LOCUS       NM_001033986            1634 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus RT1 class I, locus CE5 (RT1-CE5), transcript
            variant 2, mRNA.
ACCESSION   NM_001033986 XM_579238
VERSION     NM_001033986.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Dai KZ, Ryan JC, Naper C and Vaage JT.
  TITLE     Identification of MHC Class Ib Ligands for Stimulatory and
            Inhibitory Ly49 Receptors and Induction of Potent NK Cell
            Alloresponses in Rats
  JOURNAL   J Immunol 200 (8), 2847-2859 (2018)
   PUBMED   29531166
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Dulberger CL, McMurtrey CP, Holzemer A, Neu KE, Liu V, Steinbach
            AM, Garcia-Beltran WF, Sulak M, Jabri B, Lynch VJ, Altfeld M,
            Hildebrand WH and Adams EJ.
  TITLE     Human Leukocyte Antigen F Presents Peptides and Regulates Immunity
            through Interactions with NK Cell Receptors
  JOURNAL   Immunity 46 (6), 1018-1029 (2017)
   PUBMED   28636952
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Garcia-Beltran WF, Holzemer A, Martrus G, Chung AW, Pacheco Y,
            Simoneau CR, Rucevic M, Lamothe-Molina PA, Pertel T, Kim TE, Dugan
            H, Alter G, Dechanet-Merville J, Jost S, Carrington M and Altfeld
            M.
  TITLE     Open conformers of HLA-F are high-affinity ligands of the
            activating NK-cell receptor KIR3DS1
  JOURNAL   Nat Immunol 17 (9), 1067-1074 (2016)
   PUBMED   27455421
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Song S, Miranda CJ, Braun L, Meyer K, Frakes AE, Ferraiuolo L,
            Likhite S, Bevan AK, Foust KD, McConnell MJ, Walker CM and Kaspar
            BK.
  TITLE     Major histocompatibility complex class I molecules protect motor
            neurons from astrocyte-induced toxicity in amyotrophic lateral
            sclerosis
  JOURNAL   Nat Med 22 (4), 397-403 (2016)
   PUBMED   26928464
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Goodridge JP, Burian A, Lee N and Geraghty DE.
  TITLE     HLA-F and MHC class I open conformers are ligands for NK cell
            Ig-like receptors
  JOURNAL   J Immunol 191 (7), 3553-3562 (2013)
   PUBMED   24018270
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Lau P, Amadou C, Brun H, Rouillon V, McLaren F, Le Rolle AF, Graham
            M, Butcher GW and Joly E.
  TITLE     Characterisation of RT1-E2, a multigenic family of highly conserved
            rat non-classical MHC class I molecules initially identified in
            cells from immunoprivileged sites
  JOURNAL   BMC Immunol 4, 7 (2003)
   PUBMED   12837137
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Solier C, McLaren F, Amadou C, Le Bouteiller P and Joly E.
  TITLE     Detection of transcripts for a soluble form of the RT1-E MHC class
            Ib molecule in rat placenta
  JOURNAL   Immunogenetics 53 (4), 351-356 (2001)
   PUBMED   11491540
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Ioannidu S, Walter L, Dressel R and Gunther E.
  TITLE     Physical map and expression profile of genes of the telomeric class
            I gene region of the rat MHC
  JOURNAL   J Immunol 166 (6), 3957-3965 (2001)
   PUBMED   11238641
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   le Rolle AF, Hutchings A, Butcher GW and Joly E.
  TITLE     Cloning of three different species of MHC class I cDNAs of the RT1g
            haplotype from the NEDH rat
  JOURNAL   Immunogenetics 51 (6), 503-507 (2000)
   PUBMED   10866120
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Wainwright SD, Biro PA and Holmes CH.
  TITLE     HLA-F is a predominantly empty, intracellular, TAP-associated MHC
            class Ib protein with a restricted expression pattern
  JOURNAL   J Immunol 164 (1), 319-328 (2000)
   PUBMED   10605026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098841.1.
