LOCUS       NM_183051                757 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RT1 class II, locus DOa (RT1-DOa), mRNA.
ACCESSION   NM_183051 XM_345086
VERSION     NM_183051.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 757)
  AUTHORS   Yucesoy B, Johnson VJ, Lummus ZL, Kashon ML, Rao M,
            Bannerman-Thompson H, Frye B, Wang W, Gautrin D, Cartier A, Boulet
            LP, Sastre J, Quirce S, Tarlo SM, Germolec DR, Luster MI and
            Bernstein DI.
  TITLE     Genetic variants in the major histocompatibility complex class I
            and class II genes are associated with diisocyanate-induced Asthma
  JOURNAL   J Occup Environ Med 56 (4), 382-387 (2014)
   PUBMED   24709764
REFERENCE   2  (bases 1 to 757)
  AUTHORS   Yoon T, Macmillan H, Mortimer SE, Jiang W, Rinderknecht CH, Stern
            LJ and Mellins ED.
  TITLE     Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (28), 11276-11281 (2012)
   PUBMED   22733780
REFERENCE   3  (bases 1 to 757)
  AUTHORS   Gunther E and Walter L.
  TITLE     The major histocompatibility complex of the rat (Rattus norvegicus)
  JOURNAL   Immunogenetics 53 (7), 520-542 (2001)
   PUBMED   11685465
  REMARK    Review article
REFERENCE   4  (bases 1 to 757)
  AUTHORS   Perraudeau M, Taylor PR, Stauss HJ, Lindstedt R, Bygrave AE, Pappin
            DJ, Ellmerich S, Whitten A, Rahman D, Canas B, Walport MJ, Botto M
            and Altmann DM.
  TITLE     Altered major histocompatibility complex class II peptide loading
            in H2-O-deficient mice
  JOURNAL   Eur J Immunol 30 (10), 2871-2880 (2000)
   PUBMED   11069069
REFERENCE   5  (bases 1 to 757)
  AUTHORS   Liljedahl M, Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson
            PA, Brunmark A, Rudensky AY, Fung-Leung WP and Karlsson L.
  TITLE     Altered antigen presentation in mice lacking H2-O
  JOURNAL   Immunity 8 (2), 233-243 (1998)
   PUBMED   9492004
REFERENCE   6  (bases 1 to 757)
  AUTHORS   Arimura Y, Tang WR, Koda T and Kakinuma M.
  TITLE     Cloning and analysis of a new rat major histocompatibility complex
            class II gene, RT1.DOa
  JOURNAL   Immunogenetics 42 (2), 156-158 (1995)
   PUBMED   7607708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883042.1.
            
            On Sep 17, 2009 this sequence version replaced NM_183051.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132263, SAMD00132301
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BX883042.1         304390-304475
            87-335              BX883042.1         305824-306072
            336-617             BX883042.1         306272-306553
            618-757             BX883042.1         306646-306785
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..757
                     /gene="RT1-DOa"
                     /gene_synonym="H2-Oa"
                     /note="RT1 class II, locus DOa"
                     /db_xref="GeneID:24984"
                     /db_xref="RGD:3477"
     exon            1..86
                     /gene="RT1-DOa"
                     /gene_synonym="H2-Oa"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..757
                     /gene="RT1-DOa"
                     /gene_synonym="H2-Oa"
                     /note="histocompatibility 2, O region alpha locus"
                     /codon_start=1
                     /product="RT1 class II, locus DOa precursor"
                     /protein_id="NP_898874.2"
                     /db_xref="GeneID:24984"
                     /db_xref="RGD:3477"
                     /translation="MVLFVELVQVFLTIMSFLGPRGVWAIKADHMGSYGPAFYQSYDA
                     SGQFTHEFDGEQIFSVDLKKGEVVWRLPEFADFAYSDFQSGLMSISMIRAHLDVLVER
                     SNRTRAVSVPPRVTVFPKSRVELGKPNVLICMVEDIFPPVINITWLRNSQPITKGVTQ
                     TSFYSQPNHRFRKFHYLTFVPTAEDVYDCRVEHWGLDAPLLQHWEPQVLTPPPDTTET
                     LICGLGLALGLVGCLLGTLLMVTATRMPSTRR"
     exon            87..335
                     /gene="RT1-DOa"
                     /gene_synonym="H2-Oa"
                     /inference="alignment:Splign:2.1.0"
     exon            336..617
                     /gene="RT1-DOa"
                     /gene_synonym="H2-Oa"
                     /inference="alignment:Splign:2.1.0"
     exon            618..757
                     /gene="RT1-DOa"
                     /gene_synonym="H2-Oa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaatggtc ctctttgtgg agctggtcca ggtatttcta accataatga gcttcctggg
       61 tccccgggga gtatgggcca tcaaggccga ccacatgggc tcctacggac cagccttcta
      121 ccagtcttac gacgcctccg gacagttcac acacgaattt gacggggaac agattttctc
      181 tgtggatctg aagaaggggg aggtcgtgtg gcgtctgccc gagtttgcag acttcgcgta
      241 ctcggacttt cagagcgggc tgatgagcat ctccatgatc agagctcatc tggacgtctt
      301 ggtagaacgc tccaaccgaa ccagagccgt cagtgtgcct ccccgggtga ccgtattccc
      361 caagtctcgc gtggagctgg gaaaacccaa tgtcctcatc tgcatggtgg aagatatctt
      421 cccgcctgtg atcaatatca cctggctgcg caacagccag cccatcacta agggagtgac
      481 ccagaccagc ttctactccc agcctaacca caggttccgg aagttccact acctgacctt
      541 cgtgcccacg gcggaggatg tgtacgactg cagggtggag cactggggcc tggacgcacc
      601 gctcctccag cactgggagc cccaggtgct taccccacca ccggacacca cagagaccct
      661 gatctgtggc ctgggcctgg ctctcggcct tgtgggatgc ctcctgggca ccttgctcat
      721 ggtcacagcc acacgcatgc ccagtacccg caggtga
//
