LOCUS       NP_001008884             264 aa            linear   ROD 27-APR-2025
DEFINITION  rano class II histocompatibility antigen, D-1 beta chain precursor
            [Rattus norvegicus].
ACCESSION   NP_001008884 XP_215333
VERSION     NP_001008884.1
DBSOURCE    REFSEQ: accession NM_001008884.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 264)
  AUTHORS   Toyo-Oka,L., Mahasirimongkol,S., Yanai,H., Mushiroda,T.,
            Wattanapokayakit,S., Wichukchinda,N., Yamada,N., Smittipat,N.,
            Juthayothin,T., Palittapongarnpim,P., Nedsuwan,S., Kantipong,P.,
            Takahashi,A., Kubo,M., Sawanpanyalert,P. and Tokunaga,K.
  TITLE     Strain-based HLA association analysis identified HLA-DRB1*09:01
            associated with modern strain tuberculosis
  JOURNAL   HLA 90 (3), 149-156 (2017)
   PUBMED   28612994
REFERENCE   2  (residues 1 to 264)
  AUTHORS   Brill,L., Mandel,M., Karussis,D., Petrou,P., Miller,K., Ben-Hur,T.,
            Karni,A., Paltiel,O., Israel,S. and Vaknin-Dembinsky,A.
  TITLE     Increased occurrence of anti-AQP4 seropositivity and unique HLA
            Class II associations with neuromyelitis optica (NMO), among Muslim
            Arabs in Israel
  JOURNAL   J Neuroimmunol 293, 65-70 (2016)
   PUBMED   27049564
REFERENCE   3  (residues 1 to 264)
  AUTHORS   Hernandez,E.G., Granados,J., Partida-Rodriguez,O., Valenzuela,O.,
            Rascon,E., Magana,U., Escamilla-Tilch,M., Lopez-Reyes,A.,
            Nieves-Ramirez,M., Gonzalez,E., Moran,P., Rojas,L., Valadez,A.,
            Luna,A., Estrada,F.J., Maldonado,C. and Ximenez,C.
  TITLE     Prevalent HLA Class II Alleles in Mexico City Appear to Confer
            Resistance to the Development of Amebic Liver Abscess
  JOURNAL   PLoS One 10 (5), e0126195 (2015)
   PUBMED   25938667
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 264)
  AUTHORS   Esmaeilzadeh,H., Nabavi,M., Amirzargar,A.A., Aryan,Z., Arshi,S.,
            Bemanian,M.H., Fallahpour,M., Mortazavi,N. and Rezaei,N.
  TITLE     HLA-DRB and HLA-DQ genetic variability in patients with
            aspirin-exacerbated respiratory disease
  JOURNAL   Am J Rhinol Allergy 29 (3), e63-e69 (2015)
   PUBMED   25975240
REFERENCE   5  (residues 1 to 264)
  AUTHORS   Dunstan,S.J., Hue,N.T., Han,B., Li,Z., Tram,T.T., Sim,K.S.,
            Parry,C.M., Chinh,N.T., Vinh,H., Lan,N.P., Thieu,N.T., Vinh,P.V.,
            Koirala,S., Dongol,S., Arjyal,A., Karkey,A., Shilpakar,O.,
            Dolecek,C., Foo,J.N., Phuong le,T., Lanh,M.N., Do,T., Aung,T.,
            Hon,D.N., Teo,Y.Y., Hibberd,M.L., Anders,K.L., Okada,Y.,
            Raychaudhuri,S., Simmons,C.P., Baker,S., de Bakker,P.I.,
            Basnyat,B., Hien,T.T., Farrar,J.J. and Khor,C.C.
  TITLE     Variation at HLA-DRB1 is associated with resistance to enteric
            fever
  JOURNAL   Nat Genet 46 (12), 1333-1336 (2014)
   PUBMED   25383971
REFERENCE   6  (residues 1 to 264)
  AUTHORS   Ghosh,P., Amaya,M., Mellins,E. and Wiley,D.C.
  TITLE     The structure of an intermediate in class II MHC maturation: CLIP
            bound to HLA-DR3
  JOURNAL   Nature 378 (6556), 457-462 (1995)
   PUBMED   7477400
REFERENCE   7  (residues 1 to 264)
  AUTHORS   Riberdy,J.M., Newcomb,J.R., Surman,M.J., Barbosa,J.A. and
            Cresswell,P.
  TITLE     HLA-DR molecules from an antigen-processing mutant cell line are
            associated with invariant chain peptides
  JOURNAL   Nature 360 (6403), 474-477 (1992)
   PUBMED   1448172
REFERENCE   8  (residues 1 to 264)
  AUTHORS   Mizuki,N., Inoko,H., Mizuki,N., Tanaka,H., Kera,J., Tsuiji,K. and
            Ohno,S.
  TITLE     Human leukocyte antigen serologic and DNA typing of Behcet's
            disease and its primary association with B51
  JOURNAL   Invest Ophthalmol Vis Sci 33 (12), 3332-3340 (1992)
   PUBMED   1358857
REFERENCE   9  (residues 1 to 264)
  AUTHORS   De Palma,J.
  TITLE     Cause & effect, or ... there are lies, damn lies, and statistics
  JOURNAL   Nephrol News Issues 6 (11), 27-28 (1992)
   PUBMED   1300424
REFERENCE   10 (residues 1 to 264)
  AUTHORS   Syha-Jedelhauser,J. and Reske,K.
  TITLE     Sequence of rat cDNA clone pLR beta 112 coding for the RT1.D beta I
            chain
  JOURNAL   Nucleic Acids Res 18 (15), 4598 (1990)
   PUBMED   2388838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO563535.1, AF084933.1 and CV111238.1.
            
            On Jan 6, 2005 this sequence version replaced XP_215333.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233396.1, FQ233801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN13663593
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..264
                     /product="rano class II histocompatibility antigen, D-1
                     beta chain precursor"
                     /note="rano class II histocompatibility antigen, D-1 beta
                     chain; RT1-D beta; MHC class II RT1D beta1 chain antigen;
                     RT1 class II histocompatibility antigen, D-1 beta chain"
                     /calculated_mol_wt=27581
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2638
     Region          40..111
                     /region_name="MHC_II_beta"
                     /note="Class II histocompatibility antigen, beta domain;
                     smart00921"
                     /db_xref="CDD:197989"
     Region          122..216
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          140..144
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          155..159
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          186..190
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          197..202
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          212..215
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..264
                     /gene="RT1-Db1"
                     /gene_synonym="Db1; RT1-Db; RT1-Db1n"
                     /coded_by="NM_001008884.2:65..859"
                     /db_xref="GeneID:294270"
                     /db_xref="RGD:1593282"
ORIGIN      
        1 mvwlardscv aavillltvl sppvalvrdp tprfleqyks ecyfyngtqr vrllvryiyn
       61 reeytrfdsd vgefravtel grrdteyynk qkeyierera avdticrhny eisdrflvpr
      121 tvepkvtvyp sktqplkhhn llvcsvsdfy pgsvevrwfr ngeeekdglv stglipngdw
      181 tfqllvmlem vpqggevytc qvehpsltsp vrvewkaqst saqnkkmsgv ggivlgllfl
      241 gaglfvyfrn qkgqsglqpt glln
//
