LOCUS       NM_198741               1112 bp    mRNA    linear   ROD 28-DEC-2023
DEFINITION  Rattus norvegicus RT1 class II, locus DMa (RT1-DMa), mRNA.
ACCESSION   NM_198741 XM_215347
VERSION     NM_198741.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1112)
  AUTHORS   Zhou H, Yang Z, Mu L and Shi Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1112)
  AUTHORS   Tuncel J, Haag S, Yau AC, Norin U, Baud A, Lonnblom E, Maratou K,
            Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A,
            Stridh P, Jagodic M, Olsson T, Fernandez-Teruel A, Zubarev RA, Mott
            R, Aitman TJ, Flint J and Holmdahl R.
  CONSRTM   EURATRANS Consortium
  TITLE     Natural polymorphisms in Tap2 influence negative selection and
            CD4ratioCD8 lineage commitment in the rat
  JOURNAL   PLoS Genet 10 (2), e1004151 (2014)
   PUBMED   24586191
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1112)
  AUTHORS   Yoon T, Macmillan H, Mortimer SE, Jiang W, Rinderknecht CH, Stern
            LJ and Mellins ED.
  TITLE     Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (28), 11276-11281 (2012)
   PUBMED   22733780
REFERENCE   4  (bases 1 to 1112)
  AUTHORS   Jahnke M, Trowsdale J and Kelly AP.
  TITLE     Ubiquitination of human leukocyte antigen (HLA)-DM by different
            membrane-associated RING-CH (MARCH) protein family E3 ligases
            targets different endocytic pathways
  JOURNAL   J Biol Chem 287 (10), 7256-7264 (2012)
   PUBMED   22247549
REFERENCE   5  (bases 1 to 1112)
  AUTHORS   Lu CC, Appler JM, Houseman EA and Goodrich LV.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   6  (bases 1 to 1112)
  AUTHORS   Miyazaki T, Wolf P, Tourne S, Waltzinger C, Dierich A, Barois N,
            Ploegh H, Benoist C and Mathis D.
  TITLE     Mice lacking H2-M complexes, enigmatic elements of the MHC class II
            peptide-loading pathway
  JOURNAL   Cell 84 (4), 531-541 (1996)
   PUBMED   8598040
REFERENCE   7  (bases 1 to 1112)
  AUTHORS   Lindstedt R, Liljedahl M, Peleraux A, Peterson PA and Karlsson L.
  TITLE     The MHC class II molecule H2-M is targeted to an endosomal
            compartment by a tyrosine-based targeting motif
  JOURNAL   Immunity 3 (5), 561-572 (1995)
   PUBMED   7584146
REFERENCE   8  (bases 1 to 1112)
  AUTHORS   Denzin LK and Cresswell P.
  TITLE     HLA-DM induces CLIP dissociation from MHC class II alpha beta
            dimers and facilitates peptide loading
  JOURNAL   Cell 82 (1), 155-165 (1995)
   PUBMED   7606781
REFERENCE   9  (bases 1 to 1112)
  AUTHORS   Hermel E and Monaco JJ.
  TITLE     RT1.DMa and RT1.DMb: the rat homologues of H2-DMa and H2-DMb
  JOURNAL   Immunogenetics 42 (5), 446-447 (1995)
   PUBMED   7590989
  REMARK    Erratum:[Immunogenetics 1996;44(6):487]
REFERENCE   10 (bases 1 to 1112)
  AUTHORS   Karlsson L, Peleraux A, Lindstedt R, Liljedahl M and Peterson PA.
  TITLE     Reconstitution of an operational MHC class II compartment in
            nonantigen-presenting cells
  JOURNAL   Science 266 (5190), 1569-1573 (1994)
   PUBMED   7985028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV106229.1 and BC091107.1.
