LOCUS       NM_198740               1320 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RT1 class II, locus DMb (RT1-DMb), mRNA.
ACCESSION   NM_198740 XM_215334
VERSION     NM_198740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Zhou,H., Yang,Z., Mu,L. and Shi,Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Tuncel,J., Haag,S., Yau,A.C., Norin,U., Baud,A., Lonnblom,E.,
            Maratou,K., Ytterberg,A.J., Ekman,D., Thordardottir,S.,
            Johannesson,M., Gillett,A., Stridh,P., Jagodic,M., Olsson,T.,
            Fernandez-Teruel,A., Zubarev,R.A., Mott,R., Aitman,T.J., Flint,J.
            and Holmdahl,R.
  CONSRTM   EURATRANS Consortium
  TITLE     Natural polymorphisms in Tap2 influence negative selection and
            CD4ratioCD8 lineage commitment in the rat
  JOURNAL   PLoS Genet 10 (2), e1004151 (2014)
   PUBMED   24586191
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Yoon,T., Macmillan,H., Mortimer,S.E., Jiang,W., Rinderknecht,C.H.,
            Stern,L.J. and Mellins,E.D.
  TITLE     Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (28), 11276-11281 (2012)
   PUBMED   22733780
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Jahnke,M., Trowsdale,J. and Kelly,A.P.
  TITLE     Ubiquitination of human leukocyte antigen (HLA)-DM by different
            membrane-associated RING-CH (MARCH) protein family E3 ligases
            targets different endocytic pathways
  JOURNAL   J Biol Chem 287 (10), 7256-7264 (2012)
   PUBMED   22247549
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   de Bellocq,J.G. and Leirs,H.
  TITLE     Complementary DNA sequences encoding the multimammate rat MHC class
            II DQ alpha and beta chains and cross-species sequence comparison
            in rodents
  JOURNAL   Tissue Antigens 74 (3), 233-237 (2009)
   PUBMED   19691639
  REMARK    GeneRIF: Complementary DNA sequence encoding the multimammate rate
            MHC class II DQ beta chain and cross-species sequence comparison in
            rodents are reported.
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Yen,J.H., Tsai,W.C., Tsai,J.J., Chen,C.J., Lin,C.H., Ou,T.T.,
            Wu,C.C. and Liu,H.W.
  TITLE     HLA-DMA and HLA-DMB genotyping in patients with rheumatic diseases
  JOURNAL   Kaohsiung J Med Sci 15 (5), 263-267 (1999)
   PUBMED   10375868
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   Lindstedt,R., Liljedahl,M., Peleraux,A., Peterson,P.A. and
            Karlsson,L.
  TITLE     The MHC class II molecule H2-M is targeted to an endosomal
            compartment by a tyrosine-based targeting motif
  JOURNAL   Immunity 3 (5), 561-572 (1995)
   PUBMED   7584146
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Denzin,L.K. and Cresswell,P.
  TITLE     HLA-DM induces CLIP dissociation from MHC class II alpha beta
            dimers and facilitates peptide loading
  JOURNAL   Cell 82 (1), 155-165 (1995)
   PUBMED   7606781
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Hermel,E. and Monaco,J.J.
  TITLE     RT1.DMa and RT1.DMb: the rat homologues of H2-DMa and H2-DMb
  JOURNAL   Immunogenetics 42 (5), 446-447 (1995)
   PUBMED   7590989
  REMARK    Erratum:[Immunogenetics 1996;44(6):487]
REFERENCE   10 (bases 1 to 1320)
  AUTHORS   Morris,P., Shaman,J., Attaya,M., Amaya,M., Goodman,S., Bergman,C.,
            Monaco,J.J. and Mellins,E.
  TITLE     An essential role for HLA-DM in antigen presentation by class II
            major histocompatibility molecules
  JOURNAL   Nature 368 (6471), 551-554 (1994)
   PUBMED   8139689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM108008.1 and BC091108.1.
