGEGAESSTSRLTGSRS
                     ECHTGPALSV"
     exon            1..100
                     /gene="RT1-Db2"
                     /gene_synonym="Db2"
                     /inference="alignment:Splign:2.1.0"
     exon            101..367
                     /gene="RT1-Db2"
                     /gene_synonym="Db2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..649
                     /gene="RT1-Db2"
                     /gene_synonym="Db2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..760
                     /gene="RT1-Db2"
                     /gene_synonym="Db2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1134
                     /gene="RT1-Db2"
                     /gene_synonym="Db2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgtgtc tgtggctccc cagagacccc tgtgtggcgg ctgtggtcct gagtctgtta
       61 atgctgagtc ctcccgtggc tttggtcagg gacccccgac cacgttttct ggagcagttg
      121 aaggctgagt gtcactacgt caaggggagg gagcatgtgt ggagcgtgac cagattcatc
      181 tataaccagg aagagtttgc ccgctttgac agtgtctttg ggaagttcct ggcagtgact
      241 gagctggggc ggcccatagc tgagtacttg aacacccaga aggacatgct ggacaattac
      301 cgtgcctctg tggacaggtg cagaaataac tatgacctgg ttgatatctt catgtcgaac
      361 ttaaaagcta aacccaaggt gaccgtgtac ccttcaaaga cgcagcccct ggaataccac
      421 aacctcctgg tctgctctgt gagtgacttc taccctggca ccattgaaat cagatggttc
      481 cggaatggtg aggaggaaaa gactggagtc gtgtccaccg acctgatctc taatggagac
      541 tggacctacc agaccctggt gatgctggag acggttcctc agggtggaga ggtttacacc
      601 tgccaggtgg agcatcccag cctgaccagc cctgtcagag tggagtggag ggctcgatcc
      661 acatctgcac agaacaagat gctgagcgga gccatgggca tggcgctagg tctgttcatc
      721 ctcgcggtgg ggctgttcat ctacttaagg aatctgagag gatcagtgtc tcatggtgct
      781 ggagaaggag ccgagagttc cacatccaga ttgacgggca gcaggagtga atgtcacact
      841 gggcctgcat tgagcgtctg agacctggga gccagccccc agtgacacac tttctccaac
      901 aagaccacac ctgctccaga aagccatatc tcctaatagt gccactccct ctgatcccct
      961 gggagccatt ttctttctaa ctaccacacc gactcttatc taaaaccttg cgtgtggctc
     1021 ctcagggcag ctaagcacca cagatctcat gaagacagct agaaactgga tgagtttaga
     1081 gaggactgag gtttggttct aatgatggat gtccactcct ctgtggacct gcac
//