            
            On Sep 17, 2009 this sequence version replaced NM_198741.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091107.1, FQ233863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663615, SAMN13663617
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CV106229.1         1-17
            18-1112             BC091107.1         1-1095
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1112
                     /gene="RT1-DMa"
                     /gene_synonym="DMA1; RT1.DMa; RT1.Ma"
                     /note="RT1 class II, locus DMa"
                     /db_xref="GeneID:294274"
                     /db_xref="RGD:735053"
     exon            1..140
                     /gene="RT1-DMa"
                     /gene_synonym="DMA1; RT1.DMa; RT1.Ma"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..838
                     /gene="RT1-DMa"
                     /gene_synonym="DMA1; RT1.DMa; RT1.Ma"
                     /note="MHC class II-like alpha chain; major
                     histocompatibility complex, class II, DM alpha; RT1 class
                     II, DM alpha; class II histocompatibility antigen, M alpha
                     chain"
                     /codon_start=1
                     /product="RT1 class II, DM alpha precursor"
                     /protein_id="NP_942036.1"
                     /db_xref="GeneID:294274"
                     /db_xref="RGD:735053"
                     /translation="MEHEQKSGGLLRLLRLLWLLPHSWAVLEASPQAWWDESQNHTFR
                     HTLFCQDGFPNIGLSETYDEDALFSFDFSQNTRVPRLPEFAEWAQEQGDASAIAFDKG
                     FCDMLMQNVSPRLEGQIPVSRGLPSAEVFTLKPLEFGKPNTLVCFISNLFPPTLTVTW
                     QHHFVPVEGASPTSVSAIDGLTFQAFSYLNFTPEPFDLYSCTVTHEIDRYTAIAYWVP
                     QNALPSDLLENVLCGVAFGLGVLGLVVGIVFFIRSQRPCSGD"
     exon            141..425
                     /gene="RT1-DMa"
                     /gene_synonym="DMA1; RT1.DMa; RT1.Ma"
                     /inference="alignment:Splign:2.1.0"
     exon            426..704
                     /gene="RT1-DMa"
                     /gene_synonym="DMA1; RT1.DMa; RT1.Ma"
                     /inference="alignment:Splign:2.1.0"
     exon            705..833
                     /gene="RT1-DMa"
                     /gene_synonym="DMA1; RT1.DMa; RT1.Ma"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1088
                     /gene="RT1-DMa"
                     /gene_synonym="DMA1; RT1.DMa; RT1.Ma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagggagct gggcacccgg gagtgaaagc gctcactcgc tgagggtgtt aaggtatgga
       61 gcatgagcag aagtcaggag ggctgctgag gctgctgcgg cttctgtggc tgctgcctca
      121 ctcctgggcg gtgcttgaag cttctcccca ggcgtggtgg gatgagtcgc agaaccacac
      181 attccgtcac actctgttct gccaggatgg gtttcccaac atagggctct ccgagaccta
      241 cgacgaggac gcactcttct ccttcgactt ctcccagaac accagagtgc cccggctgcc
      301 tgagtttgct gagtgggctc aggaacaggg agatgcctct gccattgcgt ttgacaaagg
      361 cttctgcgac atgttgatgc agaatgtgag cccgcggctt gaaggtcaaa tcccagtgtc
      421 cagaggtttg ccttcggctg aggtgttcac cctgaagccc ctggagtttg gcaagcccaa
      481 cacgctggtc tgtttcatca gcaacctctt tccaccgact ttgacggtga cctggcagca
      541 tcatttcgtc cccgtggagg gagccagccc cacatccgtt tcagccatcg atgggctcac
      601 cttccaggcc ttctcttatt taaacttcac accggaaccc ttcgaccttt actcctgcac
      661 tgtgacgcac gagattgacc gctacacggc gattgcctat tgggtacccc agaacgccct
      721 gccttcagat ctcctggaga atgtactgtg cggtgtggcc ttcggcctcg gtgtgctggg
      781 cctcgtcgtg ggcattgtct tcttcatccg ctcccagaga ccttgctcag gggactgatt
      841 cttcccaagg agggcttgga actgcaccag ccaggccggc agcgatgtcc aggcatctcg
      901 cgcttaccag ggtctttcct cagagccgaa gtccccggga tcccttgggg tgcgtgccgg
      961 catgctaagg ggttccgctg tccctggact tacatccaga aaagccggag tcaggagccc
     1021 cgggccccac cagaccacta ccttatacct tccctcttcc aggaaataaa gtttatttct
     1081 taacatcaaa aaaaaaaaaa aaaaaaaaaa aa
//