            
            On Sep 17, 2009 this sequence version replaced NM_198740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226840.1, FQ233373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               FM108008.1         1-356
            357-1320            BC091108.1         293-1256
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1320
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /note="RT1 class II, locus DMb"
                     /db_xref="GeneID:294273"
                     /db_xref="RGD:735096"
     exon            1..274
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1005
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /note="MHC class II-like beta chain; major
                     histocompatibility complex, class II, DM beta; RT1 class
                     II, DM beta; class II histocompatibility antigen, M beta 1
                     chain"
                     /codon_start=1
                     /product="RT1 class II, DM beta precursor"
                     /protein_id="NP_942035.2"
                     /db_xref="GeneID:294273"
                     /db_xref="RGD:735096"
                     /translation="MAALWPLLLALSLGCIGAGGFVAHVESTCLLDDEGTPMDFTYCI
                     SFNKDLLACWDPEEGQIVPCEYGVLFKLAEFISNILNKEEGLIQRLKNGLQDCSTHTQ
                     PFWNALTHRTRTPSVQVAQTAPFNTREPVMLACYVWGFYPADVTVVWMKNGQLVTSHS
                     NKEKTAQPNGDWTYQTVSYLALTPSYWDIYTCVVQHSGTPEPIRANWTPGLSPIQTVK
                     VSVSAATLGLGFIIFCLGFFRWRKSHSSSYTPLPGSTYPEGRP"
     exon            275..556
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /inference="alignment:Splign:2.1.0"
     exon            557..841
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /inference="alignment:Splign:2.1.0"
     exon            842..958
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /inference="alignment:Splign:2.1.0"
     exon            959..994
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1293
                     /gene="RT1-DMb"
                     /gene_synonym="DMb; RT1.DMb; RT1.Mb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatttggtt gagttagtgg gtgcaacttt aagatctaag gaggggctga gtgacctggg
       61 gccacatcgg cagcaaggag caagggacct gaacaacaag taccgtcttt acctcagcgt
      121 gggaaaatca tttgtccaag ctggggcagg agaggtcccg aggcccctgc gtgaggtggc
      181 ccaggagcct gaccttcctg caccttcaga gagtggaaca tggctgcact atggccgctg
      241 ctgctggccc tgagtctggg ttgtatagga gcaggtggct ttgtggctca tgtggaaagc
      301 acgtgcttgc tggatgatga agggacccca atggacttca catactgtat ttccttcaac
      361 aaagatctgc tggcctgctg ggatccagag gagggacaaa tagtcccctg tgaatatggg
      421 gtcctgttta agttggccga attcatttca aatatcctca acaaggaaga aggcctgatc
      481 cagcgcttga aaaatgggct tcaggactgt tccacacaca cccagccctt ctggaacgcg
      541 ctgacccaca gaaccagaac gccatctgtc caagtagccc aaaccgctcc ttttaacaca
      601 agggagcctg tgatgctggc ctgctacgtc tggggcttct atccggcgga tgtgaccgtc
      661 gtgtggatga agaacgggca gcttgttact tcccacagca acaaggagaa gacggctcag
      721 cctaatgggg actggacata ccagaccgtc tcctacctag ccttaacccc ttcctactgg
      781 gacatctaca cctgcgtggt acagcacagc gggacccctg agcccatccg cgcgaactgg
      841 acacccgggc tgtcccccat ccagacagtg aaggtctctg tgtctgcagc caccctgggc
      901 ctgggcttca tcatcttctg tcttggcttc ttcagatggc gcaagtctca ctcctccagc
      961 tacactcctc tccctggatc cacctacccg gaaggacggc cctagagggc agagccccgc
     1021 gctgagaagg agatccagac ttttgatggt gccttcatgc cccccagcat cttcaggaca
     1081 ccccactttc ttgtgtcata attcctctac tcagttccac tttcccatgt aaatattggt
     1141 ggcctggggg gtattcgtaa tcaaatctgc ctcgggtgtt ttctgaggtg agctgctctg
     1201 aggagggggt tcagtgccct cctgaaagcc ccaccttgtc acagaaggca ctgtgtcacg
     1261 atcacaccta agaaataaac tggtgtggaa ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