            
            On Oct 9, 2005 this sequence version replaced XM_579238.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. This
            results in a longer protein (isoform 2) compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098841.1, MG963102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1634
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /note="RT1 class I, locus CE5"
                     /db_xref="GeneID:309607"
                     /db_xref="RGD:1595868"
     exon            1..100
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1155
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; MHC class I protein; MHC class Ib antigen; RT1
                     class I, CE7"
                     /codon_start=1
                     /product="RT1 class I, locus CE5 isoform 2 precursor"
                     /protein_id="NP_001029158.1"
                     /db_xref="GeneID:309607"
                     /db_xref="RGD:1595868"
                     /translation="MGAMAPRTLLLLLAAALAPTRTRAGSHSLRYFHTAVSRPGLGEP
                     RFIIVGYVDHTEFVRYDSDAENPRYEPRARWMEREGPEYWEQQTQIVKGHEWSFRVSL
                     RNLLGYYNQSEGGSHTLQVMSGCDMGSDQSLRRGYEQYAYDGRDYISLNEDLKTWSAA
                     DLAAQITLNKWDQAGELDYYKAYLEGPCLEWLLRYLEHGKETLMRSDPPKAHVTLHPR
                     PEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLG
                     KEQNYTCLVEHEGLPEPLTFRWEAPPSTNSNTGMSVILGTVTIIAVMAIIVVVAVIRT
                     VVRKRWIKTAFLLTSGKGVYTPAPGRDSSQSSDVSLPDCKA"
     exon            101..370
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
     exon            371..646
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
     exon            647..922
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1057
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1102
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1150
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1608
                     /gene="RT1-CE5"
                     /gene_synonym="RT1-C/E5; RT1-CE7; RT1-E2; rt1-El"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaaacagc tcggtctggg atcttagatg ggggcgatgg caccgcgcac gctgctcctg
       61 ctgctggcgg cggccctggc cccaacccgg acccgcgcgg gctcacactc gctgcggtat
      121 ttccacaccg ccgtgtcccg gcccggcctc ggggagcccc ggttcattat cgtcggctat
      181 gtggaccaca cggagttcgt gcgctacgac agcgacgcag agaatccgag atacgagccg
      241 cgggcgcggt ggatggagcg ggaggggccg gagtattggg agcagcagac acagatcgtc
      301 aagggacacg aatggagttt ccgagtgagc ctgaggaatc tgctaggcta ctacaaccag
      361 agcgagggcg gctctcacac actccaggtg atgtctggat gtgacatggg gtcggaccag
      421 agcctgcgcc gcgggtatga gcaatacgcc tatgacggcc gcgattacat ctccctgaac
      481 gaagacctga agacgtggtc ggctgcggac ttggcagcac agatcactct aaacaagtgg
      541 gatcaggctg gtgaattaga ctattacaag gcctacctgg agggtccatg cctggagtgg
      601 cttctcagat acctggagca cgggaaggag acactgatgc gctcagatcc cccaaaggca
      661 catgtgaccc ttcaccccag acctgaaggt gatgtgaccc tgaggtgctg ggccctgggc
      721 ttctaccctg ctgacatcac cctgacctgg cagttgaatg gggaggacct gacccaggac
      781 atggagcttg tggagaccag gcctgcaggg gatggaacct tccagaagtg ggcatctgtg
      841 gtggtgcctc ttgggaagga gcagaattac acatgccttg tggagcatga ggggctgcct
      901 gagcccctca cctttagatg ggaggctcct ccctccacca actccaacac gggaatgtct
      961 gttattcttg gaactgtgac catcattgca gttatggcca tcattgtagt tgtagccgtc
     1021 attagaactg ttgtgaggaa gagatggata aaaacagctt ttcttctcac aagtggaaaa
     1081 ggagtctaca cccctgctcc aggcagggac agctcccaga gctctgatgt gtctctccca
     1141 gattgtaaag catgaagaca gctgcctgga gtggactgag tgacagacga tgtgttcagg
     1201 tctctcctgt gacatccaga gccctcagtt ctctttagac accagtgtct gatgttccct
     1261 gtgattctat ggcttcagtg tgaagaactg tggagcccag cctgccctgc acttcaggac
     1321 cctgtccctg cactgcctgt gttaccttcc acattcaacc ttgctggtcc agcctggggc
     1381 tagggattgg ggacgtctgc atcctgtcac tcagtgctgc tctgagctgc aactcctcac
     1441 ttctacactg agaataagaa tctgagtgtg aacttgactg ttcacatcct tgacacacgt
     1501 gttgatggct ttttaaatta cgttattgag aatacttaga gggttttttt tggttttgtt
     1561 ttgttttctt ttgttttaaa taaatggcag gtggagaacc ttccagaaaa aaaaaaaaaa
     1621 aaaaaaaaaa aaaa
//
